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Le Touquet – Paris-Plage, France

Guedeney A.,Bichat Hospital | Matthey S.,Liverpool Hospital | Puura K.,University of Tampere
Infant Mental Health Journal

This article reviews the studies using or validating the Alarm Distress Baby Scale (ADBB; A. Guedeney & J. Fermanian,) within different countries, different populations, and different settings. After a brief summary of the theoretical backgrounds of infant social behavior, the results of the main controlled and methodologically comparable studies are summarized and discussed. Second, the results of some observational studies as well as different models of factor analysis are presented. The modified, five-item ADBB (m-ADBB) Scale is described. Finally, perspectives for future research and training are presented. © 2013 Michigan Association for Infant Mental Health. Source

Puymirat E.,University of Paris Descartes | Taldir G.,University of Paris Descartes | Aissaoui N.,University of Paris Descartes | Lemesle G.,Regional and University Hospital of Lille | And 7 more authors.
JACC: Cardiovascular Interventions

Objectives: This study sought to assess the impact of invasive strategy (IS) versus a conservative strategy (CS) on in-hospital complications and 3-year outcomes in patients with non-ST-segment elevation myocardial infarction (NSTEMI) from the FAST-MI (French Registry of Acute Coronary Syndrome). Background: Results from randomized trials comparing IS and CS in patients with NSTEMI are conflicting. Methods: Of the 3,670 patients in FAST-MI, which included patients with acute myocardial infarction (within 48 h) over a 1-month period in France at the end of 2005, 1,645 presented with NSTEMI. Results: Of the 1,645 patients analyzed, 80% had an IS. Patients in the IS group were younger (67 ± 12 years vs. 80 ± 11 years), less often women (29% vs. 51%), and had a lower GRACE (Global Registry of Acute Coronary Events) risk score (137 ± 36 vs. 178 ± 34) than patients treated with CS. In-hospital mortality and blood transfusions were significantly more frequent in patients with CS versus IS (13.1% vs. 2.0%, 9.1% vs. 4.6%). Use of IS was associated with a significant reduction in 3-year mortality and cardiovascular death (17% vs. 60%, adjusted hazard ratio [HR]: 0.44, 95% confidence interval [CI]: 0.35 to 0.55 and 8% vs. 36%, adjusted HR: 0.37, 95% CI: 0.27 to 0.50). After propensity score matching (181 patients per group), 3-year survival was significantly higher in patients treated with IS. Conclusions: In a real-world setting of patients admitted with NSTEMI, the use of IS during the initial hospital stay is an independent predictor of improved 3-year survival, regardless of age. (French Registry of Acute Coronary Syndrome [FAST-MI]; NCT00673036) © 2012 American College of Cardiology Foundation. Source

Fassa A.-A.,Bichat Hospital | Urban P.,La Tour Hospital
Advances in Cardiology

Coronary stents are used during the majority of percutaneous coronary interventions. When compared to medical therapy, they have been shown to decrease mortality for patients with acute coronary syndromes, and to improve symptom control in patients with stable angina. Their use, however, may be complicated by stent thrombosis (ST), a potentially fatal event. Early ST, which occurs during the first month following device implantation, is usually linked to procedural factors, with similar frequencies for bare metal stents and drug-eluting stents (DES). Late and very late (between 1 month and 1 year, respectively, and >1 year after the procedure) ST, which appear to be more frequent with DES, are due to factors such as incomplete stent apposition, delayed or dysfunctional endothelialization, and chronic inflammation. Furthermore, discontinuation of antiplatelet therapy (which includes the association of aspirin and thienopyridines) or resistance to these molecules may also lead to ST. New stent designs as well as the use of more potent antiplatelet therapies should contribute to reducing the incidence of ST in the future. Copyright © 2012 S. Karger AG, Basel. Source

Objective While there is consensus that treatment with disease-modifying antirheumatic drugs (DMARDs) should be started early in patients with inflammatory arthritis, confirmation that radiographic progression is inhibited with early treatment start is scarce. This study was undertaken to compare radiographic progression in patients treated with a DMARD very early in the course of their disease (within 3 months of diagnosis) and those who began DMARD treatment later. Methods Patients included in the French observational ESPOIR (ôtude et Suivi des Polyarthrites Indifférenciées Récentes [Study and Followup of Early Undifferentiated Polyarthritis]) cohort were followed up, and radiographic progression after 12 months was assessed. Propensity scores, reflecting the indication to start a DMARD, were obtained by modeling the start of DMARD therapy by disease-specific and demographic variables obtained at baseline, using logistic regression analysis. The influence of very early versus delayed DMARD start on radiographic progression was evaluated by generalized linear regression, with and without adjustment for propensity scores. Results Six hundred sixty-one patients were analyzed. In an unadjusted analysis, patients starting DMARD therapy within 3 months of diagnosis did not show a significant difference in radiographic progression score as compared to those starting DMARD therapy later (1.2 units versus 1.6 units; P = 0.37). Adjustment for the propensity score revealed a statistically significant difference in mean progression (0.8 units versus 1.7 units; P = 0.033). Analysis by propensity score quintile showed a trend suggesting that early treatment was especially beneficial for patients in the fourth and fifth quintiles (worse prognosis). Conclusion Our findings indicate that among patients with inflammatory arthritis in daily clinical practice, early initiation of DMARD therapy reduces 12-month radiographic progression. This strengthens the current recommendations for very early initiation of specific therapy in patients with early arthritis. Copyright © 2011 by the American College of Rheumatology. Source

Lazennec J.-Y.,La Pitie Salpetriere Hospital | Boyer P.,Bichat Hospital | Gorin M.,Foch Hospital | Catonne Y.,La Pitie Salpetriere Hospital | Rousseau M.A.,La Pitie Salpetriere Hospital
Clinical Orthopaedics and Related Research

Background: Appraisal of the orientation of implants in THA dislocations currently is based on imaging done with the patient in the supine position. However, dislocation occurs in standing or sitting positions. Whether measured anteversion differs in images projected in the position of dislocation is unclear. Questions/purposes: We compared measured acetabular cup orientations on axial CT scans taken with the patient in a supine position with those from CT sections at angles to the sacral slope reflecting standing and sitting positions. Methods: We retrospectively reviewed the radiographs of 328 asymptomatic patients who had THAs. Anatomic acetabular anteversion (AAA) was measured from the plain CT scan (supine position, axial CT sections). The AAA also was measured on reformatted CT scans in which the orientation was adjusted individually to the sacral slope on lateral radiographs with patients in the standing and sitting positions. Results: The mean/(SD) AAA changed from 24.2° (6.9°) in the supine position to 31.7° (5.6°) and 38.8° (5.4°) in simulated standing and sitting positions, respectively. The supine AAA correlated with the standing AAA (r = 0.857) but not with the sitting AAA (r = 0.484). Conclusions: These data suggest measurement of the AAA on a plain CT scan used in current practice is biased. In patients with recurrent posterior dislocation from a sitting position, accounting for the functional variations in measurement of the position of the acetabular cup provides more relevant information regarding component positioning. © The Association of Bone and Joint Surgeons® 2010. Source

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