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Jain S.K.,Guru Ghasidas University | Shukla M.,P.A. College | Shrivastava V.,Bhopal Institute of Technology and Science Pharmacy
Chemical and Pharmaceutical Bulletin

The aim of present study was to prepare and evaluate mouth dissolving tablets of ibuprofen (IBU). Ternary solid dispersion (SD) of IBU was prepared using PEG 4000 as carrier and Tween 80 as surfactant. The SD formulations were prepared by solvent evaporation and melt solvent method by varying ratio of PEG 4000. Different weight ratio of carrier, drug and surfactant 5:5:1, 10:5:1, 25:5:1, 35:5:1 and 45:5:1 was taken. The prepared SD formulations were characterized by Fourier Transform Infra-Red (FT-IR) spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD) and in vitro drug release. Mouth dissolving tablets of IBU were formulated using optimized SD formulation of carrier : drug : surfactant ratio, 10:5:1 along with superdisintegrants. The best developed formulation was compared with marketed tablet product of IBU. From IR and XRD studies, it may be concluded that there is change in crystalline form of drug into amorphous during formation of SD. From DSC studies, it was predicted that drug was completely dissolved in the carrier. Mouth dissolving tablets containing Ac-Di-Sol (12%) as super-disintegrant showed the fastest disintegration (202s) and in vitro drug release (84.57%). The release pattern of all developed formulations followed Peppas-Korsmeyer model as the plot between log cumulative % drug released versus log time showed good linearity (r>0.99) with a comparatively high slope (n) value within the range of 0.44-0.67. The tablets containing SD exhibited better dissolution profile than commercial tablets. © 2010 Pharmaceutical Society of Japan. Source

Gupta N.,Bhopal Institute of Technology and Science Pharmacy | Jain U.K.,Bhopal Institute of Technology and Science Pharmacy
Research Journal of Pharmacy and Technology

Wound a clinical entity is as old as mankind, often possesses problems in clinical practice. Naturally the investigative curiosity to promote the healing continues since ages. A lot of research has been envisaged to develop the better healing agents and it has been a challenging task to generate them and keep up the pace with problems encountered. Several drugs of plant, mineral, and animal origin are described in the Ayurveda for their wound healing properties. Most of these drugs are derived from plant origin. Some of these plants have been screened scientifically for the evaluation of their wound healing activity in different pharmacological models. Some Ayurvedic medicinal plants namely, Argemone mexicana, Boerhaavia diffusa, Catharanthus roseas, Diospyros cardifolia, Eclipta alba, Ficus religiosa, Hypericum perforatum, Lawsonia inermis, Merremia tridentate, and Swertia chirata, were found to be effective in experimental models. The rapidity of wound healing depends to a considerable extent on the contraction that begins a few days after injury and continues for a several weeks. In the present review attempts are made to understand various aspects of wound healing in terms of percentage closure of wound, period of complete epithelialization, tensile strength, histopathology, weight of granuloma in different wound models. © RJPT All right reserved. Source

Gupta V.,Bhopal Institute of Technology and Science Pharmacy | Jain U.K.,Bhopal Institute of Technology and Science Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences

Ajmodadi churna (AJC) is an Ayurvedic formulation containing Piper species (Piper longum in both form root and fruit and Piper nigrum) as main ingredients. It is a traditional Ayurvedic oral Herbal formulation, available as a popular proprietary, from most manufacturers of ayurvedic drugs. A selective, precise and accurate High Performance Thin Layer Chromatography (HPTLC) method has been developed for the simultaneous quantification of Piperine in Ajmodadi churna as well as its bulk drug. The method employed TLC aluminum plate precoated with silica gel 60 F254 as a stationary phase. The solvent system consists of Toluene: Ethyl acetate( 7 : 3 % v/v). This system was found to give compact spot for Piperine. Densiometric analysis was carried out in the absorbance mode at 254 nm. The linear regression analysis data for the calibration plot showed good linear relation with r2 = 0.992 and with respect to peak area for Piperine, in concentration range 0.5-20 μg/spot. The method was validated for precision (0.173), recovery (99.43%), Limit of Detection (0.063mg/ml) and Limit of Quantification (0.071mg/ml). The proposed HPTLC method can be used for the quality control of the raw materials as well as formulations. Piperine in Piper longum and Piper nigrum are reported to be the active components in the formulation AJC and can be considered as marker compounds. Therefore, HPTLC method has been developed for the estimation of these marker compounds 11, and also to develop finger print profile for the standard formulation of Ajmodadi churna so that these parameters can be compared with any marketed formulation for evaluating its purity and quality. The proposed method has been validated as per ICH guidelines.12-13 © 2010 RJPBCS. Source

Gupta N.,Bhopal Institute of Technology and Science Pharmacy | Jain U.K.,Bhopal Institute of Technology and Science Pharmacy
African Journal of Traditional, Complementary and Alternative Medicines

The present study was aimed to evaluate the wound healing activity of extract of bark part of Mimusops elengi. It is well-known plant in Indian traditional medicines. On the basis of traditional use and literature references, this plant was selected for wound healing potential. A methanolic extract of bark parts of Mimusops elengi was examined for wound healing activity in the form of ointment in three types of wound models on mice: the excision, the incision and dead space wound model. The extract ointments showed considerable response in all the above said wound models as comparable to those of a standard drug Betadine ointment in terms of wound contracting ability, wound closure time, tensile strength and dry granuloma weight. Histological analysis was also consistent with the proposal that Mimusops elengi bark extract exhibits significant wound healing. Source

Shrivastava V.,Bhopal Institute of Technology and Science Pharmacy | Shrivastava V.,University of Hyderabad | Jain U.K.,Bhopal Institute of Technology and Science Pharmacy
Biosciences Biotechnology Research Asia

The study reports on the development of a novel hepatitis b vaccine prepared by physically mixing smaller microparticles (8-12 μm; blend PCL-PLGA; containing equivalent to 10μg HBsAg) with larger microparticles (12-20 μm; blend PCL-PLA; entrapping 10μg HBsAg). The vaccine was reconstituted with alum adsorbed HBsAg (equivalent to 10μg HBsAg) and was injected in BALB/c mice subcutaneously as single dose (Total 30 μg HBsAg). The generated immune responses in mice was investigated by Enzyme Linked Immunosorbate Assay (ELISA) technique and was compared with the response generated with alum based vaccine (control group) injected three times at 0, 4, 24 weeks in mice (Total 30 μg HBsAg). The peak antibody titer (4.6491 ± 1.20) generated by vaccine formulation (test group) after single injection were comparable to the control group (4.9099 ± 0.78). The titers sustained in both test & Control groups during 25 week study period. However, at the end of 25th week the titers were slightly higher for control group. The study has shown the feasibility of blend polymeric microparticles as vaccine carrier. Source

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