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Hyderabad, India

Mohan Goud V.,Joginpally Br Pharmacy College | Rao A.S.,Bhaskar Pharmacy College
Der Pharma Chemica | Year: 2011

The present work is carried out for the synthesis of benzimidazole derivatives with well established procedures. A new series of benzimidazole derivatives were synthesized and the structures of these compounds were confirmed by IR, HNMR and Mass Spectroscopy. The title compounds were screened for analgesic and anti inflammatory activities by biological evaluation method and also for other possible pharmacological activities including antibacterial activity. Among the synthesized compounds, some have shown promisingly significant analgesic, anti-inflammatory activites and moderate antibacterial activity. Source

Cherukuvada S.,University of Hyderabad | Bolla G.,University of Hyderabad | Sikligar K.,University of Hyderabad | Sikligar K.,Bhaskar Pharmacy College | Nangia A.,University of Hyderabad
Crystal Growth and Design | Year: 2013

4-Aminosalicylic acid (p-aminosalicylic acid, PAS), an antituberculosis drug, is a model active pharmaceutical ingredient to study salt and cocrystal formation in a multiple hydrogen-bonding functionality molecule with carboxylic acid, amine, and phenol groups. A cytosine salt CYT+-PAS-, salt cocrystal hydrate CYT+-PAS--CYT-H2O, and nicotinamide cocrystal hydrate PAS-NAM-H2O, are described in this article. Furthermore, X-ray crystal structures of PAS sodium dihydrate, sulfate, and mesylate salts and dehydration/rehydration behavior of the sodium salt by powder X-ray diffraction are discussed. © 2013 American Chemical Society. Source

Vishnu Priya P.,Joginpally Br Pharmacy College | Srinivasa Rao A.,Bhaskar Pharmacy College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Objective: Evaluation of anticancer activity of various extracts of leaves of Tridax procumbens by 3-(4,5-dimethyl-thiazole-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, and trypan blue dye exclusion assay against A549 (human lung cancer cell line), Hep G2 (human liver carcinoma cell line). Methods: In vitro anticancer activity of ethanol, acetone, and aqueous leaf extracts of T. procumbens was evaluated on selected cancerous cells lines by MTT assay and trypan blue dye exclusion assay. MTT assay is based on the capacity of mitochondrial enzymes of viable cells to reduce the yellow soluble salt MTT to purple blue insoluble formazan precipitate which is then quantified spectrophotometrically at 570 nm. Trypan blue assay is based on staining of cells. Cells are then counted using hemocytometer under the microscope, non-viable cells were stained blue, viable cells remain unstained. Results: The aqueous leaf extract of T. procumbens has not shown any anticancer activity. However, potent anticancer activity was shown by the acetone and ethanol leaf extracts of T. procumbens on A549 (human lung cancer cell line), Hep G2 (human liver carcinoma cell line). Conclusion: The anticancer medicinal plant i.e., T. procumbens was studied by in vitro evaluation methods i.e., MTT assay and trypan blue exclusion assay. The acetone and ethanol leaf extract of T. procumbens have shown potent anticancer activity on selected cancerous cell lines. More efforts are needed to explore potent anticancer plants from the mother earth and save humans around the world from cancer. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved. Source

Srinivasa Rao A.,Bhaskar Pharmacy College | Ahmed M.F.,Nizam Institute of Pharmacy and Research Center | Ibrahim M.,Nizam Institute of Pharmacy and Research Center
Journal of Applied Pharmaceutical Science | Year: 2012

The aim of the study is to investigate the hepatoprotective activity of Melia azedarach L leaves extracts against simvastatin induced hepatotoxicity. The phytochemical screening was carried on the leaves extracts of Melia azedarach revealed the presence of some active ingredients such as Alkaloids, Tannins, Sponginess, Phenols, glycosides, steroids, terpenoids and flavonoids. Leaves of Melia azedarach was successively extracted with ethanol against simvastatin (20mg/kg.p.o) induced hepatotoxicity using Standard drug Silymarin (25 mg/kg). There was a significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP),serum bilirubin and decrease the total proteins content.) in simvastatin treated rats, which were restored towards normalization in Melia azedarach (300 mg/kg and 500 mg/kg) treated animals. Thus the present study ascertains that the leaf extract of Melia azedarach possesses significant hepatoprotective activity. Source

Abhimanyu K.K.,Jawaharlal Nehru Technological University | Avanapu R.S.,Bhaskar Pharmacy College
International Journal of Pharma and Bio Sciences | Year: 2015

Putranjiva roxburghii Wall (syn. Drypetes roxburghii Wall.) of Euphorbiaceae family is an evergreen tree of tropical region often cultivated as avenue tree along the road side. The Objective of the study was to develop various standardization parameters for the evaluation of trunk bark science it is largely used to cure certain ailments. Morphology, histology, powder characteristics and Scanning Electron Microscopy (SEM) of bark were observed and results were recorded. Physico-chemical parameters such as total ash value (13.5%) w/w, moisture content (6%) w/w, foaming index (less than 100), total tannin content (5% w/w), Crude fibres residue ( 32%) w/w, Fluorescence analysis, extractive value includes pet ether soluble extractive value (3.45%), ethanol (3.90%), ethyl acetate(5.14%) and aqueous extract(3.5%) w/w were analysed by chemical test and shows presence of saponins, tannins, steroids, triterpenoids. So these parameters are usefull in the authentication of Putranjiva roxburghii Wall. However the phytochemical analysis of bark of Putranjiva roxburghii in the present work is first of its kind used for the pharmacognostic and phytochemical evaluation. Source

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