Bharati Vidyapeeth Dental College and Hospital

Navi Mumbai, India

Bharati Vidyapeeth Dental College and Hospital

Navi Mumbai, India
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Kukreja I.,Bharati Vidyapeeth Dental College and Hospital | Deshmukh R.,Bharati Vidyapeeth Dental College and Hospital | Kulkarni V.,Bharati Vidyapeeth Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2013

Background: Angiogenesis is the formation of new vessels from preexisting ones which takes place by capillary sprouting. It is seen in healing, at sites of injury and collateral circulation in ischemia. It is also seen in tumors, as once the original blood supply of a tumor is exhausted it cannot grow without further blood supply. Also as the angiogenic capacity of a tumor increases, its microvasculature, that is, microvessel density (MVD) also increases. Based on this literary evidence we carried out an immunohistochemical (IHC) study to observe the relationship between the expression of vascular endothelial growth factor (VEGF) [angiogenesis] and CD 34 [MVD] in oral squamous cell carcinoma (OSCC). Aim: To evaluate the correlation between expression of VEGF and CD 34, the role of MVD in progression of OSCC and to compare the degree of angiogenesis in different grades of OSCC. Settings and Design: In this study we observed the relation between angiogenesis and MVD and the overall effect of this on oral cancer. Materials and Methods: Thirty-three cases of OSCC were stained with hematoxylin and eosin, (H and E) to confirm the diagnosis and immunohistochemically using VEGF and CD 34 antibody. The slides were evaluated for positivity and intensity of staining. Statistical Analysis: The result was subjected to statistical analysis using analysis of variance (ANOVA) test and Fisher's exact test. Results: VEGF positivity as well as MVD was found to be independent of the grade of the tumor. Tumor MVD was found to be independent of expression of VEGF.

Kale M.V.,Sinhagad Dental College and Hospital | Gadre K.S.,Bharati Vidyapeeth Dental College and Hospital | Kulkarni A.U.,Sinhagad Dental College and Hospital
BMJ Case Reports | Year: 2012

A rare case of progressive osteolysis of mandible is discussed with clinicoradiological presentation. The purpose of the case report is to make the medical community aware of this rare and fascinating disorder in the maxillofacial region. The disease is characterised by spontaneous progressive osteolysis of one or more skeletal bones. Occurrence in maxillofacial region is rare with fewer than 35 reported cases affecting the facial and jaw bones. The present case report is about the mystery of bilaterally missing ascending rami. An attempt is made to draw attention of the medical fraternity to this unusual and rare entity which can induce instability, dysfunction and cosmetic disturbances. Copyright 2012 BMJ Publishing Group. All rights reserved.

Vibhute N.A.,Deemed University | Vibhute A.H.,Bharati Vidyapeeth Dental College and Hospital | Daule N.R.,Saraswati Dhanwantari Dental College and Hospital
Indian Journal of Dermatology | Year: 2013

Cheilitis granulomatosa (CG) is a chronic swelling of the lip due to granulomatous inflammation. It is a rare inflammatory disorder first described by Miescher in 1945. It is a monosymptomatic form or an incomplete variant of Melkersson-Rosenthal syndrome; a triad of recurrent orofacial edema, recurrent facial nerve palsy and fissuring of the tongue. As the etiology remains unknown, treatment of CG is challenging. We present a case of CG in a 43-year-old female patient secondary to allergy to certain food items. The present case highlights the importance of thorough investigations in the diagnosis of this lesion as the findings mimic many other granulomatous conditions. © Indian Journal of Dermatology 2013.

PubMed | Dasmesh Institute of Research and Dental science and Bharati Vidyapeeth Dental College and Hospital
Type: Journal Article | Journal: Indian journal of dentistry | Year: 2016

To investigate the efficacy of 0.1% tacrolimus with Colgate Oraguard-B paste for the treatment of patients with oral lichen planus (OLP).One hundred and fifty patients with symptomatic OLP participated in the study, who had clinically and histopathologically proven OLP. In this study, patients were provided with 0.1% tacrolimus ointment with Colgate Oraguard-B paste as the study medication. Patients were asked to use the medication over the areas three times a day until resolution of the lesion. Patients were recalled to assess the drug response every 15 days. The duration of treatment ranged from 3 months to 4 months, with follow-up of 2 years and 6 months.The Wilcoxon signed-rank test was performed, which is a nonparametric statistical hypothesis test for comparing two related samples, matched samples or repeated measurements on a single sample to assess whether their population mean ranks differ (i.e., it is a paired difference test). In our study, the pre- and post-Visual Analogue Scale (VAS) values were compared and the mean, standard deviation and P values were calculated.Of 150 patients, 71 (47.33%) patients had complete resolution of the lesion to the topical tacrolimus therapy. Sixty-five (43.33%) patients had marked resolution of their lesions, i.e., the size of the lesion was decreased. Fourteen (9.33%) patients had remission of lesion (reduction in burning sensation and size of lesion) in symptoms as recorded by the VAS.Topical tacrolimus ointment 0.1% in Oraguard-B paste is an effective treatment for different types of OLP.

Kapoor P.,P.A. College | Deshmukh R.S.,Bharati Vidyapeeth Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2012

Background: Tumors require blood supply for their growth and dissemination. It is a well accepted paradigm that tumors recruit new blood vessels from the existing circulation (angiogenesis) and this participates in tumor invasion and metastasis. Studies in the literature provide evidence for expression of Vascular Endothelial Growth Factor (VEGF) by the tumor for neo-angiogenesis, which is not only required for the tumor growth but also its metastasis. Based on the literary evidences we carried out an Immuno-Histochemical (IHC) study for VEGF in Oral Squamous Cell Carcinoma (OSCC) tissues to provide a strong link between the factor and oral cancer. Aim: To analyze the expression of VEGF in OSCC tissues of different histological grades, clinical sizes and lymph node status and to use this as an indicator for disease progression by helping in delineating a risk population, that may benefit from an attractive adjuvant therapeutic strategy for OSCC. Settings and Design: Studies published from 1990 till 2010 have only seen the association of VEGF with tumor angiogenesis and its possible role in metastasis. This is the first study that takes into account the clinical status of the lymph nodes and VEGF expressivity in a sample size of 30 cases. Materials and Methods: 30 oral squamous cell carcinoma tissue slides were stained using Hematoxylin and Eosin stain (to confirm the diagnosis) and immunohistochemically using VEGF antibody. IHC stained slides were thereafter evaluated for the positivity and intensity. Statistical Analysis: The result was subjected to statistical analysis using Chi-square test. Results and Conclusion: VEGF positivity was seen in approximately. 90% of cases which was independent of histological grade of OSCC. However the intensity increased with the clinical size of cancer and from palpable lymph node to a tender and hard lymph node.

Kango P.G.,Bharati Vidyapeeth Dental College and Hospital | Deshmukh R.S.,Bharati Vidyapeeth Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2011

Background: Research in oral and maxillofacial pathology has unlimited potential. We use every technology available to us for better and faster reliable diagnosis. But in most institutions, private laboratories and multispecialty hospitals, tissue processing takes considerable time, and therefore delays the diagnosis, which is required in urgent cases. We, in this institution, conducted a study to hasten the processing by using a simple kitchen microwave. Aim: To analyze tissue sections processed by microwave as compared to the gold standard of conventional processing. Settings and design: Studies published from 1970 till 2008, used body tissues such as brain, liver, kidney, heart, and lungs, for microwave processing. Oral tissues were not processed in microwave till now, except one study by Dr Shivaparthasundaram et al., in 2008. This is the second such study that used a sample size of 50 cases. Materials and Methods: A kitchen microwave was used for irradiation of the tissues. Conventional processing was carried out as per departmental protocol. A total of 50 microwave-coded slides were mixed with 50 conventional slides. All 100 slides were evaluated by four different pathologists. Statistical analysis: The result was subjected to statistical analysis using Chi-square test. Result and Conclusion: It was found that to make a diagnosis, microwave-processed tissue were at par with the conventional technique. Thus, it is time to move on from conventional processing to microwave processing to yield faster and reliable results.

Hegde R.J.,Bharati Vidyapeeth Dental College and Hospital | Khare S.S.,Bharati Vidyapeeth Dental College and Hospital | Devrukhkar V.N.,Bharati Vidyapeeth Dental College and Hospital
Journal of Indian Society of Pedodontics and Preventive Dentistry | Year: 2013

A dentigerous cyst or follicular cyst is an odontogenic cyst - thought to be of developmental origin - associated with the crown of an unerupted tooth. Such cyst remain initially completely asymptomatic unless when infected. The purpose of this case report was to describe the diagnosis and management of dentigerous cyst in a 9-year-old boy. The chosen treatment was cyst enucleation and tooth extraction.

PubMed | Bharati Vidyapeeth Dental College and Hospital
Type: | Journal: The Journal of craniofacial surgery | Year: 2016

Pierre Robin sequence (formerly a syndrome) is named after the French stomatologist who, in 1923 and 1934, described the problems associated with micrognathia in newborn. It comprises mandibular micrognathia, U-shaped cleft palate, and glossoptosis. The typical symptoms are hypoxaemia, noisy breathing, snoring, stridor, cyanosis, bradycardia, feeding difficulties, and failure to thrive. Distraction osteogenesis has recently been considered as a surgical option for early intervention to lengthen the mandible and relieve respiratory problems. Piezosurgery offers a modality to make precise bone cuts preserving vital structures, minimizing the invasiveness of the surgical procedure, and offering bloodless field. We present case of 1-year-old male malnourished child with Pierre Robin sequence and tracheostomy in situ since day 11 of his birth. The staged treatment plan involving mandibular lengthening in which mandibular osteotomies were performed with the piezoelectric scalpel followed by decannulation of tracheostomy, which has been described in detail in this article.

PubMed | Bharati Vidyapeeth Dental College and Hospital
Type: Journal Article | Journal: International journal of clinical pediatric dentistry | Year: 2017

Dental caries pose distinct challenges when it comes to determining their microbial etymology. To assess whether infants born through cesarean section delivery or infants born through normal delivery influence the initial acquisition of S. The study was carried out on the premises of Bharati Hospital, Pune, wherein 40 infants (3-36 months) were enrolled for the study. Two groups were designed. Bacterial swab sampling was done in the participants for the detection of S. Bar diagram analysis and chi-square test were performed to derive p-value.The p value derived at the end of the study was 0.52. Hence, analysis of data demonstrates no significant influence of cesarean section delivery and normal delivery on oral microbiota development in infants.Initial acquisition of oral S. Initial acquisition of S. Ubeja RG, Bhat C. Mode of Delivery and Its Influence on the Acquisition of

PubMed | Bharati Vidyapeeth Dental College and Hospital
Type: Journal Article | Journal: Journal of Indian Prosthodontic Society | Year: 2016

Implant stability plays a critical role for successful osseointegration. Successful osseointegration is a prerequisite for functional dental implants. Continuous monitoring in an objective and qualitative manner is important to determine the status of implant stability. Implant stability is measured at two different stages: Primary and secondary. Primary stability comes from mechanical engagement with cortical bone. Secondary stability is developed from regeneration and remodeling of the bone and tissue around the implant after insertion and affected by the primary stability, bone formation and remodelling. The time of functional loading is dependent upon the implant stability. Historically the gold standard method to evaluate stability were microscopic or histologic analysis, radiographs, however due to invasiveness of these methods and related ethical issues various other methods have been proposed like cutting torque resistance, reverse torque analysis, model analysis etc. It is, therefore, of an utmost importance to be able to access implant stability at various time points and to project a long term prognosis for successful therapy. Therefore this review focuses on the currently available methods for evaluation of implant stability.

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