Tiruchirappalli, India

Bharathidasan University

Tiruchirappalli, India

Bharathidasan University is a university in the city of Tiruchirapalli, Tamil Nadu state, India. It has affiliated colleges in districts of the state, including Nagapattinam, Perambalur, Pudukkottai, Thanjavur, Tiruvarur and Tiruchirapalli. It is a recognised university, supported by the University Grants Commission of India. All major faculties of science and arts are represented. Wikipedia.

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Aseervatham G.S.,Bharathidasan University
Environmental science and pollution research international | Year: 2013

Oxygen is the most essential molecule for life; since it is a strong oxidizing agent, it can aggravate the damage within the cell by a series of oxidative events including the generation of free radicals. Antioxidative agents are the only defense mechanism to neutralize these free radicals. Free radicals are not only generated internally in our body system but also trough external sources like environmental pollution, toxic metals, cigarette smoke, pesticides, etc., which add damage to our body system. Inhaling these toxic chemicals in the environment has become unavoidable in modern civilization. Antioxidants of plant origin with free radical scavenging properties could have great importance as therapeutic agents in several diseases caused by environmental pollution. This review summarizes the generation of reactive oxygen species and damage to cells by exposure to external factors, unhealthy lifestyle, and role of herbal plants in scavenging these reactive oxygen species.

Lakshmanan M.,Bharathidasan University
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2011

The Landau-Lifshitz-Gilbert (LLG) equation is a fascinating nonlinear evolution equation both from mathematical and physical points of view. It is related to the dynamics of several important physical systems such as ferromagnets, vortex filaments, moving space curves, etc. and has intimate connections with many of the well-known integrable soliton equations, including nonlinear Schrödinger and sine-Gordon equations. It can admit very many dynamical structures including spin waves, elliptic function waves, solitons, dromions, vortices, spatio-temporal patterns, chaos, etc. depending on the physical and spin dimensions and the nature of interactions. An exciting recent development is that the spin torque effect in nanoferromagnets is described by a generalization of the LLG equation that forms a basic dynamical equation in the field of spintronics. This article will briefly review these developments as a tribute to Robin Bullough who was a great admirer of the LLG equation. © 2011 The Royal Society.

Radhakrishnan R.,Bharathidasan University
Plant physiology and biochemistry : PPB / Société française de physiologie végétale | Year: 2012

The possible involvement of pulsed magnetic field (PMF) pretreatment in development and yield of soybean was investigated. Seeds were subjected to 20 days with 1500 nT at 10.0 Hz of PMF for 5 h per day. PMF pretreatment increased the plant height, fresh and dry weight, and protein content with the changes of protein profile in 8 days old seedlings. In addition, activity of enzymes such as β-amylase, acid phosphatase, polyphenol oxidase and catalase was enhanced while α-amylase, alkaline phosphatase, protease and nitrate reductase activities declined due to PMF exposure. However, a considerable increment of Fe, Cu, Mn, Zn, Mg, K and Na contents with reduced level of Ca was found in PMF treated seedlings. The number of leaves, pods, seeds and length of pods, and weight of seeds were also remarkably higher in PMF treatment in contrast to controls. The results suggest that pretreatment of PMF plays important roles in improvement of crop productivity of soybean through the enhancement of protein, mineral accumulation and enzyme activities which leads to increase the growth and yield. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Sathishkannan G.,Bharathidasan University | Srinivasan K.,Bharathidasan University
Advanced Synthesis and Catalysis | Year: 2014

trans-2-Aroyl-3-arylcyclopropane-1,1-dicarboxylates upon treatment with aluminium(III) chloride (AlCl3) underwent ring-opening, fragmentation, recombination and lactonization to give highly substituted 2-pyrones. Alternatively, when treated with titanium(IV) chloride (TiCl 4), the cyclopropane diesters underwent a Nazarov cyclization to afford 1-indanones with high diastereoselectivity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Sathishkannan G.,Bharathidasan University | Srinivasan K.,Bharathidasan University
Organic Letters | Year: 2011

Activated donor-acceptor cyclopropanes underwent formal [3 + 2] cycloaddition with nitriles in the presence of SnCl4. The product 1-pyrrolines were isolated as single cis-diastereomers in moderate to good yields. © 2011 American Chemical Society.

Selvi T.,Bharathidasan University | Srinivasan K.,Bharathidasan University
Chemical Communications | Year: 2014

trans-2-Aryl-3-nitro-cyclopropane-1,1-dicarboxylates when reacted with nitriles in the presence of tin(iv) chloride afford 2,4,5-trisubstituted oxazoles in good to excellent yields. The reactions take place through in situ generation of aroylmethylidene malonates from the cyclopropanes, followed by conjugate addition of nitriles to the malonates to form nitrilium ion intermediates and subsequent cyclisation. © the Partner Organisations 2014.

Sathishkannan G.,Bharathidasan University | Srinivasan K.,Bharathidasan University
Chemical Communications | Year: 2014

A conceptually new method for synthesis of tetrasubstituted thiophenes in two steps from trans-2-aroyl-3-aryl-cyclopropane-1,1-dicarboxylates and 1,4-dithiane-2,5-diol has been developed. It involves AlCl3-mediated [3+3] annulation of the cyclopropane-derived 1,3-zwitterionic intermediates with in situ generated mercaptoacetaldehyde, followed by DBU-induced rearrangement of the resulting tetrahydrothiopyranols. The target thiophenes are produced in 55-82% yields. This journal is © the Partner Organisations 2014.

Muthusamy S.,Bharathidasan University | Sivaguru M.,Bharathidasan University
Organic Letters | Year: 2014

A facile synthesis of highly substituted as well as conjugated indene/furanone systems via a BF3·OEt2 catalyzed tandem reaction of α-diazo-esters/-amides and propargyl alcohols has been demonstrated under mild conditions. This method offers great potential for the synthesis of biologically active indene and furanone derivatives and their related polycyclic compounds. © 2014 American Chemical Society.

In diabetes mellitus (DM), sustained hyperglycemia results in the generation of reactive oxygen species, ultimately leading to increased oxidative stress and inflammation in vital tissues. In the present study, possible ameliorative effects of naringenin on hyperglycemia-mediated inflammation in experimental streptozocin (STZ)-nicotinamide-induced DM were sought. DM was induced experimentally in overnight-fasted Wistar rats (150-180 g) by intra-peritoneal injection of STZ (50 mg/kg.b.w) and of nicotinamide (110 mg/kg.b.w); control rats (n = 6) received only vehicle (0.5 ml of 0.1 M of cold citrate buffer; pH 4.5). One group of diabetic rats (n = 6) was left untreated while another group of diabetic rats (n = 6) received naringenin (50 mg/kg b.w./day) orally for 21 days. At this time, hemotological indices (erythrocyte sedimentation rate [ESR], total white blood cell [WBC] count, differential WBC percentage, and platelet count) were measured. Significant alterations in expression of gene and protein biomarkers of inflammation in hepatic and pancreatic tissues were determined by measuring mRNA levels and the level of protein expressed, respectively, as was the total nitric oxide level in these tissues. Diabetic rats showed significantly higher mean ESR values, total WBC counts, differential WBC percentages, and platelet counts than those in control rats; similarly, mean mRNA levels of C-reactive protein, pro-inflammatory cytokine, nuclear factor-κB and inducible nitric oxide synthase genes and mean intensities of expression of the corresponding proteins in the hepatic and pancreatic tissue samples from diabetic rats significantly exceeded those in control rats. However, in diabetic rats treated with naringenin, the values of hematological, mRNA transcript and protein indices of inflammation were all lower than those in diabetic rats. These results suggest that naringenin possibly alleviates hyperglycemia-mediated inflammation in experimental STZ-nicotinamide-induced DM in Wistar rats.

Ilangovan A.,Bharathidasan University | Satish G.,Bharathidasan University
Organic Letters | Year: 2013

Isatins were obtained by cross-dehydrogenative C-N annulation and dealkylative C-N annulation of 2′-N-aryl/alkylaminoacetophenones and 2′-N,N-dialkylaminoacetophenones respectively in the presence of Cu(OAc)2·H2O/NaOAc/air. However, on reaction with CuBr, 2′-N-benzylaminoacetophenones underwent selective oxidation of an α-methylene group of amine rather than the 2-acetyl group to provide corresponding benzamides exclusively. Base played an important role in selective oxidation by lowering the temperature and time. © 2013 American Chemical Society.

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