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Coimbatore, India

Bharathiar University is a state university in Coimbatore, Tamil Nadu, South India. Named after Tamil poet Subramania Bharathiar, the university was established in February 1982 under the provision of Bharathiar University Act, 1981 and was recognized by the University Grants Commission in 1985.The university is in the foothills of Marudamalai road, Coimbatore and has jurisdiction over the districts of Coimbatore, Erode and the Nilgiris. It has 104 affiliated institutions .Bharathiar University celebrated silver jubilee celebrations on 24 February 2007. The then president of India, A. P. J. Abdul Kalam, and the then chief minister of Tamil Nadu, Karunanidhi, were chief guests. Wikipedia.

Boopathi S.,Bharathiar University
Journal of molecular modeling

Alzheimer's disease (AD) is a neurodegenerative disorder that occurs due to progressive deposition of amyloid β-protein (Aβ) in the brain. Stable conformations of solvated Aβ1-42 protein were predicted by molecular dynamics (MD) simulation using the OPLSAA force field. The seven residue peptide (Lys-Leu-Val-Phe-Phe-Ala-Glu) Aβ16-22 associated with AD was studied and reported in this paper. Since effective therapeutic agents have not yet been studied in detail, attention has focused on the use of natural products as effective anti-aggregation compounds, targeting the Aβ1-42 protein directly. Experimental and theoretical investigation suggests that some compounds extracted from natural products might be useful, but detailed insights into the mechanism by which they might act remains elusive. The molecules nicotine and morin are found in cigarettes and beverages. Here, we report the results of interaction studies of these compounds at each hydrophobic residue of Aβ16-22 peptide using the hybrid ONIOM (B3LYP/6-31G**:UFF) method. It was found that interaction with nicotine produced higher deformation in the Aβ16-22 peptide than interaction with morin. MD simulation studies revealed that interaction of the nicotine molecule with the β-sheet of Aβ16-22 peptide transforms the β-sheet to an α-helical structure, which helps prohibit the aggregation of Aβ-protein. Source

Karunamoorthi K.,Jimma University | Karunamoorthi K.,Bharathiar University
Clinical Microbiology and Infection

Over many decades, malaria elimination has been considered to be one of the most ambitious goals of the international community. Vector control is a cornerstone in malaria control, owing to the lack of reliable vaccines, the emergence of drug resistance, and unaffordable potent antimalarials. In the recent past, a few countries have achieved malaria elimination by employing existing front-line vector control interventions and active case management. However, many challenges lie ahead on the long road to meaningful accomplishment, and the following issues must therefore be adequately addressed in malaria-prone settings in order to achieve our target of 100% worldwide malaria elimination and eventual eradication: (i) consistent administration of integrated vector management; (ii) identification of innovative user and environment-friendly alternative technologies and delivery systems; (iii) exploration and development of novel and powerful contextual community-based interventions; and (iv) improvement of the efficiency and efficacy of existing interventions and their combinations, such as vector control, diagnosis, treatment, vaccines, biological control of vectors, environmental management, and surveillance. I strongly believe that we are moving in the right direction, along with partnership-wide support, towards the enviable milestone of malaria elimination by employing vector control as a potential tool. © 2011 The Author. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases. Source

Sujitha M.V.,Bharathiar University | Kannan S.,Bharathiar University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

This study reports the biological synthesis of gold nanoparticles by the reduction of HAuCl4 by using citrus fruits (Citrus limon, Citrus reticulata and Citrus sinensis) juice extract as the reducing and stabilizing agent. A various shape and size of gold nanoparticles were formed when the ratio of the reactants were altered with respect to 1.0 mM chloroauric acid solution. The gold nanoparticles obtained were characterized by UV-visible spectra, transmission electron microscopy (TEM) and X-ray diffraction (XRD). TEM studies showed the particles to be of various shapes and sizes and particle size ranges from 15 to 80 nm. Selected-area electron diffraction (SAED) pattern confirmed fcc phase and crystallinity of the particles. The X-ray diffraction analysis revealed the distinctive facets (1 1 1, 2 0 0, 2 2 0 and 2 2 2 planes) of gold nanoparticles. Dynamic light scattering (DLS) studies revealed that the average size for colloid gp3 of C. limon, C. reticulata and C. sinensis are 32.2 nm, 43.4 nm and 56.7 nm respectively. The DLS graph showed that the particles size was larger and more polydispersed compared to the one observed by TEM due to the fact that the measured size also includes the bio-organic compounds enveloping the core of the Au NPs. Zeta potential value for gold nanoparticles obtained from colloid gp3 of C. limon, C. reticulata and C. sinensis are -45.9, -37.9 and -31.4 respectively indicating the stability of the synthesized nanoparticles. Herein we propose a novel, previously unexploited method for the biological syntheses of polymorphic gold nanoparticles with potent biological applications. © 2012 Elsevier B.V. All rights reserved. Source

A modest, cost effective and eco-friendly method is employed for the preparation of MnFe2O4 nanocube decorated, flexible graphene sheets, followed by polyaniline (PANI) which is wrapped by an in situ chemical oxidative polymerization method. The formation of the hybrid composites and their individual constituents are realized through X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR) and Raman spectroscopy. The MnFe2O4 nanocube decorated flexible graphene and PANI wrapped composite is visualised through transmission electron microscopic (TEM) images. The decorated MnFe2O4 particles have sizes in the range of 75-100 nm. The capacitive properties of the ternary composite is investigated and it has the obtained specific capacitance of 338 F g -1 at 0.5 mA cm-2 in 1 M NaCl aqueous electrolyte, which is 10 times greater than the pristine MnFe2O4 (32 F g -1). Similarly, the fabricated hybrid supercapacitor (MGPAC) provides the specific capacitance of about 51.87 F g-1 at 5 mV s-1 and its energy density is 10.25 W h kg-1 at 10 mA cm-2. Thus the obtained significant properties of the ternary composite are due to the distinctive characteristics of the individual constituents which leads to enhanced electrochemical properties like reducing the internal resistance and diffusion path length via the synergistic effect. This journal is © the Partner Organisations 2014. Source

Alagesan M.,Bharathiar University | Bhuvanesh N.S.P.,Texas A&M University | Dharmaraj N.,Bharathiar University
Dalton Transactions

A new set of penta-coordinated copper(ii) hydrazone complexes containing solvated methanol were synthesized by reacting the hydrazone ligands, 2-acetylpyridine benzoyl hydrazone (HL1) and 2-acetylpyridine thiophene-2-carboxylic acid hydrazone (HL2), with [CuCl2(DMSO) 2] and characterized by different spectral methods. Single crystal X-ray diffraction studies of the complexes revealed that both of them, [CuCl(L1)(MeOH)] (1) and [CuCl(L2)(MeOH)] (2), have square pyramidal geometry around the cupric ion, in which the hydrazone is coordinated through NNO atoms along with a molecule of methanol in the apical position. Interaction of the ligands HL1 and HL2 along with the corresponding copper complexes 1 and 2 with calf thymus DNA (CT-DNA) has been estimated by absorption and emission titration methods which revealed that the compounds interacted with CT-DNA through intercalation. Binding of the compounds, i.e., free ligands and complexes (1) and (2) with bovine serum albumin (BSA) protein investigated using UV-visible, fluorescence and synchronous fluorescence spectroscopic methods indicated that there occurred strong binding of copper complexes to BSA over the ligands. Further, the cytotoxicity of the compounds examined in vitro on a panel of cancerous cell lines such as a human cervical cancer cell line (HeLa), a pancreatic cancer cell line (PANC-1), an Ehrlich ascites cancer cell line (EAC) and Dalton's lymphoma ascitic cancer cells (DLA) and a normal mouse embryonic fibroblasts cell line (NIH3) demonstrated that the complexes 1 and 2 possessed superior cytotoxicity than that of well-known commercial anticancer drug cisplatin to the tumor cells but are less toxic to the normal cell line and have emerged as potential candidates for further studies. © The Royal Society of Chemistry 2013. Source

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