Coimbatore, India

Bharathiar University
Coimbatore, India

Bharathiar University is a state university in Coimbatore, Tamil Nadu, South India. Named after Tamil poet Subramania Bharathiar, the university was established in February 1982 under the provision of Bharathiar University Act, 1981 and was recognized by the University Grants Commission in 1985.The university is in the foothills of Marudamalai road, Coimbatore and has jurisdiction over the districts of Coimbatore, Erode and the Nilgiris. It has 104 affiliated institutions .Bharathiar University celebrated silver jubilee celebrations on 24 February 2007. The then president of India, A. P. J. Abdul Kalam, and the then chief minister of Tamil Nadu, Karunanidhi, were chief guests. Wikipedia.

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Anusuya N.,Coimbatore Institute of Technology | Manian S.,Bharathiar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Indigofera tinctoria L. (Fabaceae) is traditionally used in Indian and Chinese medicinal systems for various ailments including cancer, liver disorder, inflammation, ulcers and nervous disorders. Since the said curative effects are often related to antioxidant properties, different solvent (petroleum ether, benzene, chloroform, ethyl acetate, methanol and water) extracts of I. tinctoria leaves were evaluated for the antioxidant and free radical scavenging potentialby employing different in vitro assays such as reducing power assay, DPPH•, ABTS•+, NO• and•OH radical scavenging capacities, peroxidation inhibiting activity through linoleic acid emulsion system, antihemolytic assay through hydrogen peroxide induced hemolytic cells and metal ion chelating ability. Ethyl acetate, water and methanol extracts exhibited higher phenolic and tannin contents whereas benzene and ethyl acetate extracts showed higher flavonoid contents. Though all the extracts exhibited reducing power, the ethyl acetate extract was found to have more hydrogen donating ability. Ethyl acetate extract further exhibited higher DPPH• and NO• scavenging activities. All the studied extracts exhibited 22-56% •OH scavenging activities at 250μg concentration in the reaction mixture and strong peroxidation inhibition against linoleic acid emulsion system (87-96%). Methanol extract registered strong ABTS•+ scavenging activity (1434. 5 ± 236. 8 μmolg-1DM). The potential of multiple antioxidant activity of this plant is evident as the extracts possessed antihemolytic and metal ion chelating activities.

Girija S.,Bharathiar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Objective: The process of carcinogenicity presents a major challenge to scientists and provides limited tools for its control. An attempt has been made in the present research, to assess the cytotoxicity of Jatropha curcus and Jatropha gossippifolia on HeLa cell lines and also to isolate and characterise the active principle having highest anticancer activity in the methanolic and ethanolic extract of Jatropha curcus and Jatropha gossipifolia which will be certainly useful for the prevention and treatment of cancers. Methodology: Crude methanolic and ethanolic fractions of Jatropha curcus and Jatropha gossippifolia stem were examined for their anticancer activity. The anticancer activity was determined for different concentrations of the crude extract on HeLa cancer cell line by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay.The extracts were then subjected to high performance liquid chromatography LC Column: Reverse Phase C-18 was used with a detection range of 254 nm. Results: Jatropha curcus and Jatropha gossippifolia extracts showed a significant antiproliferative activity with IC50 value of 98.18 μg/ml and 110.6 μg/ml respectively and a dose dependent effect was observed The sample contains a majority of polar compounds because RP Column was able to separate the compounds fast. Of the 55 samples collected from the ethanolic extract of Jatropha curcus, the third aliquot was found to have the lowest cell viability. The thirty fifth aliquot out of the 49 isolates from the methanolic extract of Jatropha curcus was found to have the lowest cell viability. Out of the 39 isolates from the ethanolic extract of Jatropha gossipifolia, the fourteenth aliquot was found to have the lowest cell viability and the second isolate among the 37 isolates from the methanolic extract of Jatropha gossipifolia was found to have the lowest cell viability. These four aliquots were then used for further analysis and identification of the compounds responsible for the anticancer property. Conclusion: Hence the present study revealed that the isolated compounds from ethanolic and methanolic extracts of Jatropha curcus and Jatropha gossypifolia posses chemoprotective effect and can be used as a potent agent in treating cancer.

Arunachalam K.,Bharathiar University | Parimelazhagan T.,Bharathiar University
Journal of Ethnopharmacology | Year: 2013

Ethno pharmacological relevance: Ficus amplissima, commonly known as kal-itchchi, being used in folklore medicine, leaves juice is applied externally on old chronic wounds and the latex is applied on the wound. Aim: There was no scientific evidence justifying the medicinal use of Ficus amplissima, therefore the present study was aimed at evaluation of anti-inflammatory, wound healing and in-vivo antioxidant activity of the plant. Materials and methods: In the present study the acetone extract of Ficus amplissima leaves were studied for enzymatic antioxidant activity through different assays, anti-inflammatory by using carrageenan and histamine induced rat paw edema models (50 mg, 100 mg acetone extract) and wound healing activity by incorporating the two doses (1% (w/w) and 2% (w/w)) of acetone extract and simple ointment base B.P. in concentration of 0.5% (w/w) using excision and incision wound models in rats. In case of the excision wound model wound contraction and period of epithelization was studied while incision wound model was evaluated by determining tensile strength. Results: Ficus amplissima leaves expressed the potent anti-inflammatory and in-vivo antioxidant activity where 100 mg acetone extract showed high activity. Treatment of wound with ointment containing 2% (w/w) acetone extract exhibited significant (P<0.001) wound healing activity. Conclusion: The acetone extract of Ficus amplissima leaves exhibited better anti-inflammatory, wound healing and in-vivo antioxidant activity probably due to phenols constituents. © 2012 Elsevier Ireland Ltd.

Murugan R.,Bharathiar University | Parimelazhagan T.,Bharathiar University
Journal of King Saud University - Science | Year: 2014

The effect of maceration, Soxhlet and fractionation extraction from whole plant of Osbeckia parvifolia was studied for free radical scavenging and anti-inflammatory activities in vitro. The extracts were quantitatively analyzed for total phenolic, tannin and flavonoid contents using spectrophotometric methods. In vitro free radical scavenging activity of extracts were studied for DPPH (1,1-diphenyl-2-picryl-hydrazyl), ABTS+ (2,2'-azinobis (3-ethyl-benzothiozoline)-6-sulfonic acid) scavenging activities, metal ion chelating capability, lipid peroxidation, phosphomolybdenum and FRAP (Ferric reducing/antioxidant power) assays. Protein denaturation and membrane stabilization assays were employed to assess the anti-inflammatory activity of different extracts of O. parvifolia. Quantitative analysis showed that whole plant has high contents of total phenolic, tannin and flavonoid. Antioxidant assessment results registered higher anti-radical property for both macerated and Soxhlet methanol extracts compared to other solvent extracts. Successively extracted methanol extract from Soxhlet apparatus protected protein denaturation and erythrocyte membrane lysis comparable to standard Diclofenac sodium. Whole plant served as a potential source of antioxidant from natural origin and this study also provides a better technique to extract the natural antioxidant and anti-inflammatory substances from O. parvifolia. © 2013 .

Arunachalam K.,Bharathiar University | Parimelazhagan T.,Bharathiar University
Journal of Ethnopharmacology | Year: 2013

Ethnopharmacological relevance Ficus amplissima commonly known as kal-itchchi have a long history of use in Ayurveda, Siddha and Unani herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes. Aim The aim of the present study was to evaluate the effect of methanolic extract of the bark of Ficus amplissima (FAB) in streptozotocin-induced diabetic rats. Materials and methods Oral administration of FAB bark at the doses of 50 mg/kg, 100 mg/kg and 150 mg/kg was studied in normal, glucose-loaded and STZ - induced diabetic rats. Results The three doses caused significant reduction in blood glucose levels in all the models. The effect was more pronounced in 50 mg/kg and 100 mg/kg than 150 mg/kg. FAB also showed significant increase in serum insulin and body weight. The glycogen content in liver, skeletal muscle, total protein contents were markedly increased and marker enzymes of hepatic function of STZ-induced diabetic rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. FAB also showed significant anti-lipid peroxidative effect in the pancreas of STZ-induced diabetic rats. The anti-diabetic effect of FAB was compared with glibenclamide, a well known hypoglycemic drug. Histological analysis showed the regenerative effect of FAB on the β-cells of diabetic rats. Conclusion Results of this experimental study indicated that FAB possessed anti-diabetic and antioxidant activities. Hence it could be used as a natural source of antidiabetic (Type-I) and antioxidant drug. © 2013 Elsevier Ireland Ltd. All rights reserved.

Megala J.,Bharathiar University | Geetha A.,Bharathi Womens College Autonomous
Journal of Ethnopharmacology | Year: 2012

Ethnopharmacological relevance: The ethnopharmacological importance of Pithecellobium dulce is evidenced by its traditional use for gastric complications. The aim of the study is to evaluate the gastroprotective activity and the mechanism of action of hydroalcoholic fruit extract of P. dulce (HAEPD) in rats by using chemical and stress induced ulcer models. Materials and methods: Gastric ulcer was induced by administering alcohol (or) acetylsalicylic acid (or) hypothermic restraint stress to rats pretreated with HAEPD (200 mg/kg b wt for 30 day). Volume of gastric fluid, pH, acidity, activities of pepsin, H +, K +-ATPase, myeloperoxidase, mucin content, nucleic acids, glycoproteins and prostaglandin E 2 (PGE 2) levels were assessed in gastric tissues. Results: Ulcer score was significantly minimized in HAEPD administered animals. pH and acidity of gastric fluid were significantly minimized and the mucin, PGE 2 levels were significantly maintained in drug pre administered animals. The activities of H +, K +- ATPase and myeloperoxidase were found to be significantly elevated in ulcer control animals and found to be decreased in drug pretreated animals. The cell proliferation was found to be enhanced in drug received animals. The total protein bound carbohydrate to total protein ratio was found to be significantly maintained by HAEPD. The effects were found to be comparable with that of standard drug omeprazole. Conclusion: It is concluded that HAEPD possess a potent antiulcer activity probably by acting as cytoprotective and antiacid secretory agent. © 2012 Elsevier Ireland Ltd.

Karunamoorthi K.,Jimma University | Karunamoorthi K.,Bharathiar University
Clinical Microbiology and Infection | Year: 2011

Over many decades, malaria elimination has been considered to be one of the most ambitious goals of the international community. Vector control is a cornerstone in malaria control, owing to the lack of reliable vaccines, the emergence of drug resistance, and unaffordable potent antimalarials. In the recent past, a few countries have achieved malaria elimination by employing existing front-line vector control interventions and active case management. However, many challenges lie ahead on the long road to meaningful accomplishment, and the following issues must therefore be adequately addressed in malaria-prone settings in order to achieve our target of 100% worldwide malaria elimination and eventual eradication: (i) consistent administration of integrated vector management; (ii) identification of innovative user and environment-friendly alternative technologies and delivery systems; (iii) exploration and development of novel and powerful contextual community-based interventions; and (iv) improvement of the efficiency and efficacy of existing interventions and their combinations, such as vector control, diagnosis, treatment, vaccines, biological control of vectors, environmental management, and surveillance. I strongly believe that we are moving in the right direction, along with partnership-wide support, towards the enviable milestone of malaria elimination by employing vector control as a potential tool. © 2011 The Author. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.

Sankar K.V.,Bharathiar University | Selvan R.K.,Bharathiar University
Journal of Power Sources | Year: 2015

The ternary MnFe2O4/graphene/polyaniline (PANI) composite was successfully prepared for the negative electrode in hybrid supercapacitors. The MnFe2O4 particles are synthesized by polymer assisted solution combustion method without any high temperature calcinations. Similarly, the flexible graphene and PANI are prepared by eco-friendly hydrothermal and in situ polymerization method, respectively. The presence of possible functional groups and the existence of individual constituents in the composite were identified through Fourier transform infra-red spectra (FT-IR) and Raman spectra. Transmission electron microscope (TEM) image reveals that the MnFe2O4 particles are dispersed on the flexible graphene sheet and are wrapped by PANI. The ternary composite electrode delivered a specific capacitance of 241 F g-1 at 0.5 mA cm-2, which was 7.5 times higher than MnFe2O4. The calculated b-value elucidates that the charge storage mechanism in the ternary system is based on the capacitive behavior rather than intercalation. The increase in ratio between capacitive and intercalation current with respect to scan rate corroborates that the pseudocapacitive charge storage mechanism is dominant. Further, the fabricated hybrid supercapacitor provides the maximum specific capacitance and energy density of 48.5 F g-1 at 0.5 mA cm-2 and 17 Wh kg-1, respectively. In addition, the hybrid supercapacitor exhibits excellent cyclic stability of up to 5000 successive cycles. © 2014 Elsevier B.V.

Sujitha M.V.,Bharathiar University | Kannan S.,Bharathiar University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

This study reports the biological synthesis of gold nanoparticles by the reduction of HAuCl4 by using citrus fruits (Citrus limon, Citrus reticulata and Citrus sinensis) juice extract as the reducing and stabilizing agent. A various shape and size of gold nanoparticles were formed when the ratio of the reactants were altered with respect to 1.0 mM chloroauric acid solution. The gold nanoparticles obtained were characterized by UV-visible spectra, transmission electron microscopy (TEM) and X-ray diffraction (XRD). TEM studies showed the particles to be of various shapes and sizes and particle size ranges from 15 to 80 nm. Selected-area electron diffraction (SAED) pattern confirmed fcc phase and crystallinity of the particles. The X-ray diffraction analysis revealed the distinctive facets (1 1 1, 2 0 0, 2 2 0 and 2 2 2 planes) of gold nanoparticles. Dynamic light scattering (DLS) studies revealed that the average size for colloid gp3 of C. limon, C. reticulata and C. sinensis are 32.2 nm, 43.4 nm and 56.7 nm respectively. The DLS graph showed that the particles size was larger and more polydispersed compared to the one observed by TEM due to the fact that the measured size also includes the bio-organic compounds enveloping the core of the Au NPs. Zeta potential value for gold nanoparticles obtained from colloid gp3 of C. limon, C. reticulata and C. sinensis are -45.9, -37.9 and -31.4 respectively indicating the stability of the synthesized nanoparticles. Herein we propose a novel, previously unexploited method for the biological syntheses of polymorphic gold nanoparticles with potent biological applications. © 2012 Elsevier B.V. All rights reserved.

Panneerselvam C.,Bharathiar University | Murugan K.,Bharathiar University
Parasitology Research | Year: 2013

Mosquito-borne diseases with an economic impact create loss in commercial and labor outputs, particularly in countries with tropical and subtropical climates. Mosquito control is facing a threat because of the emergence of resistance to synthetic insecticides. Extracts from plants may be alternative sources of mosquito control agents because they constitute a rich source of bioactive compounds that are biodegradable into nontoxic products and potentially suitable for use to control mosquitoes. Insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. In view of the recently increased interest in developing plant origin insecticides as an alternative to chemical insecticide, this study was undertaken to assess the adulticidal, repellent, and ovicidal potential of the crude hexane, ethyl acetate, benzene, aqueous, and methanol solvent extracts from the medicinal plants Andrographis paniculata, Cassia occidentalis, and Euphorbia hirta against the medically important mosquito vector, Anopheles stephensi (Diptera: Culicidae).The adult mortality was observed after 24 h of exposure. All extracts showed moderate adulticide effects; however, the highest adult mortality was found in methanol extract of A. paniculata followed by C. occidentalis and E. hirta against the adults of A. stephensi with LC50 and LC 90 values of 210.30, 225.91, and 263.91 ppm and 527.31, 586.36, and 621.91 ppm, respectively. The results of the repellent activity of hexane, ethyl acetate, benzene, aqueous, and methanol extract of A. paniculata, C. occidentalis, and E. hirta plants at three different concentrations of 1.0, 3.0, and 6.0 mg/cm2 were applied on skin of forearm in man and exposed against adult female mosquitoes. In this observation, these three plant crude extracts gave protection against mosquito bites without any allergic reaction to the test person, and also, the repellent activity is dependent on the strength of the plant extracts. Mean percent hatchability of the ovicidal activity was observed 48 h post-treatment. The percent hatchability was inversely proportional to the concentration of extract and directly proportional to the eggs. Mortality of 100 % with methanol extract of A. paniculata exerted at 150 ppm and aqueous, methanol extract of C. occidentalis and E. hirta were exerted at 300 ppm. These results suggest that the leaf extracts of A. paniculata, C. occidentalis, and E. hirta have the potential to be used as an ideal eco-friendly approach for the control of the A. stephensi. Further detailed research is needed to identify the active ingredient in the extracts and implement the effective mosquito management program. © 2012 Springer-Verlag Berlin Heidelberg.

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