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Megala J.,Vels University | Geetha A.,Bharathi Womens College Autonomous
Food Chemistry | Year: 2010

The free radical-scavenging property and the inhibitory action on H+, K+-ATPase activity of aqueous (AEPD) and hydroalcoholic (HAEPD) fruit extracts of Pithecellobium dulce (PD) were screened in various in vitro models. HAEPD showed the greatest free radical-scavenging activity in all the experimental models. Further, HAEPD has shown a potent H+, K+-ATPase inhibitory activity and comparable to that of Omeprazole, the antiulcer drug. HPLC chromatogram of HAEPD was found to contain rich quantity of phenolic compounds and revealed the presence of flavonoids - quercitrin, rutin, kaempferol, naringin, daidzein. Thus HAEPD was found to possess a good antioxidant capacity when compared to AEPD. The study indicates that PD can be screened for antiulcer activity, since overexpression of H+, K+-ATPase results in gastric ulceration. So the free radical-scavenging and antiacid secretory activities of PD may be claimed for its traditional consumption for gastric complications. © 2010 Elsevier Ltd. All rights reserved.


Manimekalai K.,Bharathi Womens College Autonomous | Baskar Babujee J.,Anna University | Thirusangu K.,Sivet College
European Journal of Scientific Research | Year: 2012

A graph G(V, E) is said to be k-sequentially additive if there is a bijection f : V ∪ E → {k, k+1, ∪, k+|V ∪ E|-1} such that for each uv ε E, f(uv) = f(u) + f(v). If k =1, then G(V, E) is said to be 1-sequentially additive graph or a simply sequentially additive graph or briefly, an SSA-graph. In this paper we prove the existence of SSA-labeling for the graphs P2n (+) Nm, (P2 ∪ mK1) + N 2, the Y-tree Ym+1, (m, 1)-kite and (m, 2)-kite for m ° 1 or 2 (mod 3), corona Cm nK1 for m = 3, 4 and B(r,s,n-1) for rs even, K3 ∪ K1,n-2, and rK m,n-2 ∪ K1,s ∪ K1,t with certain conditions, and k-sequentially additive labeling for the one point union of K3 with the central vertex of K1,n-2 and the union of some sequentially additive disconnected graphs. © 2012 EuroJournals Publishing, Inc.


Janaki K.,Bharathi Womens College Autonomous | Radhakrishnan N.,Anna University
International Review on Computers and Software | Year: 2013

It offers, indeed, immense challenges to assess clearly the exact variance of the optimal solutions with the recent remedies, when we set out to study the locations of modern hospitals in the context of the perplexing state of affairs and the intricate decisive factors prevalent in the current scenario. In order to do so, we first identify the main classes of criteria used in location planning. In the existing hospital location analysis technique a non linear mathematical model is developed to find the highly sensitive roads. But this method has such a drawback that the obtained optimal weights are not generally distributed. To overcome this, a new expert system developed for hospital location analysis with optimization method is presented. In our proposed technique, a new expert system is developed based on the Radial Basis Function (RBF). In the RBF the weights are optimized by using the well renowned optimization technique Adaptive Artificial Bee Colony (AABC) Algorithm. After that, the different length pattern values are mined and locations are computed by using the pattern mining and clustering techniques. Thus our proposed technique performance is analyzed by using the hospital location dataset and compared with the exiting hospital locations analysis techniques and optimizations methods PSO and Conventional ABC. © 2013 Praise Worthy Prize S.r.l. - All rights reserved.


Megala J.,Bharathiar University | Geetha A.,Bharathi Womens College Autonomous
Natural Product Research | Year: 2012

This study was carried out to evaluate the acute and sub-acute toxicity profile of the hydroalcoholic fruit extract (HAEPD) of Pithecellobium dulce (Leguminosae). Albino rats were treated orally with 100, 200 and 500mg kg-1 bodyweight (BW) of HAEPD for 90 days to assess its sub-acute toxicity. HAEPD at single doses of 100, 500, 1000, 2000 and 4000mg kg -1 BW was also administered to rats to assess its acute toxicity. The rats were observed for physical discomfort, BW change and feeding habits. Pithecellobium dulce did not cause any abnormal changes in haematological or biochemical parameters. Pathologically, no gross abnormality in the tissue architecture was observed. The LD 50 was found to be 3916mg kg -1 BW and potential effective doses for efficacy studies are 100 and 300mg kg -1 BW as the minimum and maximum doses, respectively. It is concluded that HAEPD can be used safely for experimental and clinical trials. © 2012 Taylor & Francis.


Chandramohan Y.,Bharathi Womens College Autonomous | Parameswari C.S.,Bharathi Womens College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2013

The therapeutic effecicacy of a flavonoid Naringin (NG) against Cyclosporine A (CsA) induced nephrotoxicity was investigated in this study. Nephrotoxicity was induced in male albino wistar rats by injecting 25mg/kg body weight of CsA for a period of 21 days. CsA induced rats were also cotreated with 40mg of Naringin (NG/kg body weight) orally. After the experimental period the serum levels of urea, uric acid and creatinine were found to be elevated, followed by the decrease in creatinine clearance, whereas the levels of ALP, ACP were increased in serum of CsA induced rats. A significant decrease in LDH levels were observed in CsA induced animals compared to control. Immunohistochemical staining of inducible nitric oxide synthase (iNOS) expression was studied and NG co treatment significantly decreased the expression of iNOS in CsA challenged rats. This data was further evidenced by western blotting expression pattern of iNOS in experimental rats.


Nadhiya K.,Bharathi Womens College Autonomous | Haripriya D.,Bharathi Womens College Autonomous | Vijayalakshmi K.,Bharathi Womens College Autonomous
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Aim: To study the plant drug formulation that has medicinal property due to the presents of secondary metabolites with fewer side effects and less expensive. Objective: The present study was designed to investigate the Pharmacognostic, preliminary phytochemical studies and fluorescence analysis of powder sample of Benincasa hispida fruit. Method: The preliminary phytochemical analysis of Benincasa hispida was done using extracts like Ethyl acetate, Ethanol, Hydro alcohol and Aqueous. Microscopic analysis of Benincasa hispida fruit was done using Toluidine Blue staining reagent. Ash value, extractive value and loss on drying, powder analysis with chemical agents and fluorescence analysis of powder sample were performed. Result: Pharmacognostic study with Toluidine blue staining reagent shows Parenchyma, Vascular strands, Xylem, Phloem, ground tissue and crystals in transverse section of fruit. The preliminary phytochemicals studies revealed the presence of carbohydrates, Phenols, alkaloids, glycosides, flavonoids, tannins, terpenoids and saponins. Total ash is 6.89%, Acid insoluble ash 2.35%, Water soluble ash 3.12%, sulphated ash 5.42% and water soluble extract value is 45.4%, Hydro alcohol soluble extract value is 7.14, Ethanol soluble extract value is 12.58 and Ethyl acetate extract value is 6.6. Conclusion: Study reveals that phytochemicals present in the extract may have beneficial effects on many pathological conditions.


Surendran S.,Bharathiar University | Krishnamoorthy V.,Bharathi Womens College Autonomous
International Journal of Pharma and Bio Sciences | Year: 2014

The present study evaluated the effect of ethanolic extracts of Cyamopsis tetragonolobus rhizomes and Cyperus rotundus pods on the biochemical parameters of diabetic cataract induced Wistar albino rats. Healthy rats were grouped into 4: Group I - Normal, Group II - Diabetic cataract induced animals (STZ-induced diabetic rats which developed cataract), Group III - Cyamopsis tetragonolobus extract co-treated animals and Group IV - Cyperus rotundus extract co-treated animals (Treatment for 19 weeks after STZ induction). Body weight and organ weight of cataract animals decreased while plant treatment prevented this loss. Increase in values of glucose, glycated haemoglobin, insulin, creatinine, urea and uric acid levels were observed in diabetic cataract induced rats, while plant co-treated groups restored these levels. The changes in lipid and protein profile in Group II rats were prevented by the plant treatment. SGOT, SGPT, ALP and LDH increased in Group II but plant treatment retained enzymatic activities. The results signify the plant's protective nature.


Manimegalai D.K.,Bharathi Womens College Autonomous | Manikandan A.,Presidency College at Chennai | Moortheswaran S.,Presidency College at Chennai | Antony S.A.,Presidency College at Chennai
Journal of Superconductivity and Novel Magnetism | Year: 2015

In this article, undoped and Mn-doped ZnS (MnxZn1−xS; x = 0.0, 0.3, and 0.5) nano photocatalysts were synthesized successfully by a facile microwave combustion method. Powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray (EDX), and selected area electron diffraction (SAED) patterns revealed the presence of material in well-crystalline single phase with average crystallite size of about 12 nm and the material remained cubic over the whole MnxZn1−xS solid solution range. Formation of ultrafine, spherical, and homogeneous dispersed nanoparticles (NPs) with size 14 nm was confirmed by high-resolution scanning electron microscopy (HR-SEM) and high-resolution transmission electron microscopy (HR-TEM) analyses. Vibrating sample magnetometer (VSM) results confirmed a weak superparamagnetic behavior of MnxZn1−xS nanocrystals, and the values of magnetization (Ms) gradually increased with increasing the concentration of Mn2+ cations, due to the higher magnetic moment of Mn2+ ions (5 μB) replaced the nonmagnetic nature of Zn2+ ions (0 μB) in ZnS. The band gap of the samples was increased with increasing the concentration of Mn2+ ions, due to decrease in the particle size. The room temperature photoluminescence (PL) spectra of Mn2+-doped ZnS NPs showed extra peaks in yellow–orange and red region in comparison of undoped ZnS NPs. Mn2+-induced PL spectra was suggested with the significant enhancement of the PL intensity in MnxZn1−xS NPs, due to Mn2+ incorporation. The present study leads to enhance the photocatalytic activity of MnxZn1−xS NPs, and TiO2 catalyst was added. As expected, MnxZn1−xS NP-sensitized TiO2 catalyst showed enhanced photocatalytic degradation (PCD) of 4-chlorophenol (4-CP) under visible light irradiation. The alteration of MnxZn1−xS–TiO2 nanocomposites (NCs) catalysts show higher adsorption with synergistic effect and enhanced the separation of photogenerated electron–hole pairs, important to higher PCD efficiency. © 2015, Springer Science+Business Media New York.

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