Bharathi College

Lal Bahadur Nagar, India

Bharathi College

Lal Bahadur Nagar, India
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Deepakumari H.N.,Bharathi College | Jayanna B.K.,B N M Institute Of Technology | Prashanth M.K.,B N M Institute Of Technology | Revanasiddappa H.D.,University of Mysore
Archiv der Pharmazie | Year: 2016

A series of new N-(substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides were designed, synthesized, and evaluated for their anticonvulsant activity. Most of the synthesized compounds exhibited potent anticonvulsant activities in the maximal electroshock (MES) and pentylenetetrazol (PTZ) test. The most promising compound 4c showed significant anticonvulsant activity with a protective index value of 3.58. The compounds 4a–c were also found to have encouraging anticonvulsant activity in the MES and PTZ screen when compared with the standard drugs, valproate and methaqualone. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drugs. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


Chandraju S.,University of Mysore | Mythily R.,University of Mysore | Chidan Kumar C.S.,Bharathi College
Journal of Chemical and Pharmaceutical Research | Year: 2011

A rapid, sensitive extraction method was developed using the mixture Methanol-Dichloromethane-Water (MDW) (0.3:4:1v/v/v) and MeOH-H2O phase was assayed for sugar analysis. Photodiode-array detection (DAD) has been used to prove the extracted compound is UV inactive, High-performance liquid chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) coupled to electrospray ionization mass spectrometric (ESI-MS) detection in the positive ion mode gave MS and MSn fragmentation data which were employed for their structural characterization. The various standard sugars were spotted using the solvent system n-butanol-acetone-pyridine-water (10:10:5:5, v/v/v/v) in the cellulose layer for TLC analysis which indicated the presence of lactose, maltose, glucose, mannose, arabinose. This is the first assay of the sugar profile of the pomegranate skin, which can be further developed for characterization and evaluation of their quality with regards to their sugar composition.


Chandraju S.,University of Mysore | Mythily R.,University of Mysore | Chidan Kumar C.S.,Bharathi College
Journal of Chemical and Pharmaceutical Research | Year: 2011

The production of various sugars evaluated from the non edible (peel) portion of banana fruit has considerable promise in the future to achieve economical profit. Selected samples were dried, powdered and sequentially extracted with double distilled water, 80% ethanol with replicates and finally with the mixture of Methanol - Dichloromethane - Water (MDW) (0.3:4:1v/v/v). MeOH-H 2O phase was assayed for sugar analysis. The concentrated compound was UV inactive and thus the compound is subjected to HPLC coupled ELSD gave a merged single ionised peak at R t = 0.646. These crude mixtures are subjected to preparative HPLC coupled LC/MS which gives four compounds whose retention time were found to be 0.662, 0.676, 0.652, 0.684 and with corresponding mass fragments. The various standard sugars were spotted using the solvent system n-butanol - acetone - diethylamine - water (10:10:2:6 v/v/v/v) in the cellulose layer for TLC analysis which indicated the presence of glucose, fructose, sucrose and maltose.


Chandraju S.,Bharathi College | Thejovathi C.,University of Mysore | Chidan Kumar C.S.,University of Mysore
Journal of Chemical and Pharmaceutical Research | Year: 2011

Sprouting and growth of Tagetes (Asteraceae) flowering plant was made by irrigated with distillery spentwash of different concentrations. Primary treated spent wash (PTSW) was analyzed for plant nutrients such as nitrogen, phosphorous, potassium and other physical and chemical characteristics. Experimental soil was tested for chemical and physical parameters. Seeds of Tagetes (Asteraceae) were planted in different pots and irrigated with raw water (RW), 1:1, 1:2 and 1:3 spentwash. The nature of sprouting and growth was studied. It was found that the sprouting and growth of plant was very good (100%) in 1:3 SW irrigation, while very poor (25%) in 1:1 SW, moderate (80%) in 1:2 SW and 90% in RW irrigation growth.


Nagendraswamy R.,Government First Grade College | Chandraju S.,University of Mysore | Girijanagenrdaswamy,Maharanis Science College for Women | Chidankumar C.S.,Bharathi College
Biomedical and Pharmacology Journal | Year: 2010

Cultivation of some tuber/root medicinal plants was made by irrigation with distillery spentwash of different concentrations. The spentwash i.e., primary treated spentwash (PTSW), 50% and 33% spentwash were analyzed for their plant nutrients such as nitrogen, phosphorous, potassium and other physical and chemical characteristics. Experimental soil was tested for its chemical and physical parameters. Seeds of tuber/root medicinal plants (Namadhari and Mayhco) were sowed in the prepared land and irrigated with raw water (RW), 50% and 33% spentwash. The influence of spentwash on the yields of tuber/root medicinal plants at their respective maturity was investigated. It was found that the yields of all tuber/root medicinal plants were more in 33% spentwash irrigation than raw water and 50% spentwash irrigations.


PubMed | B N M Institute Of Technology, University of Mysore and Bharathi College
Type: Journal Article | Journal: Archiv der Pharmazie | Year: 2016

A series of new N-(substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides were designed, synthesized, and evaluated for their anticonvulsant activity. Most of the synthesized compounds exhibited potent anticonvulsant activities in the maximal electroshock (MES) and pentylenetetrazol (PTZ) test. The most promising compound 4c showed significant anticonvulsant activity with a protective index value of 3.58. The compounds 4a-c were also found to have encouraging anticonvulsant activity in the MES and PTZ screen when compared with the standard drugs, valproate and methaqualone. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drugs.


Nagendraswamy R.,Government First Grade College | Chandraju S.,University of Mysore | Nagendraswamy G.,Maharanis Science College for Women | Chidankumar C.S.,Bharathi College
Nature Environment and Pollution Technology | Year: 2010

Cultivation of some leafy medicinal plants was made by irrigation with distillery spentwash of different dilutions. The spentwash, I.e., primary treated spentwash (PTSW), 50% and 33% spentwash were analyzed for their plant nutrients such as nitrogen, phosphorus, potassium and other physical and chemical characteristics. Experimental soil was tested for its chemical and physical parameters. Seeds of leafy medicinal plants were sown In the prepared land and irrigated with raw water (RW) and 50% and 33% spentwash. The influence of spentwash on the yield of leafy medicinal plants at their respective maturity was investigated. It was found that the yields of all leafy medicinal plants were more in 33% spentwash irrigation than raw water and 50% spentwash irrigations.


Deepakumari H.N.,Bharathi College | Prashanth M.K.,University of Mysore | Revanasiddappa H.D.,University of Mysore
Journal of the Chilean Chemical Society | Year: 2014

A simple, rapid, selective and highly sensitive spectrophotometric method is described for the quantitative determination of the tricyclic antidepressant drugs, desipramine hydrochloride (DPH), clomipramine hydrochloride (CPH) and imipramine hydrochloride (IMH) in pure and in pharmaceutical preparations. The proposed method is based on the bromination of above drugs with known excess of bromine. The unreacted bromine is determined based on its ability to bleach the dye Eiochrome blue black R quantitatively at 530 nm for all the three drugs obeying Beer's law in the range, 0.0-8, 0.0-10 and 0.0-9.0 μg ml-1 for DPH, CPH and IMH, respectively. The molar absorptivity values were found to be 1.61 × 104, 1.62 × 104 and1.57 × 104 l mol-1cm-1, respectively with the corresponding Sandell's sensitivity values 0.0187, 0.0216 and 0.0202 μg cm-2. The limits of detection and (LOD) and quantification (LOQ) are also reported for the developed method. Intra- and inter-day precision and accuracy of the method were established according to the current ICH guidelines. Applications of the procedure to the analysis of various pharmaceutical preparations gave reproducible and accurate results. Further, the validity of the procedure was confirmed by applying the standard addition technique and the results were evaluated in terms of Student's t-test and variance ratio F-test to find out the significance of proposed method over the reference method.


Chandraju S.,University of Mysore | Beirami A.,University of Mysore | Chidan Kumar C.S.,Bharathi College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Effects of Sodium and Potassium in diet to determine baby gender in high-sugar mammals have been investigated. Diabetes mellitus is a chronic, widely spread disease in living species. Sex determination has scientific basis for prevention of genetic diseases in addition to social backgrounds.60 rats (obtained from veterinary college Bangalore), were divided in to three groups in the ratio male to female 1:5. The first group was made diabetic with Na and K, the second group was non diabetic with Na and K, group third was control unit (Non-diabetic without Na and K). It was found that the delivered offspring male to female ratio were 4.3:1, 3.3:1 and 1.03:1 for the first, second and third groups respectively. Also, it was found that non diabetic rats fed with normal food yields maximum numbers of offspring (217), while non diabetic rat fed with Na and K yields 200 and diabetic rats with Na and K yield lowest numbers of offspring (144).


Cbidan Kumar C.S.,Bharathi College
Nature Environment and Pollution Technology | Year: 2010

The residents of Mysore city are mainly dependent on bore well water for domestic and small scale Industries, especially in summer season. Hence, large number of bore wells exist in the city. Fluoride content of these bore wells water was analysed and the outcome of the results was in the view of pollution of the study area. It reveals that the fluoride concentration is within the permissible limits as prescribed by BIS and WHO. Hence, the bore well water of Mysore city can be conveniently used for drinking purpose without any pre-treatment for fluoride.

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