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Bharath University, formerly Bharath Institute of Higher Education and Research and Bharath Institute of Science and Technology , is a private deemed university in Chennai, Tamil Nadu, India. Wikipedia.

Pieger S.,University of Hamburg | Salman A.,Bharath University | Bidra A.S.,University of Connecticut Health Center
Journal of Prosthetic Dentistry | Year: 2014

Statement of problem Lithium disilicate is a relatively new and popular restorative material for esthetic and functional rehabilitations, but the evidence for clinical outcomes is not clear. Purpose The purpose of this systematic review was to analyze the short-term (1- to 5-year) and medium-term (5- to 10-year) survival rates of lithium disilicate single crowns and partial fixed dental prostheses. Material and methods An electronic search for articles in the English-language literature published between January 1998 and June 2013 was performed with the PubMed search engine. The specific search terms used were lithium disilicate, lithium silicate, IPS e max, IPS Empress, CAD CAM, pressed ceramic, monolithic, and bilayer. After applying predetermined inclusion and exclusion criteria, the definitive list of selected articles was suitable only for calculating the interval survival rate and cumulative survival rate. Results The electronic search resulted in 2033 titles. The systematic application of inclusion and exclusion criteria resulted in 12 clinical studies that addressed the clinical outcomes of lithium disilicate restorations. Of these, 2 were randomized controlled trials, 5 were prospective studies, 1 was a retrospective study, and 4 studies were descriptive in nature. All 12 studies reported on tooth-retained lithium disilicate restorations. The 2-year cumulative survival rate for single crowns was 100%, and the 5-year cumulative survival rate was 97.8%. The 2-year cumulative survival rate for fixed dental prostheses was 83.3%, and the 5-year cumulative survival rate was 78.1%. The cumulative survival rate over a 10-year period, primarily owing to data from 1 study, was 96.7% for single crowns and 70.9% for fixed dental prostheses. Conclusions For lithium disilicate single crowns, the existing evidence indicates excellent short-term survival rates, but the evidence for medium-term survival is limited. For lithium disilicate fixed dental prostheses, the evidence for short-term survival is fair, although limited, but the evidence for medium-term survival is not promising. The majority of failures in both types of restorations were reported in the posterior region. © 2014 by the Editorial Council for The Journal of Prosthetic Dentistry. Source

Das J.,SRM University | Paul Das M.,Bharath University | Velusamy P.,SRM University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2013

Simple, effective and rapid approach for the green synthesis of silver nanoparticles (AgNPs) using leaf extract of Sesbania grandiflora and their in vitro antibacterial activity against selected human pathogens has been demonstrated in the study. Various instrumental techniques were adopted to characterize the synthesized AgNPs viz. UV-Vis, FTIR, XRD, TEM, EDX and AFM. Surface Plasmon spectra for AgNPs are centered at 422 nm with dark brown color. The synthesized AgNPs were found to be spherical in shape with size in the range of 10-25 nm. The presence of water soluble proteins in the leaf extract was identified by FTIR which were found to be responsible for the reduction of silver ions (Ag+) to AgNPs. Moreover, the synthesized AgNPs showed potent antibacterial activity against multi-drug resistant (MDR) bacteria such as Salmonella enterica and Staphylococcus aureus. © 2012 Elsevier B.V. All rights reserved. Source

Jayaraman B.,Bharath University
Asian Pacific journal of cancer prevention : APJCP | Year: 2012

There have been case reports of oral squamous cell carcinoma arising from gingival overgrowth induced by phenytoin--an antiepileptic drug. However, a detailed analysis for the presence of mutations in p53 and ras genes, which are the two most frequently mutated genes in cancers, in phenytoin induced gingival overgrowth tissues has hitherto not been performed. Cellular DNA isolated from twenty gingival overgrowth tissues collected from patients undergoing phenytoin therapy were amplified using primers for p53 (exons 5-8) and H-ras (exons 1-2) genes. The PCR amplicons were then gel purified and subjected to direct sequencing analysis to screen for mutations. Direct sequencing of twenty samples of phenytoin induced gingival growth did not identify mutations in any of the exons of p53 and H-ras genes that were analyzed. Our result indicates that mutational alteration of p53 and H-ras genes is infrequent in phenytoin induced gingival growth, which thus suggests a non malignant nature of this pathology. The findings in the present study are clinically significant as a large number of epileptic patients are treated with phenytoin. Source

Nagarajan C.,Bharath University | Madheswaran M.,Muthayammal Engineering College
Iranian Journal of Electrical and Electronic Engineering | Year: 2012

This paper presents a Closed Loop control of CLL-T (Capacitor Inductor Inductor). Series Parallel Resonant Converter (SPRC) has been simulated and the performance is analysised. A three element CLL-T SPRC working under load independent operation (voltage type and current type load) is presented in this paper. The Steady State Stability Analysis of CLL-T SPRC has been developed using State Space Technique and the regulation of output voltage is done by using Fuzzy controller. The simulation study indicates the superiority of fuzzy control over the conventional control methods. The proposed approach is expected to provide better voltage regulation for dynamic load conditions. A prototype 300 W, 100 kHz converter is designed and built to experimentally demonstrate, dynamic and steady state performance for the CLL-T SPRC are compared from the simulation studies. Source

Krishnamoorthy P.,Bharath University | Jayalakshmi T.,Bharath University
Journal of Chemical and Pharmaceutical Research | Year: 2012

Silver nanoparticles are nanoparticles of silver, i.e. silver particles of between 1 nm and 100 nm in size. While frequently described as being 'silver' some are composed of a large percentage of silver oxide due to their large ratio of surface-to-bulk silver atoms.Silver nanoparticles are the most prominent one. Silver nanoparticles are nanoparticles of silver, i.e. silver particles of between 1 nm and 100 nm in size and have attracted intensive research interest. It is generally recognized that silver nanoparticles may attach to the cell wall, thus disturbing cell-wall permeability and cellular respiration. The nanoparticles may also penetrate inside the cell causingdamage by interacting with phosphorus and sulfur containing compounds such as DNA and protein. Generally, silver does not adversely affect viable cells and does not easily provoke microbial resistance. Hence silver containing materials were also employed in textile fabrics, as food additives, and in package and plastics to eliminate microorganisms. Because of such a wide range of applications, numerous methods concerning the fabrication of silver nanoparticles, as well as various silver-based compounds containing metallic silver (Ag0) have been developed.Silver nanoparticles (AgNPs) have emerged as an arch product from the field of nanotechnology. Source

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