Bharat Institute of Pharmacy

Ibrahimpatnam, India

Bharat Institute of Pharmacy

Ibrahimpatnam, India

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Elphine Prabahar A.,Chalapathi Institute of Pharmaceutical Science | Vijayaraj Kumar P.,Bharat Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2010

Two simple, rapid and sensitive extractive spectrophotometry methods have been developed for the assay of cinitapride in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of cinitapride with Bromocresol Green (BCG) and with Bromothymol Blue (BTB) in potassium hydrogen phthalate buffer pH-4 with absorption maximum at 414 nm and 416 nm for BCG and BTB, respectively. Reaction conditions were optimized to obtain the maximum colour intensity. The absorbance was found to increase linearly with increase in concentration of cinitapride, which was corroborated by the calculated correlation coefficient values (0.9999 and 0.9998). The systems obeyed Beer's law in the range of 5-40 and 2-10 μg/mL for BCG and BTB, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in tablets.


Sharma A.,Bharat Institute of Pharmacy | Singh R.,Maharishi Markandeshwar University
Mini-Reviews in Organic Chemistry | Year: 2015

Imidazole, an important azole heterocycle, having biological and medicinal properties prompted various research groups to develop different synthetic routes to this heterocycle. This review is an attempt to focus on the various synthetic routes involving conventional and new greener approaches for the synthesis of trisubstituted imidazoles. © 2015 Bentham Science Publishers.


Rao V.D.,Krishna Institute of Medical science | Jain R.K.,Krishna Institute of Medical science | Jiwani P.A.,Krishna Institute of Medical science | Padmanabhan T.N.,Krishna Institute of Medical science | And 3 more authors.
The Journal of the Association of Physicians of India | Year: 2013

To monitor the different antithrombotic drug combinations, determine the incidence, magnitude of bleeding and the association of HAS-BLED risk scoring schema with the magnitude of bleeding as defined using TIMI bleeding criteria. A prospective observational study in a cohort of patients for a period of 8 months, at one of the tertiary care center-Krishna Institute of Medical Sciences, Hyderabad, was conducted. Consecutive patients were enrolled and followed from the date of admission till the adverse events are perceived/date of discharge. Pearson Correlation Statistics (Fisher's z Transformation) is applied to assess the association between HAS-BLED risk factors and the total risk score with bleeding criteria. A total of 400 cases were collected during the 8-month study period, of which 372 satisfied the inclusion criteria. Among them 34 (9.1%) bleeding cases were reported with mean (+/- SD) age of 57.8 (+/- 14.19) years. Bleeding occurred mostly in males 79.4% and a HAS-BLED Score of > or = 3 has been observed in 67.6% (n = 23) patients out of 34 bled patients. Two antiplatelets + One anticoagulant is the most common combination which caused bleeding in 41.2% (n = 14). Stroke history, bleeding predisposition, labile INR's are the HAS-BLED risk factors which are significant (< 0.05) with the TIMI Bleeding Criteria. There was a linear correlation between the HAS-BLED risk score and the TIMI bleeding criteria-higher the risk score the more frequent is the incidence of major bleeding. A HAS-BLED risk score of > or = 3 is associated with TIMI major bleeding.


Vijayaraj Kumar P.,Bharat Institute of Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

A simple, safe and sensitive method of spectroscopic determination of sildenafil citrate in UV region was developed using 8 M urea solution as hydrotropic solubilizing agent. Sildenafil citrate showed λ-max at 293 nm and beer's law was obeyed in the concentration range of 10 - 50 μg/ml. The results of analysis have been validated statistically and by recovery studies. © 2010 RJPBCS.


Kumar P.,Hetro labs Ltd | Singh R.,Maharishi Markandeshwar University | Sharma A.,Bharat Institute of Pharmacy
Current Computer-Aided Drug Design | Year: 2015

Candida albicans is one of the most important causes of life-threating fungal infections. Lanosterol 14α-demethylase (Cytochrome P450DM) is the target enzyme of azole antifungal agents. The study involved selection and modeling of the target enzyme followed by refinement of the model using molecular dynamic simulation. The modeled structure of enzyme was validated using Ramachandran plot and Sequence determination technique. A series of chlorosubstituted imidazole analogues were evaluated for Cytochrome P450 inhibitory activity using molecular docking studies. The imidazole analogues were prepared using Chem sketch and molecular docking was performed using Molergo Virtual Docker program. The docking study indicated that all the imidazole analogues (AN1-AN45) and standard drugs i.e., Ketoconazole, Clotrimazole and Miconazole have interaction with protein residue of 14α-demethylase, Heme cofactor and the water molecules present in the active site. © 2015 Bentham Science Publishers.


Thangabalan B.,Southern Institute of Medical science | Vijayaraj Kumar P.,Bharat Institute of Pharmacy
Asian Journal of Chemistry | Year: 2011

A sensitive and rapid extractive spectrophotometeric method has been developed for the assay of acipimox in pharmaceutical formulation. The method is based on the formation of a chloroform soluble ion-pair complex between acipimox and methylene blue in a basic medium. The complex shows absorption maximum at 662 nm and the system obeys Beer's law in the concentration range of 2-10 μg/mL. The results obtained by the proposed method were validated statistically and by recovery studies.


Thangabalan B.,Southern Institute of Medical science | Kumar P.V.,Bharat Institute of Pharmacy
Asian Journal of Chemistry | Year: 2011

A reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of acipimox in bulk drug and pharmaceutical dosage forms. The quantification was carried out on Luna C18 column in isocratic mode, with mobile phase consisting of 0.1 % v/v phosphoric acid in water and acetonitrile in the ratio of 95:5 [v/v]. The mobile phase was pumped at a rate of 1.0 mL/min and the detection was carried out at 229 nm and the linearity was found to be in the range of 20-300 μg/mL. The regression equation was found to be Y = 33672x + 6367.2 with correlation coefficient [r2] of 0.9998. The percentage recovery values were found to be in the range of 99.96-100.07 %. Validation of the proposed method has also been done.

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