Huda I.G.,Bhagwant University |
Toshniwal S.S.,Vidarbha Institute of Pharmacy
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013
Objective: In the present work, chewable dispersible tablets of Pregabalin were designed by preparing taste masked granulate of Pregabalin with Eudragit EPO. Method: The taste masked granulate was prepared by granulation technique in Rapid Mixer Granulator using Eudragit EPO with a drug: Eudragit EPO ratios 1:0.15, 1:0.2, 1:0.25 and 1:0.3 (% w/w). Assay content and In-vitro decomplexation studies confirmed taste masking of granulate. Results: It was found that maximum taste masking of drug with Eudragit EPO was noted at a ratio of 1:0.25. Drug release from Drug: Eudragit EPO complex in salivary pH imparts slight after bitter taste which was overcome by addition of sucralose during granulation. A study on different flavor is studied to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity and in vitro dispersion time. Based on acceptable physical characteristic, formulations were tested for in vitro drug release pattern (in 0.06M Hydrochloride). Conclusion: The study conclusively demonstrated complete taste masking of Pregabalin, CDT and dissolution of CDT.
Singh A.,Bhagwant University |
Vijaykumar M.,National Botanical Research Institute
Der Pharmacia Lettre | Year: 2013
Now a day transdermal drug deliveries are increasing rapidly for the treatment of various diseases so the present study was conducted on different penetration enhancers for permeation of antidiabetic drug, glipizide (sulfonyl urea derivative) through skin. Different types of penetration enhancers such as terpenes and terpenoids, pyrrolidones, oxazolidinones, fatty acids etc are used for permeation enhancement of different drug molecule according to their chemical and physical nature. The experimental data demonstrated that in all penetration enhancers used in the study the N-methyl-2-pyrolidone significantly enhanced the flux of glipizide across the skin. Propylene glycol showed less permeability than control. This may be due to less partitioning of drug to stratum corneum from propylene glycol than control. Propylene glycol appears to have a protective effect on skin with respect to reducing barrier damage. After N-methyl-2-pyrolidone, oleic acid significantly increases the flux.
Chakraborty M.,Bhagwant University
Journal of Advanced Pharmaceutical Technology and Research | Year: 2014
Globally, the rate of development of myocardial diseases and hypertension is very common, which is responsible for incremental morbidity and mortality statistics. Treatment of ischemic hypertensive patients with diuretics such as hydrochlorothiazide (HCTZ) can precipitate myocardial infarction due to hypokalemia. This study was undertaken to evaluate the pharmacodynamic interaction of green tea extract (GTE) with HCTZ against ischemia-reperfusion induced myocardial toxicity. Wistar albino rats of either sex were taken and pretreated with high (500 mg/kg, p.o.) and low (100 mg/kg, p.o.) dose of GTE for 30 days. Standard, high and low dose of interactive groups received HCTZ (10 mg/kg, p.o.) for last 7 days. Ischemia-reperfusion injury was induced by modified Lagendorff apparatus, and the effect of different treatments was evaluated by percentage recovery in terms of heart rate and developed tension, serum biomarkers, and heart tissue antioxidant levels. Prophylactic treatment groups, such as high and low dose of GTE and their interactive groups with HCTZ, exhibited significant percentage recovery in terms of heart rate and developed tension. Apart from that, significant increase in superoxide dismutase and catalase, decrease in thiobarbituric acid reactive species in heart tissue, as well as significant decrease in serum lactate dehydrogenase, creatinine phosphokinase-MB and N-acetylcysteine levels have also been documented. The present findings clearly suggest that GTE dose-dependently reduces myocardial toxicity due to ischemia, and combination with HCTZ can reduce the associated side-effects and exhibits myocardial protection.
Dubey A.,Bhagwant University
International Journal of PharmTech Research | Year: 2014
Due to the drawback of conventional therapy for ocular delivery like poor bioavailability of drugs due to tear production, non productive absorption, transient residence time, impermeability of corneal epithelium. These problems can be minimized by the application of niosomal vesicular system as well as combination of drugs provides the additive effect on reduction of IOP. The aim of the present study was to develop niosomal combination formulation of timolol maleate and brimonidine tartrate for the treatment of glaucoma. Niosomal formulations of brimonidine tartrate and timolol maleate were prepared by film hydration method. Span 60 and cholesterol used as an excipient. White rabbits of both sexes, weighing between 2 to 3 kg were used for the study. The prepared vesicles were evaluated for photomicroscopic characteristics, entrapment efficiency, in vitro, ex- in vitro drug release, in vivo intra ocular pressure lowering activity. Methods employed for the preparation of vesicles were found to be simple and reproducible, produced vesicles of acceptable shape and size with unimodal frequency distribution pattern. The in vitro, ex-in vitro drug release studies showed that there was a slow and prolonged release of drug which followed zero order kinetics. The intra ocular pressure lowering activity of prepared formulations were determined and compared with pure drug solution. It was found that intra ocular pressure lowering action was sustained for longer period of time which provides additive effect with combination. Stability study data revealed that the formulations were found to be stable when stored at refrigerator temperature (2 °C to 8 °C) and at 25 °C with no change in shape and drug content. Results of the study indicated that it is possible to develop a safe and physiological effective topical niosomal formulation which is patient compliance. IOP lowering activity of the combination of timolol maleate and brimonidine tartrate in niosomes was better as compared to alone medication, which shows the additive effect of combination medication.
Singh R.,Bhagwant University |
Jain D.A.,Bhagwant University
International Journal of PharmTech Research | Year: 2013
Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. According to BCS (biopharmaceutical classification system) Telmisartan belongs to class II drug, and it is practically insoluble in water and it shows low dissolution profile and poor absorption. The present study is to improve the solubility of Telmisartan by solid dispersion techniques using various methods More than 1500 different CD derivatives have been described in the literature. Generally, CDs can be divided into naturally occurring and chemically modified CDs (18). Another classification is based on their water solubility (Table 2) (19), so one can distinguish hydrophilic, lipophilic and ionizable derivatives. α -CD, β -CD and γ-CD differ from each other depending on the presence of glucose residue. Complexation of molecules to CDs occurs through a non-covalent interaction between themolecule and the CD cavity. This is a dynamic process whereby the guest molecule continuously associates and dissociates from the host CD. CDs are insoluble inmost organic solvents; they are soluble in some polar, aprotic solvents. Although the solubility of CDs is higher in some organic solvents than in water, complexation may not occur readily in non-aqueous solvents because of the increased affinity of the guest for the solvent compared to its affinity for water.
Naresh B.,Bhagwant University
Proceedings of the 3rd IEEE International Conference on Advances in Electrical and Electronics, Information, Communication and Bio-Informatics, AEEICB 2017 | Year: 2017
In this paper, a dual band wearable rectenna is fabricated and tested to power the wearable sensors or electronics at 2.45 GHz and 5.8 GHz. The wearable rectenna substrate is designed with cotton jeans which is a textile material. RF-to-dc conversation system contains the diode rectifier and a high efficiency DC-DC step-up converter with maximum power point control (MPPT). The measured return loss bandwidth of the textile dual band antenna is 40% at 2.45 GHz and 51% at 5.8 GHz. The rectenna has maximum efficiency of 60% at -3dBm (5.8GHz) and 0dBm (2.45GHz). The rectenna has maximum efficiency of 60% at -3dBm (5.8GHz) and 0dBm (2.45GHz). © 2017 IEEE.
Ziyaurrahman A.R.,Bhagwant University |
Patel J.,P.A. College
Der Pharmacia Lettre | Year: 2012
Epilepsy is a group of disorders of CNS bearing its pathological origin in paroxysysmal cerebral dysrhythmia, clinically consisting episodes (seizure) of loss of consciousness. Boswellia serrata is a tetrahydroxy flavone that possess antiyperlipidemic, antioxidant, anti-inflammatory and antidiabetic potential. The aim of present investigation was to investigate the anticonvulsant activity of Boswellia serrata (5, 10 and 200 mg/kg) against Pentylenetetrazole (PTZ), Strychnine (STR), Isoniazid (INH) and maximal electroshock (M.E.S.) induced convulsions in mice as well as Electrical kindling seizures in rats. Diazepam and Phenytoin were used as reference anticonvulsant drugs for comparison. Intraperitoneal administration of PTZ (90mg/kg), Strychnine (50 mg/kg) and Isoniazid (300 mg/kg) resulted in hind-limb, tonic-clonic convulsion along with lethality in mice, whereas twice daily auricular stimulation resulted progressive severity of seizures in rats. It also significantly altered levels of brain Gamma amino butyric acid (GABA) along with nitric oxide (NO) and xanthine oxidase (XO) in mice. Treatment with Boswellia serrata (10 and 200 mg/kg) delayed onset of convulsion along with duration of tonicclonic convulsions as well as it significantly reduced PTZ and STR-induced mortality in mice (P < 0.05-P < 0.001). It also significantly (P < 0.001) reduced severity of electrically kindled seizures in rats and total number of rats seizure per group. Mice treated with Boswellia serrata (10 and 200 mg/kg) significantly increased level of brain GABA whereas it significantly decreased elevated level of brain NO and XO. In conclusion, the findings of present study provide pharmacological credence to anticonvulsant profile of Boswellia serrata. The protection against the convulsions and restoration of endogenous enzyme level give an innuendo to its probable mechanism of action which may be mediated through the GABAergic pathway and inhibition of oxidative injury.
Patel A.,Bhagwant University |
Patel J.,Nootan pharmacy college
Der Pharmacia Lettre | Year: 2012
In present study, mucoadhesive vaginal tablet of sertaconazole was designed using a combination of mucoadhesive polymers like Carbopol 934P, chitosan, carboxymethylcellulose sodium, sodium alginate, methyl cellulose, hydroxypropyl methylcellulose and hydroxypropyl cellulose. Effervescent was incorporated into formulations to enhance swellabilty of mucoadhesive tablet. For various drug-free formulations, the effect of effervescent on polymers swelling characteristics was investigated. Swelling, mucoadhesive property and drug release study of the tablets with different proportions of mucoadhesive polymer and effervescent in formulations were conducted. A good sustained effect and moderate bioadhesion were obtained with the tablets containing 100 mg of effervescent, with Carbopol 934P: HPMC K4M ratio of 1:1 seemed to be the optimum one for the tablet. From the ex vivo retention study it was found that the mucoadhesive polymers hold the tablet for more than 24 hours inside the vaginal tube. Our study may provide a potential vaginal tablet formulation of sertaconazole against Candida albicans.
Singh R.P.,Bhagwant University |
Jain D.A.,Bhagwant University
International Journal of ChemTech Research | Year: 2011
Volatile oil content in dried powder of C. longa rhizome was investigated by hydrodistillation and total curcuminoids content was evaluated by a UV spectrophotometer. Average yields of volatile oil and total curcuminoids in dried turmeric powder were 8.20 ±1.66%v/w and 7.57 ± 0.04%w/w, respectively. Volatile oil and total curcuminoids were evaluated for antibacterial activity by Agar diffusion method against medically important bacteria viz. B. subtilis, K. pneumonia, E. coli, Enterobacter aerogenes, Pseudomonas aeruginosa, S. auresus and P. mirabilis. Two fungi were selected viz. Aspergillus niger and Candida albicans for antifungal potential of volatile oil and total curcuminoids extracted from C.longa L. by Agar well diffusion method. Total curcuminoids content showed better antibacterial as well as antifungal activity as compare to volatile oil extracted from turmeric. Kanamycin was used as standard drug for antibacterial activity and Fluconazole as standard for antifungal activity.
Kumar S.,Bhagwant University
International Journal of Applied Engineering Research | Year: 2014
Recycling generally means reuse of waste water back in the same cycle where it is generated. The world's water is a finite and valuable resource. Wastewater recycling systems can play a major role in this approach and can potentially provide a range of sustainable development over conventional sewerage systems and on so many systems. Wastewater recycling is important due to many environmentally benefits which are Public health requirements; Environmental requirements; Appropriate technology selection; and Management system development. The water recycling process utilizes physical, biological and chemical principles to remove adulterate from water. Exploit of mechanical or physical systems to treat waste water is generally referred to as primary treatment and by biological processes to provide further treatment is referred to as secondary treatment and after all additional purification is called tertiary or advanced treatment. Recycling saves energy reduces raw material extraction and takes action on climate change. This article shows how wastewater is treated and recycled and reused is beneficial for us and also for environment. This also explores the complex relationship between waste recycling and its impacts. To obtain the full benefit we need to manage and protect it. After study we have founded that recycling is better for the environment. © Research India Publications.