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Velmurugan C.,Bhagwant University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: To evaluate the hypoglycemic and hypolipidemic effect of ethyl acetate (EAEPC) and ethanolic (EEPC) extracts from fruits of Pyrus communis by dexamethasone-induced diabetic rats. Methods: The different groups of animals were induced for diabetes with dexamethasone (10 mg/kg bw- sc) once daily for 11 days except normal control. The extracts 200mg/kg and glibenclamide 5mg/kg was administered to treat the diabetic rats once daily for 11 days. Results: The treated groups showed significant (p<0.01) anti-diabetic and hypolipidemic activity as compared to diabetic control. The extracts show beneficial effects on blood glucose like as standard. It also reduces the elevated biochemical parameters such as triglycerides (TGL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and total cholesterol (TC), increased the reduced level of high density lipoprotein (HDL) and maintains body weight. Conclusion: The both extracts could serve as good oral hypoglycemic agents and seems to be promising for the development of phytomedicines for diabetes mellitus and its complications.


Abraham T.N.,Tech Lab Group | Kumar R.,Tech Lab Group | Misra R.K.,Bhagwant University | Jain S.K.,Tech Lab Group
Journal of Applied Polymer Science | Year: 2012

In this article, we are discussing the synthesis and characterization of poly(vinyl alcohol)-based multiwalled carbon nanotubes (MWCNT) hydrogels and its evaluation studies for toxic metal ion removal. The functionalized MWCNT serves the purpose of toxic ion adsorbent and PVA is functioning as the substrate for the stable dispersion of MWCNT. We have carried out the evaluation studies using lead ions Pb(II) in batch experimental mode. The percentage removal of Pb(II) was examined by varying experimental conditions viz. dosage of adsorbent, pH of the solutions, and contact time. It was found that 80% removal was achieved under optimal conditions. This adsorption potential is found to be far better than that of simply dispersing MWCNT in water. The equilibrium adsorption follows the Freundlich adsorption isotherm model. After Pb(II) adsorption, the ions were easily desorbed using a high pH solution, completely regenerating for further removal process. This novel approach of dispersing MWCNT in hydrogel and their re-use after desorption is expected to have promising outcome in the water purification application. © 2012 Wiley Periodicals, Inc.


Gupta P.C.,University Institute of Pharmacy | Gupta P.C.,Bhagwant University | Rao C.V.,National Botanical Research Institute | Sharma N.,University Institute of Pharmacy
Pharmaceutical Biology | Year: 2013

Context: Cleome viscosa Linn. (Capparidaceae) is used traditionally in the Indian system of medicine as a carminative, anthelmintic, and diuretic, and used for healing wounds, ulcers and diarrhea. Objective: A 70% ethanol (EtOH) extract of the aerial parts of Cleome viscosa extract (CVE) was investigated for gastroprotective activity in different gastric ulcer models in order to validate ethnobotanical claims regarding the plant use in ulcers. Materials and methods: CVE (100, 200 and 400mg/kg body weight) was administered orally, twice daily for 5d, for prevention from EtOH, pylorus ligation (PL) and cold restraint stress (CRS)-induced ulcers in rats. Estimation of H+K +ATPase activity and gastric wall mucous were performed in EtOH-induced ulcer, antioxidant enzyme activities in supernatant mitochondrial fraction of CRS-induced ulcer, and gastric secretion parameters were estimated in PL-induced ulcer model Results: CVE showed significant (p<0.01) dose-dependent inhibition of lesion index in EtOH 15.93-42.30%, PL 26.34-59.28% and CRS 22.58-54.03%, respectively. CVE prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by a significant (p<0.001) decrease in superoxide dismutase, and an increase in catalase activity. A significant (p<0.01) decrease occurred in the level of H+K +ATPase, volume of gastric juice and total acidity. Simultaneously, the level of gastric wall mucus and pH were increased significantly (p<0.05). High performance thin layer chromatography analysis showed the presence of quercetin and gallic acid (0.3% and 0.25% w/w, respectively) in CVE. Conclusions: Results of our study showed that C. viscosa possesses significant gastroprotective activity, probably due to free radical scavenging activity, and validates the folklore claim. © 2013 Informa Healthcare USA, Inc.


Verma N.,IFTM University | Verma N.,Bhagwant University | Chattopadhyay P.,Indian Defence Research And Development Laboratory
Tropical Journal of Pharmaceutical Research | Year: 2012

Purpose: To develop mucoadhesive patches for buccal administration of metoprolol succinate and to evaluate their in vitro and in vivo bioadhesion. Methods: The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture absorption as well as for in vitro and in vivo bioadhesion. Results: The peak detachment force and work of adhesion for MC5 (sodium carboxymethylcellulose, i.e., Na CMC) patch were 0.87 N and 0.451 mJ respectively and the corresponding values for CH5 (chitosan) were 5.15N and 0.987 mJ. Formulation CH5 (prepared with chitosan) showed 67.1 % release, while MC5 (Na CMC) showed drug release of 81.9 % in 6 h. Basic pharmacokinetic parameters such as Cmax, Tmax and AUCtotal varied statistically (p < 0.05) when given by the buccal route compared with that of the solution given by the oral route. Conclusion: The results indicate that formulation of suitable bioadhesive buccal patches with the desired permeability is feasible. The development of bioadhesive buccal formulation for metoprolol succinate with a lower dose and few side effects may be attainable. © Pharmacotherapy Group. All rights reserved.


Mishra A.K.,IFTM Pharmacy College | Mishra A.K.,Bhagwant University | Mishra A.,IFTM Pharmacy College | Mishra A.,Birla Institute of Technology | Chattopadhyay P.,IFTM Pharmacy College
Tropical Journal of Pharmaceutical Research | Year: 2011

Ultraviolet B (UVB) rays vary with time and season and are the major cause of sunburns. Sunburned skin is a leading risk factor for melanoma and non-melanoma skin cancers. Protection against exposure to UVB rays may be achieved by a combination of various approaches such as use of broad spectrum sunscreen formulations. UV radiations (UVR) absorbed by the skin surface can produce harmful compounds called free radicals or reactive oxygen species (ROS), which can cause skin cancer and premature aging. To reduce ROS generation and damage, researchers recommend using sunscreen to protect the skin from harmful UVR. The realm of possibilities in photoprotection may include the development of sunscreens which remain at the surface of the skin for a longer time and may incorporate antioxidants that can neutralize ROS. By quenching free radicals, antioxidants may aid photoprotection effect. This review focuses on photoprotection from UVB radiation and discusses potential herbal candidates with antioxidant properties that can serve as a strong barrier in cosmeceuticals to protect skin against harmful UVB rays. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.


Sharma M.,CSIR - Central Electrochemical Research Institute | Sharma M.,Bhagwant University | Chauhan K.,CSIR - Central Electrochemical Research Institute | Shivahare R.,CSIR - Central Electrochemical Research Institute | And 9 more authors.
Journal of Medicinal Chemistry | Year: 2013

The high potential of quinazolinone containing natural products and their derivatives in medicinal chemistry led us to discover four novel series of 53 compounds of quinazolinone based on the concept of molecular hybridization. Most of the synthesized analogues exhibited potent leishmanicidal activity against intracellular amastigotes (IC50 from 0.65 ± 0.2 to 7.76 ± 2.1 μM) as compared to miltefosine (IC50 = 8.4 ± 2.1 μM) and nontoxic toward the J-774A.1 cell line and Vero cells. Moreover, activation of Th1 type and suppression of Th2 type immune responses and induction in nitric oxide generation proved that 8a and 8g induce murine macrophages to prevent survival of parasites. Compounds 8a and 8g exhibited significant in vivo inhibition of parasite 73.15 ± 12.69% and 80.93 ± 10.50% against Leishmania donovani/hamster model. Our results indicate that compounds 8a, 8g, and 9f represent a new structural lead for this serious and neglected disease. © 2013 American Chemical Society.


Singh R.P.,Bhagwant University | Jain D.A.,Bhagwant University
International Journal of ChemTech Research | Year: 2011

Volatile oil content in dried powder of C. longa rhizome was investigated by hydrodistillation and total curcuminoids content was evaluated by a UV spectrophotometer. Average yields of volatile oil and total curcuminoids in dried turmeric powder were 8.20 ±1.66%v/w and 7.57 ± 0.04%w/w, respectively. Volatile oil and total curcuminoids were evaluated for antibacterial activity by Agar diffusion method against medically important bacteria viz. B. subtilis, K. pneumonia, E. coli, Enterobacter aerogenes, Pseudomonas aeruginosa, S. auresus and P. mirabilis. Two fungi were selected viz. Aspergillus niger and Candida albicans for antifungal potential of volatile oil and total curcuminoids extracted from C.longa L. by Agar well diffusion method. Total curcuminoids content showed better antibacterial as well as antifungal activity as compare to volatile oil extracted from turmeric. Kanamycin was used as standard drug for antibacterial activity and Fluconazole as standard for antifungal activity.


Bhanushali M.D.,Bhagwant University | Shivakumar M.,KLE University
Oriental Journal of Chemistry | Year: 2013

Twelve new 3-(4-substituted benzyl)-5-(4-substituted phenyl)-1-phenyl-4, 5-dihydro-1H-pyrazole derivatives were synthesized by reacting 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one and phenyl hydrazine in ethanol. 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one were synthesized by condensation of substituted phenylacetone and substituted benzaldehyde in NaOH solution. The synthesized compounds were confirmed by spectra data. The compounds were evaluated in-vitro for their antibacterial, antifungal, anti-tubercular activity and in-vivo for their anti-inflammatory activity. Compounds P25, P29, P31 and P 32 were found to exhibit good antimicrobial and anti-inflammatory activity.


Kumar S.,Bhagwant University
International Journal of Applied Engineering Research | Year: 2014

Recycling generally means reuse of waste water back in the same cycle where it is generated. The world's water is a finite and valuable resource. Wastewater recycling systems can play a major role in this approach and can potentially provide a range of sustainable development over conventional sewerage systems and on so many systems. Wastewater recycling is important due to many environmentally benefits which are Public health requirements; Environmental requirements; Appropriate technology selection; and Management system development. The water recycling process utilizes physical, biological and chemical principles to remove adulterate from water. Exploit of mechanical or physical systems to treat waste water is generally referred to as primary treatment and by biological processes to provide further treatment is referred to as secondary treatment and after all additional purification is called tertiary or advanced treatment. Recycling saves energy reduces raw material extraction and takes action on climate change. This article shows how wastewater is treated and recycled and reused is beneficial for us and also for environment. This also explores the complex relationship between waste recycling and its impacts. To obtain the full benefit we need to manage and protect it. After study we have founded that recycling is better for the environment. © Research India Publications.


Gadhave M. V.,Bhagwant University | Banerjee S. K.,VJSMs Vishal Institute of Pharmaceutical Education and Research
International Journal of Pharmaceutical and Clinical Research | Year: 2014

Embelin, a chemical constituent obtained from Embelia ribes Burm. Having several therapeutic activities like anthelmintic, antimicrobial, enzyme inhibitory, hepatoprotective, antihyperlipidemic, etc. The poor water solubility and poor micromeritic properties of Embelin lead to low dissolution rate and poor flow during tabletting. The aim of present study was to enhance solubility, dissolution rate and improvement of micromeritic properties of the poorly soluble drug. The spherical agglomerate of Embelin was prepared by solvent change method in the presence of hydrophilic polymer in different concentration. The solvent system used was acetone, water and dichloromethane as good solvent, anti-solvent and bridging liquid respectively. Spherical agglomerates were subjected for determination of percent drug content and particle size analysis. The agglomerates obtained evaluated using by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Powder Diffraction (XRD) and Scanning Electron Microscopy (SEM) analysis. The FTIR and DSC study showed no interaction between drug and polymer. XRD studies showed a decrease in crystallinity of agglomerates. Spherical agglomerates showed improvement in solubility, dissolution rate and micromeritic properties in comparison to that of the pure drug. The SEM also showed that the agglomerate possess a good spherical shape. © 2014 International Journal of Pharmaceutical and Clinical Research. All rights reserved.

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