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Kamra H.T.,Bhagat Phool Singh Medical College for women | Agarwal R.,Bhagat Phool Singh Medical College for women | Rana P.,Bhagat Phool Singh Medical College for women | Kalra R.,PGi | And 4 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Thyroid disease is most common endocrine disorder and is different from other endocrine diseases because of its visible swelling and ease of diagnosis. If left untreated, thyroid disease makes a person more prone for heart disease, infertility and osteoporosis. In India, significant burden of thyroid diseases exist with an estimation of around 42 million cases. The thyroid status and autoimmune status of adult Indian population in the post iodinization phase is largely unknown.Aim: The main objective of this study was to generate valuable epidemiological data regarding the prevalence of thyroid disorders in rural population of Khanpur Kalan, Sonepat in the post-iodinisation era in India. To assess whether thyroid autoimmunity or goitrogens along with environmental factors play role in the development of thyroid.This paper is being presented in view that no such study has been carried out in the rural population of this region in Haryana.Materials and Methods: The present study was conducted in Department of Pathology, Bhagat Phool Singh Medical College for Women, Khanpur Kalan, Sonepat between August 2011 to July 2013. It included retrospective analysis of cytomorphology of fine needle aspiration cytology material of 206 patients presenting with thyroid nodule in the Department of Pathology.Results: The commonest age group affected was 31-40 yrs. The female patients (93.4%) outnumbered the male patients(6.6%).The cytomorphological analysis of 206 patients revealed 190 cases (92.2%) of neoplastic lesions, 10 cases (4.8%) were neoplastic and 6 cases (2.9%) had indeterminate cytomorphology. Maximum number (65.5%) of patients was suffering with goiter followed by lymphocytic thyroiditis (26.2%). Amongst the malignant cases three cases were of papillary carcinoma and one case of medullary carcinoma. Two out of the six cases of follicular neoplasm proved to be follicular adenoma on histopathology. Four patients with high T3 levels were under treatment with neomercazole. They showed change in cytomorphology from hyperplasia to colloid goiter. Only one case of acute suppurative thyroiditis was reported which shows rarity of its type.Conclusion: The increased prevalence of goiter in this post iodinisation era can be attributed to goitrogens, autoimmune thyroid disease and micronutrient deficiency of iron and selenium. Higher prevalence of autoimmune thyroiditis in females is linked with both genetic and environmental factors such as infection, stress. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.

PubMed | Bhagat Phool Singh Medical College for Women and Indus International Hospital
Type: | Journal: International journal of mycobacteriology | Year: 2017

Nontubercular mycobacteria (NTM) is not known to be associated with fistula-in-ano.A total of 311 consecutive fistula-in-ano patients operated on over 2years were analyzed. The histopathology of fistula-in-ano tract lining was performed in all the cases and other tests [real-time polymerase chain-reaction (RT-PCR), Gene Xpert, mycobacterial culture] were completed in patients with a high index of suspicion of having mycobacterial disease.Two patients had histopathological features suggestive of mycobacterial disease. Out of these, one patient had NTM and another had mycobacterium tuberculosis (MTB) on RT-PCR. Four patients had normal histopathology features but tested positive on RT-PCR (two for NTM and two for MTB). Therefore, a total of six patients tested for mycobacterial disease (three for NTM and three for MTB). Mycobacterium culture was studied in two patients (both NTM) but was negative. Five out of six patients (two NTM and three MTB) presented with delayed recurrences after operations (6-18months after complete healing).Nontubercular mycobacteria can cause fistula-in-ano. It could be an undiagnosed contributory factor in fistula recurrence. Mycobacterial disease (both tubercular and nontubercular) may be associated with delayed recurrence of fistula. RT-PCR is a highly sensitive test and can differentiate between NTM and MTB. It should perhaps be performed in all recurrent and refractory cases.

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