Shenzhen BGI

Shenzhen, China

Shenzhen BGI

Shenzhen, China

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Ye B.-G.,South China University of Technology | Wu X.-M.,South China University of Technology | Li J.-X.,Shenzhen BGI | Zhou Y.,Shenzhen BGI | Wang D.-P.,Shenzhen BGI
2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010 | Year: 2010

The images, in high-throughput genome sequencing of sequencing by synthesize, consist of A, C, G, T base fluorescence images, and the fluorophore emission spectra partially overlap, which causes cross-talk problem. This paper presents a method of correlation analysis, construct the calibration matrix to eliminate interference of the fluorophore. The experiment result shows the method provided in this article is effective to correct cross-talk influence, and get the deconvolution of the clusters signal. © 2010 IEEE.

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