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Ankara, Turkey

Dundar O.,Haydarpasa Military Education and Research Hospital | Pektas M.K.,Haseki Education and Research Hospital | Bodur S.,Afyon Kocatepe University | Bakir L.V.,Beytepe Military Hospital | Cetin A.,Beytepe Military Hospital
Journal of Obstetrics and Gynaecology Research

Aim The present study aims to evaluate how components of complete blood count are altered in women with a history of recurrent pregnancy loss. Material and Methods This was a retrospective evaluation of 60 women who had a history of recurrent pregnancy loss, 60 healthy women who had a first trimester pregnancy and 60 healthy parous women. Results When compared with pregnant women and healthy controls, the women with a history of recurrent pregnancy loss had significantly higher red cell distribution width (RDW) and platelet distribution width (PDW) (P=0.001 for both). Thrombophilia was detected in 31.7% of the women who had a history of recurrent pregnancy loss (19 out of 60). When compared to the women without thrombophilia, the women with thrombophilia had significantly lower body mass index (P=0.034) but significantly higher RDW, PDW and plateletcrit (respectively, P=0.043, P=0.001 and P=0.002). There were significant and positive correlations between RDW and PDW (r=0.615, P=0.001), RDW and plateletcrit (r=0.343, P=0.007) and PDW and plateletcrit (r=0.340, P=0.008) in women with a history of recurrent pregnancy loss. Conclusion An elevation in PDW and RDW values was found to be associated with recurrent pregnancy loss. © 2014 The Authors. Source

Demirkol S.,Gulhane Medical Academy | Kucuk U.,Gulhane Medical Academy | Baysan O.,Gulhane Medical Academy | Balta S.,Gulhane Medical Academy | And 6 more authors.

Aims: The aim of this study is to investigate the effect of mitral stenosis (MS) on left atrial (LA) function using two-dimensional speckle tracking echocardiography (2DSTE). Methods and Results: The study subjects consisted of 52 patients with asymptomatic MS and 52 control subjects. LA function was assessed using prototype speckle tracking software and manual tracking method. Maximal LA volume (LAVmax) and minimal LA volume (LAVmin) and LA volume before atrial contraction (LAVpre-a) were measured. Using these volumes, LA reservoir, conduit and booster pump fuction parameters were calculated. Indexed LAVmax, LAVmin, and LAVpre-a measurements via speckle tracking were highly correlated with manual tracing methods in both groups. Expansion index (67.8 ± 36.4 vs. 148.3 ± 44.2), diastolic emptying index (37.7 ± 12.9 vs. 58.0 ± 8.5), passive emptying (37.3 ± 14.1 vs. 70.4 ± 10.4) and passive emptying index (13.3 ± 6.3 vs. 41.3 ± 10.6) were decreased significantly in MS patients (P < 0.001). In contrast active emptying index (62.6 ± 4.1 vs. 29.5 ± 10.1) increased in MS group (P < 0.001) while active emptying (28.1 ± 13.0 vs. 28.3 ± 6.9) remained same among both groups. Conclusions: This is the first study relating LA volumes and function assessed by 2DSTE to MS. 2D speckle tracking analysis of LA volume is relatively easy and provides more detailed information regarding the changes in LA volumes during the cardiac cycle. © 2012, Wiley Periodicals, Inc. Source

Fici F.,University of Milan Bicocca | Celik T.,Gulhane Military Medical Academy | Balta S.,Gulhane Military Medical Academy | Iyisoy A.,Gulhane Military Medical Academy | And 8 more authors.
Journal of Cardiovascular Pharmacology

High level of circulating red cell distribution width (RDW) and neutrophil/lymphocyte (N/L) ratio may reflect ongoing vascular inflammation and play an important role in pathophysiology of hypertension. We evaluate the effects of nebivolol and metoprolol on the RDW and N/L in new essential hypertensive patients. After baseline assessment, 72 patients were randomly allocated to 5 mg/d of nebivolol (n = 37, 20 men) or 100 mg/d of metoprolol (n = 35, 18 men) and treated for 6 months. Blood pressure (BP), heart rate (HR), RDW, and N/L were measured before and after treatment. BP significantly decreased with both drugs (P < 0.001). Analog reduction was observed for resting HRs (P < 0.001), but metoprolol caused greater HR fall as compared with nebivolol (P < 0.001). After 6 months of treatment, nebivolol significantly lowered not only RDW but also the total white blood cell and N/L (P < 0.001, P = 0.023, P = 0.017, respectively). No changes were observed in metoprolol group. Percent decrease in RDW was found to be significantly higher in nebivolol than in the metoprolol group (P = 0.001) and remained also after correction for confounders (P = 0.012). Nebivolol improved RDW and N/L to a greater extent than metoprolol in patients with hypertension. These favorable effects may participate, together with the BP reduction, at the favorable properties of the drug in hypertension. © 2013 by Lippincott Williams & Wilkins. Source

Gokce S.M.,Gulhane Military Medical Academy | Gorgulu S.,Gulhane Military Medical Academy | Gokce H.S.,Beytepe Military Hospital | Bengi O.,Gulhane Military Medical Academy | And 3 more authors.
International Journal of Oral and Maxillofacial Surgery

Bimaxillary orthognathic surgery (BOS) is commonly used in the correction of severe Class III deformities (mandibular prognathism with maxillary retrognathism). The postural response of the pharyngeal airway after mandibular setback and maxillary advancement procedures is clinically crucial for maintaining optimum respiration. Patients might suffer from obstructive sleep apnoea, postoperatively. The aim of this study was to determine the effects of BOS on pharyngeal airway space, respiratory function during sleep and pulmonary functions. 21 male patients were analysed using cephalometry, spirometry for pulmonary function tests, and a 1 night sleep study for full polysomnography before and 17 ± 5 months after BOS. The data show that the hyoid bone repositioned to the inferior, the tongue and soft palate displaced to the posterior, narrowed at the oropharynx and hypopharynx and widened at the nasopharynx and velopharynx levels significantly (p < 0.05). The alterations indicated decreased airway resistance and better airflow. As a consequence of polysomnography evaluation, the sleep quality and efficiency of the patients improved significantly after BOS. Patients who undergo BOS should be monitored with pulmonary function tests and polysomnography pre- and postoperatively to detect any airway obstruction. © 2012 International Association of Oral and Maxillofacial Surgeons. Source

Demirci H.,Gazi University | Erdamar H.,Beytepe Military Hospital | Karakoc A.,Gazi University | Arslan M.,Gazi University
International Journal of Clinical Practice

Objective: Thyroid fine needle aspiration biopsy (TFNAB) is the gold standard in the differential diagnosis of the thyroid nodules. In general, no analgesia is needed before this procedure. However, it is usually believed that the patients may be more comfortable if the procedure is performed under local anaesthetics. In this study, we examined the impact of the use of dermal anaesthetic on the patient's level of discomfort during palpation-guided TFNAB. Methods: Fifty female patients with nodular goitre were enrolled in this study. Patients were randomised into two groups: a placebo cream was applied to group 1 patients (25 females; mean age 47.45 ± 11.61 years), and local anaesthesia (EMLA® 5% cream) was applied to group 2 patients (25 females; mean age 50.89 ± 12.01 years) approximately 1 h before TFNAB. All patients were asked to mark the pain they felt during the TFNAB on Visual Analogue Scale. Results: The pain scores during TFNAB were 27.73 ± 20.01 mm and 24.79 ± 21.98 mm in the placebo group and in the EMLA ® group respectively. There was no significant difference between the groups (p = 0.496). Conclusions: Topical anaesthesia before palpation-guided TFNAB provides no benefit. © 2008 Blackwell Publishing Ltd. Source

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