Beyoglu Eye Training and Research Hospital

İstanbul, Turkey

Beyoglu Eye Training and Research Hospital

İstanbul, Turkey
SEARCH FILTERS
Time filter
Source Type

Karakus S.H.,Beyoglu Eye Training and Research Hospital | Basarir B.,Beyoglu Eye Training and Research Hospital | Pinarci E.Y.,Baskent University | Kirandi E.U.,Beyoglu Eye Training and Research Hospital | Demirok A.,Beyoglu Eye Training and Research Hospital
Eye (Basingstoke) | Year: 2013

Purpose To evaluate the efficacy and safety of photodynamic therapy (PDT) with half-dose verteporfin in patients with chronic central serous chorioretinopathy (CCSC) and retinal functional changes, by functional acuity contrast test (FACT).MethodsIn this study, 27 eyes of 24 patients with CCSC were treated with PDT with half-dose verteporfin. Best-corrected visual acuity (BCVA), central foveal thickness (CFT) and resolution of subretinal fluid on optical coherence tomography (OCT), and leakage on fluorescein angiography (FA) and indocyanine green angiography (ICGA) were assessed. Contrast sensitivity test was performed at baseline and at 12th month for investigating retinal functional changes.ResultsThe mean follow-up period was 25.33±11.08 months. The mean age was 43.7±8.6 years. Seventeen patients were male (70.8%) and seven patients were female (29.2%). Post PDT at 1st, 3rd, 6th, 12th month and at last follow-up, BCVA were significantly improved compared with the baseline BCVA (P<0.001), and CFT post PDT were significantly thinner than the baseline measurement (P<0.001). There was significant difference between pre-and post-PDT 12th month contrast sensitivities at all five different spatial frequency channels (P<0.01).ConclusionsHalf-dose PDT is an effective and safe method in the treatment of CCSC with anatomical and functional success. The measurement of contrast sensitivity by FACT can be useful for evaluating the functional effectiveness of half-dose PDT for CCSC. © 2013 Macmillan Publishers Limited All rights reserved.


Ozgurhan E.B.,Beyoglu Eye Training and Research Hospital | Akcay B.I.S.,Umraniye Training and Research Hospital | Kurt T.,Beyoglu Eye Training and Research Hospital | Yildirim Y.,Beyoglu Eye Training and Research Hospital | Demirok A.,Istanbul Medeniyet University
Journal of Refractive Surgery | Year: 2015

PURPOSE: To report the outcomes of accelerated corneal collagen cross-linking in patients with thin corneas (minimum corneal thickness < 400 μm). METHODS: Thirty-four eyes of 34 patients with a minimum corneal thickness less than 400 μm were included. All patients underwent accelerated corneal collagen cross-linking (irradiance power of 30 mW/cm2 at 3 minutes with a total surface dose of 5.4 J/cm2). Uncorrected (UDVA) and corrected distance visual acuity (CDVA), manifest refraction (diopters [D]), and topography were evaluated at baseline and at the 1-, 6-, and 12-month follow-up visit. Endothelial cell density (cells/mm2) was calculated preoperatively and postoperatively at 12 months. The corneal stromal demarcation line was measured using anterior segment optical coherence tomography at 1 month postoperatively. RESULTS: The mean age of all patients (14 women and 20 men) was 23.08 ± 3.90 years (range: 16 to 29 years). UDVA and CDVA increased but not significantly. UDVA improved from 0.67 ± 0.32 (20/93 ± 20/41 Snellen) to 0.56 ± 0.28 logMAR (20/72 ± 20/38 Snellen) (P = .033) and CDVA improved from 0.49 ± 0.19 (20/61 ± 20/30 Snellen) to 0.42 ± 0.19 logMAR (20/52 ± 20/30 Snellen) (P = .009) at the last follow-up visit. The mean spherical and cylindrical refractions did not significantly change (P = .100 and 0.139, respectively). At the last follow-up visit, the flat keratometry decreased from 47.40 ± 2.52 to 46.95 ± 2.48 D, steep keratometry decreased from 51.04 ± 3.71 to 50.62 ± 3.57 D, and apex keratometry decreased from 57.58 ± 4.49 to 56.26 ± 4.47 D (P = .001, = .0019, = .001, respectively) from baseline. The mean endothelial cell density changed from 2,726.02 ± 230.21 to 2,714.58 ± 218.26 cells/mm2 at 12 months postoperatively (P =.086). CONCLUSION: The results of this study revealed that accelerated corneal collagen cross-linking stabilized the progression of keratoconus without a significant endothelial cell density loss during the 12 months of follow-up. Copyright © SLACK Incorporated.


Ozgurhan E.B.,Beyoglu Eye Training and Research Hospital | Kara N.,University of Gaziantep | Cankaya K.I.,Beyoglu Eye Training and Research Hospital | Kurt T.,Beyoglu Eye Training and Research Hospital | Demirok A.,Beyoglu Eye Training and Research Hospital
Journal of Refractive Surgery | Year: 2014

PURPOSE: To compare the efficiency and safety of accelerated corneal cross-linking in pediatric patients with progressive keratoconus. METHODS: In this retrospective interventional case series, 44 eyes of 38 pediatric patients with progressive keratoconus were enrolled. All consecutive patients underwent accelerated corneal cross-linking with settings of 30 mW/cm2 for 4 minutes, corresponding to a total dose of 7.2 J. The efficacy and safety of the procedure were assessed over a 24-month follow-up period. RESULTS: Mean ± standard deviation age of 10 girls and 28 boys was 15.3 ± 2.1 years (range: 9 to 18 years). Uncorrected distance visual acuity improved significantly from 0.52 ± 0.36 to 0.39 ± 0.26 logMAR (P = .002), and corrected distance visual acuity improved significantly from 0.38 ± 0.24 to 0.30 ± 0.20 logMAR (P < .001). Mean spherical and cylindrical refraction were not significantly altered (P > .001 for both). At the last follow-up visit, the flat keratometry value decreased from baseline from 46.4 ± 3.0 to 46.0 ± 2.9 diopters and the steep keratometry value decreased from 50.6 ± 4.2 to 50.1 ± 4.0 diopters (P < .001 for both). The total higher-order aberrations, coma, and astigmatism II values were also significantly decreased at 24 months after treatment (P < .05 for all). No serious complications were recorded during the follow-up. CONCLUSIONS: The findings revealed that accelerated corneal cross-linking halted the keratoconus progression without relevant side effects in pediatric patients over a 24-month follow-up period. Visual acuity, keratometric values, and corneal aberrations also improved. Copyright © SLACK Incorporated


Kaya V.,Beyoglu Eye Training and Research Hospital | Utine C.A.,Yeditepe University | Ylmaz O.F.,Beyoglu Eye Training and Research Hospital
Cornea | Year: 2012

Purpose:: To monitor corneal thickness during the corneal collagen cross-linking procedure in corneal ectatic diseases, by using isoosmolar riboflavin solution with 20% dextran and hypoosmolar riboflavin solution without dextran. Methods:: The corneal thickness measurements were obtained at 5 different time points: after epithelial removal, after isotonic riboflavin solution application for 30 minutes, after hypotonic riboflavin solution application for 10 minutes, and after 10 and 30 minutes of isotonic riboflavin solution application. Results:: A total of 9 eyes of 9 patients with progressive keratoconus (n=8) and pellucid marginal degeneration (n=1) were included in this study. After epithelial debridement, the thinnest pachymetric readings were between 331 and 399 μm (average, 376.11 ± 19.88 μm). The thinnest pachymetric measurements decreased significantly after the application of isoosmolar riboflavin solution for 30 minutes (by 55.22 ± 13.40 μm) and increased significantly after hypoosmolar riboflavin application for 10 minutes (by 59.56 ± 29.71 μm) (P < 0.01 for both). This artificial swelling effect was transient, and the thinnest pachymetric readings decreased significantly after 10 and 30 minutes of isoosmolar riboflavin application compared with thickness at the end of hypoosmolar riboflavin application (by 50.22 ± 29.68 μm and 65.11 ± 27.94 μm, respectively) (P < 0.01 for both). Conclusions:: The iatrogenic swelling effect of the hypoosmolar riboflavin solution might be short acting and not durable throughout the UVA application in collagen cross-linking procedure. © 2012 by Lippincott Williams & Wilkins.


Kapran Z.,Istanbul University | Ozkaya A.,Beyoglu Eye Training and Research Hospital | Uyar O.M.,Maltepe University
Ophthalmic Surgery Lasers and Imaging Retina | Year: 2013

BACKGROUND AND OBJECTIVE: To investigate the outcomes of vitrectomy, subretinal tissue plasmin-ogen (tPA) injection, gas tamponade, and upright positioning in patients with hemorrhagic neovas-cular age-related macular degeneration (AMD). PATIENTS AND METHODS: Retrospective, noncom-parative case series. Records of patients who were diagnosed with submacular hemorrhage secondary to neovascular AMD and underwent treatment with the combined method between 2004 and 2010 were reviewed. The main outcome measure was the difference between preoperative and postoperative best corrected visual acuity (BCVA). RESULTS: In 10 eyes of 10 patients, mean preoperative and postoperative BCVA values were 1.75 and 1.23 logMAR, respectively (P = .011), after a mean follow-up time of 38.7 ± 26.5 months (range: 10 to 71 months). Eight of 10 patients (80%) gained at least three lines. CONCLUSION: In patients with hemorrhagic neo-vascular AMD, treatment with vitrectomy, sub-retinal tPA injection, gas tamponade, and upright positioning was associated with better visual outcomes than those reported for patients with untreated disease.


Ozkaya A.,Beyoglu Eye Training and Research Hospital | Alkin Z.,Beyoglu Eye Training and Research Hospital | Yazici A.T.,Beyoglu Eye Training and Research Hospital | Demirok A.,Istanbul Medeniyet University
Retina | Year: 2014

PURPOSE:: To compare the efficacy of intravitreal ranibizumab for the treatment of neovascular age-related macular degeneration between phakic and pseudophakic eyes with visual acuity 0.5 Snellen equivalent. METHODS:: This was a retrospective, interventional, comparative study. The newly diagnosed neovascular age-related macular degeneration patients with visual acuity of 0.5 Snellen equivalent were included in the study. The patients were divided into two subgroups: phakic group and pseudophakic. All patients received three consecutive monthly intravitreal ranibizumab injections, and then, reinjection was performed as needed. Patients were examined monthly, and the data at the baseline, at Months 3, 6, 9, and 12 were evaluated. The changes in visual acuity, central retinal thickness, and the number of injections were compared between the groups. RESULTS:: The study included 96 eyes of 96 patients (56 phakic and 40 pseudophakic). Mean Snellen visual acuity at the baseline, at Months 3, 6, 9, and 12 was 0.56 ± 0.09, 0.64 ± 0.15, 0.62 ± 0.21, 0.60 ± 0.22, and 0.61 ± 0.20 for the phakic group; and 0.55 ± 0.08, 0.63 ± 0.14, 0.60 ± 0.13, 0.58 ± 0.14, and 0.59 ± 0.13 for the pseudophakic group, respectively. The change in mean visual acuity and central retinal thickness at the study visits was not statistically significant between the 2 groups (P > 0.05 for all). Mean injection number at Month 12 was 4.5 and 4.3 in the phakic and pseudophakic group, respectively (P = 0.5). CONCLUSION:: Intravitreal ranibizumab treatment on an as-needed treatment regimen is effective in preserving vision and improving central retinal thickness in both the phakic and pseudophakic group of neovascular age-related macular degeneration patients with good baseline visual acuity. © by Opthamic Communication Society, Inc. Unauthorized reproduction of this article is prohibited.


Celik H.U.,Beyoglu Eye Training and Research Hospital | Alagoz N.,Beyoglu Eye Training and Research Hospital | Yildirim Y.,Beyoglu Eye Training and Research Hospital | Agca A.,Beyoglu Eye Training and Research Hospital | And 3 more authors.
Journal of Cataract and Refractive Surgery | Year: 2012

Purpose: To assess accelerated corneal collagen crosslinking (CXL) applied concurrently with laser in situ keratomileusis (LASIK) in a small group of patients. Setting: Beyoglu Eye Research and Training Hospital, Istanbul, Turkey. Design: Prospective pilot interventional case series. Methods: In May 2010, patients had LASIK with concurrent accelerated CXL in 1 eye and LASIK only in the fellow eye to treat myopia or myopic astigmatism. The follow-up was 12 months. The attempted correction (spherical equivalent) ranged from -5.00 to -8.50 diopters (D) in the LASIK-CXL group and from -3.00 to -7.25 D in the LASIK-only group. Main outcome measures were manifest refraction, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, and the endothelial cell count. Results: Eight eyes of 3 women and 1 man (age 22 to 39 years old) were enrolled. At the 12-month follow-up, the LASIK-CXL group had a UDVA and manifest refraction equal to or better than those in the LASIK-only group. No eye lost 1 or more lines of CDVA at the final visit. The endothelial cell loss in the LASIK-CXL eye was not greater than in the fellow eye. No side effects were associated with either procedure. Conclusions: Laser in situ keratomileusis with accelerated CXL appears to be a promising modality for future applications to prevent corneal ectasia after LASIK treatment. The results in this pilot series suggest that evaluation of a larger study cohort is warranted. Financial Disclosure: Drs. Yilmaz and Marshall are paid consultants to Avedro, Inc. No other author has a financial or proprietary interest in any material or method mentioned. © 2012 ASCRS and ESCRS.


Cakir M.,Beyoglu Eye Training and Research Hospital | Cekic O.,Beyoglu Eye Training and Research Hospital | Yilmaz O.F.,Beyoglu Eye Training and Research Hospital
European Journal of Ophthalmology | Year: 2010

PURPOSE. To evaluate the efficacy of C3F8 gas-assisted pneumatic displacement in the treatment of massive submacular hemorrhage, with and without the use of tissue plasminogen activator (tPA). METHODS. Twenty-one eyes of 21 patients with recently developed (up to 10 days) dense submacular hemorrhage underwent intravitreal injection of pure C 3F8 gas (0.4-0.5 mL) followed by face-down positioning for pneumatic displacement. Seven of them received additional intravitreal injection of 25-50 μg tPA. The primary etiology of submacular hemorrhage was age-related macular degeneration (n=16), myopic choroidal neovascularization (n=2), retinal arterial macroaneurysm (n=2), and trauma (n=1). Visual acuity and displacement of hemorrhage were the main outcome measures. RESULTS. Follow-up period was 6-12 months. Effective displacement of hemorrhage was obtained in 20 of 21 patients within 7 days. Final median Snellen visual acuity (0.18) was found significantly improved compared to baseline (0.03) (p<0.001). Visual acuity improvement was similar in both groups (p=0.72). CONCLUSION. Intravitreal injection of C3F8 effectively displaced thick submacular hemorrhage and improved visual acuity independently from primary cause. Additional tPA use in this study had no impact on the final outcomes. © 2010 Wichtig Editore.


Kaya V.,Beyoglu Eye Training and Research Hospital | Utine C.A.,Yeditepe University | Yilmaz O.F.,Beyoglu Eye Training and Research Hospital
Journal of Refractive Surgery | Year: 2011

PURPOSE: To examine the corneal collagen cross-linking (CXL) effect with a customized epithelial debridement technique in thin corneas using anterior segment optical coherence tomography (OCT) and confocal microscopy. METHODS: Two patients with keratoconus who underwent a customized epithelial debridement technique (preserving the epithelium in thinner corneal regions where the deepithelialized corneal thickness was <400 μm) and subsequent CXL were examined by anterior segment OCT and in vivo confocal microscopy 1 month postoperatively. RESULTS: Anterior segment OCT showed the demarcation line in the peripheral deepithelialized corneal areas, but it was not detectable in the central corneal regions corresponding to the cone where the epithelium was preserved. In vivo confocal microscopy analysis revealed total loss of keratocytes together with the intense honey-comb-like stromal edema in the anterior ∼320 μm of the cornea in the deepithelialized areas. This effect was mild under the intact epithelium with preservation of keratocytes and only a mild increase in stromal reflectivity. CONCLUSIONS: In this confocal microscopy study, the corneal stroma under the intact epithelium seemed to be spared from the collagen CXL effect by the customized epithelial debridement technique. Copyright © SLACK Incorporated.


Optic nerve head drusen are acellular, calcified deposits which may be found in buried or exposed drusen form. Choroidal neovascularisation secondary to optic nerve head drusen is rarely seen in childhood. This case report summarises the clinical and therapeutic outcomes of a 13-year-old girl with unilateral choroidal neovascularisation secondary to optic nerve head drusen. The patient was successfully treated with a single intravitreal ranibizumab injection. After a month from the injection the visual acuity increased dramatically and maintained at the same level during 9 months of follow-up time. There was no complication related to the injection.

Loading Beyoglu Eye Training and Research Hospital collaborators
Loading Beyoglu Eye Training and Research Hospital collaborators