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Pierce, NJ, United States

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Pierce, NJ, United States

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Christian B.J.,Hazelton Wisconsin Inc. | Bechtel D.H.,Best Foods
Regulatory Toxicology and Pharmacology | Year: 2014

The subchronic (90-day) toxicity of a "core" version of EPG was assessed in rats. Crl:CD-1®(ICR)BR rats (70/sex) received diets containing a constant level of 5% EPG (w/w) or adjusted to deliver 0 (control), 0.5, 1, or 2. g/kg of body weight/day (g/kg bw/day). Subsets of animals from each group (20/sex) were evaluated after 30. days (interim sacrifice); the remainder after 90. days. EPG intake at all dose levels was associated with lower mean liver vitamin E levels; liver vitamin A and serum vitamin D were also lower, but less consistently. Animals given 5% EPG had higher fecal output (males) and cholesterol (males and females) without corresponding changes in serum cholesterol. Urinary pH was also mildly lower in males given 5% EPG. However, detailed evaluation of general health and assessment of blood, organs and tissues showed no evidence that EPG administration compromised the nutritional requirements of the animals, caused a state of fat-soluble vitamin deficiency, or caused' toxicity to any organ system. Based on the results of this study, it was not possible to establish a no-observable-effect level (NOEL). The possible effect of EPG on vitamin levels in the absence of any clinical signs of deficiency was not considered "adverse" per se. As such, the 2. g/kg and 5% EPG level were considered to represent a no-observable-adverse-effect levels (NOAELs). © 2014 Elsevier Inc.


News Article | December 6, 2016
Site: www.newsmaker.com.au

This report studies Sauces in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with Production, price, revenue and market share for each manufacturer, covering  Clorox  Heinz  Kikkoman  McCormick  PepsiCo  Unilever  Hellmann's  Kraft Heinz  Frenchs Classic Mustard  Tostitos Salsa  Best Foods Mayonnaise Market Segment by Regions, this report splits Global into several key Regions, with production, consumption, revenue, market share and growth rate of Sauces in these regions, from 2011 to 2021 (forecast), like  North America  Europe  China  Japan  Southeast Asia  India Split by product type, with production, revenue, price, market share and growth rate of each type, can be divided into  Type I  Type II  Type III Split by application, this report focuses on consumption, market share and growth rate of Sauces in each application, can be divided into  Application 1  Application 2  Application 3 Global Sauces Market Research Report 2016  1 Sauces Market Overview  1.1 Product Overview and Scope of Sauces  1.2 Sauces Segment by Type  1.2.1 Global Production Market Share of Sauces by Type in 2015  1.2.2 Type I  1.2.3 Type II  1.2.4 Type III  1.3 Sauces Segment by Application  1.3.1 Sauces Consumption Market Share by Application in 2015  1.3.2 Application 1  1.3.3 Application 2  1.3.4 Application 3  1.4 Sauces Market by Region  1.4.1 North America Status and Prospect (2011-2021)  1.4.2 Europe Status and Prospect (2011-2021)  1.4.3 China Status and Prospect (2011-2021)  1.4.4 Japan Status and Prospect (2011-2021)  1.4.5 Southeast Asia Status and Prospect (2011-2021)  1.4.6 India Status and Prospect (2011-2021)  1.5 Global Market Size (Value) of Sauces (2011-2021) 2 Global Sauces Market Competition by Manufacturers  2.1 Global Sauces Production and Share by Manufacturers (2015 and 2016)  2.2 Global Sauces Revenue and Share by Manufacturers (2015 and 2016)  2.3 Global Sauces Average Price by Manufacturers (2015 and 2016)  2.4 Manufacturers Sauces Manufacturing Base Distribution, Sales Area and Product Type  2.5 Sauces Market Competitive Situation and Trends  2.5.1 Sauces Market Concentration Rate  2.5.2 Sauces Market Share of Top 3 and Top 5 Manufacturers  2.5.3 Mergers & Acquisitions, Expansion 3 Global Sauces Production, Revenue (Value) by Region (2011-2016)  3.1 Global Sauces Production and Market Share by Region (2011-2016)  3.2 Global Sauces Revenue (Value) and Market Share by Region (2011-2016)  3.3 Global Sauces Production, Revenue, Price and Gross Margin (2011-2016)  3.4 North America Sauces Production, Revenue, Price and Gross Margin (2011-2016)  3.5 Europe Sauces Production, Revenue, Price and Gross Margin (2011-2016)  3.6 China Sauces Production, Revenue, Price and Gross Margin (2011-2016)  3.7 Japan Sauces Production, Revenue, Price and Gross Margin (2011-2016)  3.8 Southeast Asia Sauces Production, Revenue, Price and Gross Margin (2011-2016)  3.9 India Sauces Production, Revenue, Price and Gross Margin (2011-2016) For more information or any query mail at [email protected] About Us Wise Guy Reports is part of the Wise Guy Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe. Wise Guy Reports understand how essential statistical surveying information is for your organization or association. Therefore, we have associated with the top publishers and research firms all specialized in specific domains, ensuring you will receive the most reliable and up to date research data available.


Tyl R.W.,Rti International | Bechtel D.H.,Best Foods
Regulatory Toxicology and Pharmacology | Year: 2014

This one-generation study assessed the potential of esterified propoxylated glycerol (EPG) to affect reproduction and offspring development in rats. Male and female Crl:CD(SD)BR rats (30/sex/group) were exposed to EPG at 0, 0.5, 1, and 2g/kgbw/day or at 5% (w/w) in the diet prior to (13weeks), during, and after two consecutive matings. For dams, exposure continued through gestation and lactation; F1a and F1b pups were weaned to the respective diet (for up to 91days). No consistent treatment-related effects were observed in: body weights/gains; feed consumption; clinical observations; mating indices; survival, growth and development of litters, litter sizes, body weights, sex ratios (lower % males/litter at 1 and 2g/kgbw/day), acquisition of developmental landmarks, behavioral indices, or histology of selected organs. Lower serum vitamin D, liver vitamin A, and liver vitamin E levels were seen in some EPG-treated groups. None of the reductions were judged to be biologically significant. A/G ratio was greater among males receiving 2g/kgbw/day and 5%. In the absence of any other related effects, the biological significance of this finding is doubtful. © 2014 Elsevier Inc.


Wedig J.,T.P.S Inc. | Bechtel D.H.,Best Foods
Regulatory Toxicology and Pharmacology | Year: 2014

The subchronic (90-day) toxicity of esterified propoxylated glycerol (EPG) was assessed in micropigs. Animals (5/sex/group) received feed containing 5%, 10%, and 17% EPG, mixed accordingly throughout the study to deliver 1.5, 3, and 5. g/kg bw/day of EPG, respectively. Corn oil served as the vehicle control (0. g/kg bw/day). Subsets of animals were evaluated at Week 6; the remainder between Weeks 12 and 14. With the exception of liver and serum vitamin levels, statistically significant difference between control and EPG groups were seen sporadically, and with no apparent connection to treatment and/or no consistency across time intervals. EPG intakes of 3 and 5. g/kg. bw/day, but not at 1.5. g/kg. bw/day were associated with significantly lower serum 25-OH vitamin D levels. Serum total vitamin D levels were significantly lower across all EPG groups. There were also trends toward lower levels of liver vitamins A and E among EPG-treated animals, but the effects were less consistent. The effects on vitamin levels observed in EPG-treated animals were not accompanied by any signs of vitamin deficiency (e.g., effects on growth, clinical signs, or clinical pathology), and might have been related to the larger mass of EPG acting as a lipid "sink" during transit in the gastrointestinal tract. © 2014 Elsevier Inc.


Bechtel D.H.,Best Foods
Regulatory Toxicology and Pharmacology | Year: 2014

This article introduces a series of articles addressing the safety of esterified propoxylated glycerols (EPGs), a family of fat- and oil-like substances that resemble triglycerides in structure and appearance, but have been modified to prevent or limit their digestion when consumed in food. A general summary of the history, composition, metabolism, and safety of EPGs is provided. © 2014 Elsevier Inc.


Bechtel D.H.,Best Foods
Regulatory Toxicology and Pharmacology | Year: 2014

Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soyate were non-mutagenic in reverse mutation assays (maximum concentration 1000. μg/plate) using Salmonella typhimurium and Escherichia coli. Heated and unheated H-EPG-05 HR/SO 9:1 and EPG-05 HR/ST 45:55 were likewise non-mutagenic in reverse mutation assays in S. typhimurium strains TA98 and TA100 (maximum concentration 5000. μg/plate). H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soyate, were devoid of mutagenic activity in a mouse lymphoma assay in L5178Y tk +/- cells (maximum concentration 200. μg/plate for H-EPG-05 HR/SO 9:1; 100. μg/plate for H-EPG-05 soyate and H-EPG-14 soyate), and a chromosomal aberration test using human lymphocytes (maximum concentration 50. μg/plate for H-EPG-05 HR/SO 9:1 and H-EPG-05 soyate; 60. μg/plate for H-EPG-14 soyate). All assays were conducted with and without metabolic activation. Additionally, H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soyate were non-genotoxic in unscheduled DNA synthesis tests in rats (maximum dose 2000. mg/kg). Based on the results of these assays it was concluded that these versions of EPG were not genotoxic under any of the conditions of the assays performed. © 2014 Elsevier Inc.


Tyl R.W.,Rti International | Bechtel D.H.,Best Foods
Regulatory Toxicology and Pharmacology | Year: 2014

The safety of a "core" version of esterified propoxylated glycerols (EPGs) was assessed in a developmental toxicity study in New Zealand white rabbits, Hra:(NZW)SPF. Four groups each of 18 inseminated female rabbits received diets ad libitum containing concentrations of 0%, 2.5%, 5%, and 10% EPG (w/w) with 6% corn oil (w/w). No treatment-related effects were observed in any maternal toxicity parameter, including maternal body weight and weight gain, feed consumption, or clinical signs of toxicity. There were no statistically significant treatment-related effects in gestational parameters, including pre- and post-implantation loss, litter size, sex ratio, fetal body weight, and crown-rump length. The incidences of fetal external, visceral, and skeletal malformations or variations were also comparable across groups. A no-observable-adverse-effect level (NOAEL) of 10% EPG (approximately 4.76. g/kg bw/day) for both maternal and developmental toxicity is proposed based on the results of this study. © 2014 Elsevier Inc.


Bechtel D.H.,Best Foods
Regulatory Toxicology and Pharmacology | Year: 2015

A solid form of esterified propoxylated glycerol (EPG) was administered to 16 healthy male volunteers in butter-like spread and baked goods, resulting in intakes that rose in 30-g increments from 30 to 150 g; each level was administered on a single day, followed by a 2-day washout period. Elevated serum transaminase (ALT and/or AST) and lower HDL cholesterol levels were noted at 60 g and greater, possibly related to changes in the diet (high-carbohydrate and increasingly low-fat), rather than to EPG itself. There was no apparent association between EPG consumption and adverse effects reported. In general, EPG had no effect on bowel function, except in a single subject, who reported increased frequency of movements during the 2 days that followed consumption of 150 g EPG. All abnormal values returned to normal after the study, and subjects were otherwise asymptomatic. Accordingly, the effects on transaminase and HDL levels observed in this study were considered possibly adaptive and not clinically significant. Experimental animal studies, including lifetime studies, had shown no effects on these parameters. More importantly, the effect was associated with intakes of 60-150 g EPG, which exceeds the approximate intake of 20 g/day or less expected from currently intended commercial food uses. © 2015 The Author.


This double-blind, randomized, controlled study assessed the effect of esterified propoxylated glycerol (EPG) on fat-soluble vitamins and select nutrients in human subjects. For 8weeks, 139 healthy volunteers consumed a core diet providing adequate caloric and nutrient intakes. The diet included items (spread, muffins, cookies, and biscuits) providing EPG (10, 25, and 40g/day) vs. margarine alone (control). EPG did not significantly affect circulating retinol, α-tocopherol, or 25-OH D2, but circulating β-carotene and phylloquinone were lower in the EPG groups, and PIVKA-II levels were higher; 25-OH D3 increased but to a lesser extent than the control. The effect might be related to EPG acting as a lipid "sink" during gastrointestinal transit. No effects were seen in secondary endpoint measures (physical exam, clinical pathology, serum folate, RBC folate, vitamin B12, zinc, iron, calcium, phosphorus, osteocalcin, RBP, intact PTH, PT, PTT, cholesterol, HDL-C, LDL-C, triglycerides). Gastrointestinal adverse events (gas with discharge; diarrhea; oily spotting; oily evacuation; oily stool; liquid stool; soft stool) were reported more frequently by subjects receiving 25 or 40g/day of EPG. In general, the incidence and duration of these symptoms correlated directly with EPG dietary concentration. The results suggest 10g/day of EPG was reasonably well tolerated. © 2014 Elsevier Inc.


PubMed | Best Foods
Type: Journal Article | Journal: Regulatory toxicology and pharmacology : RTP | Year: 2015

A solid form of esterified propoxylated glycerol (EPG) was administered to 16 healthy male volunteers in butter-like spread and baked goods, resulting in intakes that rose in 30-g increments from 30 to 150 g; each level was administered on a single day, followed by a 2-day washout period. Elevated serum transaminase (ALT and/or AST) and lower HDL cholesterol levels were noted at 60 g and greater, possibly related to changes in the diet (high-carbohydrate and increasingly low-fat), rather than to EPG itself. There was no apparent association between EPG consumption and adverse effects reported. In general, EPG had no effect on bowel function, except in a single subject, who reported increased frequency of movements during the 2 days that followed consumption of 150 g EPG. All abnormal values returned to normal after the study, and subjects were otherwise asymptomatic. Accordingly, the effects on transaminase and HDL levels observed in this study were considered possibly adaptive and not clinically significant. Experimental animal studies, including lifetime studies, had shown no effects on these parameters. More importantly, the effect was associated with intakes of 60-150 g EPG, which exceeds the approximate intake of 20 g/day or less expected from currently intended commercial food uses.

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