Ankara, Turkey
Ankara, Turkey
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Erer D.,Besevler | Ozer A.,Besevler | Demirtas H.,Besevler | Gonul I.I.,Gazi University | And 6 more authors.
Drug Design, Development and Therapy | Year: 2016

Objectives: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental rat model. Materials and methods: Wistar albino rats underwent 2 hours of ischemia via infrarenal aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the reperfusion period. Effects of agents on renal, lung, and skeletal muscle (gastrocnemius) tissue specimens were examined. Results: Renal medullary congestion, cytoplasmic swelling, and mean tubular dilatation scores were significantly lower in the alprostadil-treated group than those found in the I/R-only group (P<0.0001, P=0.015, and P<0.01, respectively). Polymorphonuclear leukocyte infiltration, pulmonary partial destruction, consolidation, alveolar edema, and hemorrhage scores were significantly lower in alprostadil- and iloprost-treated groups (P=0.017 and P=0.001; P<0.01 and P<0.0001). Polymorphonuclear leukocyte infiltration scores in skeletal muscle tissue were significantly lower in the iloprost-treated group than the scores found in the nontreated I/R group (P<0.0001). Conclusion: Alprostadil and iloprost significantly reduce lung tissue I/R injury. Alprostadil has more prominent protective effects against renal I/R injury, while iloprost is superior in terms of protecting the skeletal muscle tissue against I/R injury. © 2016 Erer et al.

Karabulut R.,Besevler | Turkyilmaz Z.,Besevler | Sonmez K.,Besevler | Basaklar A.C.,Besevler
Indian Journal of Surgery | Year: 2013

Selective conservative therapy has not gained popularity in the management of abdominal gunshot wounds, and standard practice is mandatory exploration irrespective of clinical signs and symptoms. In this report, we describe a 10-year-old boy with an abdominal gunshot wound with stable vital signs who was managed conservatively. © Association of Surgeons of India 2012.

Dikmen K.,Besevler | Ferahkose Z.,Besevler | Turhan B.,Besevler | Caliskan G.T.,Besevler | And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

In this paper, a 74 years old male patient with complaints of dysphagia and hemoptysis is presented. Endoscopy revealed black colored mass protruding to the lumen at distal esophagus. Diagnosis of malignant melanoma was confirmed with biopsy. Examinations for staging purposes revealed masses at sigmoid colon and cecum. Biopsy was performed with colonoscopy. The mass at the sigmoid colon was diagnosed as adenocarcinoma and the mass at the cecum was diagnosed as villous adenoma. Although the treatment strategy is not straightforward, surgical treatment is the most important step. For this reason, patient underwent three field esophagectomy, anterior resection and right hemicolectomy in the first place. The patient is currently receiving his adjuvant chemotherapy and immunotherapy at postoperative 6th month. According to our knowledge, concurrence of these tumors with two different origins has only been reported in 1 patient before. Our patient has the significance of being the second reported case. © 2015, E-Century Publishing Corporation. All rights reserved.

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