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Montigny-le-Bretonneux, France

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Bertin Pharma | Date: 2013-06-04

Chemical products for use in science, namely, reagents for use with tandem mass spectrometry; diagnostic preparations for scientific purposes for use with tandem mass spectrometry. Chemical or biological products, namely, reagents designed for medical science, diagnostic products for medical purposes, namely, reagents; substances and reagents for biological purposes, namely, assay reagents for the analysis of body fluids, tissues, cells or organs. Pharmaceutical research and development services, scientific studies and diagnostics in the field of life sciences; technical research in the field of life sciences; chemical analysis; chemical research; biological research; subcontracting support services in connection with research and development, namely, scientific research for medical purposes, pharmaceutical research and development services, and diagnostic and scientific research in the field of life sciences.


Trademark
Bertin Pharma and Ste De Pharmacologie Et Dimmunologie Bio | Date: 2006-11-07

REAGENTS FOR SCIENTIFIC, RESEARCH AND MEDICAL RESEARCH USES; DIAGNOSTIC REAGENTS FOR SCIENTIFIC OR RESEARCH USE. [ PHARMACEUTICAL PRODUCTS FOR USE IN THE TREATMENT OF CARDIOLOGICAL, NEUROLOGICAL AND NEUROVIROLOGICAL DISORDERS; PHARMACEUTICAL PRODUCTS WITH ANTI-RETRO VIRAL PROPERTIES AND IMMUINOMODULATORS AND USED FOR TILE TREATMENT OF AIDS, PRION DISEASES, CANCER, ENDOCRINOLOGY DISORDERS, AND IMMUNE DISORDERS ]. PHARMACOLOGY RESEARCH IN CARDIOLOGY, NEUROLOGY AND NEUROVIROLOGY; PHARMACOLOGY RESEARCH IN VIVO AND IN VITRO RELATING TO MOLECULES WITH ANTI-RETRO VIRAL PROPERTIES AND TO IMMUNOMODULATORS; HUMAN AND ANIMAL PHARMACOKINETIC RESEARCH AND METABOLISM RESEARCH; BIOAVALLABILITY AND BIOEQUIVALENCE RESEARCH;RESEARCH ON PHARMACOKINETIC AND METABOLIC MODELS;RESEARCH SERVICES, NAMELY, DEVELOPMENT OF DOSAGE AND MEASUREMENT OF MEDICATED MOLECULES; PRODUCTION OF NEW CHEMICAL ENTITIES AND METABOLITES BY BIO TRANSFORMATION;EVALUATION OF MICROBIOLOGICAL SAFETY WITH REGARD TO INFECTIOUS AGENTS; IMMUNOSSAY AND ENZYME IMMUNOASSAY DEVELOPMENT FOR PHARMACEUTICAL PRODUCTS AND ENDOGENOUS SUBSTANCES.


Marvalin C.,Bertin Pharma | Azerad R.,Bertin Pharma | Azerad R.,University of Paris Descartes
Journal of Molecular Catalysis B: Enzymatic | Year: 2011

In a typical series of experiments, several polyphenol O-β-d- glucuronides (including human metabolites) deriving from two flavonoids (naringenin, quercetin) and several stilbenoids (trans-resveratrol, rhapontigenin, deoxyrhapontigenin) have been obtained from the aglycones or their natural glycosides (Naringenin-7-O-glucoside, rutin, piceid, rhapontin or deoxyrhapontin), in a one step biotransformation and in moderate to high yields by incubation with a Streptomyces sp. strain M52104. Regioselectively glucuronidated products have been separated by chromatographic methods, then extensively characterized by MS and NMR. In all cases glucuronidation is β-stereospecific, but not completely regioselective. When present, the 4′(para)-hydroxyl group is generally favoured, then the 7-OH-group of flavonoids (corresponding to the 3-OH of stilbenoids). Several pure O-β-d-glucuronidated derivatives, commercially not available, have been prepared in high purity by this method. © 2011 Elsevier B.V. All Rights Reserved.


Marvalin C.,Bertin Pharma | Azerad R.,Bertin Pharma | Azerad R.,University of Paris Descartes
Xenobiotica | Year: 2011

The production in multimilligram amounts of 4- and 5-hydroxylated metabolites of (R)- or (S)-propranolol by biotransformation with two fungal strains, an Absidia sp. M50002 and a Cunninghamella sp. M50036, was carried out, starting from either the racemic drug or pure enantiomers. While both enantiomers of propranolol were hydroxylated in the 5-position by incubation with strain M50002, the strain M50036 operated a chiral discrimination, resulting in the exclusive formation of the 4-hydroxy-(R)-enantiomer. In addition, a Streptomyces sp. strain M52104, isolated from a soil sample, was selected for the high-yield regioselective β-glucuronidation of propranolol and its 4- and 5-hydroxylated derivatives. NMR and mass spectroscopic data have been extensively used for the unambiguous characterization of 4- and 5-hydroxylated and glucuronidated derivatives, all of them corresponding to the major animal and human metabolites of propranolol, a typical substrate of CYP2D6. © 2011 Informa UK, Ltd.


Delhanty P.J.D.,Erasmus MC | Huisman M.,Erasmus MC | Julien M.,Alize Pharma | Mouchain K.,Bertin Pharma | And 4 more authors.
Clinical Endocrinology | Year: 2015

Context: The acylated/unacylated ghrelin (AG/UAG) ratio has been reported to range from 0.02 to 0.3, suggesting biologically relevant independent regulation of each ghrelin isoform. However, AG is deacylated to UAG by esterases in blood samples, and esterase inhibition is critical for their accurate measurement. Our hypothesis is that at least part of the variation in reported AG and UAG values is due to inconsistent sample preparation. Design: A non-interventional study. Quantification with two different, commercially available, ELISA formats of AG and UAG in venous plasma stabilized or not with 4-(2-aminoethyl) benzenesulphonyl fluoride (AEBSF) and stored for 0-6 months at -20 or -80 °C. Participants: Healthy, non-obese, adults (n = 8; 4 women), age 26-42 yrs, after an overnight fast. Measurements: AG and UAG stability following different methods of sample treatment and storage. Results: Non-AEBSF plasma contained low AG and high UAG (>270 pg/ml) indicating rapid conversion of AG to UAG. However, AEBSF plasma, stored at -80 °C and measured at 0, 1, 3 and 6 months contained AG and UAG ranges of 12-350 and 17-170 pg/ml, respectively. Mean (SEM) AG/UAG ratios were 1.7(0.3), 1.2(0.2), 1.5(0.3) and 1.8(0.5) at each time point with no significant effect of storage period. Conclusions: AG and UAG levels measured in AEBSF-stabilized plasma indicate that the AG/UAG ratio is markedly higher than previously described and that UAG is a physiological component of the circulation. This highlights the importance of immediately stabilizing blood samples on collection for determination of both AG and UAG concentrations and provides a valuable tool for their measurement in physiological and interventional studies. © 2014 John Wiley & Sons Ltd.

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