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Beppu, Japan

Beppu University is a private university in Ōita Prefecture, Japan. It has campuses at the cities of Beppu and Ōita.The predecessor of the school was founded in 1908, and it was chartered as a university in 1954. Wikipedia.

Kiyohara C.,Kyushu University | Horiuchi T.,Beppu University | Takayama K.,Kyushu University | Nakanishi Y.,Kyushu University
Cytokine | Year: 2014

Evidence is accumulating that chronic inflammation may have an important mechanism for the development and progression of lung cancer. Therefore, genetic polymorphisms in genes that involved in the inflammatory response may be associated with lung cancer risk. We evaluated the role of tumor necrosis factor α (TNFA) rs1799724, interleukin 1β (IL1B) rs16944, IL6 rs1800796, myeloperoxidase (MPO) rs2333227 and C-reactive protein (CRP) rs2794520 in a case-control study comprised of 462 lung cancer cases and 379 controls in a Japanese population. Unconditional logistic regression was used to assess the adjusted odds ratios (OR) and 95% confidence intervals (95% CI). CRP rs2794520 (OR=1.64, 95% CI=1.19-2.26) and IL6 rs1800796 (OR=1.41, 95% CI=1.02-1.96) were associated with lung cancer risk. In addition, we assessed interactions between the polymorphisms and smoking. The polymorphisms did not significantly modify the association between smoking and lung cancer. As TNFA triggers a cytokine cascade, the modifying effect of the TNFA rs1799724 genotypes on the association of any of the remaining polymorphisms with lung cancer risk was also examined. There was a significant interaction between TNFA rs1799724 and MPO rs2333227 (Pinteraction=0.058). Future studies involving larger control and case populations will undoubtedly lead to a more thorough understanding of the role of the polymorphisms involved in the inflammation pathway in lung cancer. © 2013 Elsevier Ltd. Source

Appropriate management of cardiovascular diseases (CVDs) related to chemotherapy for solid tumors is important for safe oncologic treatment. However, prediction of the onset and progression of CVDs has not generally been established in Japan. We carried out a retrospective analysis of advanced or recurrent solid tumor patients who received chemotherapies in a single institution. Patient characteristics, chemotherapy regimens, adverse events, CVDs before chemotherapy, and diagnosis of CVDs in association with chemotherapy were assessed. During the period from April 2006 to March 2012, 394 patients were examined. Cardiac diseases (CDs), hypertension (HT), or arterial thrombosis or venous thromboembolism were prevalent in 37 (9.4%), 22 (5.6%), five (1.3%), and 14 (3.5%) cases, respectively. HT (14.5%) and venous thrombosis (5.8%) were frequent in patients who received bevacizumab-containing chemotherapy. Four cases with left ventricular dysfunction experienced a decrease of ejection fraction and early filling/atrial filling (E/A) and E/A tended to decrease before ejection fraction. Ninety (62.1%) of 145 cases showed an increase in the D-dimer (DD) level before chemotherapy, and a further increase in DD level was found when venous thrombosis occurred. Relative risks of the disease progression of HT, CD, and thromboembolism because of chemotherapy were 1.3, 1.9, and 3.6, respectively. A decrease in E/A and an increase in DD were suggested to be valuable for early diagnosis of the respective onsets of left ventricular dysfunction and venous thrombosis related to chemotherapy. We conclude that patients with previous CD tend to have disease progression of CD during chemotherapy. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Source

Takahashi Y.,Beppu University
Nihon Geka Gakkai zasshi | Year: 2012

The single-nucleotide polymorphism (SNP)-based genome-wide association study (GWAS) is now widely performed because of the development of new SNP genotyping technologies from 2007 onward. The GWAS provides a powerful approach to identify regions of the genome that harbor genetic variants conferring risk for disease without prior knowledge of location or function. During the past few years, the GWAS has identified numerous robust associations between specific chromosomal loci and different types of cancer. For nearly all regions identified in the GWAS, the per allele effect sizes estimated are < 1.5 and the mechanism of SNP in carcinogenesis was not clear. Consequently, GWAS findings underscore the complex nature of cancer. The combined effects may be sufficiently great to be useful for risk prediction, targeted screening, and prevention, particularly as more loci are identified. Some loci, such as 8q24, were identified as a cancer susceptibility region for many unrelated cancers, and therefore an investigation of those loci may disclose new mechanisms of carcinogenesis or unknown genes including noncoding RNA. Furthermore, the development of new strategies for GWAS analysis is expected. Source

Nishio M.,Kyushu University | Otsubo K.,Kyushu University | Maehama T.,Japan National Institute of Infectious Diseases | Mimori K.,Beppu University | Suzuki A.,Kyushu University
Cancer Science | Year: 2013

The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer. © 2013 Japanese Cancer Association. Source

STUDY DESIGN.: Retrospective diagnostic analysis.Objectives. To establish a new scoring system, the Dumbbell scoring system (DSS), for preoperative evaluation of the malignant potential of spinal dumbbell tumors (SDTs). SUMMARY OF BACKGROUND DATA.: Among SDTs, benign tumors such as Schwannomas occur frequently while malignant SDTs, including malignant peripheral nerve sheath tumors (MPNSTs), are uncommon. No scoring system has been developed to preoperatively diagnose the malignant potential of SDTs. METHODS.: We retrospectively reviewed the records of 59 consecutive patients with SDTs. The following imaging features were recorded: tumor size, tumor shape, tumor boundary, pattern of enhancement of intratumoral lesions (homogeneous or heterogeneous), and cyst formation in the tumors on MRI; and enlargement of neural foramina and scalloping or osteolytic destruction of surrounding bones on CT. The prevalence of characteristic imaging features in malignant and benign SDTs were evaluated, and appropriate cut-off points for the DSS score were obtained using receiver operating characteristics. RESULTS.: Twenty cases were confirmed to be malignant tumors. Pathological diagnoses of the malignant SDTs were as follows: 11 cases of MPNST, 3 cases of malignant lymphoma, and 1 case each of extraskeletal Ewingʼs saroma, hemangiopericytoma, hemangioendothelioma, malignant myoepithelioma, neuroblastoma, and plasmacytoma. The DSS was based on four characteristic imaging features confirmed as significant predictors of malignant SDTs, namely, maximal diameter greater than 5?cm, irregularly lobulated tumor, tumor boundary indistinguishable from surrounding tissues, and osteolytic bone destruction. Malignant SDTs showed a higher DSS score (median 5.5 points) than did benign SDTs (median 0 point). The optimum cut-off value for the DSS score was 3 points, and the sensitivity and specificity for the diagnosis of malignant SDTs were 90% and 84.6%, respectively. CONCLUSION.: This scoring system may be helpful for preoperative decision-making. If the DSS score is equal to or higher than 3, biopsies was recommended to confirm the histological diagnosis.Level of Evidence: 4 Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Source

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