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Washington, NC, United States

Bennett College is a private four-year historically black liberal arts college for women. Located in Greensboro, NC, it was founded in 1873 as a normal school educating newly emancipated slaves. It became a women's college in 1926 and is one of only two historically black colleges that enroll women only. Today it serves roughly 780 undergraduate students. Wikipedia.

Thomas Z.I.,North Carolina Central University | Gibson W.,North Carolina Central University | Gibson W.,Bennett College | Sexton J.Z.,North Carolina Central University | And 7 more authors.
British Journal of Cancer | Year: 2011

Background:Inflammatory breast cancer (IBC) is an aggressive subtype of breast cancer with distinct molecular profiles. Gene expression profiling previously identified sonic hedgehog (SHH) as part of a gene signature that is differentially regulated in IBC patients.Methods:The effects of reducing GLI1 levels on protein expression, cell proliferation, apoptosis and migration were determined by immunoblots, MTT assay, Annexin-V/PI assay and conventional and automated cell migration assays.Results:Evaluation of a panel of breast cancer cell lines revealed elevated GLI1 expression, typically a marker for hedgehog-pathway activation, in a triple-negative, highly invasive IBC cell line, SUM149 and its isogenic-derived counterpart rSUM149 that has acquired resistance to ErbB1/2 targeting strategies. Downregulation of GLI1 expression in SUM149 and rSUM149 by small interfering RNA or a small molecule GLI1 inhibitor resulted in decreased proliferation and increased apoptosis. Further, GLI1 suppression in these cell lines significantly inhibited cell migration as assessed by a wound-healing assay compared with MCF-7, a non-invasive cell line with low GLI1 expression. A novel high-content migration assay allowed us to quantify multiple effects of GLI1 silencing including significant decreases in cell distance travelled and linearity of movement.Conclusion:Our data reveal a role for GLI1 in IBC cell proliferation, survival and migration, which supports the feasibility of targeting GLI1 as a novel therapeutic strategy for IBC patients. © 2011 Cancer Research UK All rights reserved. Source

Patrick P.G.,Bennett College | Dale Tunnicliffe S.,University of London
Journal of Biological Education | Year: 2014

The purpose of this study was to report United States of America (USA) science teachers' understandings of the internal structures of the human body. The 71 science teachers who participated in this study attended a frog/pig, two-hour dissection workshop at the 2004 National Science Teachers Association (NSTA) conference in Atlanta, Georgia. The study population consisted of 47 females and 24 males. Prior to the workshop, teachers were given a blank piece of standard paper and were asked to write the following information: 1) gender; 2) subjects taught and subject most often taught; 3) why did you attend this workshop; 4) the number of years you have taught; and 5) if you employ dissection in your classroom. On the same paper, teachers were asked to draw what they thought was inside the human body (15 minutes). Each drawing was scored using a rubric. The number of years a teacher taught and whether or not they used dissection in their classroom did appear to influence their scores. Additionally, the teachers demonstrated a similar pattern to that shown by students in previous studies. The teachers were able to draw individual organs, but they were not able to draw the organs in relation to the organ systems. Source

Obaidat M.,City University of New York | Ali M.,City University of New York | Shahwan I.,City University of New York | Obaidat M.S.,Monmouth University | Obeidat S.,Bennett College
Journal of Networks | Year: 2013

To enhance the Quality of service (QoS) communications over mobile ad hoc networks (MANETs), this paper proposes QoS-Aware Multipath Routing Protocol (QMRP). Delay is the most crucial factor for multimedia applications which can be minimized by providing more than one path between source-destination pair as well as choosing the path based on the quality in terms of reliability and stability of the link. To the best of our knowledge no one before included projected load; load introduced by the node requesting a path to a destination into the delay computation for a path between source-destination pair as well as maintaining loop freedom through the neighbor hop list of the source. The originality of the proposed protocol comes from the fact that it introduces this new parameter into route quality computation which makes QMRP unlike its precursors providing more accurate measure of the realistic delay as well as maintaining loop freedom of multiple node disjoint paths using neighbor hop list. Cross layer communications between physical (PHY), MAC and routing layers interact to achieve QoS against the network and channel dynamics by minimizing delay and choosing more reliable and stable paths without requiring any additional resources. Performance evaluation of the proposed protocol against a single path AODV routing protocol using OPNET has been conducted. Results show that QMRP outperforms AODV in terms of E2E delay, packet delivery fraction (PDF) and route discovery frequency. However, routing overhead for QMRP is more than that of AODV due to the discovery of more one path in each route discovery process. © 2013 ACADEMY PUBLISHER. Source

Graves J.L.,North Carolina A&T State University | Tajkarimi M.,North Carolina A&T State University | Cunningham Q.,North Carolina A&T State University | Campbell A.,Bennett College | And 3 more authors.
Frontiers in Genetics | Year: 2015

The recent exponential increase in the use of engineered nanoparticles (eNPs) means both greater intentional and unintentional exposure of eNPs to microbes. Intentional use includes the use of eNPs as biocides. Unintentional exposure results from the fact that eNPs are included in a variety of commercial products (paints, sunscreens, cosmetics). Many of these eNPs are composed of heavy metals or metal oxides such as silver, gold, zinc, titanium dioxide, and zinc oxide. It is thought that since metallic/metallic oxide NPs impact so many aspects of bacterial physiology that it will difficult for bacteria to evolve resistance to them. This study utilized laboratory experimental evolution to evolve silver nanoparticle (AgNP) resistance in the bacterium Escherichia coli (K-12 MG1655), a bacterium that does not harbor any known silver resistance elements. After 225 generations of exposure to the AgNP environment, the treatment populations demonstrated greater fitness vs. control strains as measured by optical density (OD) and colony forming units (CFU) in the presence of varying concentrations of 10 nm citrate-coated silver nanoparticles (AgNP) or silver nitrate (AgNO3). Genomic analysis shows that changes associated with AgNP resistance were already accumulating within the treatment populations by generation 100, and by generation 200 three mutations had swept to high frequency in the AgNP resistance stocks. This study indicates that despite previous claims to the contrary bacteria can easily evolve resistance to AgNPs, and this occurs by relatively simple genomic changes. These results indicate that care should be taken with regards to the use of eNPs as biocides as well as with regards to unintentional exposure of microbial communities to eNPs in waste products. © 2015 Graves, Tajkarimi, Cunningham, Campbell, Nonga, Harrison and Barrick. Source

Blake B.H.,Bennett College | Blake B.H.,University of North Carolina at Greensboro
Journal of Mammalogy | Year: 2012

When isolated, pups of muroid rodents emit ultrasonic vocalizations, an indication that they are stressed by being alone and exposed to cooling temperatures. Rate of vocalizations is greatest at the end of their 1st week and beginning of the 2nd week, declines in the 2nd week as eyes open and thermoregulation becomes fully established, and ceases in the 3rd week. Young of 1 vole species, the prairie vole (Microtus ochrogaster), vocalize significantly more than those of other species, which has been attributed to the social structure of the species, because they have monogamous mating behavior and high level of biparental care. To determine whether this vocalizing behavior is typical of vole species with monogamous social systems, I examined calling behavior in another monogamous species with biparental care, the pine (or woodland) vole (M. pinetorum), and I compared it to that of a polygynous species that has only maternal care, the meadow vole (M. pennsylvanicus). Pups were isolated for 20 min at 22°C ± 2°C and the number of ultrasonic calls they emitted was monitored. Pine vole pups vocalized at high rates, similar to prairie voles, emitting a mean of 47 calls/min at the ages when calling was greatest (816 days). In contrast, meadow vole pups vocalized significantly less, emitting a mean of 9 calls/min at the age of greatest calling (59 days). Pine voles continued vocalizing to 23 days, like prairie voles but different from other vole species, including meadow voles, which cease calling earlier. I conclude that young voles of monogamous species, which are highly affiliative and have paternal as well as maternal care, respond to the stress of isolation more strongly than do other vole species and emit more ultrasonic vocalizations than species that are less social and have less parental care. © 2012 American Society of Mammalogists. Source

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