Mahmoud A.M.,Beni Suef University
Experimental and Toxicologic Pathology | Year: 2012
Flavonoids are non-nutritive dietary components that are widely distributed in plants. The present study was undertaken to examine the protective influence of rutin, a polyphenolic flavonoid, on oxidative stress during ammonium chloride (AC)-induced hyperammonemia by measuring the levels of oxidative damage as well as antioxidant status. The levels of tissue (liver, brain and kidney) lipid peroxides and the antioxidants (total thiols, catalase, reduced glutathione and glutathione peroxidase) were analyzed. Hyperammonemia was induced by daily intraperitoneal injections of AC at a dose of 100. mg/kg body weight for 8. weeks. Decreased levels of tissue lipid peroxidation accompanied with increased antioxidant levels in hyperammonemic rats were observed during oral administration of rutin (50. mg/kg body weight), which clearly shows the antioxidant property of rutin. The study of induction of the antioxidant status is considered to be a reliable marker for evaluating the antiperoxidative effect of the polyphenolic compound. Our present findings show the protective role of rutin against lipid peroxidation and suggest that rutin possesses antioxidant potential that may be used for therapeutic purposes. © 2011 Elsevier GmbH.
Saber S.G.,Beni Suef University
Cretaceous Research | Year: 2012
Three stratigraphic sections (Wadi El Dakhl, Abu Darag and Gabal Ataqa) of mixed siliciclastic/carbonate rocks mark the Cenomanian-Turonian sequence exposed on the western side of the Gulf of Suez. This sequence is differentiated into two rock-units: the Galala Formation of Cenomanian age, and the Turonian Wata/Maghara El Hadida Formation. They comprise various sedimentary facies belts that reflect minor fluctuations of sea-level from mudflat to deep subtidal setting. Four facies belts are recognized in this succession. They are peritidal clastic (mudflat, mixed flat and sandflat facies), peritidal carbonate, shallow subtidal (high energy shallow subtidal; low energy, shallow subtidal; and storm-influenced, shallow subtidal, open marine facies) and deep subtidal. Five sequence boundaries marking relative sea-level falls divide the Cenomanian-Turonian succession into four depositional sequences. These boundaries are: Lower Cretaceous/Cenomanian (SB1), Middle Cenomanian (SB2), Middle Turonian (SB3), Late Turonian (SB4) and Turonian/Coniacian (SB5). These delineate four well-defined third-order depositional sequences. They enclose shallowing-upward (prograding) parasequences and record the fourth order relative sea-level fluctuations. Each depositional sequence shows lowstand (LST), transgressive (TST) and highstand (HST) systems tracts and packages of facies. These sequences are compared with those of neighbouring areas to differentiate local, regional and global factors that controlled sedimentation within the study area. © 2012 Elsevier Ltd.
Mansour E.,Beni Suef University
Journal of Non-Crystalline Solids | Year: 2011
Fourier transformation infrared spectra, density and DC electrical conductivity of 30Li2O • xCeO2(70 - x)B 2O3 glasses, where x ranged between 0 and 15 mol%, have been investigated. The results suggested that CeO2 plays the role of network modifier up to 7.5 mol%. At higher concentrations it plays a dual role; where most of ceria plays the role of network former. The density was observed to increase with increasing CeO2 content. The effect on density of the oxides in the glasses investigated is in the succession: B2O 3 < Li2O < CeO2. Most of CeO2 content was found to be associated with B2O3 network to convert BO3 into B O4 - units. The contribution of Li+ ions in the conduction process is much more than that due to small polarons. The conductivity of the glasses is mostly controlled by the Li+ ions concentration rather than the activation energy for CeO 2 > 5 mol%. Lower than 5 mol% CeO2 the conductivity is controlled by both factors. The dependence of W on BO4 - content supports the idea of ionic conduction in these glasses. © 2010 Elsevier B.V. All rights reserved.
Khalifa Z.S.,Beni Suef University
Solar Energy Materials and Solar Cells | Year: 2014
Titanium dioxide thin films were deposited by metal-organic chemical vapor deposition (MOCVD) on soda-lime and indium tin oxide (ITO) coated glass substrates at 400 C. X-ray diffraction (XRD) studies revealed that the deposited films have a pure anatase phase. Thickness of the film was measured by scanning electron microscopy (SEM). Atomic force microscopy was used to study the morphology of the deposited films. Depth profiling was monitored by using secondary ion mass spectroscopy (SIMS). Cyclic voltammetry indicates that the transport of Li ions in the TiO2 thin film is diffusion limited. Chronoamperometry and its corresponding optical modulation measurements show that the increase of the quantity of inserted charge causes the appearance of two absorption bands, and a blueshift of the TiO2 film absorption edge. The observed optical changes were attributed to band gap broadening. © 2014 Elsevier B.V.
Ahmed R.G.,Beni Suef University
Food and Chemical Toxicology | Year: 2011
This study tested whether maternal exposure to 2,3,7,8-tetrachlorodibenzo-. p-dioxin (TCDD) may disrupt the development of neuroendocrine system of their offspring during the perinatal period. TCDD (0.2 or 0.4μg/kg body weight) was orally administered to pregnant rats from gestation day (GD) 1 to lactation day (LD) 30. Potential effects on neuroendocrine function were evaluated by measuring serum thyroid hormone levels in pregnant rats and their offspring and measuring some biochemical parameters in cerebellum of these offspring on GD 16 and 19, and LD 10, 20, and 30. In both treated groups, a decrease in serum thyroxine (T4), triiodothyronine (T3) and increase in thyrotropin (TSH) levels were noticed during the tested days in dams and offspring, as well as GH levels were decreased in offspring with respect to control group. In cerebellum of control offspring, the levels of monoamines, γ-aminobutyric acid (GABA) and acetylcholinesterase (AchE) were found to be increased from GD 16 to LD 30. The hypothyroid conditions due to both maternal administrations of TCDD produced inhibitory effects on monoamines and AchE, and stimulatory actions on GABA in cerebellum of offspring. These alterations were dose and age dependent. Overall, these results suggest that TCDD may act as neuroendocrine disruptor. © 2011.
Salem H.F.,Beni Suef University
International Journal of Nanomedicine | Year: 2010
The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS) was first developed and then dispersed in a thermosensitive gel matrix. The selected nanoparticles showed an average particle size of 267 nm and a zeta potential approaching-41 mV. The in vitro release profile of PNS from the F127 plus methyl cellulose gel followed zero order kinetics and correlated linearly with the weight percentage of gel dissolved, demonstrating that the overall rate of release of PNS is controlled by dissolution of the pluronic F127/methyl cellulose (MC) gel (r2 >. 0.99). The pharmacokinetic parameters of the PNS (6 mg/mL) in pluronic F127/MC gel were evaluated in comparison with the control progesterone suspension. After the administration of PNS in F127/MC gel into the rats, a maximum serum concentration of 22.1 ± 1.9 ng/mL was reached at a Tmaxof 4.05 ±0.1 h. The terminal half life was 12.7 ±0.8 h. The area under the curve AUC0-∞ of the injected formula was 452.75 ± 42.8 ng·h/mL and the total mean residence time was 18.57 ± 1.44 h. The PNS in gel was significantly different from the control in rate and extent at P <, 0.001. The natural progesterone which was nanosized and formulated in a thermosensitive gel significantly sustained the action of natural progesterone so that it could be injected every 36 h instead of every day. Moreover, this formula is expected to provide a much safer choice than the use of semi-synthetic progesterone. © 2010 Salem, publisher and licensee Dove Medical Press Ltd.
Kassem A.M.,Beni Suef University
International Journal of Electrical Power and Energy Systems | Year: 2012
This paper presents the optimum photovoltaic (PV) water pumping system using maximum power point tracking technique (MPPT). The optimum is suspended to reference optimal power. This optimal technique is developed to assure the optimum chopping ratio of buck-boost converter. The presented MPPT technique is used in photovoltaic water pumping system in order to optimize its efficiency. An adaptive controller with emphasis on Nonlinear Autoregressive Moving Average (NARMA) based on artificial neural networks approach is applied in order to optimize the duty ratio for PV maximum power at any irradiation level. In this application, an indirect data-based technique is taken, where a model of the plant is identified on the basis of input-output data and then used in the model-based design of a neural network controller. The proposed controller has the advantages of fast response and good performance. The PV generator DC motor pump system with the proposed controller has been tested through a step change in irradiation level. Simulation results show that accurate MPPT tracking performance of the proposed system has been achieved. Further, the performance of the proposed artificial neural network (ANN) controller is compared with a PID controller through simulation studies. Obtained results demonstrate the effectiveness and superiority of the proposed approach. © 2012 Elsevier Ltd. All rights reserved.
Kassem A.M.,Beni Suef University
International Journal of Electrical Power and Energy Systems | Year: 2012
This paper investigates the application of the model predictive control (MPC) approach to control the voltage and frequency of a stand alone wind generation system. This scheme consists of a wind turbine which drives an induction generator feeding an isolated load. A static reactive power compensator (SVAR) is connected at the induction generator terminals to regulate the load voltage. The rotor speed, and thereby the load frequency are controlled via adjusting the mechanical power input using the blade pitch-angle control. The MPC is used to calculate the optimal control actions including system constraints. To alleviate computational effort and to reduce numerical problems, particularly in large prediction horizon, an exponentially weighted functional model predictive control (FMPC) is employed. Digital simulations have been carried out in order to validate the effectiveness of the proposed scheme. The proposed controller has been tested through step changes in the wind speed and the load impedance. Simulation results show that adequate performance of the proposed wind energy scheme has been achieved. Moreover, this scheme is robust against the parameters variation and eliminates the influence of modeling and measurement errors. © 2012 Elsevier Ltd. All rights reserved.
Sayed A.R.,Beni Suef University
Tetrahedron | Year: 2012
A novel and efficient synthesis of 1,3,4-thiadiazines, bis-1,3,4- thiadiazoles, [1,2,4]triazino[3,4-b][1,3,4]thiadiazine, and thiazolines is reported from the reaction of α-haloketo hydrazonoyl halides with carbonothioic dihydrazide or its analogues. The structures were elucidated on the basis of their elemental analysis, spectral data and an alternative synthetic route. © 2011 Elsevier Inc. All rights reserved.
Ahmed R.G.,Beni Suef University
Journal of Endocrinology | Year: 2013
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that can severely disrupt the endocrine system. In the present study, early-weanedmale ratswere administered a single dose of 2,3,6-20,50-pentachlorinated biphenyl (PCB 95; 32 mg/kg per day, by i.p. injection) for two consecutive days (postnatal days (PNDs) 15 and 16) and killed 24 and 48 h after the administration of the last dose. Compared with the control group, administration of PCB 95 induced a reduction (P!0.01) in serum concentrations of thyroxine, triiodothyronine, and GH and an increase (P!0.01) in the serum concentration of TSH at PNDs 17 and 18. These conspicuous perturbations led to some histopathological deterioration in the thyroid gland characterized by follicular degeneration, edema, fibrosis, hemorrhage, luminal obliteration, and hypertrophy with reduced colloidal contents at PND 18. The dyshormonogenesis and thyroid dysgenesismay be attributed to the elevation ofDNAfragmentationatPNDs 17 and 18. Furthermore, this hypothyroid state revealed higher (P!0.01) serum concentrations of leptin, adiponectin, and tumor necrosis factor and lower (P!0.01) serum concentrations of IGF1 and insulin at both PNDs compared with the control group. Interestingly, the body weight of the neonates in the PCB 95 group exhibited severe decreases throughout the experimental period in relation to that of the control group. These results imply that PCB 95 may act as a disruptor of the developmental hypothalamic-pituitary-thyroid axis. Hypothyroidism caused by PCB 95 may impair the adipokine axis, fat metabolism, and in general postnatal development. Thus, further studies need to be carried out to understand this concept. © 2013 Society for Endocrinology.