Bengal Institute of Pharmaceutical science

Kalyani, India

Bengal Institute of Pharmaceutical science

Kalyani, India
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Biswas M.,Bengal Institute of Pharmaceutical science | Haldar P.,Jadavpur University
Pharmacognosy Research | Year: 2013

Background: Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes. Objective: The present study was aimed at the evaluation of in vitro antileishmanial effect of triterpenoid fraction from T. dioica root (CETD). Materials and Methods: The antileishmanial activity of CETD was evaluated against Leishmania donovani (strain MHOM/IN/83/AG83)) promastigotes by in vitro promastigote cell toxicity assay by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide). Potassium antimonyl tartrate was used as reference. Results: Here, CETD markedly inhibited the growth of L. donovani promastigotes in vitro in a concentration dependent manner and demonstrated IC 50 value of 18.75 μg/ml. The reference drug potassium antimonyl tartrate exhibited IC 50 of 7.52 μg/ml. Conclusion: From the present study it can be inferred that the triterpenoid fraction of T. dioica root exhibited remarkable antileishmanial activity against Leishmania donovani promastigotes in vitro.


Haldar P.K.,Jadavpur University | Biswas M.,Bengal Institute of Pharmaceutical science | Karan T.K.,Jadavpur University | Ghosh A.K.,JKK Nataraja Dental College and Hospital
Indian Journal of Pharmaceutical Education and Research | Year: 2012

In the present study, the petroleum ether extract of Dregea volubilis (PEDV) was evaluated for its protective effect on paracetamol-induced liver damage in Wistar rats. Serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), total protein, bilirubin, cholesterol, triglyceroides; and liver biochemical parameters such as lipid peroxidation, reduced glutathione (GSH) content and catalase (CAT) activity were estimated. Overall biochemical observations indicated that PEDV exerted remarkable hepatoprotective efficacy against paracetamol-induced hepatic damage in rats that is may be due to its augmenting endogenous antioxidant mechanisms.


Mukhopadhyay R.,University of Nottingham | Kundu S.,Ajanta Pharma Ltd. Charkop | Debnath M.,Bengal Institute of Pharmaceutical science | Biswas M.,Bengal Institute of Pharmaceutical science
Indian Journal of Traditional Knowledge | Year: 2017

Yoga is considered to be one of the oldest sciences developed as per precedence, where merging certain simple postural movements with basic physiological actions, have proved to be revitalising for both mind and body. The present study is focussed upon the basic chemistry that underlies this phenomenon. The impacts of yoga upon the DNA repair mechanism of the body, where we have tried to find out how Yoga can activate the glutathione production in the body, which is the innate antioxidant agent. Thus, helps to prevent and/ or alleviate necrotic pathophysiological conditions as well. We have also compared cases where people doing yoga are living a better life than people who are debarred from it, where improvement in their mental well-being as revealed Electro Encephalogram investigations. © 2017, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.


Ghosh A.K.,JKK Nataraja Dental College and Hospital | Sen D.,Bengal Institute of Pharmaceutical science
Pharmacognosy Research | Year: 2010

A new alkaloid namely 1-(4′-methoxyphenyl)-aziridine was isolated from the leaf of Abies webbiana Lindl. (Pinaceae), grown in Sikkim Himalayan region of India. Its chemical structure was elucidated on the basis of elemental and spectral analyses. This is the first experimental report of the isolation of any alkaloid from A. webbiana.


Biswas M.,Bengal Institute of Pharmaceutical science | Haldar P.K.,Jadavpur University
Tropical Journal of Pharmaceutical Research | Year: 2010

Purpose: Terminalia arjuna Roxb (Combretaceae) is commonly known as Arjjhan and Arjun in Bengal, India. The anti-leishmanial and anticancer activities of a pentacyclic triterpenoid isolated from its leaves were evaluated. Methods: Dried and crushed leaves of Terminalia arjuna were de-fatted with petroleum ether (40 -60°C) and extracted with methanol. The extract was subjected to column chromatography and column fractions were monitored on TLC plates developed in a suitable solvent system. Structures of the isolated pure compounds were elucidated by infra-red spectroscopy, mass spectrometry and nuclear magnetic resonance spectroscopy. One of the compounds was screened for anti-leishmanial activity against promastigotes of Leishmania donovani, and anti-cancer activity on K562 leukaemic cell line. Results: A pentacyclic triterpenoid, characterized as 3β-hydroxyurs-12-en-28-oic acid (together with ß-D-glucoside) and designated ursolic acid, was successfully isolated. The structure was determined on the basis of spectroscopic analyses. In vitro anti-leishmanial activity against promastigotes of Leishmania donovani (strain AG 83) and anti-cancer activity on K562 leukaemic cell line were shown by the isolated ursolic acid. Conclusion: The methanol extract of the leaves of Terminalia arjuna led to the isolation of a pentacyclic triterpenoid, ursolic acid. This compound demonstrated in vitro anti-leishmanial and anti-cancer activities. © Pharmacotherapy Group.


Biswas M.,Bengal Institute of Pharmaceutical science | Haldar P.K.,Jadavpur University
Journal of Natural Science, Biology and Medicine | Year: 2010

This study evaluated the in vitro antioxidant potential of petroleum ether (60-80°C), chloroform, and methanol extract of the fruits of Dregea volubilis Benth (Asclepiadaceae). The different antioxidant assays, including total antioxidant activity, reducing power, free radical, super oxide anion radical, nitric oxide scavenging, lipid peroxidation, and total phenolic content were studied. The extracts exhibited potent total antioxidant activity that increased with increasing amount of extract concentration, which was compared with standard drug vitamin C at different concentrations as extracts. The different concentrations of all the extracts and vitamin C showed inhibition on lipid peroxidation. In addition, all the extracts had effective reducing power, free radical scavenging, super oxide anion scavenging, nitric oxide scavenging, lipid peroxidation, and total phenolic content depending on concentration. These various antioxidant activities were compared with standard antioxidant such as vitamin C at different concentration as different extracts.


Biswas M.,Bengal Institute of Pharmaceutical science | Kar B.,Jadavpur University | Kumar R.B.S.,Jadavpur University | Haldar P.K.,Jadavpur University
Pharmaceutical Biology | Year: 2011

Context: Terminalia arjuna Roxb. (Combretaceae), commonly known as Arjuna, is a large tree grown throughout the Indian peninsula and used traditionally for several medicinal purposes. Objective: To evaluate antihyperglycemic and antioxidant role of methanol extract of T. arjuna leaf (META) in Wistar rats. Materials and methods: Hyperglycemia was induced in rats by single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight). Three days after STZ induction, the hyperglycemic rats were treated with META orally at the dose of 100 and 200 mg/kg body weight daily for 15 days. Glibenclamide (0.5 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on every fifth day during the 15-day treatment. Serum biochemical parameters such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), cholesterol, and total protein were estimated. Antioxidant properties were assessed by estimating hepatic lipid peroxidation, reduced glutathione (GSH), and catalase (CAT). Results and discussion: META at the dose of 100 and 200 mg/kg orally significantly (P < 0.001) and dose-dependently reduced and normalized blood glucose levels as compared with that of STZ control group. Serum biochemical parameters were significantly (P < 0.001) restored toward normal levels in META-treated rats as compared with STZ control. META treatment also significantly (P < 0.001) decreased lipid peroxidation and recovered GSH level and CAT activity toward normal as compared with STZ control. Conclusion: The present study infers that T. arjuna leaf demonstrated remarkable antihyperglycemic activity in STZ-induced diabetic rats. The potential antihyperglycemic action is plausibly due to its underlying antioxidant role. © 2011 Informa Healthcare USA, Inc.


PubMed | Bengal Institute of Pharmaceutical science
Type: Journal Article | Journal: Journal of traditional and complementary medicine | Year: 2016

The effect of an Ayurvedic poly-herbo-mineral formulation Kumarabharana Rasa (KR) in the management of chronic tonsillitis (Tundikeri) in children has been assessed in this study. This clinical study was a double-arm study with a pre- and post-test design at the outpatient level in a tertiary Ayurveda hospital attached to a teaching institute located in district headquarters in Southern India. Patients (n=40) with chronic tonsillitis satisfying diagnostic criteria and aged between 5 and 10 years were selected from the outpatient Department of Kaumarbhritya, SDM College of Ayurveda and Hospital, Hassan. Among them, 20 patients were treated with Kumarabharana rasa (tablet form) at a dose of 500mg once daily for 30 days (Group A). The other 20 patients were treated with Godhuma Vati (placebo) at a dose of 500mg once daily for 30 days (Group B). In both groups, Madhu was the Anupana advised. After completion of 30 days of treatment, the patients were assessed on the following day and another investigation took place 15 days later. Statistically significant effects (p<0.05) in the reduction of all signs and symptoms of chronic tonsillitis after KR treatment were observed. These results indicate that Kumarabharana Rasa has an ameliorative effect in reducing the signs and symptoms of chronic tonsillitis.


Sen D.,Bengal Institute of Pharmaceutical science | Chatterjee T.K.,Jadavpur University
Journal of Advanced Pharmaceutical Technology and Research | Year: 2013

Febrifugine and its derivatives are effective against Plasmodium falciparum. Using PHASE algorithm, a five-point pharmacophore model with two hydrogen bond acceptor (A), one positively ionizable (P) and two aromatic rings (R), was developed to derive a predictive ligand-based statistically significant 3D-quantitative structure-activity relationship (QSAR) model (r2 = 0.972, SD = 0.3, F = 173.4, Q2 = 0.712, RMSE = 0.3, Person-R = 0.94, and r2pred = 0.8) to explicate the structural attributes crucial for antimalarial activity. The developed pharmacophore model and 3D QSAR model can be a substantial tool for virtual screening and related antimalarial drug discovery research.


Biswas S.K.,Bengal Institute of Pharmaceutical science | Debnath M.,Bengal Institute of Pharmaceutical science
Indian Journal of Traditional Knowledge | Year: 2017

Yoga is considered as one of the important measure for prevention of diseases and promotion of health, practiced in India since time immemorial and presently emphasized greatly by the Government of India. In spite, procedural part of Yoga, viz. Asana, is more popular among common people, but actual application of Yoga meant in a wider way. Yoga, in therapeutic purpose, includes both the physical and psychological aspects. Similar approach is also described in Ayurveda. The preventive aspects of therapeutics are the primary aim of Ayurveda and it is predicted that the idea of Ayurveda percolated in Yoga too. Importance of preventive therapeutics is now a great concern in bio-medical sciences. An attempt has been made in the present article regarding concomitant applications of both the Yoga and Ayurveda in prevention of certain diseases like respiratory problems, cardio-vascular diseases, hepato-billiary diseases and diabetes mellitus. © 2017, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.

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