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Arun Raj G.R.,Sdm College | Shailaja U.,Sdm College | Debnath P.,Sdm College | Banerjee S.,Bengal Institute of Pharmaceutical science | Rao P.N.,Sdm College
Journal of Traditional and Complementary Medicine | Year: 2016

The effect of an Ayurvedic poly-herbo-mineral formulation Kumarabharana Rasa (KR) in the management of chronic tonsillitis (Tundikeri) in children has been assessed in this study. This clinical study was a double-arm study with a pre- and post-test design at the outpatient level in a tertiary Ayurveda hospital attached to a teaching institute located in district headquarters in Southern India. Patients (n = 40) with chronic tonsillitis satisfying diagnostic criteria and aged between 5 and 10 years were selected from the outpatient Department of Kaumarbhritya, SDM College of Ayurveda and Hospital, Hassan. Among them, 20 patients were treated with Kumarabharana rasa (tablet form) at a dose of 500 mg once daily for 30 days (Group A). The other 20 patients were treated with Godhuma Vati (placebo) at a dose of 500 mg once daily for 30 days (Group B). In both groups, Madhu was the Anupana advised. After completion of 30 days of treatment, the patients were assessed on the following day and another investigation took place 15 days later. Statistically significant effects (p < 0.05) in the reduction of all signs and symptoms of chronic tonsillitis after KR treatment were observed. These results indicate that Kumarabharana Rasa has an ameliorative effect in reducing the signs and symptoms of chronic tonsillitis. © 2014 Center for Food and Biomolecules, National Taiwan University.

Banerjee S.,Bengal Institute of Pharmaceutical science | Adhikari A.,Rg Kar Medical College And Hospital | Debnath P.K.,Gananath Sen Institute of Ayurvdiya and Research
Journal of Complementary and Integrative Medicine | Year: 2015

Ayurveda described diabetes mellitus (DM) as Madhumeha. This ancient evidence-based system of medicine enumerated various herbs and formulations for its management, which needs scientific validation. Whereas translational "bedside to bench" approach in biomedical research is an upcoming concept, its application in traditional and complementary medicine can be interesting. The intersecting concepts in the field Ayurveda and translational research needs "omics" approach. The Ayurvedic biology concepts about DM have its close relations with present systems biology approach. Metabolic changes causing tissue damage connected with genetic and immunological irregularities leading to insulin resistance coincide with ancient knowledge. Combinatorial therapy according to Prakriti type as elucidated by Ayurgenomics should be carried on for further research. "Bedside to bench" approaches in research utilizing metabolomics and pharmacogenomics approach can be a major step towards changing the therapeutic strategy towards diabetes. Prameha which is described as the pre-diabetic state is a novel concept in Ayurvedic etiopathogenesis, while metabolomic parameters like lipid level in urine can be a thrust area of research to have a pre-diabetic screening method in high-risk populations. This tradition-guided research paradigm can open up novel opportunities in traditional knowledge-inspired systems biology and drug discovery against diabetes. © 2015 by De Gruyter 2015.

Banerjee S.,Bengal Institute of Pharmaceutical science | Adhikari A.,Rg Kar Medical College And Hospital
Journal of Evidence-Based Complementary and Alternative Medicine | Year: 2015

The purpose of the study was to assess the health-related quality of life and treatment satisfaction of diabetes patients (n = 36) with foot ulcers undergoing insulin and ayurvedic adjunct therapy. Retrospective hospital based cross-sectional design considered patients with diabetes foot ulcers undergoing 4-week treatment with insulin and ayurvedic combinatorial therapy. The Audit of Diabetes Dependent Quality of Life Questionnaire and Diabetes Treatment Satisfaction Questionnaire were completed for the assessment. The mean duration of diabetes among participants was 9.32 ± 5.3 years. Assessment of Diabetes Treatment Satisfaction Questionnaire (total treatment satisfaction) score was found to be 26.0139 ± 5.20369, and Audit of Diabetes Dependent Quality of Life Questionnaire (average weighted impact) score was −3.0819 ± 1.83003. Relationship with diabetes complications showed that Audit of Diabetes Dependent Quality of Life Questionnaire score (P =.383) had no relationship, but Diabetes Treatment Satisfaction Questionnaire score (P =.039) showed significance. Integrated approaches for diabetes foot ulcer management with insulin and ayurvedic management have a favorable impact on patient-perceived quality of life. © The Author(s) 2014.

Biswas M.,Bengal Institute of Pharmaceutical science | Haldar P.K.,Jadavpur University
Journal of Natural Science, Biology and Medicine | Year: 2010

This study evaluated the in vitro antioxidant potential of petroleum ether (60-80°C), chloroform, and methanol extract of the fruits of Dregea volubilis Benth (Asclepiadaceae). The different antioxidant assays, including total antioxidant activity, reducing power, free radical, super oxide anion radical, nitric oxide scavenging, lipid peroxidation, and total phenolic content were studied. The extracts exhibited potent total antioxidant activity that increased with increasing amount of extract concentration, which was compared with standard drug vitamin C at different concentrations as extracts. The different concentrations of all the extracts and vitamin C showed inhibition on lipid peroxidation. In addition, all the extracts had effective reducing power, free radical scavenging, super oxide anion scavenging, nitric oxide scavenging, lipid peroxidation, and total phenolic content depending on concentration. These various antioxidant activities were compared with standard antioxidant such as vitamin C at different concentration as different extracts.

Biswas M.,Bengal Institute of Pharmaceutical science | Karan T.K.,Jadavpur University | Kar B.,Jadavpur University | Kumar R.B.S.,Jadavpur University | Haldar P.K.,Jadavpur University
Asian Journal of Chemistry | Year: 2011

In present study, the methanolic extract of Terminalia arjuna was evaluated for its protective effect on paracetamol-induced liver damage in Wistar rats. Serum biochemical parameters viz., serum glutamine oxaloacetate transaminase, serum glutamine pyruvate transaminase, serum alkaline phosphatase (SALP), total protein, bilirubin, cholesterol, triglyceroides and liver biochemical parameters such as lipid peroxidation, reduced glutathione (GSH) content and catalase (CAT) activity were estimated. Serum and liver biochemical observations indicated that methanolic extract of Terminalia arjuna exerted remarkable hepatoprotective efficacy against paracetamol-induced hepatic damage in Wistar rats that is may be due to its augmenting endogenous antioxidant mechanisms.

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