Belorussian State Medical University

Minsk, Belarus

Belorussian State Medical University

Minsk, Belarus

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PubMed | Belorussian State Medical University
Type: Clinical Trial | Journal: Bulletin of experimental biology and medicine | Year: 2015

We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy after 12-month follow-up revealed slowing down of the disease progression in 10 patients in comparison with the control group consisting of 15 patients. The cell therapy was safe for the patients.


Sullivan A.K.,Foundation Medicine | Raben D.,Copenhagen University | Reekie J.,University College London | Rayment M.,Foundation Medicine | And 18 more authors.
PLoS ONE | Year: 2013

Improved methods for targeting HIV testing among patients most likely to be infected are required; HIDES I aimed to define the methodology of a European wide study of HIV prevalence in individuals presenting with one of eight indicator conditions/diseases (ID); sexually transmitted infection, lymphoma, cervical or anal cancer/dysplasia, herpes zoster, hepatitis B/C, mononucleosis-like illness, unexplained leukocytopenia/thrombocytopenia and seborrheic dermatitis/exanthema, and to identify those with an HIV prevalence of >0.1%, a level determined to be cost effective. A staff questionnaire was performed. From October 2009- February 2011, individuals, not known to be HIV positive, presenting with one of the ID were offered an HIV test; additional information was collected on previous HIV testing behaviour and recent medical history. A total of 3588 individuals from 16 centres were included. Sixty-six tested positive for HIV, giving an HIV prevalence of 1.8% [95% CI: 1.42-2.34]; all eight ID exceeded 0.1% prevalence. Of those testing HIV positive, 83% were male, 58% identified as MSM and 9% were injecting drug users. Twenty percent reported previously having potentially HIV-related symptoms and 52% had previously tested HIV negative (median time since last test: 1.58 years); which together with the median CD4 count at diagnosis (400 cell/uL) adds weight to this strategy being effective in diagnosing HIV at an earlier stage. A positive test was more likely for non-white individuals, MSM, injecting drug users and those testing in non-Northern regions. HIDES I describes an effective strategy to detect undiagnosed HIV infection. All eight ID fulfilled the >0.1% criterion for cost effectiveness. All individuals presenting to any health care setting with one of these ID should be strongly recommended an HIV test. A strategy is being developed in collaboration with ECDC and WHO Europe to guide the implementation of this novel public health initiative across Europe. © 2013 Sullivan et al.


Zalesskaya G.A.,National Academy of Sciences of Belarus | Laskina O.V.,Belorussian State Medical University
Journal of Applied Spectroscopy | Year: 2013

We have studied the effect of in vivo irradiation of blood by radiation at different wavelengths (254 nm, 632.8 nm, and 670 nm), which can be absorbed by blood, on the absorption spectra and gas composition of venous blood for individual patients. We have determined the differences in short-term and long-term changes in both spectral characteristics and the gas composition of blood induced by irradiation. During and immediately after irradiation, for all the patients we observed an increase in the partial pressure of oxygen and a decrease in the partial pressure of carbon dioxide in venous blood. After irradiation was completed, the changes in the partial pressures of blood gases were different for different patients: the gas pressures both increased and decreased, depending on the photo-induced changes in the level of hemoglobin oxygen saturation in venous blood. © 2013 Springer Science+Business Media New York.


Lisenko S.A.,Belarusian State University | Firago V.A.,Belarusian State University | Kugeiko M.M.,Belarusian State University | Kubarko A.I.,Belorussian State Medical University
Journal of Applied Spectroscopy | Year: 2016

We have developed a method for on-the-fl y retrieval of the volume concentration of blood vessels, the average diameter of the blood vessels, the blood oxygenation level, and the molar concentrations of chromophores in the bulbar conjunctiva from its diffuse reflectance spectra, measured when the radiation delivery and detection channels are spatially separated. The relationship between the diffuse reflectance spectrum of the conjunctiva and its unknown parameters is described in terms of an analytical model, constructed on the basis of a highly accurate approximation analog of the Monte Carlo method. We have studied the effect of localization of hemoglobin in erythrocytes and localization of erythrocytes in the blood vessels on the power of the retrieval of structural and morphological parameters for the conjunctiva. We developed a device for obtaining video images of the conjunctiva and contactless measurements of its diffuse reflectance spectrum. By comparing simulated diffuse reflectance spectra of the conjunctiva with the experimental measurements, we established a set of chromophores which must be taken into account in the model for reproducing the experimental data within the measurement error. We observed absorption bands for neuroglobin in the experimental spectra, and provided a theoretical basis for the possibility of determining its absolute concentrations in the conjunctiva. We have shown that our method can detect low bilirubin concentrations in blood. © 2016 Springer Science+Business Media New York


Chistyakova G.G.,Belorussian State Medical University | Shalukho N.M.,Belarusian National Technical University | Izobello Yu.N.,Grodno Scientific Research and Design Institute
Glass and Ceramics (English translation of Steklo i Keramika) | Year: 2014

Composite stomatological light-cured materials with a polymer matrix, bonding layer and inorganic filling (glass) are examined. The requirements imposed on these materials by modern therapeutical stomatology are indicated. The composition and some technological aspects of the production of the new material are presented. An investigation of the physical-mechanical properties of the new composite material (strength, water absorption, polymerization depth) showed that these indices are on par with the best foreign analogs. © 2014 Springer Science+Business Media New York.


Kirillov V.A.,Belorussian State Medical University | Kuchuro J.I.,Belorussian State Medical University
Journal of Applied Spectroscopy | Year: 2014

We have used EPR dosimetry on tooth enamel to show that the combined effect of x-rays with effective energy 34 keV and gamma radiation with average energy 1250 keV leads to a significant increase in the reconstructed absorbed dose compared with the applied dose from a gamma source or from an x-ray source or from both sources of electromagnetic radiation. In simulation experiments, we develop an approach to estimating the contribution of diagnostic x-rays to the exposure dose formed in the tooth enamel by the combined effect of x-rays and gamma radiation. © 2014, Springer Science+Business Media New York.


Kirillov V.A.,Belorussian State Medical University | Kuchuro I.I.,Belorussian State Medical University
Journal of Applied Spectroscopy | Year: 2010

Based on study of spectral and relaxation characteristics, we have established that paramagnetic centers induced in tooth enamel by x-rays and gamma radiation are identical in nature. We show that for the same exposure dose, the intensity of the electron paramagnetic resonance (EPR) signal induced by x-radiation with effective energy 34 keV is about an order of magnitude higher than the amplitude of the signal induced by gamma radiation. We have identified a three-fold attenuation of the EPR signal along the path of the x-radiation from the buccal to the lingual side of a tooth, which is evidence that the individual had undergone diagnostic x-ray examination of the dentition or skull. We have shown that the x-ray exposure doses reconstructed from the EPR spectra are an order of magnitude higher than the applied doses, while the dose loads due to gamma radiation are equal to the applied doses. The data obtained indicate that for adequate reconstruction of individual absorbed doses from EPR spectra of tooth enamel in the population subjected to the combined effect of x-radiation and accidental external gamma radiation as a result of the disaster at the Chernobyl nuclear power plant, we need to take into account the contribution to the dose load from diagnostic x-rays in examination of the teeth, jaw, or skull. © 2010 Springer Science+Business Media, Inc.


Baeshko A.A.,Belorussian State Medical University | Shestak N.G.,Belorussian State Medical University
Angiologii͡a i sosudistai͡a khirurgii͡a = Angiology and vascular surgery | Year: 2015

The article contains a review of the materials presented at the XVII World Congress of the International Union of Phlebology held in Boston in September 2013. Analysed herein are the opinions and experience of phlebologists from various countries. The contributors discussed various aspects of using foam sclerotherapy and thermal methods of ablation, briefly representing the results of studies concerning thromboses and embolisms, anatomy of veins and methods of ultrasound examination, epidemiology of chronic venous diseases (CVDs), relapses of varicose veins, pharmacotherapy of CVDs, etc.


PubMed | Belorussian State Medical University
Type: Journal Article | Journal: Stomatologiia | Year: 2016

this study aims to estimate significance of the descriptive dental epidemiology in evaluation of the long-term effect of the Community program for prevention of dental caries.The descriptive dental epidemiology data of DMFT 12-year-old children in Belarus and Russia were analyzed since 1961 to 2014.Meta-analysis of publications indicated that prevalence of dental caries has dropped from average 3.7-3.8 DMFT at baseline to 2.2-2.6 DMFT after 20 years of the programs implementation in Belarus and Russia accordingly. However, during last 5-6 years a negative trend was assumed.Based on long-term DMFT monitoring, the community programs in Belarus and Russia were effective in reducing dental caries by 30-40% for about 30-years period. However, the observed trend was not stable perhaps due to insufficient scientific support of programs.


PubMed | Belorussian State Medical University
Type: Journal Article | Journal: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery | Year: 2015

The article contains a review of the materials presented at the XVII World Congress of the International Union of Phlebology held in Boston in September 2013. Analysed herein are the opinions and experience of phlebologists from various countries. The contributors discussed various aspects of using foam sclerotherapy and thermal methods of ablation, briefly representing the results of studies concerning thromboses and embolisms, anatomy of veins and methods of ultrasound examination, epidemiology of chronic venous diseases (CVDs), relapses of varicose veins, pharmacotherapy of CVDs, etc.

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