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Capobianco M.,Regional Multiple Sclerosis Center | Motuzova Y.,Belorussian State Medical University | Frau J.,University of Cagliari | Cocco E.,University of Cagliari | And 3 more authors.
Neurological Sciences | Year: 2012

High-dose cyclophosphamide followed by autologous haematopoietic stem cell transplantation (HDCAHSCT) is a treatment option for aggressive and refractory multiple sclerosis (MS). Natalizumab is a monoclonal antibody approved for relapsing-remitting (RR) MS unresponsive to immunomodulating drugs. Nothing is known about the use of natalizumab in patients after HDC-AHSCT. We describe five female RR-MS patients with incomplete response to HDC-AHSCT. Natalizumab was then administered with abolition of both MRI and clinical activity. No severe adverse events, in particular opportunistic infections such as Progressive Multifocal Leukoencephalopathy (PML), were observed. Our results suggest that the use of natalizumab in aggressive RR-MS after HDC-AHSCT could be effective and safe. The very longterm risk of adverse events due to sequential aggressive immunosuppression has to be established. © 2011 Springer-Verlag. Source


Chistyakova G.G.,Belorussian State Medical University | Shalukho N.M.,Belarusian National Technical University | Izobello Yu.N.,Grodno Scientific Research and Design Institute
Glass and Ceramics (English translation of Steklo i Keramika) | Year: 2014

Composite stomatological light-cured materials with a polymer matrix, bonding layer and inorganic filling (glass) are examined. The requirements imposed on these materials by modern therapeutical stomatology are indicated. The composition and some technological aspects of the production of the new material are presented. An investigation of the physical-mechanical properties of the new composite material (strength, water absorption, polymerization depth) showed that these indices are on par with the best foreign analogs. © 2014 Springer Science+Business Media New York. Source


Zalesskaya G.A.,National Academy of Sciences of Belarus | Laskina O.V.,Belorussian State Medical University
Journal of Applied Spectroscopy | Year: 2013

We have studied the effect of in vivo irradiation of blood by radiation at different wavelengths (254 nm, 632.8 nm, and 670 nm), which can be absorbed by blood, on the absorption spectra and gas composition of venous blood for individual patients. We have determined the differences in short-term and long-term changes in both spectral characteristics and the gas composition of blood induced by irradiation. During and immediately after irradiation, for all the patients we observed an increase in the partial pressure of oxygen and a decrease in the partial pressure of carbon dioxide in venous blood. After irradiation was completed, the changes in the partial pressures of blood gases were different for different patients: the gas pressures both increased and decreased, depending on the photo-induced changes in the level of hemoglobin oxygen saturation in venous blood. © 2013 Springer Science+Business Media New York. Source


Potapnev M.P.,Belorussian State Medical University
Bulletin of Experimental Biology and Medicine | Year: 2015

We studied a new method of treatment of amyotrophic lateral sclerosis with autologous mesenchymal stem cells. Autologous mesenchymal stem cells were injected intravenously (intact cells) or via lumbar puncture (cells committed to neuronal differentiation). Evaluation of the results of cell therapy after 12-month follow-up revealed slowing down of the disease progression in 10 patients in comparison with the control group consisting of 15 patients. The cell therapy was safe for the patients. © 2015, Springer Science+Business Media New York. Source


Rudoy A.S.,Belorussian State Medical University | Zemtsovsky E.V.,Saint Petersburg State University
Russian Journal of Cardiology | Year: 2015

The article focuses on the review of the main methods of aorta visualization. The methods are described, as the algorithm of investigation method selection, strategy of patient’s management with aorta dilation. Special attention is paid for the patients with genetic disorders that may cause aorta dilation. © 2015, Silicea-Poligraf. All rights reserved. Source

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