PubMed | Belo Horizonte., Belo Horizonte. Electronic address, Federal University of Minas Gerais and Federal University of Pernambuco
Type: | Journal: The Journal of nutritional biochemistry | Year: 2016
Alcoholism is a multifactorial and complex disorder responsible for 5.9% of deaths worldwide. Excessive consumption of ethanol (Et-OH) induces alcoholic liver disease (ALD), a condition comprising a spectrum of clinical signs and morphological changes, ranging from fatty liver (steatosis) to more severe forms of chronic liver injury. Secondary cofactors, such as nutritional and hepatotoxic comorbid conditions, can also contribute to liver disease development. Here we investigated the effects in the progression of ALD following short-term exposure to diet high in refined carbohydrates (HC), a high-sugar and -butter (HSB) hypercaloric diet and acute Et-OH consumption. HSB diet increased the body weight (BW) and adiposity independently of acute Et-OH consumption. HC diet did not affect BW but increased the adiposity, while acute Et-OH alone did not affect BW and adiposity. All groups of mice developed steatosis except the control group. Exposure to acute Et-OH and HSB diet increased the number of neutrophils and macrophages, and apoptosis in the liver. This combination also increased the number of circulating neutrophils and reduced mononuclear cells in the blood. Thus, short-term exposure to HSB diet and acute Et-OH intake is linked to increased liver injury. These findings offer important clues to understand the hepatic injuries associated with short exposure to hypercaloric diets and acute Et-OH.
Bertolini M.D.M.E.,University of Campinas |
Kempen J.,Belo Horizonte |
Lourenco E.J.V.,State University of Rio de Janeiro |
Telles D.D.M.,State University of Rio de Janeiro
Journal of Prosthetic Dentistry | Year: 2014
Well-placed dental implants are a prerequisite of functional and esthetically successful dental implant - supported crowns. The presence of soft tissue is essential for excellent esthetics because the dental implant or titanium abutment may become visible if the soft-tissue contour is not acceptable. This clinical report describes the use of a custom ceramic implant abutment designed with computer-aided design and computer-aided manufacturing (CAD/CAM) technology by milling a zirconia framework that was cemented extraorally to a prefabricated titanium abutment with a reduced diameter. This ceramic abutment has the strength and precise fit of a titanium interface and also the esthetic advantages of shaded custom-milled zirconia, with no visible metal.
Junior G.V.,Rua Tenente Garro |
Dellaretti M.,Belo Horizonte |
De Carvalho G.T.C.,Belo Horizonte |
Brandao R.A.C.S.,Belo Horizonte |
And 2 more authors.
Brain Tumor Pathology | Year: 2011
Tumors of the pineal region are rare in adulthood, accounting for approximately 1% of intracranial neoplasms in this age range. Papillary tumor of the pineal region (PTPR) was first described by Jouvet et al. in 2003. In 2007, PTPR was included by the World Health Organization as a distinct entity in their new classification of central nervous system tumors. We report a case of PTPR, and undertake a literature review of this rare neuroepithelial neoplasm. Patients with PTPR need long-term follow up, and new cases should be well documented so that we can gain a better understanding of this neoplasm. © 2011 The Japan Society of Brain Tumor Pathology.
Buvat J.,Center Detudes Et Of Traitement Of La Pathologie Of Lappareil Reproducteur Et Psychosomatique |
Maggi M.,University of Florence |
Gooren L.,Medical Center |
Guay A.T.,Harvard University |
And 7 more authors.
Journal of Sexual Medicine | Year: 2010
Introduction. Endocrine disorders may adversely affect men's sexual function. Aim. To provide recommendations based on best evidence for diagnosis and treatment of endocrine-related male sexual dysfunctions. Methods. The Endocrine Aspects of Male Sexual Dysfunctions Committee, including 11 members from eight countries and four continents, collaborated with the Endocrine subcommittee of the Standards Committee of the International Society for Sexual Medicine. Medical literature was reviewed in detail, followed by extensive internal committee discussion over 2 years, then public presentation and discussion with the other experts before finalizing the report. Main Outcome Measure. Recommendations based on grading of evidence-base medical literature and interactive discussion. Results. From animal studies, it is derived that testosterone modulates mechanisms involved in erectile machinery, including expression of enzymes that both initiate and terminate erection. In addition, testosterone is essential for sexual motivation. Whether these findings could be extrapolated to human erections is unclear. Testosterone plays a broad role in men's overall health. Recent studies have established strong associations between low testosterone and metabolic and cardiovascular imbalances. In some studies, low testosterone decreased longevity; however, longitudinal studies do not support the predictive value of low testosterone for further cardiovascular events. The article proposes a standardized process for diagnosis and treatment of endocrine-related male sexual dysfunctions, updating the knowledge on testosterone and prostate safety. There is no compelling evidence that testosterone treatment causes prostate cancer or its progression in men without severe testosterone deficiency (TD). The possible roles of prolactin and thyroid hormones are also examined. Conclusions. Men with erectile dysfunction, hypoactive sexual desire and retarded ejaculation, as well as those with visceral obesity and metabolic diseases, should be screened for TD and treated. Prospective interventional studies are required before screening for TD in more conditions, including cardiovascular diseases, and considering correction as preventive medicine as much data suggests. Buvat J, Maggi M, Gooren L, Guay AT, Kaufman J, Morgentaler A, Schulman C, Tan HM, Torres LO, Yassin A, and Zitzmann M. Endocrine aspects of male sexual dysfunctions. © 2010 International Society for Sexual Medicine.
Dantas R.R.A.,Belo Horizonte
Seminars in Ophthalmology | Year: 2010
The lacrimal drainage system consists of the lacrimal puncta, inferior and superior canaliculi, common canaliculus, lacrimal sac, and nasolacrimal duct. It is classically divided into upper and lower portions. Obstruction of the drainage system can be congenital or acquired, and may result in persistent epiphora and mucopurulent discharge. This paper discusses the etiology, clinical picture, diagnosis, and surgical treatment of lacrimal drainage system obstruction. © 2010 Informa UK Ltd.
De Menezes Bedran E.G.,Belo Horizonte |
Correia Pereira M.V.,Belo Horizonte |
Bernardes T.F.,Belo Horizonte
Seminars in Ophthalmology | Year: 2010
Ectropion is the most frequent eyelid malposition, characterized by the eversion of the margin and exposure of the conjunctiva and the cornea. It is classified as congenital (primary and secondary) and acquired (involutional, paralytic, mechanical and cicatricial). Congenital ectropion is rare and it is usually associated with other malformations such as euryblepharon, ptosis, epicanthus inversus, and blepharophimosis syndrome. Involutional ectropion is the most frequent form of acquired eyelid eversion and a result of multiple factors. The mechanisms involved in its pathogenesis are discussed in this review. Cicatricial ectropion is caused by the shortening of the anterior lamella of the lid, secondary to congenital malformations, trauma, burns, skin conditions, scarring skin tumors, medications, allergies, blepharoplasty complications, and involutional changes that result in loss of skin elasticity. Mechanical ectropion is caused by eyelid tumors or inflammatory disorders that cause orbicularis spasm. The evaluation of the patient, selection of treatment and surgical techniques are described in detail. © 2010 Informa UK Ltd.
Garib D.G.,University of Sao Paulo |
Bressane L.B.,University of Sao Paulo |
Janson G.,University of Sao Paulo |
Gribel B.F.,Belo Horizonte
American Journal of Orthodontics and Dentofacial Orthopedics | Year: 2016
Introduction The objectives of this study were to evaluate the prevalence and long-term behavior of extraction space reopening in patients with Class I malocclusion and to identify some associated factors. Methods A sample of 43 patients met the inclusion criteria. Dental casts at the onset of treatment, after treatment, and 1 and 5 years after debonding were used. Initial and final cephalometric radiographs were used to measure the amount of incisor retraction. Cochran tests were used to compare the numbers of open and closed extraction spaces after treatment and at 1 and 5 years after debonding (P <0.05). Initial incisor crowding, amounts of anterior retraction, and angulations between the canines and the second premolars were compared between patients with and without space reopening with t tests. Results Of the sample, 30.23% had extraction space reopening. The frequency of open spaces significantly increased between the final and the 1-year posttreatment dental casts and decreased between the casts at 1 and 5 years posttreatment. Patients with space reopening had less initial anterior crowding and greater amounts of mandibular incisor retraction during treatment. Conclusions There was a high prevalence of space reopening 1 year after treatment. However, these spaces tended to decrease by 5 years after treatment. © 2016 American Association of Orthodontists.
Maggi M.,University of Florence |
Buvat J.,Center Detude Et Of Traitement Of La Pathologie Of Lappareil Reproducteur Et Of La Psychosomatique |
Corona G.,University of Florence |
Corona G.,Azienda Usl Bologna Maggiore Bellaria Hospital |
And 2 more authors.
Journal of Sexual Medicine | Year: 2013
Introduction. Besides hypogonadism, other endocrine disorders have been associated with male sexual dysfunction (MSD). Aim. To review the role of the pituitary hormone prolactin (PRL), growth hormone (GH), thyroid hormones, and adrenal androgens in MSD. Methods. A systematic search of published evidence was performed using Medline (1969 to September 2011). Oxford Centre for Evidence-Based Medicine-Levels of Evidence (March 2009) was applied when possible. Main Outcome Measures. The most important evidence regarding the role played by PRL, GH, thyroid, and adrenal hormone was reviewed and discussed. Results. Only severe hyperprolactinemia (>35ng/mL or 735mU/L), often related to a pituitary tumor, has a negative impact on sexual function, impairing sexual desire, testosterone production, and, through the latter, erectile function due to a dual effect: mass effect and PRL-induced suppression on gonadotropin secretion. The latter is PRL-level dependent. Emerging evidence indicates that hyperthyroidism is associated with an increased risk of premature ejaculation and might also be associated with erectile dysfunction (ED), whereas hypothyroidism mainly affects sexual desire and impairs the ejaculatory reflex. However, the real incidence of thyroid dysfunction in subjects with sexual problems needs to be evaluated. Prevalence of ED and decreased libido increase in acromegalic patients; however, it is still a matter of debate whether GH excess (acromegaly) may create effects due to a direct overproduction of GH/insulin-like growth factor 1 or because of the pituitary mass effects on gonadotropic cells, resulting in hypogonadism. Finally, although dehydroepiandrosterone (DHEA) and its sulfate have been implicated in a broad range of biological derangements, controlled trials have shown that DHEA administration is not useful for improving male sexual function. Conclusions. While the association between hyperprolactinemia and hypoactive sexual desire is well defined, more studies are needed to completely understand the role of other hormones in regulating male sexual functioning. © 2012 International Society for Sexual Medicine.
PubMed | Belo Horizonte and Sacred Heart University of Brazil
Type: Journal Article | Journal: Brazilian oral research | Year: 2016
The aim of this research was to evaluate age-related changes in the smile of Brazilian women. The sample consisted of 249 Brazilian women who had not undergone previous orthodontic treatment or facial surgery. They were divided into four groups, according to age: G1 (20-29), G2 (30-39), G3 (40-49) and G4 (50 or older). Standardized front view photographs were taken while smiling and at rest. Measurements were evaluated by ANOVA and post-hoc Tukey. The Chi-square test was applied for qualitative variables. Upper lip thickness at rest and exposure of upper incisors on smiling decreased with age. Most individuals (60.9%) exhibited a medium smile. High smiles were more often seen in G1 (45%) and less frequently in G4 (18.8%), whereas the opposite occurred with the low smile, i.e., G4 (21.9%) and G1 (6.7%). Variations among the groups were observed in the transverse exposure of the teeth on smiling. In G1 and G3, there was a balance between tooth exposures, so that the teeth were exposed as far as the premolars and/or molars. Most of the women (56.3%) in G2 exposed their teeth as far as the first molars on smiling, whereas most of those (40.6%) in G4 exposed their teeth only as far as the first premolars on smiling. As age increased, there was decreased exposure of the upper incisors, decreased upper lip thickness and lower exposure of teeth vertically and transversely.
PubMed | Hospital Infantil Joao Paulo II, Institute Previdencia Dos Servidores Do Estado Of Minas Gerais and Belo Horizonte
Type: Journal Article | Journal: Trends in psychiatry and psychotherapy | Year: 2016
The broad autism phenotype (BAP) is a milder manifestation of the defining symptoms of the syndrome in individuals without autism. This study conducted a systematic review of studies about behavioral characteristics of interpersonal relationships, communication and rigidity, as well as about three cognitive models, Theory of Mind, central coherence and executive function, in parents of individuals with autism. The indexed databases were LILACS, IBECS, Web of Science, and MEDLINE, and the studies retrieved were published between 1991 and March 2012. Parents of individuals with autism have more difficulties in interpersonal relationships and in pragmatic language use and have more rigidity traits. The inclusions of the cognitive theories in the group of BAP characteristics were inconclusive.