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Buvat J.,Center Detudes Et Of Traitement Of La Pathologie Of Lappareil Reproducteur Et Psychosomatique | Maggi M.,University of Florence | Gooren L.,Medical Center | Guay A.T.,Harvard University | And 7 more authors.
Journal of Sexual Medicine | Year: 2010

Introduction. Endocrine disorders may adversely affect men's sexual function. Aim. To provide recommendations based on best evidence for diagnosis and treatment of endocrine-related male sexual dysfunctions. Methods. The Endocrine Aspects of Male Sexual Dysfunctions Committee, including 11 members from eight countries and four continents, collaborated with the Endocrine subcommittee of the Standards Committee of the International Society for Sexual Medicine. Medical literature was reviewed in detail, followed by extensive internal committee discussion over 2 years, then public presentation and discussion with the other experts before finalizing the report. Main Outcome Measure. Recommendations based on grading of evidence-base medical literature and interactive discussion. Results. From animal studies, it is derived that testosterone modulates mechanisms involved in erectile machinery, including expression of enzymes that both initiate and terminate erection. In addition, testosterone is essential for sexual motivation. Whether these findings could be extrapolated to human erections is unclear. Testosterone plays a broad role in men's overall health. Recent studies have established strong associations between low testosterone and metabolic and cardiovascular imbalances. In some studies, low testosterone decreased longevity; however, longitudinal studies do not support the predictive value of low testosterone for further cardiovascular events. The article proposes a standardized process for diagnosis and treatment of endocrine-related male sexual dysfunctions, updating the knowledge on testosterone and prostate safety. There is no compelling evidence that testosterone treatment causes prostate cancer or its progression in men without severe testosterone deficiency (TD). The possible roles of prolactin and thyroid hormones are also examined. Conclusions. Men with erectile dysfunction, hypoactive sexual desire and retarded ejaculation, as well as those with visceral obesity and metabolic diseases, should be screened for TD and treated. Prospective interventional studies are required before screening for TD in more conditions, including cardiovascular diseases, and considering correction as preventive medicine as much data suggests. Buvat J, Maggi M, Gooren L, Guay AT, Kaufman J, Morgentaler A, Schulman C, Tan HM, Torres LO, Yassin A, and Zitzmann M. Endocrine aspects of male sexual dysfunctions. © 2010 International Society for Sexual Medicine. Source

Maggi M.,University of Florence | Buvat J.,Center Detude Et Of Traitement Of La Pathologie Of Lappareil Reproducteur Et Of La Psychosomatique | Corona G.,University of Florence | Corona G.,Endocrinology Unit | And 2 more authors.
Journal of Sexual Medicine | Year: 2013

Introduction. Besides hypogonadism, other endocrine disorders have been associated with male sexual dysfunction (MSD). Aim. To review the role of the pituitary hormone prolactin (PRL), growth hormone (GH), thyroid hormones, and adrenal androgens in MSD. Methods. A systematic search of published evidence was performed using Medline (1969 to September 2011). Oxford Centre for Evidence-Based Medicine-Levels of Evidence (March 2009) was applied when possible. Main Outcome Measures. The most important evidence regarding the role played by PRL, GH, thyroid, and adrenal hormone was reviewed and discussed. Results. Only severe hyperprolactinemia (>35ng/mL or 735mU/L), often related to a pituitary tumor, has a negative impact on sexual function, impairing sexual desire, testosterone production, and, through the latter, erectile function due to a dual effect: mass effect and PRL-induced suppression on gonadotropin secretion. The latter is PRL-level dependent. Emerging evidence indicates that hyperthyroidism is associated with an increased risk of premature ejaculation and might also be associated with erectile dysfunction (ED), whereas hypothyroidism mainly affects sexual desire and impairs the ejaculatory reflex. However, the real incidence of thyroid dysfunction in subjects with sexual problems needs to be evaluated. Prevalence of ED and decreased libido increase in acromegalic patients; however, it is still a matter of debate whether GH excess (acromegaly) may create effects due to a direct overproduction of GH/insulin-like growth factor 1 or because of the pituitary mass effects on gonadotropic cells, resulting in hypogonadism. Finally, although dehydroepiandrosterone (DHEA) and its sulfate have been implicated in a broad range of biological derangements, controlled trials have shown that DHEA administration is not useful for improving male sexual function. Conclusions. While the association between hyperprolactinemia and hypoactive sexual desire is well defined, more studies are needed to completely understand the role of other hormones in regulating male sexual functioning. © 2012 International Society for Sexual Medicine. Source

While only one worker has been confirmed dead, the local governor said the mining disaster caused the most environmental damage of any in the state's history. It could cost the mine's owners a fortune to clean up and repair. Walls of water filled with mining waste cascaded downhill when the dams burst on Thursday, engulfing the village of Bento Rodrigues and its 600 residents in a sea of mud while also flooding others far removed from the open-pit mine. Little remains of the village but ruined walls and cars lying twisted in sludge. Search helicopters buzzed overhead as rescuers tried to save a horse trapped in the mud. "I heard screaming and saw the water coming fast, about 15 to 20 meters high (49-66 feet)," said survivor Antonio Santos, a construction worker who was at home when the dams broke. Bento Rodrigues is about 93 miles (150 km) southeast of Belo Horizonte, Brazil's third-largest city and the capital of the mining state of Minas Gerais. "Within 10 minutes the whole lower part of the village was destroyed, about 80 percent of it," he said in a gymnasium crowded with survivors in the nearby city of Mariana. Santos said he knew of four people who were swept away, including two children and two adults in their 50s. Mine operator Samarco's chief executive officer said a tremor in the vicinity of the mine may have caused the dams to burst, but that it was too early to establish the exact cause. The company said one worker died and 13 were missing. Firefighters initially put the death toll at two but later said they could not immediately confirm more than one fatality connected to the mine disaster. They said the count could rise because many people were still unaccounted for in six villages hit by floods unleashed by the successive bursting of the two dams holding waste, or iron ore tailings, from the mine. Samarco is a 50-50 venture between BHP Billiton and Brazil's Vale, the world's largest iron ore miner. The company said it had set no date to restart the mine, which produces about 30 million tons of iron ore annually. Output is shipped to Brazil's coast and converted into pellets for export to steel mills. The cleanup bill and potential environmental lawsuits could be more costly than the loss of output and come at a bad time for BHP Billiton and Vale, with iron ore prices at their lowest in a decade and one quarter of their 2011 level. A lawyer specializing in environmental and mining cases said it was too early to estimate the financial setback for the mining companies, since the cause of the disaster was still unknown. "It impossible to calculate now, but it is not going to be cheap," said Danilo Miranda, of the Marcelo Tostes law firm. The head of the local miners union, Ronaldo Bento, said it was too early to say whether the company had been negligent. Shares of Vale closed down 5.7 percent in Sao Paulo trading and BHP Billiton also dropped 5.7 percent in New York. A Minas Gerais state prosecutor in charge of environmental crimes, Carlos Ferreira Pinto, said he would seek a temporary suspension of Samarco's license on Monday. Samarco CEO Ricardo Vescovi said the company had been working on the drainage system for the dams. But both had valid licenses from environmental authorities, who last inspected them in July, according to Samarco. The University of Sao Paulo's seismic center reported four weak tremors in the general area of the mine in the hour before the disaster. But Vescovi said there had been no sign of any breach in the dams immediately after the tremors occurred. Analysts at Clarksons Platou Securities said the likelihood of a lengthy stoppage at the Samarco mine, which accounts for about one-fifth of seaborne pellet market, could lift iron ore prices. Prices were not immediately affected, however, and continued to fall on Friday. Pellet prices have plunged by one-third this year to their lowest in six years amid a global glut and waning Chinese demand. So-called tailings ponds, masses of finely ground waste rock mixed with water left over from extracting more valuable minerals, can contain harmful chemicals, adding to fears of potential contamination from the Samarco dam bursts. The company sought to play down those fears, saying there were no chemical elements that posed health risks when the accident occurred. It was the second major tailings dam disaster in Minas Gerais in 12 years. In 2003, 1.2 billion liters of waste from a tailings dam at a closed cellulose mill broke, flooding local rivers, cutting off fresh water to more than 600,000 people, and killing fish all the way to the Atlantic Ocean.

Home > Press > SENAI Outfits New Tribology Lab with Bruker UMT TriboLab Systems: Brazil’s National Service for Industrial Training Invests in Six Bruker Tribometers Abstract: Bruker has announced the installation of six UMT TriboLab Mechanical Testers at the Tribology Laboratory of Innovation SENAI Institute for Surface Engineering in Belo Horizonte, Brazil. Established by Brazil’s National Service of Industrial Training (SENAI), the new state-of-the-art laboratory will utilize the TriboLab systems to carry out research and development of products focused on the evaluation of materials performance for resistance to wear. The TriboLab systems enable the new laboratory to test real-use conditions across an extremely wide range of industrial products, from automotive engine components and hydraulic pumps to cutting tools and aeronautical turbines. “After our purchase of six UMT TriboLab systems we received visitors from large companies who were very interested to learn about our laboratory,” said Dr. Karyne Juste, ISI Surface Engineering Researcher at SENAI. “They were really impressed with the large number of different tribological tests that we are now able to offer. Working in different market segments, such as mining, automotive, and aeronautical industries, our visitors also emphasized the great relevance of having these services available in Brazil.” “Bruker was very pleased to help equip such an important tribology laboratory in Brazil,” added James Earle, Vice President and General Manager of Bruker’s Tribology, Stylus and Optical Metrology Business. “The TriboLab systems that have been installed allow them to run a comprehensive range of tests, from nanoindentation up to high-load tribology testing under vacuum. SENAI is a very important reference customer, and we look forward to working with Dr. Juste and her team as they support customers throughout South America with advanced tribology testing.” About Bruker Corporation For more than 50 years, Bruker has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance, scientific research instruments and high-value analytical solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics. About UMT TriboLab The UMT was first introduced in 2000 and rapidly became the quasi-standard for tribology and mechanical test labs around the world. With an improved platform offering many new ease-of-use and productivity features, the UMT TriboLaboffers comprehensive TriboScript™ software package to allow users to intuitively program complex motions and to control applied forces with unprecedented accuracy. Modular environmental chambers can be added or removed in minutes to enable users to adjust temperature or humidity to simulate real-world conditions. Other features include an integrated high-torque motor, built-in analog sensor protection for increased safety, and a comprehensive range of accessories to facilitate a wide range of tribology tests. Only the UMT TriboLab system enables easy and accurate transformation from rotary to reciprocating or linear motion, sub-Newton to kilo-Newton force measurement, or environmental testing from room temperature up to 1000°C. About SENAI The National Service for Industrial Training (Serviço Nacional de Aprendizagem Industrial, SENAI) is responsible for professional and vocational training and also seeks to cultivate international business relationships. With the newly planned research institutes, SENAI intends not just to promote vocational training for industry and business, but also to promote applied research across the country. Currently, SENAI has a total of 26 innovation institutes across nearly all federal states in Brazil, with each institute operating in a specific technical area. The SENAI Institute of Innovation on Surface Engineering offers solutions for increased performance, reliability, competitiveness and quality of products, components and systems by changing their surface properties. For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

de Brito M.G.,Belo Horizonte | Chamone T.L.,Belo Horizonte | da Silva F.J.,Av. Amilcar Savassi S N | Wada M.Y.,SCS | And 5 more authors.
Revista do Instituto de Medicina Tropical de Sao Paulo | Year: 2011

The Ministry of Health's National Human Rabies Control Program advocates pre-exposure prophylaxis (PEP) for professionals involved with animals that are at risk of contracting rabies. We report an antemortem and postmortem diagnosis of rabies in a veterinarian who became infected when handling herbivores with rabies. The antemortem diagnosis was carried out with a saliva sample and a biopsy of hair follicles using molecular biology techniques, while the postmortem diagnosis used a brain sample and conventional techniques. The veterinarian had collected samples to diagnose rabies in suspect herbivores (bovines and caprines) that were subsequently confirmed to be positive in laboratory tests. After onset of classic rabies symptoms, saliva and hair follicles were collected and used for antemortem diagnostic tests and found to be positive by RT-PCR. Genetic sequencing showed that the infection was caused by variant 3 (Desmodus rotundus), a finding confirmed by tests on the brain sample. It is essential that professionals who are at risk of infection by the rabies virus undergo pre-exposure prophylaxis. This study also confirms that molecular biology techniques were used successfully for antemortem diagnosis and therefore not only allow therapeutic methods to be developed, but also enable the source of infection in human rabies cases to be identified accurately and quickly. Source

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