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East Falmouth, MA, United States

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East Falmouth, MA, United States

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News Article | June 12, 2017
Site: www.prweb.com

JUNO Nominated Male Vocalist of the Year, Steph Carse, is returning home to Canada to share his story, his passion to inspire an anti-bullying movement and to give a rare country-inspired live performance. The Daystar Canada TV network will host the debut of Carse’s television special, “My Shining Hour,” in both one-hour and 30-minute versions. The show premieres on Monday, June 12th at 9:00pm-10:00pm ET and will play in heavy rotation over the next 30 days broadcasting to 10.25 million homes. Daystar Canada is also the exclusive destination to find Carse’s new “My Shining Hour” album, DVD and companion devotional. On the self-produced program, Carse shares the experience of his music career, which has taken him from the top of the charts, to living out of his car, to the release of his new album “My Shining Hour.” Told through music and narrative, Carse travels with viewers from Las Vegas to Africa, from Israel to his new home in Florida and beyond, sharing his journey of music, restoration and his true calling. Pioneered by FrontGate Media, this innovative content and product partnership between an artist and Daystar Canada is the first of its kind for the network. Through the show and on the Daystar Canada website (http://canada.daystar.com), fans can purchase a Personal Pack that includes the “My Shining Hour” CD, DVD and Devotional, as well as a Small Group Evangelism Pack that includes 5 of the Personal Packs at a special price. On June 17, Carse will travel back to Montreal to perform as a special guest at “The Country Party - Once Upon A Time at the Bell Center.” A themed party with capacity for 15,000 attendees, fans will experience an event that merges music and humor under the rich and colorful theme of country. Carse will be performing several songs, including his new single “Awesome,” the theme song for the Y i Count anti-bullying campaign (http://www.yicount.org). Tickets to The Country Party can be purchased here: http://www.evenko.ca/fr/evenements/12352/p-a-methot/centre-bell/06-17-2017. To celebrate Carse’s return to Montreal, Le Journal de Montreal printed a 2-page feature story on Carse in a recent issue. Le Journal de Montreal boasts a readership of over 3 million. http://www.journaldemontreal.com/2017/05/20/je-nai-jamais-cherche-lattention (French) http://www.stephcarse.com/welcome/interview-in-journal-de-montreal-may-20th-2017 (English) Carse, a native of Mascouche, Quebec, is excited to return to his roots. “I’ve been working for three years on the TV special and on new music, so it’s thrilling to be able to share both the “My Shining Hour” show and kick off our Y i Count campaign in Canada with so many who have supported me since the beginning. I can’t wait to spend some quality time with great friends, family and fans.” As a songwriter, performer and recording artist, Carse has sold over 500,000 albums worldwide and received a 5-star review for his 36-show run in Las Vegas from Jerry Fink of The Las Vegas Sun. Known for his impeccable 4-octave vocal range, his story was featured in the PBS Documentary “A Portrait of Steph Carse.” In 1994, Carse was nominated for Male Vocalist of the Year in the JUNO Awards. In 1998, Carse achieved another career milestone when he was chosen to participate in the opening ceremony for PortoFino Universal Studios Florida. Backed by a 25-piece orchestra and choir, Steph performed at the ribbon cutting, which also featured the Mayor of PortoFino, Italy as an honored guest. Dedicated to championing worthy causes, Carse co-wrote and performed the anthem "Reach Out," the official song for The American Red Cross. He also wrote and performed the title track for the album "Holiday Heroes," for The Special Olympics in Canada. The “Holiday Heroes” album generated over $2 million in net profit for The Special Olympics. Carse has now launched his non-profit Y i Count to provide a platform for this generation, and help them understand their true value and potential, the power of words, and to counteract the aftermath of bullying. As a television producer, Carse won 5 awards from The Florida Motion Picture and Television Association, including Best Feature Film and Best Male Vocalist, for the one-hour TV special “Reach Out” that he produced for PBS. “A truly talented performer with a distinctive voice style and the vocal range to master any work he performs,” - Diane Bliss of PBS. “The singing sensation with Oscar-winning good looks and a voice to match.” - Jason Buchanan of The New York Times “Steph’s voice and music convey a great passion for his art,” - Eric Schilling, 16-time GRAMMY Award winner for Engineering/Mixing whose credits include Santana, Johnny Mathis, Dave Grusin, Michael Bolton, Frank Sinatra, Ray Charles, Rod Stewart, Dion, and more. Steph Carse is available for interviews. For more information or to schedule a time before or during the event, please contact:


News Article | August 11, 2017
Site: www.prweb.com

After a successful launch on Daystar Canada, Juno-Nominated Male Vocalist of the Year Steph Carse is honored to share his personal story through the “My Shining Hour” TV event airing worldwide on the Daystar Television Network tomorrow, August 12. “My Shining Hour” will air twice, from 7:30-8:30am and from 8:00-9:00pm ET. A short trailer for the “My Shining Hour” TV Special is available on YouTube at https://youtu.be/fmFPxePab_A. On the self-produced program, Carse shares the experiences of his music career, which has taken him from the top of the charts, to living out of his car, to the recording of his new album “My Shining Hour”. Told through music and narrative, Carse takes viewers from Canada to the U.S., to Africa, and to Israel sharing his journey of music, restoration and discovering his true calling. Always a champion of worthy causes, Carse co-wrote and performed the anthem "Reach Out," the official song for The American Red Cross. He also wrote and performed the title track for the album "Holiday Heroes" for The Special Olympics in Canada. The “Holiday Heroes” album generated over $2 million in net profit for The Special Olympics. Carse has launched his Y i Count anti-bullying campaign to provide a platform for this generation, helping them to understand their true value and potential and the power of words, and to counteract the aftermath of bullying. The special debuts the Y i Count theme song, “Awesome.” See Steph’s recent performance of “Awesome” at the Bell Center in Montreal: https://www.youtube.com/watch?v=SXRoinumw8I As a songwriter, performer and recording artist, Carse has sold over half a million albums worldwide and received a 5-star review for his 36-show run in Las Vegas from Jerry Fink of The Las Vegas Sun. Known for his impeccable 4-octave vocal range, his story was featured in the PBS Documentary “A Portrait of Steph Carse.” As a television producer, Carse won 5 awards from The Florida Motion Picture and Television Association, including Best Feature Film and Best Male Vocalist, for the one-hour TV special “Reach Out” that he produced for PBS. Praise for Carse’s work includes: “A truly talented performer with a distinctive voice style and the vocal range to master any work he performs,” - Diane Bliss of PBS. “The singing sensation with Oscar-winning good looks and a voice to match.” - Jason Buchanan of The New York Times. “Steph’s voice and music convey a great passion for his art,” - Eric Schilling, 16-time GRAMMY Award winner.


Tamm S.L.,Bell Center
Biological Bulletin | Year: 2015

Ctenophores, or comb jellies, are geotactic with a statocyst that controls the activity of the eight ciliary comb rows. If a ctenophore is tilted or displaced from a position of vertical balance, it rights itself by asymmetric frequencies of beating on the uppermost and lowermost comb rows, turning to swim up or down depending on its mood. I recently discovered that the statocyst of ctenophores has an asymmetric architecture related to the sagittal and tentacular planes along the oral-aboral axis. The four groups of pacemaker balancer cilia are arranged in a rectangle along the tentacular plane, and support a superellipsoidal statolith elongated in the tentacular plane. By controlled tilting of immobilized ctenophores in either body plane with video recording of activated comb rows, I found that higher beat frequencies occurred in the sagittal than in the tentacular plane at orthogonal orientations. Similar tilting experiments on isolated statocyst slices showed that statolith displacement due to gravity and the resulting deflection of the mechanoresponsive balancers are greater in the sagittal plane. Finally, tilting experiments on a mechanical model gave results similar to those of real statocysts, indicating that the geometric asymmetries of statolith design are sufficient to account for my findings. The asymmetric architecture of the ctenophore statocyst thus has functional consequences, but a possible adaptive value is not known. © 2015 Marine Biological Laboratory.


Stevenson J.W.,Providence College | Stevenson J.W.,Bell Center | Conaty E.A.,Providence College | Conaty E.A.,Bell Center | And 10 more authors.
PLoS ONE | Year: 2016

The amyloid precursor protein (APP) is a causal agent in the pathogenesis of Alzheimer's disease and is a transmembrane protein that associates with membrane-limited organelles. APP has been shown to co-purify through immunoprecipitation with a kinesin light chain suggesting that APP may act as a trailer hitch linking kinesin to its intercellular cargo, however this hypothesis has been challenged. Previously, we identified an mRNA transcript that encodes a squid homolog of human APP770. The human and squid isoforms share 60% sequence identity and 76% sequence similarity within the cytoplasmic domain and share 15 of the final 19 amino acids at the C-terminus establishing this highly conserved domain as a functionally import segment of the APP molecule. Here, we study the distribution of squid APP in extruded axoplasm as well as in a well-characterized reconstituted organelle/microtubule preparation from the squid giant axon in which organelles bind microtubules and move towards the microtubule plus-ends. We find that APP associates with microtubules by confocal microscopy and co-purifies with KI-washed axoplasmic organelles by sucrose density gradient fractionation. By electron microscopy, APP clusters at a single focal point on the surfaces of organelles and localizes to the organelle/microtubule interface. In addition, the association of APP-organelles with microtubules is an ATP dependent process suggesting that the APP-organelles contain a microtubule-based motor protein. Although a direct kinesin/APP association remains controversial, the distribution of APP at the organelle/microtubule interface strongly suggests that APP-organelles have an orientation and that APP like the Alzheimer's protein tau has a microtubule-based function. © 2016 Stevenson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Dundon S.E.R.,Dartmouth College | Chang S.-S.,University of California at Los Angeles | Kumar A.,U.S. National Institutes of Health | Occhipinti P.,Dartmouth College | And 4 more authors.
Molecular Biology of the Cell | Year: 2016

Nuclei in syncytia found in fungi, muscles, and tumors can behave independently despite cytoplasmic translation and the homogenizing potential of diffusion. We use a dynaction mutant strain of the multinucleate fungus Ashbya gossypii with highly clustered nuclei to assess the relative contributions of nucleus and cytoplasm to nuclear autonomy. Remarkably, clustered nuclei maintain cell cycle and transcriptional autonomy; therefore some sources of nuclear independence function even with minimal cytosol insulating nuclei. In both nuclear clusters and among evenly spaced nuclei, a nucleus' transcriptional activity dictates local cytoplasmic contents, as assessed by the localization of several cyclin mRNAs. Thus nuclear activity is a central determinant of the local cytoplasm in syncytia. Of note, we found that the number of nuclei per unit cytoplasm was identical in the mutant to that in wild-type cells, despite clustered nuclei. This work demonstrates that nuclei maintain autonomy at a submicrometer scale and simultaneously maintain a normal nucleocytoplasmic ratio across a syncytium up to the centimeter scale. © 2016 Dundon et al.


Ryan J.F.,University of Florida | Schnitzler C.E.,University of Florida | Schnitzler C.E.,Human Genome Research Institutes | Tamm S.L.,Bell Center
EvoDevo | Year: 2016

Here we present a report on Ctenopalooza: A meeting of ctenophorologists held at the Whitney Laboratory for Marine Bioscience in St. Augustine, FL, USA, on March 14-15, 2016. In this report, we provide a summary of each of the sessions that occurred during this two-day meeting, which touched on most of the relevant areas of ctenophore biology. The report includes some major themes regarding the future of ctenophore research that emerged during Ctenopalooza. More information can be found at the meeting Web site: http://ctenopalooza.whitney.ufl.edu. © 2016 The Author(s).


Peinado G.,National University of Colombia | Osorno T.,National University of Colombia | Del Pilar Gomez M.,National University of Colombia | Del Pilar Gomez M.,Bell Center | And 2 more authors.
Proceedings of the National Academy of Sciences of the United States of America | Year: 2015

Melanopsin, the photopigment of the "circadian" receptors that regulate the biological clock and the pupillary reflex in mammals, is homologous to invertebrate rhodopsins. Evidence supporting the involvement of phosphoinositides in light-signaling has been garnered, but the downstream effectors that control the light-dependent conductance remain unknown. Microvillar photoreceptors of the primitive chordate amphioxus also express melanopsin and transduce light via phospholipase-C, apparently not acting through diacylglycerol. We therefore examined the role of calcium in activating the photoconductance, using simultaneous, high time-resolution measurements of membrane current and Ca2+ fluorescence. The light-induced calcium rise precedes the onset of the photocurrent, making it a candidate in the activation chain. Moreover, photolysis of caged Ca elicits an inward current of similar size, time course and pharmacology as the physiological photoresponse, but with a much shorter latency. Internally released calcium thus emerges as a key messenger to trigger the opening of light-dependent channels in melanopsin-expressing microvillar photoreceptors of early chordates. © 2015, National Academy of Sciences. All rights reserved.


PubMed | Bell Center
Type: Journal Article | Journal: The Biological bulletin | Year: 2015

Ctenophores, or comb jellies, are geotactic with a statocyst that controls the activity of the eight ciliary comb rows. If a ctenophore is tilted or displaced from a position of vertical balance, it rights itself by asymmetric frequencies of beating on the uppermost and lowermost comb rows, turning to swim up or down depending on its mood. I recently discovered that the statocyst of ctenophores has an asymmetric architecture related to the sagittal and tentacular planes along the oral-aboral axis. The four groups of pacemaker balancer cilia are arranged in a rectangle along the tentacular plane, and support a superellipsoidal statolith elongated in the tentacular plane. By controlled tilting of immobilized ctenophores in either body plane with video recording of activated comb rows, I found that higher beat frequencies occurred in the sagittal than in the tentacular plane at orthogonal orientations. Similar tilting experiments on isolated statocyst slices showed that statolith displacement due to gravity and the resulting deflection of the mechanoresponsive balancers are greater in the sagittal plane. Finally, tilting experiments on a mechanical model gave results similar to those of real statocysts, indicating that the geometric asymmetries of statolith design are sufficient to account for my findings. The asymmetric architecture of the ctenophore statocyst thus has functional consequences, but a possible adaptive value is not known.

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