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Sogaard O.S.,Aarhus University Hospital | Reekie J.,University College London | Ristola M.,University of Helsinki | Jevtovic D.,Institute for Infectious and Tropical Diseases | And 8 more authors.
Journal of Infection

Objectives: This study aimed to determine incidence rates (IR) and identify risk factors for severe bacterial non-AIDS infections (SBnAI) requiring hospital admission. Methods: Data from the prospective EuroSIDA cohort were utilized to determine IRs of first diagnosis of the following SBnAI requiring hospital admission: bacteremia, endocarditis, meningitis, peritonitis, pneumonia, osteitis, and pyolonephritis. Incidence rate-ratios (IRRs) and risk factors were assessed by Poisson regression. Results: During 35,839 person-years of follow-up (PYFU), 275 patients were diagnosed with SBnAI (IR = 7.67 per 1000 PYFU, 95% confidence interval: 6.79-8.64). The most frequent infections were pneumonia (IR = 5.36, 4.63-6.17), bacteremia (IR = 1.14, 0.82-1.55), and pyelonephritis (IR = 0.67, 0.43-1.00). A strong risk factor for SBnAI was reduced estimated glomerular filtration rate [eGFR] (adjusted IRR = 5.07, 2.12-12.1 and IRR = 2.73, 1.63-4.56 for eGFR ≤ 60 and 60.1-90 compared to eGFR > 90, respectively). No current combined antiretroviral therapy (cART) compared with current cART use increased the risk of SBnAI (adjusted IRR = 2.96, 2.03-4.32). Other risk factors for SBnAI included current CD4+ count <350 cells/μL, female gender, age, infection with HIV through IDU, prior AIDS diagnosis, and anaemia. Conclusions: Enhanced attention directed towards people with comorbidity is warranted to limit the burden of these infections. © 2013 The British Infection Association. Source

Kovganko V.N.,Belarusian National Technical University | Kovganko N.N.,Belarus State Medical University
Russian Journal of General Chemistry

Ethyl 3-(4-hydroxyphenyl)-3-ketopropionate was synthesized by acylation of acetoacetic ester with 4-acetoxybenzoyl chloride, followed by cleavage of aroylacetoacetic ester and hydrolysis of the protecting acetate group. Further esterification of the phenol hydroxy group with 4-alkoxybenzoic acids resulted in the synthesis of mesogenic 3-aryl-3-keto ester used to produce copper(II) metallomesogenic complexes. © 2013 Pleiades Publishing, Ltd. Source

Voitikova M.V.,National Academy of Sciences of Belarus | Khursa R.V.,Belarus State Medical University
Nonlinear Phenomena in Complex Systems

This paper presents an effective hemodynamic classification algorithm for blood pressure (BP) monitoring data. The proposed approach takes into account two aspects of the hemodynamic states detection, namely the linear regression modeling of BP parameters and the classification block on the base of Data Mining algorithm called Support Vector Machine (SVM). At first, 4 features are extracted from the BP signals and then these features are reduced to only 2, finally, the SVM-classifier is used to classify the hemodynamic states. The proposed classification method is applied to clinical database. Thus 9 types of the hemodynamic states, including latent hypertension and high-risk hypertension, can be discriminated by SVM-classifier with the accuracy of 96%. Source

Bucksch M.,Jena University Hospital | Ziegler M.,Jena University Hospital | Kosayakova N.,Jena University Hospital | Mulatinho M.V.,Fernandes Figueira Institute | And 11 more authors.
Journal of Histochemistry and Cytochemistry

A new multicolor fluorescence in situ hybridization (mFISH) probe set is presented, and its possible applications are highlighted in 25 clinical cases. The so-called heterochromatin-M-FISH (HCM-FISH) probe set enables a one-step characterization of the large heterochromatic regions within the human genome. HCM-FISH closes a gap in the now available mFISH probe sets, as those do not normally cover the acrocentric short arms; the large pericentric regions of chromosomes 1, 9, and 16; as well as the band Yq12. Still, these regions can be involved in different kinds of chromosomal rearrangements such as translocations, insertions, inversions, amplifications, and marker chromosome formations. Here, examples are given for all these kinds of chromosomal aberrations, detected as constitutional rearrangements in clinical cases. Application perspectives of the probe set in tumors as well as in evolutionary cytogenetic studies are given. © The Author(s) 2012. Source

Mocroft A.,University College London | Ryom L.,Copenhagen University | Begovac J.,University of Zagreb | D'Arminio Monforte A.,Institute of Infectious Diseases | And 6 more authors.

Objectives: To determine the relationship between measures of renal function [current estimated glomerular filtration rate (eGFR) and proportion of follow-up with a low eGFR (%FU ≤60 ml/min)] and fatal/nonfatal AIDS, non-AIDS events and all-cause mortality. Design: An observational, longitudinal cohort study of 12 155 persons from EuroSIDA. Methods: Persons with at least one eGFR measurement after 1 January 2004, using the CKD-EPI formula, were included. Poisson regression analyses were used to determine whether current eGFR or %FU of 60 ml/min or less were independent prognostic markers for clinical events. Results: During 61 425 person-years of follow-up (PYFU), the crude incidence of deaths was 11.1/1000 PYFU [95% confidence interval (CI) 10.0-12.1] at current eGFR more than 90 ml/min and 199.6 (95% CI 1144.3-254.3/1000 PYFU) when current eGFR was 30 ml/min or less. Corresponding figures for AIDS were 12.2 (11.1-13.3) and 63.9 (36.5-103.7) and for non-AIDS were 16.0 (14.8-17.3) and 203.6 (147.7-259.5). After adjustment, current eGFR of 30 ml/min or less was a strong predictor of death [adjusted incidence rate ratios (aIRR) 4.35; 95% CI 3.20-5.91] and non-AIDS events (3.63; 95% CI 2.57-5.13), although the relationship with AIDS was less strong (1.45; 95% CI 1.01-2.08). After adjustment, %FU of 60 ml/min or less was associated with a 22% increased incidence of death (aIRR 1.22 per 10% longer; 95% CI 1.18-1.27), a 13% increased incidence of non-AIDS events (95% CI 1.08-1.18) and a 15% increased incidence of AIDS events (95% CI 1.06-1.24). Conclusion: Both current eGFR and %FU of 60 ml/min or less were associated with death and non-AIDS events in HIV-positive persons. Our findings highlight the association between underlying renal dysfunction and morbidity and mortality in HIV infection, although reverse causality cannot be excluded. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

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