Yu H.,Chinese Peoples Liberation Army |
Xie L.-F.,Chinese Peoples Liberation Army |
Chen K.,Chinese Peoples Liberation Army |
Yang G.-Y.,Chongqing Medical University |
And 15 more authors.
Chinese Medical Journal
Background: Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus. Methods: This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level. Results: In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 ± 5.40 years and 9.59 ± 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio [OR] 446.99, 95% confidence interval [CI ] 42.37-4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47-38.03), dyslipidemia (OR 2.65, CI 1.54-4.56), diastolic blood pressure (OR 1.02, CI 1.00-1.04), and body mass index (OR 0.95, CI 0.92-0.99) are independent factors for early-onset T2DM. Conclusions: We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus. © 2016 Chinese Medical Journal. Source
Fan Y.,Beijing Yanhua Hospital |
Ren D.,Beijing Yanhua Hospital |
Qin Y.,Beijing Yanhua Hospital |
Li D.,Beijing Yanhua Hospital |
And 3 more authors.
Cancer Research and Clinic
Objective: To explore the effect of individualized chemotherapy plans which was designed depend on secific genetic characters in patients with advanced cancer. Methods: The surgery or biopsy specimen samples from 25 patients with advanced recurrent tumors (study group) were analyzed. Different gene mRNA expressions were detected by PCR and sequencing. According to detection results, the most appropriate chemotherapy would be applied on 25 cases patients of study group. The chemotherapy from traditional experience and evidence-based medical evidence were applied for 20 cases patients of control group. The difference of RR and disease control rate (DCR) between two groups were compared. Results: The DCR and RR were 84 % (21/25) and 44 % (11/25) in study group, 35 % (7/20) and 15 % (3/20) in control group. The DCR and RR in study group were significantly higher than those in control group (P < 0.01). Conclusion Individualized chemotherapy could improve the efficient and prolong the survival period of the patients with advanced recurrent tumors. Source