Beijing Tongren Eye Center

Beijing, China

Beijing Tongren Eye Center

Beijing, China

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Alshareef R.A.,McGill University | Barteselli G.,Genentech | You Q.,Beijing Tongren Eye Center | You Q.,University of California at San Diego | And 4 more authors.
British Journal of Ophthalmology | Year: 2016

Purpose To analyse the topographic changes in retinal ganglion cells (RGCs) in eyes with unilateral naive branch retinal vein occlusion (BRVO) in comparison to normal fellow eyes and to healthy control eyes. Methods We performed a retrospective analysis of 66 eyes (33 subjects) with naive unilateral BRVO who underwent spectral-domain optical coherence tomography using Cirrus HD-OCT. We also included 67 eyes of 48 age-matched healthy volunteers as control group. Average, minimum and sectoral macular ganglion cell-inner plexiform layer (GCIPL) thickness, macular retinal nerve fibre layer (RNFL) thickness and outer retinal thickness were collected. Comparison of the GCIPL, RNFL and outer retinal thicknesses among study eyes, normal fellow eyes and control groups was performed. Results The average and minimum macular GCIPL thicknesses were constantly and diffusely reduced in BRVO compared with normal fellow eyes and healthy controls (p<0.001 for each GCIPL sector). The average macular RNFL thickness was reduced in BRVO eyes compared with normal fellow eyes (p=0.01) and tended to be lower than controls (p=0.07). The minimum RNFL thickness in eyes with BRVO was significantly reduced when compared with fellow eyes ( p<0.001) and control eyes (p<0.001). The average outer retina thickness was thicker in BRVO eyes compared with both fellow eyes (p<0.001) and controls (p<0.001). Conclusions A significant reduction of the macular GCIPL and RNFL thicknesses was observed in eyes with BRVO. This finding is suggestive of RGCs degeneration; the neuroprotective effect of current therapeutic options might be an important consideration when evaluating treatment strategies and prognosticating visual outcome in BRVO eyes. © 2016 by the BMJ Publishing Group Ltd.


Alshareef R.A.,McGill University | You Q.,University of California at San Diego | You Q.,Beijing Tongren Eye Center | Barteselli G.,Genentech | And 3 more authors.
Ophthalmic Surgery Lasers and Imaging Retina | Year: 2016

BACKGROUND AND OBJECTIVE: To investigate the topographic changes in macular ganglion cell inner plexiform layer (GCIPL) thickness in eyes with retinitis pigmentosa (RP). PATIENTS AND METHODS: Forty-five eyes of 25 subjects with RP who underwent spectral-domain optical coherence tomography (SD-OCT) using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) were analyzed retrospectively. A control group of 67 eyes of 48 age-matched healthy volunteers was also included for comparison. Average, minimum, and sectoral macular GCIPL, as well as retinal nerve fiber layer (RNFL) and outer retinal (OR) thicknesses, were collected and compared between RP and control groups. RESULTS: The average and sectoral macular GCIPL thicknesses were significantly reduced in RP eyes compared with controls (P <.0001). Average macular RNFL thickness was reduced in RP eyes compared with controls (P <.054). CONCLUSIONS: In eyes with RP, display reduced GCIPL, RNFL, and OR thickness. The identification of alteration in RNFL, OR, and GCIPL thickness may be useful for future therapeutic implications.


Ge X.,Beijing Tongren Eye Center | Huang D.-S.,Capital Medical University | Shi J.-T.,Beijing Tongren Eye Center | Ma J.-M.,Beijing Tongren Eye Center
Asian Pacific Journal of Cancer Prevention | Year: 2013

Objective: To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS). Methods: We retrospectively analyzed the clinical data for30 patients (16 males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in the Department of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012. International Rhabdomyosarcoma Organization Staging Standards indicated that among the 30 patients, 4 cases were in phase II, 20 were in phase III, and 6 were in phase IV. All patients underwent a multidisciplinary collaborative model of comprehensive treatment (surgery, chemotherapy, external radiotherapy, 125I radioactive particle implantation, and autologous peripheral blood stem-cell transplantation). Results: Follow-up was conducted until March 2013, with a median follow-up time of 47.2 months (5 to 95 months), and 7 deaths occurred. The 2-year estimated survival rate reached 86.1%, the ≥3-year estimated survival rate was 77%, and the 5-year estimated survival rate was 70.6%. Conclusions: The multidisciplinary collaborative model can be a safe and effective approach to the comprehensive treatment of children with orbital RMS. It has clinical significance in improving the tumor remission rate.


Wan X.-H.,Beijing Institute of Ophthalmology | Wan X.-H.,Beijing Tongren Eye Center | Wan X.-H.,Capital Medical University | Cai X.-G.,Beijing Tongren Eye Center | And 9 more authors.
Chinese Medical Journal | Year: 2013

Background Optical Quality Analysis System II (OQAS, Visiometrics, Terrassa, Spain) that uses double-pass (DP) technique is the only commercially available device that allows objective measurement of ocular retinal image quality. This study aimed to evaluate the impact of spectacle lenses on the ocular optical quality parameters and the validity of the optometer within OQAS. Methods Seventy eyes of healthy volunteers were enrolled. Optical quality measurements were performed using OQAS with an artificial pupil diameter of 4.0 mm. Three consecutive measurements were obtained from spectacle correction corresponding to subjective refraction and from the OQAS built-in optometer separately. The modulation transfer function cutoff frequency, the Strehl ratio, the width of the point spread function (PSF) at 10% of its maximal height (PSF10), and the width of the PSF at 50% of its maximal height (PSF50) were analyzed. Results There was no significant difference in any of the parameters between the spectacle correction and the optometer correction (all P >0.05, paired t-test). A good agreement was found between both the methods and a good intraobserver repeatability in both the correction methods. Difference in best focus between two methods was the only parameter associated significantly with optical quality parameter differences. Best focus difference, built-in optometer correction with or without external cylindrical lens, and age were associated significantly with PSF10 difference. No linear correlation between refractive status and optical quality measurement difference was observed. A hyperopic bias (best focus difference of (0.50±0.44) D) and a relatively better optical quality using spectacle correction in high myopia group were found. Conclusions OQAS based on DP system is a clinically reliable instrument. In patients with high myopia, measurements using built-in optometer correction should be considered and interpreted with caution.

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