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Alshareef R.A.,McGill University | Barteselli G.,Genentech | You Q.,Beijing Tongren Eye Center | You Q.,University of California at San Diego | And 4 more authors.
British Journal of Ophthalmology | Year: 2016

Purpose To analyse the topographic changes in retinal ganglion cells (RGCs) in eyes with unilateral naive branch retinal vein occlusion (BRVO) in comparison to normal fellow eyes and to healthy control eyes. Methods We performed a retrospective analysis of 66 eyes (33 subjects) with naive unilateral BRVO who underwent spectral-domain optical coherence tomography using Cirrus HD-OCT. We also included 67 eyes of 48 age-matched healthy volunteers as control group. Average, minimum and sectoral macular ganglion cell-inner plexiform layer (GCIPL) thickness, macular retinal nerve fibre layer (RNFL) thickness and outer retinal thickness were collected. Comparison of the GCIPL, RNFL and outer retinal thicknesses among study eyes, normal fellow eyes and control groups was performed. Results The average and minimum macular GCIPL thicknesses were constantly and diffusely reduced in BRVO compared with normal fellow eyes and healthy controls (p<0.001 for each GCIPL sector). The average macular RNFL thickness was reduced in BRVO eyes compared with normal fellow eyes (p=0.01) and tended to be lower than controls (p=0.07). The minimum RNFL thickness in eyes with BRVO was significantly reduced when compared with fellow eyes ( p<0.001) and control eyes (p<0.001). The average outer retina thickness was thicker in BRVO eyes compared with both fellow eyes (p<0.001) and controls (p<0.001). Conclusions A significant reduction of the macular GCIPL and RNFL thicknesses was observed in eyes with BRVO. This finding is suggestive of RGCs degeneration; the neuroprotective effect of current therapeutic options might be an important consideration when evaluating treatment strategies and prognosticating visual outcome in BRVO eyes. © 2016 by the BMJ Publishing Group Ltd.

Tian B.,Beijing Tongren Eye Center
Ophthalmology in China | Year: 2014

Panretinal photocoagulation (PRP) is the only well tested and best working treatment method for diabetic retinopathy (DR). Since the number of DR patients has greatly inclined, mainland China has promoted universal standardization of PRP technology and has actively engaged in technology improvement through academic forums. This article provides opinions and suggestions on the following topics: standardization of rules, method, and timing of PRP in primary ophthalmic units, improvement of PRP technique, and full understanding the relationship between PRP and macular edema. Copyright © 2014 by the Editorial Board of OPHTHALMOLOGY IN CHINA.

Lu W.,Beijing Tongren Eye Center
Ophthalmology in China | Year: 2012

There are interrelation among psychophysics, neuronal anatomy neurophysiology and clinical binocular vision phenomena. Based on neuronal anatomy, there are two corresponding area bilateral retina projecting at fixate direction of Vieth-Müller circle. There are corresponding area between binocular fovea, the temporal area of retina in right eye and nasal area of retina in left eye, the nasal retina in left eye and the temporal retina in right eye. The two separated corresponding area projecte to the brain via different pathway. The parvocellular pathway is mostly dealing with formcolor and fine stereopsis. The magnocellular pathway is mostly dealing with movement space sign and granulate stereopsis. It is very helpful for our practice to understand the clinical binocular vision phenomena more deeply based on this neuronal anatomy.

Ge X.,Beijing Tongren Eye Center | Huang D.-S.,Capital Medical University | Shi J.-T.,Beijing Tongren Eye Center | Ma J.-M.,Beijing Tongren Eye Center
Asian Pacific Journal of Cancer Prevention | Year: 2013

Objective: To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS). Methods: We retrospectively analyzed the clinical data for30 patients (16 males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in the Department of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012. International Rhabdomyosarcoma Organization Staging Standards indicated that among the 30 patients, 4 cases were in phase II, 20 were in phase III, and 6 were in phase IV. All patients underwent a multidisciplinary collaborative model of comprehensive treatment (surgery, chemotherapy, external radiotherapy, 125I radioactive particle implantation, and autologous peripheral blood stem-cell transplantation). Results: Follow-up was conducted until March 2013, with a median follow-up time of 47.2 months (5 to 95 months), and 7 deaths occurred. The 2-year estimated survival rate reached 86.1%, the ≥3-year estimated survival rate was 77%, and the 5-year estimated survival rate was 70.6%. Conclusions: The multidisciplinary collaborative model can be a safe and effective approach to the comprehensive treatment of children with orbital RMS. It has clinical significance in improving the tumor remission rate.

Wang D.,Capital Medical University | Li Y.,Beijing Tongren Eye Center | Wang C.,Capital Medical University | Xu L.,Beijing Institute of Ophthalmology | And 7 more authors.
Stroke | Year: 2014

Background and Purpose: Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS-: Patients with acute ischemic stroke as part of a hospital-based study group were compared with the participants of the population-based group Beijing Eye Study. The retina was imaged by spectral-domain optical coherence tomography for the detection of localized RNFLDs. RESULTS-: The study included 154 patients with acute ischemic stroke and 2890 subjects from the Beijing Eye Study for whom optical coherence tomographic images of the retinal nerve fiber layer and data on a previous cerebral stroke were available. In logistic regression analysis, acute stroke was significantly associated with localized RNFLDs (P<0.001; odds ratio, 6.23; 95% confidence interval, 4.17-9.30) after adjusting for age, male sex, arterial hypertension, diabetes mellitus, and higher concentration of the C-reactive protein. In a similar manner, previous stroke was associated with localized RNFLDs (P=0.04; odds ratio, 1.48; 95% confidence interval, 1.02-2.16) in multivariate analysis. In a reverse manner, presence of localized RNFLDs was associated with cerebral stroke (P<0.001; odds ratio, 3.54; 95% confidence interval, 2.68-4.67) after adjusting for age, sex, and prevalence of diabetes mellitus. CONCLUSIONS-: Localized RNFLDs showed a strong association with previous or acute cerebrovascular stroke and vice versa after adjustment for other systemic and ocular factors. Localized RNFLDs that can be assessed by noninvasive optical coherence tomographic imaging may be added to the panoply of retinal morphological features of stroke. © 2014 American Heart Association, Inc.

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