Beijing Sport University , founded on November 1, 1953, has contributed greatly to the sustainable development of Chinese sport and physical education and has enjoyed the fame as one of the key sport universities in China.In the past five decades, over 30,000 students of sports-related majors have graduated from BSU. There is a wide range of academic courses and majors studies, and the number of master and doctoral positions ranks the first among its counterparts in China.Currently, BSU consists of seven colleges, two elite sports schools and has a large number of qualified teachers, among whom 227 are professors and associate professors. Its excellent staff and facilities can satisfy the needs of teaching, training and scientific research. BSU has established friendly cooperative relations and intercollegiate relations with 28 universities and tens of non-governmental organizations in 16 countries.BSU was instrumental in the popularization of skateboarding in China. Wikipedia.
Zhang Y.,Beijing Sport University
Protein and peptide letters | Year: 2017
Apelin, an endogenous ligand of the G-protein-coupled receptor APJ, is a novel myokine and may play a key role in regulating energy metabolism. The purpose of the present study was to investigate the effects of hypoxic exposure, exercise, and hypoxic exercise training on the expression of apelin and APJ in skeletal muscle of obese mice. Sixty two-months old C57BL/6J mice were randomly divided into two groups: Ten in normal diet group (N) and 50 in the high fat diet (HFD) groups. After two months of feeding, the HFD mice, whose body weight was 20% higher than the average weight of the N group, were selected as obese mice and further allocated into four groups: Control (C), Exercise (E), Hypoxia (H), and Exercise plus Hypoxia (E+H), at 8-9 mice/group. Besides body weight, measured variables in skeletal muscle were protein/mRNA levels of apelin/APJ, AMPKα-Thr172 phosphorylation, hypoxia inducible factor-1α (HIF-1α), mRNA levels of peroxisome proliferator-activated receptor α (PPARα), estrogen-related receptor (ERRα), and nuclear respiratory factor 1 (NRF1). Obese mice had significantly lower mRNA and protein expressions of apelin/ APJ in skeletal muscles than the normal body weight mice. After four weeks of interventions, hypoxic exercise training decreased body weight and increased mRNA and protein expressions of apelin and APJ, mRNA expression of ERRα, and protein expression of HIF-1α. These results indicate that changes of body weight may be associated with the levels of apelin/APJ expressions in skeletal muscle. Copyright© Bentham Science Publishers; For any queries, please email at email@example.com.
Wang P.,Beijing Sport University
Modern Physics Letters B | Year: 2017
In this paper, multi-soliton solutions of the fifth-order Kaup-Kupershmidt (KK) equation have been derived via the auxiliary function in conjunction with the bilinear method. These solutions have not been previously obtained. Propagation and interactions of three solitons have been presented analytically. The direction of the soliton is related to the signs of the parameters aj. The distances of the solitons are related to the values of the parameters aj. © 2017 World Scientific Publishing Company.
Li S.,Beijing Sport University |
Li S.,Xichang College |
Laher I.,University of British Columbia
Trends in Pharmacological Sciences | Year: 2015
Sedentary lifestyles, limited physical exercise, and prolonged inactivity undoubtedly increase chronic diseases, including obesity, type 2 diabetes, and cardiovascular diseases. It is widely acknowledged that exercise induces a number of physiological adaptations that have beneficial effects in the prevention and treatment of these chronic metabolic diseases. Unfortunately, exercise compliance is extremely low and often not possible. The development of exercise science and molecular techniques has increased our understanding of the molecular pathways responsive to exercise. Knowledge of these molecular targets has led to the development of chemical interventions that can mimic the beneficial effects of exercise without requiring actual muscle activity. This review focuses on the concept of 'exercise pills' and how they mimic the effects produced by physical exercise including oxidative fiber-type transformation, mitochondrial biogenesis, increased fat oxidation, angiogenesis, and improvement of exercise capacity. We also review candidate exercise pills, and contrast the beneficial effects and molecular mechanisms between physical exercise and exercise pills. © 2015 Elsevier Ltd. All rights reserved.
Shi L.,Beijing Sport University |
Liao J.,Beijing Sport University |
Liu B.,Beijing Sport University |
Zeng F.,Beijing Sport University |
Zhang L.,Loma Linda University
Drug Discovery Today | Year: 2015
Hypertension is the major risk factor for the development of stroke, coronary artery disease, heart failure and renal disease. The underlying cellular and molecular mechanisms of hypertension are complex and remain largely elusive. MicroRNAs (miRNAs) are short, noncoding RNA fragments of 22-26 nucleotides and regulate protein expression post-transcriptionally by targeting the 3′-untranslated region of mRNA. A growing body of recent research indicates that miRNAs are important in the pathogenesis of arterial hypertension. Herein, we summarize the current knowledge regarding the mechanisms of miRNAs in cardiovascular remodeling, focusing specifically on hypertension. We also review recent progress of the miRNA-based therapeutics including pharmacological and nonpharmacological therapies (such as exercise training) and their potential applications in the management of hypertension. © 2015 Elsevier Ltd.
Zhao S.-T.,Guangzhou University |
Zhao L.,Beijing Sport University |
Li J.-H.,Guangzhou University
Neurochemical Research | Year: 2013
Humanin (HN) has been proved to be an extensive neuroprotective peptide against AD-related and unrelated insults, but little is know about the effect of HN in inflammation response. Current studies indicated the receptors of HN have a close relationship with immune system, which led us to hypothesize HN might have a role in inflammatory response. In this study, we used lipopolysaccharide (LPS) to induce astrocyte inflammation response. This model in vitro allowed us to study the effect of HN on the pure response of astrocyte without the exogenous influence between cells in vivo. Our results showed that 1.0 μg/ml LPS induced a significant activation of astrocyte, shown as the marked increase in the glial fibrillary acidic protein (GFAP) expression, the cell viability and the number of 5-bromo-2′-deoxyuridine (BrdU)-positive living cells. Pretreatment with HN (5, 10, 20 μM) led to a significant inhibition in astrocyte overactivation in a concentration dependent manner. We also found pretreatment with HN decreased the level of proinflammatory cytokines, interleukin (IL)-6, IL-1β and tumor necrosis factor α (TNFα) induced by LPS. Furthermore, we noticed HN couldn't completely reverse the above inflammatory injury. Our findings imply that HN partly antagonizes inflammation injury induced by LPS and the protective effect of HN on astrocyte is concentration-dependent. © 2012 Springer Science+Business Media New York.
Xiao C.-M.,Beijing Institute of Graphic Communication |
Zhuang Y.-C.,Beijing Sport University
Journal of the American Geriatrics Society | Year: 2015
Objectives To investigate the effectiveness of a 6-month Liuzijue qigong (LQG) program in promoting physical and psychosocial function in individuals with chronic obstructive pulmonary disease (COPD). Design Single-blind, randomized controlled trial. Setting Seven hospital respiratory care centers in Beijing. Participants Individuals with COPD (N = 126; mean age 71.1 ± 2.7, range 65-85). Methods Participants were randomly assigned to one of two groups: LQG (n = 63) and control (n = 63). Subjects in the LQG group received a LQG program consisting of four 45-minute sessions each week and daily walking for 30 minutes for 6 months. Control subjects walked daily for 30 minutes. Data collection was performed at baseline, at 6 weeks, and at 6 months. Primary outcomes involved functional capacity, and secondary outcomes involved quality of life. Results The LQG group had greater improvements in the 6-minute walk test (P =.02); specific airway conductance (P =.02); monitored functional task evaluation (P =.04); Medical Outcomes Study 36-item Short-Form Health Survey (SF-36; general health (P <.001), mental health (P =.03)); Chronic Respiratory Questionnaire (dyspnea (P =.05), emotion (P =.05), and mastery (P =.04) at 6-month follow-up. After 6 months, the control group had significant improvement only on the SF-36 mental health (P =.02). Conclusion LQG promoted functional capacity and quality of life in older adults with COPD at 6 months and is a good alternative home exercise program for older adults in the rehabilitation of COPD. © 2015 The American Geriatrics Society.
Wang P.,Beijing Sport University
European Physical Journal D | Year: 2014
In this paper, we investigate a generalized inhomogeneous fifth-order nonlinear Schrödinger equation, generated by deforming the inhomogeneous Heisenberg ferromagnetic spin system through the space curve formalism. Based on the Ablowitz-Kaup-Newell-Segur system, infinitely many conservation laws will be obtained. Via the introduction of the auxiliary functions, bilinear form and N-soliton solutions have been derived with symbolic computation. Propagation and interaction of solitons have been studied through the analytical results. Effects of the inhomogeneous functions f = μ 1 x + ν 1 and h = μ 2 x + ν 2 on the soliton velocity and interactions have been discussed graphically and analytically. © 2014 EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg.
Shi L.,Beijing Sport University
Arteriosclerosis, Thrombosis, and Vascular Biology | Year: 2016
OBJECTIVE—: Regular exercise is an effective nonpharmacological means of preventing and controlling hypertension. However, the molecular mechanisms underlying its effects remain undetermined. The hypothesis that hypertension increases the functional coupling of large-conductance Ca-activated K (BKCa) channels with ryanodine receptors in spontaneously hypertensive rats (SHR) as a compensatory response to an increase in intracellular Ca concentration in cerebral artery smooth muscle cells was assessed here. It was further hypothesized that exercise training would prevent this increase in functional coupling. APPROACH AND RESULTS—: SHR and Wistar–Kyoto (WKY) rats were randomly assigned to sedentary groups (SHR-SED and WKY-SED) and exercise training groups (SHR-EX and WKY-EX). Cerebral artery smooth muscle cells displayed spontaneous transient outward currents at membrane potentials more positive than −40 mV. The amplitude of spontaneous transient outward currents together with the spontaneous Ca sparks in isolated cerebral artery smooth muscle cells was significantly higher in SHR-SED than in WKY-SED. Moreover, hypertension displayed increased whole-cell BKCa, voltage-gated Ca channel, but decreased KV currents in cerebral artery smooth muscle cells. In SHRs, the activity of the single BKCa channel increased markedly, and the protein expression of BKCa (β1, but not α-subunit) also increased, but KV1.2 decreased significantly. Exercise training ameliorated all of these functional and molecular alterations in hypertensive rats. CONCLUSIONS—: These data indicate that hypertension leads to enhanced functional coupling of ryanodine receptors–BKCa to buffer pressure–induced constriction of cerebral arteries, which attributes not only to an upregulation of BKCa β1-subunit function but also to an increase of Ca release from ryanodine receptors. However, regular aerobic exercise efficiently prevents augmented coupling and so alleviates the pathological compensation and restores cerebral arterial function. © 2016 American Heart Association, Inc.
Zhou Y.,Beijing Sport University |
Li Y.,Chinese Winter Sport Federation |
Wang R.,Beijing Sport University
Journal of Electromyography and Kinesiology | Year: 2011
Objective: To investigate the feasibility of a non-invasive and instant method to evaluate the degree of exercise-induced muscle damage. Methods: Thirteen male college athletes (23.4 ± 1.0. year, 180.03 ± 3.51. cm, 75.93 ± 6.70. kg) took part in the trial. Measures included serum creatine kinase (CK) after eccentric and endurance exercise, and surface electromyography (sEMG) during knee extension and flexion on a Biodex unit. Relation analysis was employed between sEMG and serum CK after the eccentric and endurance exercise. Results: There were positive correlations between serum CK at 24 and 48. h after eccentric exercise and the AREA of sEMG for the slow isokinetic contraction before eccentric exercise (r=0.69, P<0.01 and 0.64, P<0.05, respectively). The zero crossing rate (ZCR) immediately after exercise was negatively correlated with serum CK at 48. h after exercise for the slow and fast tests (r=-0.63 and -0.59, P<0.05, respectively). Mean power frequency (MPF) and ZCR of sEMG at 6. h post endurance exercise were positively correlated with serum CK at 24. h (r=0.73 and 0.69, P<0.05, respectively) for the fast isokinetic test. Conclusions: Exercise-induced muscle damage as evaluated by serum CK was associated with the AREA of sEMG after eccentric exercise. The ZCR of sEMG was a good predictor of muscle damage after endurance exercise. © 2010 Elsevier Ltd.
Luo X.H.,Beijing Sport University
Proceedings of the International Conference on Management, Information and Educational Engineering, MIEE 2014 | Year: 2015
This essay starts with the demonstration of the value of internet sports information sharing, and by analyzing the advantages and the growing process of music, art, cars and other professional internet sharing platforms, we can gain enlightenment and as well as get comprehension to the current situation of sports information: sports information sharing platform far behind, the lack of professional websites, the serious fragmented of sports information and so on. Therefore, this essay proposes the scheme of the integration of sports information resources sharing, which aims at offering suggestions for relevant department when building sports sharing platform, and providing services for more sports enthusiasts, practitioners and academics. © 2015 Taylor & Francis Group, London.