Beijing Puren Hospital

Beijing, China

Beijing Puren Hospital

Beijing, China
SEARCH FILTERS
Time filter
Source Type

Ma Y.-H.,Beijing Puren Hospital | Yu C.,Peking University | Yu C.,Capital Medical University | Kayoumu A.,Peking University | And 3 more authors.
Journal of Biomedical Research | Year: 2015

Maternally inherited familial hypercholesterolemia (FH) impairs glucose metabolism and increases cardiovascular risks in the offspring to a greater degree than paternal inherited FH. However, it remains unknown whether hypertriglyceridemia affects glucose metabolism via inheritance. In this study, we sought to compare the impact of maternally and paternally inherited hypertriglyceridemia on glucose and lipid metabolism in mice. ApoCIII transgenic mice with severe hypertriglyceridemia were mated with non-transgenic control mice to obtain 4 types of offspring: maternal non-transgenic control and maternal transgenic offspring, and paternal control and paternal transgenic offspring. Plasma triglycerides (TG), total cholesterol (TC), fasting plasma glucose (FPG) and fasting insulin (FINS) were measured. ApoCIII overexpression caused severe hypertriglyceridemia, but the transgenic female mice had unaltered fertility with normal pregnancy and birth of pups. The 4 groups of offspring had similar birth weight and growth rate. The plasma TG of maternal and paternal transgenic offspring were nearly 40-fold higher than maternal and paternal control mice, but there was no difference in plasma TG between maternal and paternal transgenic offspring. Although the FPG of the 4 groups of animals had no difference, the maternal transgenic mice showed impaired glucose tolerance, increased FINS levels and higher homeostasis model assessment insulin resistance index (HOMA-IR) than the other 3 groups. In conclusion, maternally inherited hypertriglyceridemia in ApoCIII transgenic mice displayed impaired glucose tolerance, hyperinsulinemia and increased HOMA-R, while paternally inherited hypertriglyceridemia did not have such impacts. © 2015 by the Journal of Biomedical Research.


Mu W.-J.,Beijing Puren Hospital | Ren X.-L.,Peking University | Zhang H.-Y.,Peking University | Feng W.-Y.,Peking University
Chinese Journal of New Drugs | Year: 2014

Objective: To investigate the clinical characteristics, causes and common allergenic drugs of drug-induced hypersensitivity syndrome (DIHS), and to provide references for rational drug use in clinical practice. Methods: One case of DIHS in our hospital was reported, and relevant literature published in domestic medical journals through 1994-2013 were retrieved and statistically analyzed. Results: According to reports in the literature and case in our hospital, a total of 48 patients who suffered from drug-induced hypersensitivity syndrome were collected and comprehensively summarized. 100% patients had medication history, 97.9% had high fever, and 97.9% had abnormal liver function. In 18 patients, alanine aminotransferase (ALT) activity increased 10 times more than the upper limit of normal levels, renal dysfunction occurred in 22.9% of patients, peripheral blood eosinophilia occurred in 66.7%, and superficial lymph nodes appeared in 75%. Main treatment was use of glucocorticoids. Three patients died of multiple organ failure. Conclusion: DIHS occurs occasionally; and safety monitoring should be carried out in patients during application of drugs in order to reduce the incidence of ADR.


PubMed | Capital Medical University, Beijing Puren Hospital and Peking University
Type: Journal Article | Journal: Journal of biomedical research | Year: 2015

Maternally inherited familial hypercholesterolemia (FH) impairs glucose metabolism and increases cardiovascular risks in the offspring to a greater degree than paternal inherited FH. However, it remains unknown whether hypertriglyceridemia affects glucose metabolism via inheritance. In this study, we sought to compare the impact of maternally and paternally inherited hypertriglyceridemia on glucose and lipid metabolism in mice. ApoCIII transgenic mice with severe hypertriglyceridemia were mated with non-transgenic control mice to obtain 4 types of offspring: maternal non-transgenic control and maternal transgenic offspring, and paternal control and paternal transgenic offspring. Plasma triglycerides (TG), total cholesterol (TC), fasting plasma glucose (FPG) and fasting insulin (FINS) were measured. ApoCIII overexpression caused severe hypertriglyceridemia, but the transgenic female mice had unaltered fertility with normal pregnancy and birth of pups. The 4 groups of offspring had similar birth weight and growth rate. The plasma TG of maternal and paternal transgenic offspring were nearly 40-fold higher than maternal and paternal control mice, but there was no difference in plasma TG between maternal and paternal transgenic offspring. Although the FPG of the 4 groups of animals had no difference, the maternal transgenic mice showed impaired glucose tolerance, increased FINS levels and higher homeostasis model assessment insulin resistance index (HOMA-IR) than the other 3 groups. In conclusion, maternally inherited hypertriglyceridemia in ApoCIII transgenic mice displayed impaired glucose tolerance, hyperinsulinemia and increased HOMA-R, while paternally inherited hypertriglyceridemia did not have such impacts.


Xie Y.,Peking Union Medical College | Zhao Z.,Beijing Puren Hospital | Li P.,Peking Union Medical College | Wang Y.,Peking Union Medical College | And 7 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Aim: To document the clinicopathological characteristics and analyze the possible reasons for misdiagnosis or missed diagnosis of hepatoid adenocarcinoma of the stomach (HAS), using data from a single center. Methods: We retrospectively analyzed 19 patients initially diagnosed as HAS and 7 patients initially diagnosed as common gastric cancer with high levels of serum α-fetoprotein (AFP). All had undergone surgical treatment, except 3 patients only had biopsies at our hospital. Immunohistochemistry for AFP and Hepatocyte antigen was performed. Final diagnosis for these 26 patients were made after HE and immunohistochemistry slides reviewed by 2 experienced pathologists. Prognostic factors were determined by univariate analysis. Results: Nineteen cases were confirmed to be HAS. A total of 4 out of 19 cases initially diagnosed as HAS and 4 out of 7 cases initially diagnosed as common gastric adenocarcinoma were misdiagnosed/missed diagnosed, thus, the misdiagnosis/missed diagnosis rate was 30.8% (8/26). The incidence of HAS among gastric cancer in our center was 0.19% (19/9915). Sixteen (84.2%) patients showed T stages greater than T2, 12 (70.6%) patients had positive lymph nodes in 17 available patients and 3 (15.8%) of the patients with tumors presented liver metastasis at the time of diagnosis. Histologically, cytoplasmic staining types included 10 cases of eosinophilic, 1 case of clear, 5 cases of clear mixed with eosinophilic and 3 cases of basophilic. Fourteen (73.7%) patients expressed AFP, whereas only 6 (31.6%) were hepatocyte-positive. Univariate analysis showed that N stage (HR 2.429, P=0.007) and tumor AFP expression (HR 0.428, P=0.036) were significantly associated with disease-free survival. The median overall survival time was 12.0 months, and the median disease-free survival time was 7.0 months. Four (80%) of 5 N0 patients and 2 (50%) of 4 N1 patients survived without progression, but no N2-3 patients survived. Conclusion: HAS remains easily being misdiagnosed/missed diagnosed based on a pathological examination, probably because the condition is rare and has various cytoplasmic types. Although the survival rate for HAS is poor, a curative effect may be achieved for N0 or N1 cases. © 2015 E-Century Publishing Corporation. All rights reserved.


Liu M.,Capital Medical University | Hou Q.,Beijing Puren Hospital | Guo X.,Capital Medical University | Wang S.,Capital Medical University | Ma Z.,Capital Medical University
Experimental and Therapeutic Medicine | Year: 2014

The aim of the present study was to retrospectively evaluate the incidence and morphological features of coronary artery fistulas (CAFs) detected by dual-source computed tomography coronary angiography (DS-CTCA). Between January 2011 and January 2013, 19,584 consecutive patients that had undergone electrocardiogram-triggering DS-CTCA were retrospectively reviewed. Image reconstructions were performed and image quality was evaluated. The medical information of the patients with CAF was reviewed from the medical records. Among the 19,584 patients, 66 patients were diagnosed with CAFs by CTCA, including 60 patients with coronary pulmonary artery fistulas (CPAFs) and six with coronary left ventricular fistulas. Therefore, the incidence of CAFs was 0.34%. Image quality was considered to be excellent in 61 patients and moderate in five cases. CPAFs were identified as small and tortuous vessels in 24 patients and dilated vessels close to the surface of the pulmonary artery (PA) in 36 patients. The coronary left ventricular fistulas were identified as dilated vessels that were draining into the posterior wall of the left ventricle. Among the 66 patients, 54 patients had one traceable fistula and the remaining 12 patients were shown to have two fistula vessels. The average diameter of the detected fistulas, measured with CTCA, was 3.1±1.9 mm. A high-density flow jet of contrast agent shunting from the fistula into the low density PA was observed in 46 patients with CPAF. The results indicate that DS-CTCA is a reliable noninvasive tool that allows the accurate delineation of CAFs.


Chen Y.-D.,Capital Medical University | Feng J.,Beijing Puren Hospital | Fang T.,Capital Medical University | Yang M.,Beijing University of Chemical Technology | And 2 more authors.
Chinese Medical Journal | Year: 2013

Background Few studies were reported on the comparison of clinical outcomes between intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) in the treatment of glioblastoma multiforme (GBM). This study aimed to determine whether IMRT improves clinical outcomes compared with 3D-CRT in patients with GBM. Methods The records of 54 patients with newly-diagnosed GBM from July 2009 to December 2010 were reviewed. The patients underwent postoperative IMRT or 3D-CRT with concurrent and adjuvant temozolomide. Kaplan-Meier method and log rank test were used to estimate differences of patients' survival. Results The median follow-up was 13 months. Of the 54 patients, fifty (92.6%) completed the combined modality treatment. The 1-year overall survival rate (OS) was 79.6%. The pattern of failure was predominantly local. A comparative analysis revealed that no statistical difference was observed between the IMRT group (n=21) and the 3D-CRT group (n=33) for 1-year OS (89.6% vs. 75.8%, P=0.795), or 1-year progression-free survival (PFS) (61.0% vs. 45.5%, P=0.867). In dosimetric comparison, IMRT seemed to allow better sparing of organs at risk than 3D-CRT did (P=0.050, P=0.055). However, there was no significant difference for toxicities of irradiation between the IMRT group and the 3D-CRT group. Conclusions Our preliminary results suggested that delivering standard radiation doses by IMRT is unlikely to improve local control or overall survival for GBM compared with 3D-CRT. Given this lack of survival benefit and increased costs ofIMRT, the utilization ofIMRTtreatment for GBM needs to be carefully rationalized.


Rong F.,Beijing Puren Hospital | Mo B.,Capital Medical University | Liu W.,Capital Medical University
International Eye Science | Year: 2012

AIM: To observe the photoreceptor integrity by spectral-domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME) with or without serous retinal detachment(SRD), and assess their association with visual acuity. METHODS: In this prospective study, consecutive patients were observed by SD-OCT with central subfield mean thickness (CSMT) ≥300μm and without definite macular traction or compact hard exudates in central 500μm. They were divided into two groups: with or without SRD. The integrity of photoreceptor was observed in the central 500μm. The integrity of external limiting membrane(ELM) in all eyes and the integrity of inner and outer segments(IS/OS) in eyes without SRD was classified as existent or completely absent. In SRD eyes, the integrity of IS/OS was classified into another two grades: preserved or atrophic. BCVA between different integrity of IS/OS or ELM were compared. RESULTS: In all the 56 eyes of 41 patients, there were 32 eyes detected without SRD and 24 eyes with SRD. In eyes without SRD, BCVA was significantly poorer in eyes with completely absent IS/OS or ELM than those with existent IS/OS or ELM(t=-7.938, P=0.000; t= -7.347, P=0.000). In eyes with SRD, BCVA was also significantly poorer in eyes with atrophic IS/OS than those with preserved IS/OS(t=-4.354, P=0.000), but there was no significant difference in BCVA between eyes with or without completely absent ELM (t=-0.895, P=0.381). CONCLUSION: In patients of diabetic macular edema, the integrity of subfoveal IS/OS was closely related to BCVA. But the associations between the integrity of ELM and BCVA might not consistent in eyes with or without SRD.


PubMed | Capital Medical University and Beijing Puren Hospital
Type: | Journal: World journal of surgical oncology | Year: 2016

Unilateral adult thalamic gliomas are rarely reported. In this study, the authors aimed to analyze the clinical, radiological, and pathological features of adult primary unilateral thalamus gliomas (UTGs).Clinical data of 33 UTGs in adults who underwent surgical treatment between 2005 and 2014 at the Beijing Tiantan Hospital were collected and retrospectively studied. Follow-up evaluation was performed.This study included 21 males and 12 females with a mean age of 43.1 years. The most common symptoms were headache (75.8%, 25/33 patients) and motor deficits (42.4%, 14/33 patients). Radiological results showed that enhancement was common (90.9%, 30/33 patients) and included cystic appearances in 9 cases (27.3%). All patients underwent maximal safe tumor resection. Gross total resection (GTR) was achieved in 19 cases, subtotal resection (80%) in 9 cases, and partial resection (<80%) in 5 cases. Molecular pathology results were available in 15 cases. After surgery, 25 patients received postoperative adjuvant therapy based on the remaining pathology. The median follow-up period of all 33 patients with UTGs was 17 months (1 week~49 months). Twenty-four patients experienced tumor recurrence. The 1-year and 2-year progression-free survival (PFS) rates were 49.0 and 10.2%, respectively. The 1-year and 2-year overall survival (OS) rates were 68.1 and 25.9%, respectively. Survival analyses revealed that several predictive factors were correlated with better prognosis, among which, GTR and tumor with cystic appearances were significantly associated with a longer survival.Adult UTGs displayed a wide spectrum of clinical features. GTR can be achieved in adult UTGs with acceptable complications and conferred a better prognosis. Tumor with cystic appearance may indicate better prognosis. More patients and longer follow-up periods are needed to further elucidate the biological features of adult UTGs.


PubMed | Capital Medical University and Beijing Puren Hospital
Type: Journal Article | Journal: Experimental and therapeutic medicine | Year: 2014

The aim of the present study was to retrospectively evaluate the incidence and morphological features of coronary artery fistulas (CAFs) detected by dual-source computed tomography coronary angiography (DS-CTCA). Between January 2011 and January 2013, 19,584 consecutive patients that had undergone electrocardiogram-triggering DS-CTCA were retrospectively reviewed. Image reconstructions were performed and image quality was evaluated. The medical information of the patients with CAF was reviewed from the medical records. Among the 19,584 patients, 66 patients were diagnosed with CAFs by CTCA, including 60 patients with coronary pulmonary artery fistulas (CPAFs) and six with coronary left ventricular fistulas. Therefore, the incidence of CAFs was 0.34%. Image quality was considered to be excellent in 61 patients and moderate in five cases. CPAFs were identified as small and tortuous vessels in 24 patients and dilated vessels close to the surface of the pulmonary artery (PA) in 36 patients. The coronary left ventricular fistulas were identified as dilated vessels that were draining into the posterior wall of the left ventricle. Among the 66 patients, 54 patients had one traceable fistula and the remaining 12 patients were shown to have two fistula vessels. The average diameter of the detected fistulas, measured with CTCA, was 3.11.9 mm. A high-density flow jet of contrast agent shunting from the fistula into the low density PA was observed in 46 patients with CPAF. The results indicate that DS-CTCA is a reliable noninvasive tool that allows the accurate delineation of CAFs.


PubMed | Chinese PLA General Hospital and Beijing Puren Hospital
Type: Journal Article | Journal: Zhongguo shi yan xue ye xue za zhi | Year: 2015

To investigate the inductive therapeutic effects of imatinib combined with VP low dose regiment on adult patients with Ph-positive acute lymphoblastic leukemia (Ph(+) ALL).Fourteen newly diagnosed adult patients with Ph(+) ALL were treated with VP regimen, and imatinib (400 mg/d) was added at the 8(th) day. VP regimen would be stopped when neutropenia lasted for 1 week or complicated with infection, fever, etc. Therapeutic effects were assessed by bone marrow morphology and quantitative analysis of BCR/ABL:ABL at the 28(th) - 33(rd) day. Patients could be treated with imatinib combined with chemotherapy for consolidation and maintenance therapy or were treated with allogeneic hematopoietic stem cell transplantation after complete remission.Fourteen cases obtained CR1 after first course of treatment, the median decline of BCR/ABA:ABL was 55.89 (10.25 -180.97) %; during the induction chemotherapy, pulmonary infection occurred in 3 patients, diarrhea in 1 patients, facial edema in 3 patients, however, all these patients were cured after symptomatic treatment, only 1 patient died of relapse after transplantation.In the period of tyrosine kinase inhibitor (TKI), inductive chemotherapy combined with imatinib and low dose VP can obtaine satisfactory CR rate and decrease the toxicity of the traditional drugs. It is suggested that TKI combined with VP regimen chemotherapy can achieve CR1 and make possible for allo-HSCT, from which patients can achieve the long-term survival.

Loading Beijing Puren Hospital collaborators
Loading Beijing Puren Hospital collaborators