Beijing Medking Pharmaceutical Technology Co.

Changping, China

Beijing Medking Pharmaceutical Technology Co.

Changping, China

Time filter

Source Type

Wang Y.,Beijing University of Technology | Yan H.,Beijing University of Technology | Ma C.,Beijing Medking Pharmaceutical Technology Co. | Lu D.,Beijing Medking Pharmaceutical Technology Co.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

A series of novel 8-azapurine carbocyclic nucleoside hydrazones were synthesized through a useful procedure starting from amino alcohol and pyrimido dichloride. All the products were characterized by 1H NMR, 13C NMR and HRMS spectral analysis and the stereochemical structure of key intermediate was also confirmed by a single crystal X-ray diffraction crystallographic analysis. Moreover, the anticancer activities were evaluated in vitro against human liver cancer Huh-7 cell line and human breast cancer A549 cell line. © 2015.


PubMed | Beijing University of Technology and Beijing Medking Pharmaceutical Technology Co.
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2015

A series of novel 8-azapurine carbocyclic nucleoside hydrazones were synthesized through a useful procedure starting from amino alcohol and pyrimido dichloride. All the products were characterized by (1)H NMR, (13)C NMR and HRMS spectral analysis and the stereochemical structure of key intermediate was also confirmed by a single crystal X-ray diffraction crystallographic analysis. Moreover, the anticancer activities were evaluated in vitro against human liver cancer Huh-7 cell line and human breast cancer A549 cell line.

Loading Beijing Medking Pharmaceutical Technology Co. collaborators
Loading Beijing Medking Pharmaceutical Technology Co. collaborators