Time filter

Source Type

Hong X.,Southern Medical University | Hong X.,Beijing Key Laboratory of Pediatric Organ Failure | Liu C.,Southern Medical University | Liu C.,Beijing Key Laboratory of Pediatric Organ Failure | And 14 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2017

Objectives: Most pulmonary artery sling (PA sling) children receive left pulmonary artery (LPA) re-implantation and tracheoplasty simultaneously under cardiopulmonary bypass, but postoperative complications of tracheoplasty remain great challenges. This study aimed to find out what kinds of children can survive under LPA re-implantation without tracheal intervention. Methods: The data of 21 PA sling/tracheal stenosis children with mild, moderate even severe respiratory symptom receiving LPA re-implantation at first surgery in our hospital were reviewed. Complete tracheal ring was confirmed by fiberoptic bronchoscopy in all the children preoperatively. The clinical outcome and the severity of trachea stenosis (tracheal diameter and length) were evaluated, and effectiveness of various managements was analyzed. Results: 21 PA sling/tracheal stenosis children received surgical treatment including LPA re-implantation, tracheoplasty and tracheal stent. 5 children needed intubation and mechanical ventilation for severe respiratory symptoms preoperatively. All children received LPA re-implantation alone at first operation to relieve the trachea compression. For extubation failure, tracheal intervention was employed in 8 children, and 5 children received slide tracheoplasty and one discharged after recovery. The remaining 3 children received tracheal stent implantation, but finally died. The diameter and length of tracheal stenosis was significantly different between the children without tracheal intervention and children who needed tracheal intervention. The diameter of the narrowest trachea in non-tracheal intervention groupwas significantly wider than that in tracheal intervention group (3.18 ± 0.98 versus 2.31 ± 0.55, P=0.036), and the ratio of stenosis tracheal/total tracheal length (from vocal cords to trachea carina) was statistically different (35.38 ± 14.24 versus 51.00 ± 14.14, P=0.024). Conclusions: PA sling Children/tracheal stenosis undergoing LPA re-implantation without tracheal intervention achieved a good outcome. PA sling/tracheal stenosis children who have the lesser respiratory symptoms and a larger diameter of narrowest trachea, would have higher possibility for surviving to discharge by LPA re-implantation alone. © 2017, E-Century Publishing Corporation. All rights reserved.


Guo Y.,Sourthern Medical University | Guo Y.,Beijing Key Laboratory of Pediatric Organ Failure | Guo Y.,Inner Mongolia University | Chai Q.,Inner Mongolia Peoples Hospital | And 5 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Autoimmune disease systemic lupus erythematosus (SLE) is associated with increased expression of pro-inflammatory cytokines such as interferons (IFNs) and specific interleukins (ILs), which are induced by toll-like receptors (TLRs). The present study aimed to examine the serum levels of cytokines, the activation of TLR-7 and TLR-8 of peripheral blood mononuclear cells (PBMCs) from pediatric SLE patients, and to investigate the response of those PBMCs to viral RNA via the TLR-7 and TLR-8 signaling. Results demonstrated that pediatric SLE patients had increased serum concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, and IFN-α, and promoted activation of TLR-7 and TLR-8, compared to control subjects. Moreover, the peripheral blood mononuclear cells (PBMCs) from pediatric SLE patients were more sensitive to the stimulation by the transfection with viral RNA from influenza virus, with a promoted activation of TLR-7 and TLR-8 signaling. In conclusion, pro-inflammatory cytokines, such as IL-1β, IL-6, IL-8, IL-10, and IFN-α were promoted in pediatric SLE patients, with an increased activation of TLR-7 and TLR- 8 to the stimuli, such as virus infection. It implies the TLR-7 and TLR-8 activation by virus infection might play an important role in the pathogenesis of pediatric SLE. © 2015 E-Century Publishing Corporation. All rights reserved.


Hong X.,Affiliated Bayi Childrens Hospital | Hong X.,Beijing Key Laboratory of Pediatric Organ Failure | Liu C.,Affiliated Bayi Childrens Hospital | Liu C.,Beijing Key Laboratory of Pediatric Organ Failure | And 14 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Objective: Increasing congenital heart disease (CHD) neonates receive cardiac surgery especially after two-child policy in China. This study was to investigate the risk factors for the mortality of CHD neonates after cardiopulmonary bypass (CPB). Methods: CHD neonates (n=123) undergoing CPB were prospectively enrolled. According to the early outcome, neonates were divided into survivor group and non-survivor group. The demographics and peri-operative factors were collected and compared between them. Variables with significant difference in univariate analysis were screened out by forward likelihood selection procedure, and included for multivariable logistic regression analysis. Results: A total of 23 neonatesdied after CPB. The overall in-hospital mortality was 18.70%. Univariate analysis indicated that the RACHS-1 score (P=0.029), time of CPB (P=0.003), incidence of cardiac arrest (CA) (P=0.005), proportion of neonates receiving extracorporeal membrane oxygenation (ECMO) (P=0.040) and lactate level (P=0.003) were significantly different between two groups. These 5 variables with significant difference in univariate analysis were screened out by forward likelihood selection procedure and multivariatelogistic regression analysis was performed. Results showed the odds ratio (OR) of death was increased by 1.009 for every unit increase in the time of CPB (OR: 1.009, P=0.046) and by 4.937 for CA present postoperatively (OR: 4.937, P=0.009). Conclusion: Long CPB and postoperative presence of CA were independent risk factors for mortality in neonates after CPB. Thus, clinicians should shorten the time of CPB and take measures to reduce CA, aiming to reduce the post-operative mortality. © 2016, E-Century Publishing Corporation. All rights reserved.

Loading Beijing Key Laboratory of Pediatric Organ Failure collaborators
Loading Beijing Key Laboratory of Pediatric Organ Failure collaborators