Beijing Key Laboratory of Mental Disorders

Beijing, China

Beijing Key Laboratory of Mental Disorders

Beijing, China
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Yang N.-B.,Capital Medical University | Yang N.-B.,Beijing Key Laboratory of Mental Disorders | Tian Q.,Capital Medical University | Tian Q.,Beijing Key Laboratory of Mental Disorders | And 11 more authors.
BMC Psychiatry | Year: 2017

Background: Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia. However, due to the measurement methods of PPI, findings about the relationship between PPI and clinical symptoms, cognitive performances have been equivocal. Methods: Seventy-five schizophrenia patients (SZ) and 50 healthy controls (HC) were assessed in a modified acoustic PPI paradigm, named perceived spatial separation-induced PPI (PSS-PPI), compared to perceived spatial co-location PPI (PSC-PPI) with inter-stimulus interval (ISI) of 120 ms. Repeatable Battery for the Assessment of Neuropsychological Status and the Stroop Color-Word Test were administered to all subjects. Results: Significant decrease in the modified PPI was found in the patients as compared to the controls, and effect sizes (Cohen'd) for patients vs. HCs % PPI levels achieved a significant level (PSC-PPI d = 0.84, PSS-PPI d = 1.27). A logistic regression model based on PSS-PPI significantly represented the diagnostic grouping (χ2 = 29.3; p < 0.001), with 85.2% area under ROC curve in predicting group membership. In addition, patients exhibited deficits in neurocognition. Among patients of "non-remission", after controlling for gender, age, education, duration, recurrence times, onset age, cigarettes per day and chlorpromazine equivalent dosage, PSS-PPI levels were associated with positive and negative symptoms, PANSS total and thought disorder (P1, P6, P7, N5, N7, G9). In multiple linear regression analyses, male and higher attention scores contributed to better PSC-PPI and PSS-PPI in controls group, while larger amount of smoke and longer word-color interfere time contributed to poor PSS-PPI. In patients' group, higher education and attention scores contributed to better PSS-PPI, while repeated relapse contributed to poor PSS-PPI. Conclusions: The acoustic perceived spatial separation-induced PPIs may bring to light the psychopathological symptoms, especially for thought disorder, and the mechanism(s) of the novel PPI paradigm was associated with attention function. © 2017 The Author(s).


Li A.-N.,Beijing Key Laboratory of Mental Disorders | Li A.-N.,Beijing Anding Hospital | Dong F.,Beijing Key Laboratory of Mental Disorders | Dong F.,Beijing Anding Hospital | And 10 more authors.
Pharmacopsychiatry | Year: 2015

Introduction: The prescribing of clozapine in China is common because of its outstanding efficacy and low price. There have been many cases of clozapine overdose in China. However, studies about the pharmacokinetics after overdose in the Chinese have rarely been reported. Population pharmacokinetics (PopPK) can analyze sparse data, and it is appropriate to compute clozapine pharmacokinetics after overdose. Methods: There were 47 clozapine overdose cases. We constructed a single-compartment first-order elimination PopPK model. We also considered some covariates that can influence the pharmacokinetics parameters. Results: 21 cases were included in the analysis. When the reported toxic dosage was 3 740 mg, the elimination rate constant of the population was 0.0258(h−1). The elimination half-life was 26.9 h. The coefficient of random variation was 17%. Discussion: PopPK can solve the problem of sparse data after overdose. The area under the concentration-time curve after clozapine overdose exhibited the “two peaks phenomenon.” The reported toxic dosage could impact clozapine elimination after overdose. Delayed absorption of clozapine is the best explanation for this finding. Copyright © 2015, Georg Thieme Verlag KG. All rights reserved.

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