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Leigongjian, China

Gong H.T.,Capital Medical University | Ma X.L.,Beijing Jian Gong Hospital | Chen B.X.,Capital Medical University | Xu X.Y.,Capital Medical University | And 3 more authors.
Genetics and Molecular Research | Year: 2013

The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1 receptor are associated with blood pressure response to angiotensin II receptor blockers in hypertensive Chinese patients. After a 2-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy with 80 mg/day telmisartan and then were followed up for 8 weeks. The 1166A/C, 573T/C, -810A/T, and -521C/T polymorphisms of the AT1R gene were determined through PCR and RFLP analysis. The relationship between these polymorphisms and changes in blood pressure was observed and evaluated after 8 weeks of treatment. Patients with the AT1R -521CC genotype had a significant reduction in diastolic blood pressure compared to those carrying the T allele. No significant reduction in blood pressure was found in individuals with the 1166A/C, 573T/C, or -810A/T polymorphisms of the AT1R gene. We conclude that only the AT1R -521CC genotype is associated with a significant decrease in blood pressure in response to telmisartan treatment in Chinese hypertensive patients. © FUNPEC-RP. Source


Sun J.L.,Aviation General Hospital | Han R.,Xinjiang Medical University | Guo J.H.,Peking University | Li X.Y.,Chinese Peoples Liberation Army | And 2 more authors.
Cell Biochemistry and Biophysics | Year: 2013

The aim of this study was to determine the diagnostic value of treadmill exercise test (TET) in patients with coronary heart disease (CHD) by comparing the diagnostic conclusions with coronary angiography (CAG). Patients (445) with CHD and suspected CHD underwent TET and CAG, and the corresponding diagnostic conclusions were compared. (1) Out of the 200 cases that had the positive result with TET, 150 cases had been diagnosed CHD by means of CAG; Out of the 245 cases that had the negative result during TET, only 39 cases had been diagnosed CHD by means of CAG. The sensitivity, specificity, positive predictive value, negative predictive value, the false positive incidence, the false negative incidence, and agreement rate in diagnosis of CHD by TET were 79. 36, 80. 40, 75. 00, 84. 08, 25. 00, 15. 92, and 80. 00 %, respectively. The patients with multi-vessel disease had a higher positive rate of TET as compared with those with single-vessel disease (P < 0. 05). (2) The parameters for 189 cases positive CAG (patients diagnosed CHD by CAG) and 256 cases negative CAG (the control group), including the general exercise time, peak heart rate, and the beginning time of ST depression, were lower than that of control group (P < 0. 05). However, the extent of ST depression and duration of ST depression were higher in these patients than in the control group (P < 0. 05). (3) 189 cases positive CAG, include 87 cases of single coronary artery and 102 cases of binary or more coronary arteries (the control group). The parameters, including the general exercise time, peak heart rate, and the beginning time of ST depression, were lower than the control group (P < 0. 05). However, the extent of ST depression and duration of ST depression were higher in these patients than the control group (P < 0. 05). The TET is valuable for noninvasive diagnosis of CHD, especially for patients with multi-vessel disease. © 2012 Springer Science+Business Media, LLC. Source


Sun J.L.,Aviation General Hospital | Han R.,Xinjiang Medical University | Guo J.H.,Peking University | Li X.Y.,Chinese Peoples Liberation Army | And 2 more authors.
Cell Biochemistry and Biophysics | Year: 2012

The objective of the study was to evaluate the effect of ibutilide on canine cardiac sinoatrial and atrioventricular nodes (AVNs). For this purpose, 18 mongrel dogs were injected intravenously with ibutilide and the changes in heart rate, sinus node recovery time, and AVN were measured. Our data show that ibutilide administration caused significant suppression of the sinus atrial node, the peak response time was 20-30 min, and the heart rate was restored to pre-drug administration level. After receiving ibutilide, 1 animal had a 5 s sinus pause, and after 5 min of ibutilide administration, 1 dog showed 2:1 atrioventricular conduction. Therefore, it was concluded that ibutilide had a suppressive effect on the sinoatrial node and AVN. © 2012 Springer Science+Business Media, LLC. Source


Sun J.-l.,Aviation General Hospital | Han R.,Xinjiang Medical University | Guo J.-h.,Peking University | Li X.-y.,Chinese Peoples Liberation Army | And 2 more authors.
Cell Biochemistry and Biophysics | Year: 2012

This study aims to observe the effects of ibutilide on canine cardiac pacing threshold and on induction rates of atrial fibrillation. Eighteen mongrel dogs were anesthetized and administrated with ibutilide. The pacing thresholds and induction rates of atrial fibrillation were measured with and without ibutilide (10-min infusion dose was 0.10 mg kg-1, followed by a maintaining dose of 0. 01 mg min-1 30 min later). This study found that ibutilide increases pacing thresholds in dogs. Moreover, there were significant differences between pacing thresholds with and without ibutilide (P < 0.05). Further, ibutilide significantly reduces the induction rates of atrial fibrillation (P < 0.05). Our findings indicate that pacing voltage changes should be closely monitored in patients taking anti-arrhythmic drugs, who are treated with cardiac stimulation or have undergone pacemaker implantation. We also found that ibutilide is an effective drug in preventing or controlling atrial fibrillation. © 2012 Springer Science+Business Media, LLC. Source


Sun J.L.,Aviation General Hospital | Huang W.M.,Xinjiang Medical University | Huang W.M.,Peking University | Guo J.H.,Peking University | And 3 more authors.
Cell Biochemistry and Biophysics | Year: 2013

The objective of the study was to explore the prevalence and characteristics of myocardial bridging in patients who underwent coronary angiography and to also evaluate the correlation between bridged coronary segments and atherosclerosis. For this purpose, clinical materials of 1,500 patients who had received coronary angiography were retrospectively analyzed. The location and length of the myocardial bridge were recorded as well as the extent and location of coronary artery stenosis was described. Segments proximal and distal to the bridging were evaluated for coronary arteriosclerosis as were the remaining coronary segments. We found that myocardial bridging was present in 179 (11. 9 %) patients. Bridges were frequently (84. 9 %) localized in the mid-distal segment of the left anterior descending (LAD) artery. Myocardial bridging was not considered a significant risk factor for coronary atherosclerosis (odds ratio 0. 58) compared with traditional cardiovascular risk factors. The incidence of coronary arteriosclerosis in the distal segments was significantly less affected than the proximal segments (P < 0. 01). It was, therefore, concluded that myocardial bridging frequently localized in the mid-distal segment of the LAD artery. The presence of myocardial bridging promotes proximal atherosclerosis but it is not an additional risk factor for coronary atherosclerosis. © 2012 Springer Science+Business Media New York. Source

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