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Li K.,Beijing Jishuitan Hospital | Ma Y.-M.,Beijing Jishuitan Hospital | Liu D.,Beijing Jishuitan Hospital | Su Y.-B.,Beijing Jishuitan Hospital | And 7 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2015

Objective: To evaluate the value of bone mineral density (BMD) measurements by quantitative computed tomography (QCT) in diagnosis of osteoporosis for the elderly men. Methods: Totally 314 male subjects older than 60 years underwent both QCT and dual energy X-ray absorptiometry (DXA). The differences between the detect rates of DXA and QCT on osteoporosis were compared. Results: The detect rate of DXA (lumbar vertebrae A-P projection, hip) on osteoporosis (35/314, 11.15%) was lower than that of QCT (141/314, 44.90%; χ2=88.70, P<0.05). Conclusion: QCT BMD measurements of lumbar vertebra plays an important role on the early diagnosis of osteoporosis in elderly Chinese men. Copyright © 2015 by the Press of Chinese Journal of Medical Imaging and Technology.


Zhang Y.,Peking University | Zhou Z.,Hebei Medical University | Wu C.,Beijing Institute of Traumatology and Orthopedics | Zhao D.,Beijing Institute of Traumatology and Orthopedics | And 7 more authors.
Korean Journal of Radiology | Year: 2016

Objective: To investigate the bone mineral density (BMD) of cervical vertebrae in a population-stratified manner and correlate with that of the lumbar vertebrae. Materials and Methods: Five hundred and ninety-eight healthy volunteers (254 males, 344 females), ranging from 20 to 64 years of age, were recruited for volumetric BMD (vBMD) measurements by quantitative computed tomography. Basic information (age, height, weight, waistline, and hipline), and vBMD of the cervical and lumbar vertebrae (C2–7 and L2–4) were recorded. Comparisons among sex, age groups and different levels of vertebrae were analyzed using analysis of variance. Linear regression was performed for relevance of different vertebral levels. Results: The vBMD of cervical and lumbar vertebrae was higher in females than males in each age group. The vBMD of the cervical and lumbar vertebrae in males and the vBMD of lumbar vertebrae in females decreased with aging. In each age group, the vBMD of the cervical vertebrae was higher than that of the lumbar vertebrae with gradual decreases from C2 to C7 except for C3; moreover, the vBMD of C6 and C7 was significantly different from that of C2–5. Correlations of vBMD among different cervical vertebrae (females: r = 0.62–0.94; males: r = 0.63–0.94) and lumbar vertebrae (males: r = 0.93– 0.98; females: r = 0.82–0.97) were statistically significant at each age group. Conclusion: The present study provided normative data of cervical vertebrae in an age- and sex-stratified manner. Sex differences in vBMD prominently vary with age, which can be helpful to design a more comprehensive pre-operative surgical plan. © 2016 The Korean Society of Radiology.


Cheng X.-G.,Beijing Jishuitan Hospital | Li K.,Beijing Jishuitan Hospital | Ou S.-X.,Guangzhou General Hospital of Guangzhou Command | Tang G.-Y.,Tongji University | And 4 more authors.
Journal of Clinical Densitometry | Year: 2016

This study compares spinal volumetric bone mineral density (vBMD) with spinal areal bone mineral density (aBMD) among young adults from 3 eastern provincial capital cities in Mainland China. A total of 416 young adults (age range: 20-40 yr) from 3 eastern provincial capital cities (Beijing, Shanghai, and Guangzhou) in Mainland China were recruited in this study. From each subject, the vBMD of the lumbar spine was measured by the Mindways quantitative computed tomography system. Moreover, the aBMD of the lumbar spine, measured by the dual-energy X-ray absorptiometry, was extracted from a previous multicenter large-scale study, and the 420 participants were matched by age, gender, height, weight, as well as geographic territory. The vBMD and the aBMD values were further compared and analyzed. Generally, the bone mineral density (BMD) results were significantly different among participants from the 3 cities (p <0.05). Specifically, both vBMD and aBMD values of participants from Beijing were significantly different from those from Guangzhou (p <0.05). Additionally, a statistically significant difference in aBMD values was also found between participants from Beijing and Shanghai (p <0.05). However, no significant differences were found between participants from Shanghai and Guangzhou in terms of the aBMD and vBMD values (p 1 > 0.05 and p 2 > 0.05). Interestingly, the overall mean vBMD value was 5.9% greater in women than those in men for all the 3 cities (p <0.001). This study demonstrated an overall heterogeneity in spinal BMD among young adults from 3 eastern provincial capital cities in Mainland China. Specifically, the taller and heavier young adults from the northern part of China have smaller spinal vBMD but higher spinal aBMD values than those who were shorter and lighter from the southern part of China. © 2016 International Society for Clinical Densitometry.


PubMed | Beijing Jishuitan Hospital, Tongji University, Guangzhou General Hospital of Guangzhou Command and Beijing Institute of Traumatology and Orthopedics
Type: | Journal: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry | Year: 2016

This study compares spinal volumetric bone mineral density (vBMD) with spinal areal bone mineral density (aBMD) among young adults from 3 eastern provincial capital cities in Mainland China. A total of 416 young adults (age range: 20-40yr) from 3 eastern provincial capital cities (Beijing, Shanghai, and Guangzhou) in Mainland China were recruited in this study. From each subject, the vBMD of the lumbar spine was measured by the Mindways quantitative computed tomography system. Moreover, the aBMD of the lumbar spine, measured by the dual-energy X-ray absorptiometry, was extracted from a previous multicenter large-scale study, and the 420 participants were matched by age, gender, height, weight, as well as geographic territory. The vBMD and the aBMD values were further compared and analyzed. Generally, the bone mineral density (BMD) results were significantly different among participants from the 3 cities (p<0.05). Specifically, both vBMD and aBMD values of participants from Beijing were significantly different from those from Guangzhou (p<0.05). Additionally, a statistically significant difference in aBMD values was also found between participants from Beijing and Shanghai (p<0.05). However, no significant differences were found between participants from Shanghai and Guangzhou in terms of the aBMD and vBMD values (p


Wang Q.-Q.,Beijing Institute of Traumatology and Orthopedics | Wu C.-A.,Beijing Institute of Traumatology and Orthopedics | Zhang Y.-Z.,Beijing Institute of Traumatology and Orthopedics | Yuan Y.,Beijing Institute of Traumatology and Orthopedics | Zhao D.-H.,Beijing Institute of Traumatology and Orthopedics
Medical Journal of Chinese People's Liberation Army | Year: 2014

Objective: To assess the relationship between the lipid level and the risk of cervical disc degeneration. Methods: A standardized case-control study of cervical disc herniation was formulated. One hundred and one patients with cervical disc herniation, and 102 patients with wounded limbs as control were admitted to Beijing Jishuitan Hospital from January 2012 to May 2013. The data of demographics, history of hypertension and type 2 diabetes, smoking and drinking habit were collected from all the patients. At the time of hospitalization, levels of total cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol and highdensity lipoprotein (HDL) cholesterol in fasting blood were measured by automatic biochemical analyzer in all patients, and the group matched case-control study was performed to assess the relationship between the lipid level and cervical disc degeneration. Results: No differences were found in gender and age between cases and controls. Compared with controls, the levels of total cholesterol and triglyceride were significantly higher in the patients, with the values of 4.88mmol/L vs 4.47mmol/L (P=0.002) and 1.89 mmol/L vs 1.28mmol/L (P=0.003), respectively. Triglyceride level was significantly correlated with cervical disc degeneration after adjustment for multiple covariates through logistic regression. The summary odds ratio (95% confidence interval) per 1mmol/ L increase of triglyceride was 1.90(1.25, 2.90), and that of triglyceride was an independent predictive factor for cervical disc herniation after adjustment of total cholesterol and triglyceride levels. Conclusion: Elevated triglyceride level may increase the risk of cervical disc herniation. However, more evidences are needed to validate the cause and effect.


Wang Q.,Beijing Institute of Traumatology and Orthopedics
Wei sheng yan jiu = Journal of hygiene research | Year: 2011

To evaluate the effects of different doses of phytoestrogen (genitein) combined with calcium and vitamin D3 on preventing osteoporosis in ovariectomized (OVX) mice. 63 female CD-1 mice, 29g average weight, were randomly divided into 7 groups. Including Sham group, OVX group and groups of treatment with calcium, vitamin D3 and genistein in high dose (GH, 67 mg/kg), genistein in moderate does (GM, 33.5 mg/kg), genistein in low dose(GL,16.75 mg/kg), pure genistein (G) and pure 17-betaestradiol (E2). After six weeks treatment, bone mineral density (BMD), bone mineral content (BMC), Biomechanical characteristics bone strength and bone biochemical markers were measured in all mice. In the groups of GH, GM and GL, it was stimulative effect of genistein on elevating uterine weight in ovariectomized mice and the effect in GL group is lower. BMD, BMC, length and width of femora were significantly increased in GM group mice than those in OVX mice (P < 0.01), as well as BMD of femora in GL group mice were markedly increased (P < 0.01). Peak load and resilience of femora were the most conspicuously increased in GL group mice than those in others treatment group mice (P < 0.01). In GL group, bone alkaline phosphatase (BALP) increased and tartrate-resistant acid phosphatase (TRAP) decreased (P < 0.01). It was lower stimulative effect of low dose of phytoestrogen (genitein) combined with calcium and vitamin D3 on elevating uterine weight in ovariectomized mice. Low dose of Phytoestrogen (genistein) combined with calcium and vitamin D3 might increase BMD, improve the mechanical strength of bone, promote bone fromation and inhibit bone resorption significantly. It might reduce the dose of genistein administrated and be safter than E2.


Wang N.,Beijing Institute of Traumatology and Orthopedics | Zhao D.-H.,Beijing Institute of Traumatology and Orthopedics | Wu C.-A.,Beijing Institute of Traumatology and Orthopedics | Tian W.,Ji Shui Tan Hospital | Xiao B.,Ji Shui Tan Hospital
National Medical Journal of China | Year: 2010

Objective: To acquire information on the IVD (intervertebral disc) proteome and analyze the differences of identified proteins during IVD development and maturation by a shotgun proteomics approach so as to identify the global protein expression patterns of IVD tissues from fetus and adults. Methods: A 24-week fetus, a 25- and a 30-year-old adult IVD samples were collected and SDS-PAGE, RP-HPLC MS/MS shotgun analyses were performed. Bioinformational analysis with International Protein Index (IPI) database and functional classification with Gene Ontology Annotation (GOA) database were used to evaluate the results. Results: A total of 524 proteins were identified in fetal IVD sample while 181 and 172 proteins were observed in 25 and 30-year-old samples respectively. Forty-eight proteins existed in three samples while 84 proteins in the 25-years-old and 30-years-old samples but not in fetus. Only 174 high-quality proteins existed in fetal sample while 20 high-quality proteins in 25-year-old and 30-year-old samples. The physico-chemical characteristics of identified proteins displayed similar trends in three samples. Conclusions: This study represents the first presentation of a global proteomic map of fetal and adult IVD samples using shotgun technology. Substantial differences exist in number and variety of proteins between development and mature IVD. This contributes to our overall knowledge in of biochemical components, metabolic regulation and biological mechanics in IVD.


PubMed | Beijing Institute of Traumatology and Orthopedics
Type: Journal Article | Journal: Wei sheng yan jiu = Journal of hygiene research | Year: 2011

To evaluate the effects of different doses of phytoestrogen (genitein) combined with calcium and vitamin D3 on preventing osteoporosis in ovariectomized (OVX) mice.63 female CD-1 mice, 29g average weight, were randomly divided into 7 groups. Including Sham group, OVX group and groups of treatment with calcium, vitamin D3 and genistein in high dose (GH, 67 mg/kg), genistein in moderate does (GM, 33.5 mg/kg), genistein in low dose(GL,16.75 mg/kg), pure genistein (G) and pure 17-betaestradiol (E2). After six weeks treatment, bone mineral density (BMD), bone mineral content (BMC), Biomechanical characteristics bone strength and bone biochemical markers were measured in all mice.In the groups of GH, GM and GL, it was stimulative effect of genistein on elevating uterine weight in ovariectomized mice and the effect in GL group is lower. BMD, BMC, length and width of femora were significantly increased in GM group mice than those in OVX mice (P < 0.01), as well as BMD of femora in GL group mice were markedly increased (P < 0.01). Peak load and resilience of femora were the most conspicuously increased in GL group mice than those in others treatment group mice (P < 0.01). In GL group, bone alkaline phosphatase (BALP) increased and tartrate-resistant acid phosphatase (TRAP) decreased (P < 0.01).It was lower stimulative effect of low dose of phytoestrogen (genitein) combined with calcium and vitamin D3 on elevating uterine weight in ovariectomized mice. Low dose of Phytoestrogen (genistein) combined with calcium and vitamin D3 might increase BMD, improve the mechanical strength of bone, promote bone fromation and inhibit bone resorption significantly. It might reduce the dose of genistein administrated and be safter than E2.

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