Beijing Geriatric Hospital

Beijing, China

Beijing Geriatric Hospital

Beijing, China
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Wang J.T.,Beijing Geriatric Hospital | Yin L.,General Hospital of PLA | Chen Z.,Beijing Geriatric Hospital
Neural Regeneration Research | Year: 2013

Most hypotheses concerning the mechanisms underlying Parkinson's disease are based on altered synaptic transmission of the nigrostriatal system. However, extrasynaptic transmission was recently found to affect dopamine neurotransmitter delivery by anisotropic diffusion in the extracellular matrix, which is modulated by various extracellular matrix components such as fibronectin. The present study reviewed the neuroprotective effect of fibronectin in extrasynaptic transmission. Fibronectin can regulate neuroactive substance diffusion and receptor activation, and exert anti- neuroinflammatory, adhesive and neuroprotective roles. Fibronectin can bind to integrin and growth factor receptors to transactivate intracellular signaling events such as the phosphatidylinositol 3-kinase/protein kinase B pathway to regulate or amplify growth factor-like neuroprotective actions. Fibronectin is assembled into a fibrillar network around cells to facilitate cell migration, molecule and ion diffusion, and even drug delivery and treatment. In addition, the present study analyzed the neuroprotective mechanism of fibronectin in the pathogenesis of Parkinson's disease, involving integrin and growth factor receptor interactions, and discussed the possible therapeutic and diagnostic significance of fibronectin in Parkinson's disease.


Huang S.-J.,Capital Medical University | Wang X.-H.,Qingdao University | Liu Z.-D.,Capital Medical University | Cao W.-L.,Beijing Geriatric Hospital | And 3 more authors.
Drug Design, Development and Therapy | Year: 2017

Background and aim: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB). Methods: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.3. Results: A significantly lower vitamin D level was found in TB patients vs controls; vitamin D deficiency (VDD) was associated with an increased risk of TB, although such an association was lacking in the African population and in the human immunodeficiency virus-infected African population. A significantly lower vitamin D level was found in human immunodeficiency virus-TB-coinfected African patients receiving antiretroviral treatment who developed TB-associated immune reconstitution inflammatory syndrome vs those who did not develop TB-associated immune reconstitution inflammatory syndrome. VDD was associated with an increased risk of developing active TB in those subjects with latent TB infection and with an increased risk of tuberculin skin test conversion/ TB infection conversion, and the trend toward a lower vitamin D level in active TB patients vs latent TB infection subjects did not reach statistical significance, indicating that VDD was more likely a risk factor than a consequence of TB. This concept was further strengthened by our result that anti-TB treatment did not affect vitamin D level in TB patients receiving the treatment. Conclusion: Our analyses revealed an association between vitamin D and TB. VDD is more likely a risk factor for TB than its consequence. More studies are needed to determine whether vitamin D supplementation is beneficial to TB prevention and treatment. © 2017 Huang et al.


Parisiadou L.,U.S. National Institute on Aging | Parisiadou L.,Northwestern University | Yu J.,U.S. National Institute on Aging | Yu J.,Beijing Geriatric Hospital | And 10 more authors.
Nature Neuroscience | Year: 2014

Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack of LRRK2 promoted the synaptic translocation of PKA and increased PKA-mediated phosphorylation of actin-disassembling enzyme cofilin and glutamate receptor GluR1, resulting in abnormal synaptogenesis and transmission in the developing SPNs. Furthermore, PKA-dependent phosphorylation of GluR1 was also aberrantly enhanced in the striatum of young and aged Lrrk2 -/- mice after treatment with a Drd1 agonist. Notably, a Parkinson's disease-related Lrrk2 R1441C missense mutation that impaired the interaction of LRRK2 with PKARIIβ also induced excessive PKA activity in the SPNs. Our findings reveal a previously unknown regulatory role for LRRK2 in PKA signaling and suggest a pathogenic mechanism of SPN dysfunction in Parkinson's disease. © 2014 Nature America, Inc.


Chen Z.,Beijing Geriatric Hospital | Yu J.,Beijing Geriatric Hospital | Yu J.,Peking University | Song Y.,Beijing Geriatric Hospital | Chui D.,Peking University
Ageing Research Reviews | Year: 2010

Following the global trend of population aging, China became an aging society at the end of the 20th century. The ever-growing medical demands of the elderly, the lag in medical insurance policy, and the late development of geriatric services make the present situation of public health in China worrying. To meet these challenges, the Beijing municipal government has actively adjusted its development strategies and has been building up a medical service and healthcare system suitable for the elderly. The core of the system is a three-level management of geriatric diseases: prevention and treatment for chronic diseases, functional rehabilitation, long-term care, and family attendance at rural and urban community health service centers (stations); post-acute rehabilitation, long-term care, and palliative treatment in the specialized geriatric hospitals of every district (county); and rescue and treatment for acute and serious geriatric diseases in the geriatric sections of all general hospitals and Beijing Geriatric Hospital. By raising awareness and gaining support from all of society, the implementation of this system will benefit millions of elderly people and promote the sustainable financial development and social harmony of Beijing. © 2010 Elsevier B.V.


Wang P.,CAS Institute of Psychology | Wang P.,University of Chinese Academy of Sciences | Li J.,CAS Institute of Psychology | Li H.,CAS Institute of Psychology | Zhang S.,Beijing Geriatric Hospital
Behavioral and Brain Functions | Year: 2013

Background: It has been established that the overall performance of associative memory was disproportionately impaired in contrast to item memory in aMCI (Amnestic mild cognitive impairment) patients, but little is known about the specific aspects of the memory process that show differences between aMCI and healthy controls. By comparing an item-item associative learning test with an individual item learning test, the present study investigated whether the rate of learning was slower in associative memory than in item memory in aMCI. Furthermore, we examined whether deficits in intertrial acquisition and consolidation contributed to the potential disproportionate impairments in the learning rate of associative memory for aMCI patients. In addition, we further explored whether the aMCI-discriminative power of the associative memory test increases more than that of the item memory test when the number of learning-test trials increases.Methods: A group of 40 aMCI patients and 40 matched control participants were administered a standardized item memory test (Auditory Verbal Learning Test, AVLT) and a standardized associative memory test (Paired Associative Learning Test, PALT), as well as other neuropsychological tests and clinical assessments.Results: The results indicated that the learning rate deficits in aMCI patients were more obvious for associative memory than for item memory and that the deficits resulted from impairments in both intertrial acquisition and consolidation. In addition, the receiver operating characteristic curve and logistical regression analysis revealed that the discriminative power of the associative memory test for aMCI was larger than that of the item memory test, especially with more than one learning-test trials.Conclusions: Due to more deficits in learning rate of associative memory than that of item memory, the discriminative power for aMCI tended to be larger in associative memory than in item memory when the number of learning-test trials increased. It is suggested that associative memory tests with multiple trials may be particularly useful for early detection of aMCI. © 2013 Wang et al.; licensee BioMed Central Ltd.


Yang B.,Beijing Geriatric Hospital | Jiang H.,Beijing Geriatric Hospital | Yu M.,Beijing Geriatric Hospital | Zhang H.,Beijing Geriatric Hospital
Cancer Research and Clinic | Year: 2015

Objective To observe the prevalence of cancer-associated anemia and its effect on elderly patients with advanced cancer. Methods Functional Assessment of Cancer Therapy-Anemia Version 4 (FACT-An) was used to investigate the quality of life (QOL) of 86 elderly patients with advanced cancer. The patients were divided into anemia group and non-anemia group. The influence factors for QOL of the elderly patients with advanced cancer were examined, and a multivariate regression was used. Results The prevalence of cancer-associated anemia in elderly patients with advanced cancer was 61.63 % (53/86). The scores in physical well-being (16.03±4.14 vs 12.47±4.68, P = 0.001), emotional well-being (11.30±3.98 vs 9.45±4.04, P = 0.041), functional well-being (13.61 ±3.74 vs 10.30±4.02, P < 0.001), additional concerns (57.39±7.28 vs 40.06±10.45, P < 0.001) and FACT-An (111.70±13.19 vs 84.34±18.95, P < 0.001) of the non-anemia group were all significantly higher than those of the anemia group. The multivariate regression analysis results indicated that hemoglobin (P < 0.001), comorbidities (P = 0.002), performance status (P = 0.018), age (P = 0.030) were the influence factors for QOL of elderly patients with advanced cancer. Conclusion The morbidity of anemia in elderly patients is increased and it affects the QOL of senior patients with advanced cancer.


Wang J.,Beijing Geriatric Hospital | Chen Z.,Beijing Geriatric Hospital | Song Y.,Beijing Geriatric Hospital
Ageing Research Reviews | Year: 2010

Falls are a common and serious problem for aged people, causing an enormous amount of morbidity, mortality and burden to both the immediate family and the society in terms of healthcare utilization and costs. In the Chinese mainland, epidemiological data indicates a predilection for single falls, with women more at risk than men. A variety of risk factors such as weakness, unsteady gait, mental confusion and use of certain medications are associated with falls in the elderly. Addressing these risk factors can be expected to reduce rates of falling. Targeted fall risk assessments are the most effective preventive procedures, and include a plethora of assessment instruments that have been developed and designed for different purposes over the decades. Strategies for control of elderly falls have been established differently, taking into account the complex physiological and pathological conditions of the elderly. The optimal approach involves interdisciplinary assessments, physical exercise, medical intervention, environmental inspection and hazard abatement. In China, the 25 million falls suffered annually by the estimated 20 million elderly population exacts direct medical costs of about 5 billion yuan and social costs of 60-80 billion yuan. Fall-prevention strategies will thus have profound social and economic benefits. © 2010 Elsevier B.V.


Song Y.,Beijing Geriatric Hospital | Wang J.,Beijing Geriatric Hospital
Ageing Research Reviews | Year: 2010

Studies of senile dementia (SD) on the Chinese mainland, done over the decades, have furthered the understanding of its epidemiology, basic and clinical medical aspects, and effects on health economics, to name a few areas. There are 6-7 million Chinese people with SD, with an incidence of 5-7% of people over 65 years of age. In this group, Alzheimer's accounts for 50-60% of SD. The pathogenesis of Alzheimer's disease has been investigated, and known risk factors include β-amyloid, formaldehyde, acetyl cholinesterase, inflammation, neuronal dysfunction and death. Mild cognitive impairment (MCI) is an independent risk factor of SD. Comprehensive treatment can improve clinical efficacy, and quality of life can be improved by appropriate and reasonable care and rehabilitation therapy. However, swallowing disorders, infection and systemic failure remain the main causes of death among SD patients. In the Chinese mainland, SD extracts a total annual economic loss of 83.5-97.4 billion yuan and is responsible for 51.3-59.8 billion yuan in annual healthcare costs. Despite the progress to date, basic research and drug development for SD are needed. Also, a more evidence-based approach to Chinese medicine research would be prudent. Such research results can hopefully provide valuable cues for governmental decision-making and assist in addressing and halting the incidence of SD in China. © 2010 Elsevier B.V.


Li J.H.,Beijing Geriatric Hospital
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

To observe the clinical efficacy of treating middle-aged and aged patients with knee osteoarthritis (KOA) of yang-deficiency induced cold-damp syndrome (YDICDS) by ozone combined Fugui Gutong Granule (FGG). Using a prospective, randomized controlled clinical trial, 200 KOA patients of YDICDS were randomly assigned to four groups. i.e., the control group (Group A), the Chinese medicine treatment group (Group B), the ozone group (Group C), and the Chinese-r medicine treatment plus ozone group (Group D).Patients in Group A took Voltaren Tablet. Those in Group B took FGG. Those in Group C received ozone injection (10 -18 mL) from knee joint cavity at 25 mg/L, once weekly for 4 weeks in total. Those in Group D received injection from knee joint cavity and took FGG. The therapeutic course for all was one month. The efficacy was assessed using visual analogue scale (VAS) and Western Ontario MacMaster University Osteoarthritis index (WOMAC). The VAS score was obviously lower in Group D than in Group B and Group A at 24 h and 1 week (P <0. 05). After one month of treatment, the VAS score was obviously lower in Group D than in Group A, B, and C (P < 0.05). After treatment the total integral of WOMAC was 25.34 +/- 2.12 in Group D, obviously lower than that in Group A (44.72 +/- 6.57), Group B (40.58 +/- 5.98), and Group C (38.53 +/- 5. 13), showing statistical difference (P <0.05). The pain score, the joint stiffness score, the score for daily activities were lower in Group D than in Group A (P <0.05). The cured and markedly effective rate was 76.0% in Group D, higher than that of Group A (25. 0%), Group B (25. 0%), and Group C (43.8%), respectively (P < 0.05). Ozone combined FGG had advantages in alleviating joint pain, and improving joint stiffness and daily activities of middle-aged and aged patients with KOA of YDICDS.


To establish whether the structural parameters provided by GDx can be used to reflect functional damage in the mean defect of visual field. 97 (191 eyes) patients with primary open angle glaucoma underwent examination with GDx and Octopus 1-2-3 automatic perimeter. The relationship between the retinal nerve fiber layer parameters and mean defect of visual field was analysed by ANOVA, Pearson's correlation(r), scatter plot and linear regression. The parameters of GDx decreased with increasing mean defect of visual field, measured both globally and regionally; r: SA = -0.58, TSNIT = -0.52, IA = -0.52, NFI = -0.48 and IES = -0.33. All parameters were negative correlation with mean defect of visual field and there was significant correlation among these parameters, except IES (P < 0.05). The superior mean defect of visual field increased with decreasing inferior RNFL (r = -0.61), inferior visual field mean defect increased with decreasing superior RNFL (r = -0.59). There were significant correlation among these parameters. Quantitative measures of the retinal nerve fiber layer using GDx were correlated with mean defect of visual field in patients with glaucoma. GDx can be used for follow up.

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