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Li J.H.,Beijing Geriatric Hospital
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2013

To observe the clinical efficacy of treating middle-aged and aged patients with knee osteoarthritis (KOA) of yang-deficiency induced cold-damp syndrome (YDICDS) by ozone combined Fugui Gutong Granule (FGG). Using a prospective, randomized controlled clinical trial, 200 KOA patients of YDICDS were randomly assigned to four groups. i.e., the control group (Group A), the Chinese medicine treatment group (Group B), the ozone group (Group C), and the Chinese-r medicine treatment plus ozone group (Group D).Patients in Group A took Voltaren Tablet. Those in Group B took FGG. Those in Group C received ozone injection (10 -18 mL) from knee joint cavity at 25 mg/L, once weekly for 4 weeks in total. Those in Group D received injection from knee joint cavity and took FGG. The therapeutic course for all was one month. The efficacy was assessed using visual analogue scale (VAS) and Western Ontario MacMaster University Osteoarthritis index (WOMAC). The VAS score was obviously lower in Group D than in Group B and Group A at 24 h and 1 week (P <0. 05). After one month of treatment, the VAS score was obviously lower in Group D than in Group A, B, and C (P < 0.05). After treatment the total integral of WOMAC was 25.34 +/- 2.12 in Group D, obviously lower than that in Group A (44.72 +/- 6.57), Group B (40.58 +/- 5.98), and Group C (38.53 +/- 5. 13), showing statistical difference (P <0.05). The pain score, the joint stiffness score, the score for daily activities were lower in Group D than in Group A (P <0.05). The cured and markedly effective rate was 76.0% in Group D, higher than that of Group A (25. 0%), Group B (25. 0%), and Group C (43.8%), respectively (P < 0.05). Ozone combined FGG had advantages in alleviating joint pain, and improving joint stiffness and daily activities of middle-aged and aged patients with KOA of YDICDS. Source


Wang P.,CAS Institute of Psychology | Wang P.,University of Chinese Academy of Sciences | Li J.,CAS Institute of Psychology | Li H.,CAS Institute of Psychology | Zhang S.,Beijing Geriatric Hospital
Behavioral and Brain Functions | Year: 2013

Background: It has been established that the overall performance of associative memory was disproportionately impaired in contrast to item memory in aMCI (Amnestic mild cognitive impairment) patients, but little is known about the specific aspects of the memory process that show differences between aMCI and healthy controls. By comparing an item-item associative learning test with an individual item learning test, the present study investigated whether the rate of learning was slower in associative memory than in item memory in aMCI. Furthermore, we examined whether deficits in intertrial acquisition and consolidation contributed to the potential disproportionate impairments in the learning rate of associative memory for aMCI patients. In addition, we further explored whether the aMCI-discriminative power of the associative memory test increases more than that of the item memory test when the number of learning-test trials increases.Methods: A group of 40 aMCI patients and 40 matched control participants were administered a standardized item memory test (Auditory Verbal Learning Test, AVLT) and a standardized associative memory test (Paired Associative Learning Test, PALT), as well as other neuropsychological tests and clinical assessments.Results: The results indicated that the learning rate deficits in aMCI patients were more obvious for associative memory than for item memory and that the deficits resulted from impairments in both intertrial acquisition and consolidation. In addition, the receiver operating characteristic curve and logistical regression analysis revealed that the discriminative power of the associative memory test for aMCI was larger than that of the item memory test, especially with more than one learning-test trials.Conclusions: Due to more deficits in learning rate of associative memory than that of item memory, the discriminative power for aMCI tended to be larger in associative memory than in item memory when the number of learning-test trials increased. It is suggested that associative memory tests with multiple trials may be particularly useful for early detection of aMCI. © 2013 Wang et al.; licensee BioMed Central Ltd. Source


Chen J.-H.,Beijing Geriatric Hospital
National Medical Journal of China | Year: 2011

Objective: To establish whether the structural parameters provided by GDx can be used to reflect functional damage in the mean defect of visual field. Methods: 97 (191 eyes) patients with primary open angle glaucoma underwent examination with GDx and Octopus 1-2-3 automatic perimeter. The relationship between the retinal nerve fiber layer parameters and mean defect of visual field was analysed by ANOVA, Pearson's correlation (r), scatter plot and linear regression. Results: The parameters of GDx decreased with increasing mean defect of visual field, measured both globally and regionally; r:SA = -0.58, TSNIT = -0.52, IA = -0.52, NFI = -0.48 and IES = -0.33.All parameters were negative correlation with mean defect of visual field and there was significant correlation among these parameters, except IES(P < 0.05). The superior mean defect of visual field increased with decreasing inferior RNFL (r = -0.61), inferior visual field mean defect increased with decreasing superior RNFL (r = -0.59). There were significant correlation among these parameters. Conclusion: Quantitative measures of the retinal nerve fiber layer using GDx were correlated with mean defect of visual field in patients with glaucoma. GDx can be used for follow up. © 2011 by the Chinese Medical Association. Source


To establish whether the structural parameters provided by GDx can be used to reflect functional damage in the mean defect of visual field. 97 (191 eyes) patients with primary open angle glaucoma underwent examination with GDx and Octopus 1-2-3 automatic perimeter. The relationship between the retinal nerve fiber layer parameters and mean defect of visual field was analysed by ANOVA, Pearson's correlation(r), scatter plot and linear regression. The parameters of GDx decreased with increasing mean defect of visual field, measured both globally and regionally; r: SA = -0.58, TSNIT = -0.52, IA = -0.52, NFI = -0.48 and IES = -0.33. All parameters were negative correlation with mean defect of visual field and there was significant correlation among these parameters, except IES (P < 0.05). The superior mean defect of visual field increased with decreasing inferior RNFL (r = -0.61), inferior visual field mean defect increased with decreasing superior RNFL (r = -0.59). There were significant correlation among these parameters. Quantitative measures of the retinal nerve fiber layer using GDx were correlated with mean defect of visual field in patients with glaucoma. GDx can be used for follow up. Source


Li R.,Chinese Academy of Sciences | Li R.,CAS Institute of Psychology | Yu J.,Chinese Academy of Sciences | Yu J.,Southwest University | And 8 more authors.
PLoS ONE | Year: 2013

Alzheimer's disease (AD) is associated with abnormal functioning of the default mode network (DMN). Functional connectivity (FC) changes to the DMN have been found in patients with amnestic mild cognitive impairment (aMCI), which is the prodromal stage of AD. However, whether or not aMCI also alters the effective connectivity (EC) of the DMN remains unknown. We employed a combined group independent component analysis (ICA) and Bayesian network (BN) learning approach to resting-state functional MRI (fMRI) data from 17 aMCI patients and 17 controls, in order to establish the EC pattern of DMN, and to evaluate changes occurring in aMCI. BN analysis demonstrated heterogeneous regional convergence degree across DMN regions, which were organized into two closely interacting subsystems. Compared to controls, the aMCI group showed altered directed connectivity weights between DMN regions in the fronto-parietal, temporo-frontal, and temporo-parietal pathways. The aMCI group also exhibited altered regional convergence degree in the right inferior parietal lobule. Moreover, we found EC changes in DMN regions in aMCI were correlated with regional FC levels, and the connectivity metrics were associated with patients' cognitive performance. This study provides novel sights into our understanding of the functional architecture of the DMN and adds to a growing body of work demonstrating the importance of the DMN as a mechanism of aMCI. Copyright: © 2013 Li, et al. Source

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