Beijing Datsing Gio Technology Co.

Beijing, China

Beijing Datsing Gio Technology Co.

Beijing, China
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Lu M.,General Hospital of PLA | Zhang X.-S.,General Hospital of PLA | Chang L.,Beijing Datsing Gio Technology Co. | Cui X.-A.,Beijing Datsing Gio Technology Co. | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Foreign injectable sulphate calcium has good biocompatibility, injectability and in situimmobilization, moulding based on adaptation to the shape of bone defects, but the price is expensive. OBJECTIVE: To explore the optimal fabricating parameters of bone repair materials with a-calci urn sulfate hemihydrates as the main component, and to study the performance and characterization METHODS: α-Calciumsulfate hemihydrates powder was mixed with sodium hyaluronate at liquid-solid-ratios of 0. 2, 0. 25, 0. 3, 0. 35, 0. 4 mL/g using vapor-heat method to prepare injectable bone materials. Performance, setting time and compressive strength of the injectable bone was detected. The best liquid-solid-ratio was 0. 3 mL/g. a-Calcium sulfate hemihydrates powder was mixed with calcium sulfate dihydrate powder (1%, 2%, 3% mass fractionas) to fabricate injectable bone materials. Performance, setting time and compressive strength of the injectable bone was also detected; meanwhile, the biosafety of the injectable bone was determined. The injectable bone material that was made at the liquid-solid-ratio of 0. 3 mL/g and by 2% calcium sulfate dihydrate was implanted into Ba-ma swine models of thoracic bone defects. At the time points of 8, 16 and 24 weeks after implantation, histological observation was done. RESULTS AND CONCLUSION: The injectable bone material was made at the liquid-solid-ratio of 0. 3 mL/g and by 2% calcium sulfate dihydrate. The initinl and final setting time was 4. 0-5. 0 minutes and 8. 0-9. 0 minutes, respectively. The compressive strength of the injectable bone reached (8. 93±0. 23) MPa. These findings indicate that the injectable boen material has good performance, initial setting time and compressive strength meeting the requirements of clinical application and good biosafety. Animal experiments show that the injectable bone can provide space for new bone in creeping substitution way by auto-degradation, with osteogenic activity. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.

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