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Huang S.,Beijing Childrens Hospital
Zhonghua er ke za zhi. Chinese journal of pediatrics | Year: 2010

To investigate the clinical characteristics of children with Castleman's disease and to improve doctors' awareness of this disease. Clinical characteristics of 5 cases with Castleman's disease were observed and analyzed and relevant reports in literature were reviewed. (1) All the five patients' histories were long, and the first symptoms of them were painless lymphnode enlargement, and all of them were at school age; 3 patients' abdominal lymphnodes were enlarged, mediastinum lymphnodes enlarged in 3 cases, cervical lymphnodes were involved in 3 cases; (2) The clinical subtypes: the disease in 3 cases was localized Castleman's disease (LCD), all of their pathological subtype was hyaline vascular variant (HV). The rest of them were multicentric Castleman's disease (MCD), whose pathology was plasma cell variant (PC), and both of them had a febrile symptoms; (3) The white blood cells, C-reactive protein and ferritin levels were all elevated to different extents. Four of them had viral infections, and their cellular immune function was abnormal; (4) The LCD patients' prognosis was good after the complete resection. There is no standard therapy for MCD, the available therapies include antiviral, immune modulatory regimens, CD20 B cell monoclonal antibody and chemotherapy, but the prognosis was worse than that of LCD. Castleman's disease is rare in children, which can be misdiagnosed because it has no specific manifestations. The prognosis depends on the subtype. Source

Fang T.,Capital Medical University | Yan R.,Sanbo Neurosurgical Hospital | Fang F.,Beijing Childrens Hospital
Journal of Neurosurgery: Pediatrics | Year: 2014

The authors describe the case of a spontaneous out-of-body experience (OBE) in a 15-year-old right-handed boy with intractable epilepsy in whom psychosis had been misdiagnosed. After successful resection of a right temporoparietal focal cortical dysplasia, the OBE and seizures resolved. The authors analyzed the underlying causes of the OBE and discussed the mechanism of the OBE caused by an epileptic lesion. © AANS, 2014. Source

Mishra V.,University of Texas Southwestern Medical Center | Cheng H.,Beijing Childrens Hospital | Cheng H.,Capital Medical University | Gong G.,Beijing Normal University | And 3 more authors.
Frontiers in Human Neuroscience | Year: 2013

The human brain development is a complicated yet well-organized process. Metrics derived from diffusion tensor imaging (DTI), including fractional anisotropy (FA), radial (RD), axial (AxD), and mean diffusivity (MD), have been used to noninvasively access the microstructural development of human brain white matter (WM). At birth, most of the major WM tracts are apparent but in a relatively disorganized pattern. Brain maturation is a process of establishing an organized pattern of these major WM tracts. However, how the linkage pattern of major WM tracts changes during development remains unclear. In this study, DTI data of 26 neonates and 28 children around puberty were acquired. 10 major WM tracts, representing four major tract groups involved in distinctive brain functions, were traced with DTI tractography for all 54 subjects. With the 10 by 10 correlation matrices constructed with Spearman's pairwise inter-tract correlations and based on tract-level measurements of FA, RD, AxD, and MD of both age groups, we assessed if the inter-tract correlations become stronger from birth to puberty. In addition, hierarchical clustering was performed based on the pairwise correlations of WM tracts to reveal the clustering pattern for each age group and pattern shift from birth to puberty. Stronger and enhanced microstructural inter-tract correlations were found during development from birth to puberty. The linkage patterns of two age groups differ due to brain development. These changes of microstructural correlations from birth to puberty suggest inhomogeneous but organized myelination processes which cause the reshuffled inter-tract correlation pattern and make homologous tracts tightly clustered. It opens a new window to study WM tract development and can be potentially used to investigate atypical brain development due to neurological or psychiatric disorders. © 2013 Mishra, Cheng, Gong, He, Dong and Huang. Source

Guo L.,Chinese Academy of Sciences | Xu X.,Beijing Childrens Hospital | Song J.,Chinese National Institute for Viral Disease Control and Prevention | Wang W.,Chinese Academy of Sciences | And 3 more authors.
Journal of Medical Virology | Year: 2010

Human astroviruses (HAstVs) have been recognized as one of the major causes of acute gastroenteritis in children. To provide more insight into the prevalence of HAstV gastroenteritis in China, 664 fecal samples were collected from children affected with acute gastroenteritis in Beijing from March 2005 to November 2007. The samples were analyzed genetically. All eight serotypes (genotypes) of HAstVs were screened using RT-PCR assays targeting the ORF2 region in the study. The assays detected HAstVs in 52 (7.8%) of the patients, with HAstV-1 (50/52) being the dominant genotype during the study period. Two minor genotypes, HAstV-6 and HAstV-3, were also detected. Partial sequencing of the 50 HAstV-1 strains showed that the homology of the nucleotide sequence of the ORF1a region between these strains was 88.4-100%, whereas the homology of the amino acid sequences was 95.6-100%. In the ORF2 partial region, the nucleotide identities ranged from 91.5% to 100%, and amino acid identities ranged from 97.3% to 100%. The identity of the whole genome sequence between four randomly examined HAstV-1 strains was 91-99%. No recombination events were observed in HAstVs in this study. The findings of this study will provide baseline data for HAstVs surveillance and control. © 2010 Wiley-Liss, Inc. Source

Diao M.,Capital Institute of Pediatrics | Li L.,Capital Institute of Pediatrics | Zhang J.-Z.,Beijing Childrens Hospital | Cheng W.,Monash Medical Center
Journal of Pediatric Surgery | Year: 2010

Background: Conventionally, an adult's standard of a 40-cm loop is adopted in Roux-Y hepatojejunostomy (RYHJ) in choledochal cyst (CDC) in children, irrespective of patient size. The redundant length of the jejunal limb may lead to complications. We compared the outcome of an individualized short Roux loop with the standard loop length in RYHJ in children with CDC. Methods: Two hundred eighteen children with CDC undergoing laparoscopic RYHJ were prospectively randomized into 2 groups: (1) conventional group (CG; n = 108) where a standard 35-40 cm Roux-loop length was used regardless of the child's size and (2) short loop group (SLG; n = 110) in which the Roux-loop length was based on the distance between hepatic hilum and umbilicus. Ultrasonography, upper gastrointestinal contrast studies, and laboratory tests were conducted during the follow-up period. Results: The mean Roux-loop length of SLG was significantly shorter than that of CG (Student t test, P < .05). There was no significant difference between the 2 groups in age, operative blood loss, operative time, postoperative hospital stay, and duration of drainage. In CG, 2 of (1.8%) 108 patients developed Roux-loop obstruction, whereas none was detected in SLG (0%). Mild reflux was detected in 2 CG patients and 1 SLG patient 1 month postoperatively, all of which subsided 6 months later. No episodes of cholangitis were observed in either group. Conclusions: An individualized short Roux-loop length in RYHJ is as effective as the conventional Roux-loop length. © 2010 Elsevier Inc. All rights reserved. Source

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