PubMed | Beijing Chaoyang Hospital Beijing and Peoples Hospital of the Xinjiang Uygur Autonomous Region
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015
To investigate the correlation of macrophage inflammatory protein-1 (MIP-1) gene single nucleotide polymorphisms (SNP) with the susceptibility to pigeon breeders lung (PBL) in Chinese Uygur population.A total of 92 Uygur from Xinjiang, China were enrolled in the study. Among them, there were 32 patients with PBL, 30 negative controls with history of exposure to pigeons and 30 normal controls without pigeons contact. SNP genotyping for 24 SNPs of MIP-1 were performed.Genotype distribution of MIP-1 SNPs rs1049191, rs1049195, rs3210166, rs1130374 and rs5029407 were significantly different among the three groups (P<0.05).MIP-1 SNPs rs1049191, rs1049195, rs3210166, rs1130374 and rs5029407 might have correlation with the susceptibility to pigeon breeders lung in Chinese Uygur population.