Entity

Time filter

Source Type


Xin N.,Beijing Institute of Technology | Yang F.-J.,University of Sichuan | Li Y.,Beijing Institute of Technology | Li Y.-J.,Beijing Institute of Technology | And 4 more authors.
Phytomedicine | Year: 2013

Dragon's blood is a bright red resin obtained from Dracaena cochinchinensis (Lour.) S.C.Chen (Yunnan, China). As a traditional Chinese medicinal herb, it has great traditional medicinal value and is used for wound healing and to stop bleeding. Its main biological activity comes from phenolic compounds. In this study, phenolic compounds were made into dropping pills and their protective effects were examined by establishing focal cerebral ischemia rats model used method of Middle Cerebral Artery Occlusion (MCAO), and by investigating indexes of neurological scores, infarct volume, cerebral index, cerebral water content and oxidation stress. Compared to model group, high, middle and low groups of Dragon's blood dropping pills could improve the neurological function significantly (p < 0.01) and reduce cerebral infarct volume of focal cerebral ischemia rats remarkably (p < 0.05-0.01). Meanwhile, each group could alleviate cerebral water content and cerebral index (p < 0.05-0.01) and regulate oxidative stress of focal cerebral ischemia rats obviously (p < 0.05-0.01). Activities of middle group corresponded with that treated with positive control drug. The results obtained here showed that Dragon's blood dropping pills had protective effects on focal cerebral ischemia rats. © 2013 Elsevier GmbH. All rights reserved. Source


Liu F.,Beijing Institute of Technology | Dai R.-J.,Beijing Institute of Technology | Lu F.,Beijing Institute of Technology | Meng W.-W.,Beijing Institute of Technology | And 2 more authors.
Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology | Year: 2014

Using various chromatographic techniques including column chromatography of silica gel, polyamide and Sephadex-LH20, four flavanes, two stilbenes and four steroids are isolated from the total phenols extract of dragon's blood. These compounds are identified by analyzing the chemical characters and spectroscopic data of the 1H NMR, 13C NMR and MS. They are 4', 7-dihydroxyflavane, 7-hydroxy-4'-methoxyflavane, 4', 7-dihydroxy-3'-methoxy-8-methylflavane, 4', 7-dihydroxyhomoisoflavane, pterostilbene, trans-4', 5-dihydroxy-3-methoxy-diphenylthene, stigmasterol, 4-methyl-cholesta-7-ene-3β-ol, cycloartanol and diosgenin. Among them, 4', 7-dihydroxy-3'-methoxy-8-methylflavane, trans-4', 5-dihydroxy-3-methoxy-diphenylethene, cycloartanol and 25(R)-diosgenin are isolated from the resin of Dracaena Co. chinchinensis(Lour.)S. C. Chen for the first time. Source


Jia S.-H.,Beijing Institute of Technology | Lv F.,Beijing Institute of Technology | Dai R.-J.,Beijing Institute of Technology | Meng W.-W.,Beijing Institute of Technology | And 2 more authors.
Journal of Asian Natural Products Research | Year: 2014

Two new C-21 steroidal glycosides, dregeosides D (1) and E (2), were isolated from the roots of Dregea sinensis. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR spectra and HR-ESI-MS analysis. Finally, the inhibited effects of the isolated compounds on interleukin 2 receptor were evaluated by enzyme-linked immunosorbent assay. © 2014 Taylor & Francis. Source


Jia S.,Beijing Institute of Technology | Liu X.,Beijing Institute of Technology | Dai R.,Beijing Institute of Technology | Meng W.,Beijing Institute of Technology | And 3 more authors.
Phytochemistry Letters | Year: 2015

The phytochemical investigation of the roots of Dregea sinensis Hemsl yielded six new polyhydroxy steroidal glycosides (1-6). The chemical structures have been elucidated on the basis of extensive one- and two-dimensional NMR spectroscopy, as well as by mass spectrometry. The cytotoxic activity of these compounds were evaluated in vitro while compounds 3 and 4 showed weak activity against human leukemia cells (HL-60) with IC50 values of 14.10 μM and 19.16 μM, respectively. © 2015 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe. Source


Teng Z.Q.,Beijing Institute of Technology | Li Y.J.,Beijing Institute of Technology | Dai R.J.,Beijing Institute of Technology | Gu H.,Beijing Institute of Technology | And 6 more authors.
Asian Journal of Chemistry | Year: 2012

A simple, rapid and sensitive HPLC-UV method for determining 2"-O-rhamnosylswertisin in rat plasma was developed. Sample preparations were carried out by protein precipitation with acetonitrile, followed by the evaporation of the acetonitrile to dryness. The analyses were carried out on a Kromasil C 18 (250 mm × 4.6 mm, 5 μm) column kept at room temperature (25 ± 3 °C) using a mobile phase composed of acetonitrile-water-glacial acetic acid (19.9:80:0.1, v/v/v). The flow rate was 1 mL min -1. The recovery, stability, inter- and intra-day precisions and accuracy for all samples were satisfactory. The method was applied to the pharmacokinetics study of 2"-O-rhamnosylswertisin after oral administration of 13 g kg -1 Belamcanda chinensis leaves extract to Wistar rats. Pharmacokinetics after intravenous administration of 10 mg kg -1 of 2"-O-rhamnosylswertisin and the absolute bioavailability was also studied. Source

Discover hidden collaborations