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Shi C.,Shanghai University of Traditional Chinese Medicine | Li H.,Beijing Army General Hospital | Yang Y.,Shanghai University of Traditional Chinese Medicine | Hou L.,Harvard University
Mediators of Inflammation | Year: 2015

Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring the unknown bioactivities of artemisinin derivatives. In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions. © 2015 Chenchen Shi et al. Source


Zhu H.Y.,Beijing Army General Hospital
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2012

Avascular necrosis is a progressively devastating disease and primarily affects weight-bearing joints. The hip is the most commonly affected joint. In early stage, nonoperative (including pharmacologic intervention and biophysical treatments) and operative modalities for protecting hip joint have become the main therapeutic methods. However there is still no satisfied mothod with reasonable effect. According to the treatment of the avascular necrosis of the femoral head of the pre-collapse stage, core decompression with modification of technique is still one of the safest and most commonly employed procedures. Recently there have been attempts to enhance the effect of core decompression with use of various growth and differentiation factors. Which is the hot spot of current research. Early diagnosis is the key to the treatment of the avascular necrosis of the femoral head. Comprehensive treatment which is based on the core decompression is still the main treatment of today. Source


Wang D.,National Spinal Injuries Center | Sun T.,Beijing Army General Hospital
Spinal Cord | Year: 2011

Study design: Literature review. Objective: To study the progress that has been made in neural plasticity for the past few decades. Setting: United Kingdom/China. Methods: An electronic search of relevant publications through PubMed was conducted using two key words: 'axonal regeneration' and 'neural plasticity'. The search included publications of the past three decades of all languages and of both animal and human studies. After confirmation of immense increase of publications on neural plasticity, reviewing of neural plasticity alone was conducted. The review covered only the most important and clinically relevant publications. For convenience of reading by busy clinicians, discussions focused on cellular and functional levels, and only the most investigated molecules were mentioned. The size of references is also planned to be concise rather than comprehensive into three digits. Results: Neural plasticity is about memory and learning. The entire process of neural plasticity is presented in the sequence of (1) lesion-induced plasticity, (2) clearance of debris, (3) collateral sprouting (4) potentiation. The recent discovery and understanding of the important role of Chondroitinase in clearance of debris is discussed in detail. Conclusion: Neural plasticity has enormous potentials in facilitating functional recovery. It is a realistic target than structural axonal regeneration at current level of neuroscience. © 2011 International Spinal Cord Society All rights reserved. Source


Li S.,Beijing Army General Hospital
Chinese Journal of Gastroenterology | Year: 2015

Crohn's disease (CD) is a chronic, progressive and destructive intestinal inflammatory disease, frequently associated with tissue and functional damage in intestinal tract. There is no specific clinical feature at its early stage, 30%~50% of the patients are associated with various complications at the time of diagnosis and are quite difficult to cure. Opportunistic screening performed in high risk population is a valuable strategy for early finding (pre-lesion of CD) and early diagnosis (CD without complication). Colonoscopy and screening of serum and fecal markers might be the methods for early diagnosis. Early treatment may alter the natural history of the disease. COPYRIGHT © 2015 by the Editorial Office of Chinese Journal of Gastroenterology. Source


Li S.Y.,Beijing Army General Hospital
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2010

To evaluate the clinical efficacy, feasibility and safety of sphincter-preservation with telescopic anastomosis of colon and rectal mucosa in low-middle rectal cancer. A retrospective analysis was carried out in 371 patients with low-middle rectal cancer in whom telescopic anastomosis was used. There were 224 males and 147 females, with a mean age of 57.9 (21-99) years. The lower margins of the tumors located between 5-8 cm from the anal verge. On histopathology, there were 361 adenocarcinomas, including 138 well-differentiated, 201 moderately differentiated, 11 poorly differentiated, 11 mucinous adenocarcinoma, and 10 adenomas with neoplastic changes. According to the Duke's stage classification, 120 were TNM stage I, 222 stage II, 26 stage III, and 3 stage IV. Three hundred and eighteen (318/371, 85.7%) cases were followed up, and the median follow up time was 5.8 years. Postoperative complications were observed, including 16(4.3%) cases with anastomotic leak, and 8 (2.1%) with anastomotic stenosis. All the patients resumed normal bowel function during 12-24 weeks after operation, with 1-3 times per day. The local recurrence rate was 6.3% (20/318). Hepatic and lung metastasis was 14.5% (46/318) and 2.5% (8/318), respectively. The 5-year survival rate was 69.7%. The sphincter-preservation with telescopic anastomosis procedure is safe and effective for low-middle rectal cancer, and the sphincter function can be well-preserved. Source

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