Brea, CA, United States
Brea, CA, United States

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Patent
Beckman Coulter Inc. | Date: 2015-04-27

The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation.


Patent
Beckman Coulter Inc. | Date: 2016-09-30

The invention concerns a laboratory product transport element for a laboratory transport system with an energy receiver and/or energy accumulator to provide drive power, at least one signal receiver to receive control signals, a control unit to generate drive signals as a function of at least one control signal obtained from the at least one signal receiver, movement devices for independent movement of the laboratory product transport element on a transfer path as a function of the drive signals of the control unit, in which the drive devices are driven by the drive power and at least one holder to hold a laboratory product being transported. The invention also concerns a laboratory transport system with at least one laboratory product transport element according to an embodiment of the invention and a transfer path arrangement. The invention also concerns methods for operation of laboratory transport systems according to an embodiment of the invention.


Patent
Beckman Coulter Inc. | Date: 2016-06-21

The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.


Patent
Beckman Coulter Inc. | Date: 2015-08-06

Embodiments of the invention are directed to a transfer apparatus and a transport system which may be used in automated medical laboratory in-vitro diagnostic systems for handling patient samples. The transfer apparatus an embodiment of the invention comprises a rotatable disc and a lane gate. The transport system according to an embodiment of the invention comprises a transfer path arrangement including at least a first input lane and two output lanes at the transfer apparatus (i.e., the rotatable disc and the lane gate). The rotatable disc and the lane gate are cooperatively structured to function together to move at least one laboratory product transport element between the at least one input lane and the two output lanes of the transport system. The laboratory product transport element transports laboratory products, such as patient samples.


Patent
Beckman Coulter Inc. | Date: 2015-07-29

Embodiments of the present invention encompass automated systems and methods for analyzing white blood cell parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological sample with an evaluation of white blood cell conditions in the individual.


Patent
Beckman Coulter Inc. | Date: 2016-08-12

An analytical laboratory system and method for processing samples is disclosed. A sample container is transported from an input area to a distribution area by a gripper comprising a means for inspecting a tube. An image is captured of the sample container. The image is analyzed to determine a sample container identification. A liquid level of the sample in the sample container is determined. A scheduling system determines a priority for processing the sample container based on the sample container identification. The sample container is transported from the distribution area to a subsequent processing module by the gripper.


Patent
Beckman Coulter Inc. | Date: 2016-06-23

Methods and apparatuses for determining exosome purity are disclosed. In an example embodiment, a laboratory instrument apparatus includes an analytical centrifuge configured to rotate a solution causing a plurality of particles to separate. The analytical centrifuge is also configured to perform an interference measurement on the solution and/or three absorbance measurements on the solution. A computer processor communicatively coupled to the analytical centrifuge is configured to determine an exosome purity of the solution based on the three absorbance measurements and/or the interference measurement.


Patent
Beckman Coulter Inc. | Date: 2015-08-05

In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.


Patent
Beckman Coulter Inc. | Date: 2016-09-12

The present invention provides methods and systems to combine the capabilities of a hematology analyzer with those of a flow cytometer to yield a far more powerful analytical system than either device alone. In one embodiment, a method of analyzing a cell sample includes receiving a first data generated by an analysis of a first aliquot of the sample on a first particle analyzer having a fluorescence measurement device such as a flow cytometer, detecting at least one unresolved cell population in the first data, and accessing a second data stored on a storage device wherein the second data was previously generated by interrogating a second aliquot of the sample using at least one of a cell volume measurement device and a cell conductivity measurement device in a second particle analyzer such as a hematology analyzer. The unresolved cell population in the first data is then resolved using the second data. Corresponding system embodiments are also disclosed.


Patent
Beckman Coulter Inc. | Date: 2016-12-14

The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.

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