Time filter

Source Type

Cao M.,Anhui University | Song X.,Anhui University | Zhang Y.,Anhui University | Xu C.,Anhui University | And 5 more authors.
Journal of Nano Research | Year: 2017

pH responsive polymeric nanoparticles have emerged as a promising technology platform for targeted and controlled drug delivery in recent years. In this paper, endosomal pH-activatable doxorubicin (DOX) and core-crosslinked polymeric nanoparticles (DCNPs) were prepared and investigated for potent growth inhibition of human cancer cells in vitro. In vitro drug release studies, DOX conjugated nanoparticles with hydrazone bond showed a pH sensitive release phenomenon, that is, the releasing is significantly faster at mildly acidic condition with pH of 5.5 than that at physiological condition. Confocal laser scanning microscope (CLSM) observations revealed that DOX conjugated nanoparticles delivered and released DOX into the cytosols as well as cell nuclei of Hela cells following 6 h incubation. MTT assays demonstrated that these pH-sensitive DOX nanoparticles exhibited high antitumor effect to HeLa cells. The conjugated DOX polymeric nanoparticles may be a promising candidate as a nanoscale and pH-sensitive drug delivery vehicle for cancer therapy. © 2017 Trans Tech Publications.


Wu K.,Bayingolin Vocational and Technical College | Yang J.,Bayingolin Vocational and Technical College
Materials Research Bulletin | Year: 2013

The carbon coated Li3V2(PO4) 3/reduced graphene oxide (LVP@C/rGO) composite is successfully synthesized by a conventional solid-state reaction, which is easily scaled up. LVP grains coated with a thin layer (∼8 nm) of carbon are adhered to the surface of the rGO layer and/or enwrapped into the rGO sheets, which can facilitate the fast charge transfer within the whole electrode and to the current collector. As a cathode material, the LVP@C/rGO electrode delivers an initial discharge capacity of 177 mAh g-1 at 0.5 C with capacity retention of 96% during the 50th cycle in a wide voltage range of 3.0-4.8 V. A superior rate capability is also achieved, e.g., exhibiting a discharge capacity of 96 mAh g-1 at a high C rate of 10 C. © 2012 Elsevier Ltd.


Wu K.,Bayingolin Vocational and Technical College
Ionics | Year: 2012

The Li 3V 2(PO 4) 3/multiwalled carbon nanotubes (LVP/MWCNTs) composite is successfully synthesized by a sol-gel route using oxalic acid as the chelating reagent. Its structure and physicochemical properties are investigated using X-ray diffraction, field-emission scanning electron microscopy, and electrochemical methods. LVP particles are well mixed with MWCNTs, and most of them are around 100 nm. The galvanostatic charge-discharge tests show that LVP/MWCNTs electrode owns an initial discharge capacity of 126 mAh g -1 at 0. 5 C with capacity retention of 94% during the 100th cycle in the voltage range of 3. 0-4. 3 V. A superior rate capability is also achieved, e. g., exhibiting discharge capacities of 75 and 58 mAh g -1 at high C rates of 10 and 15 C, respectively. © 2011 Springer-Verlag.


Zhu J.,Bayingolin Vocational and Technical College | Yang R.,Bayingolin Vocational and Technical College | Wu K.,Bayingolin Vocational and Technical College
Ionics | Year: 2013

The Li3V2(PO4)3/reduced graphene oxide (LVP/rGO) composite is successfully synthesized by a conventional solid-state reaction with a high yield of 10 g, which is suitable for large-scale production. Its structure and physicochemical properties are investigated using X-ray diffraction, Raman spectra, field-emission scanning electron microscopy, transmission electron microscopy, and electrochemical methods. The rGO content is as low as ~3 wt%, and LVP particles are strongly adhered to the surface of the rGO layer and/or enwrapped into the rGO sheets, which can facilitate the fast charge transfer within the whole electrode and to the current collector. The galvanostatic charge-discharge tests show that the LVP/rGO electrode delivers an initial discharge capacity of 177 mAh g-1 at 0. 5 C with capacity retention of 88 % during the 50th cycle in a wide voltage range of 3. 0-4. 8 V. A superior rate capability is also achieved, e. g., exhibiting discharge capacities of 137 and 117 mAh g-1 during the 50th cycle at high C rates of 2 and 5 C, respectively. © 2012 Springer-Verlag.

Loading Bayingolin Vocational and Technical College collaborators
Loading Bayingolin Vocational and Technical College collaborators