Bayindir Hospital

Ankara, Turkey

Bayindir Hospital

Ankara, Turkey
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Bayar S.A.,Baskent University | Kucukerdonmez C.,Izmir University | Oner O.,Fehime Faik Kocagoz Hospital | Akova Y.A.,Bayindir Hospital
International Ophthalmology | Year: 2014

The aim of this study is to evaluate the efficacy and safety of subconjunctival bevacizumab injection(s) in the treatment of impending recurrent pterygia. Twenty-three eyes of 23 patients who developed impending recurrence after pterygium surgery with conjunctival autografting and were treated with subconjunctival bevacizumab injection(s) (2.5 mg/0.1 mL) were included in the study. Anterior segment photographs were taken prior to and at 1 week, 1, 3 and 6 months after the injection, and at the end of the follow-up period. Image analysis was performed using an image processing and analysis software program. Recurrence rate and complications were recorded. The mean age and follow-up time of the patients were 51.2 ± 6.2 (31-60 years) and 16.8 ± 3.1 (12-22 months), respectively. The average number of injections was 2 ± 0.78 (1-3). Sixteen eyes required re-injection (two injections in nine eyes, three injections in seven eyes), due to progression of vascularization. There were significant differences between size percentage of lesions before injection and at 1 week, 1, 3 and 6 months after the injection (p < 0.05 for all). Corneal recurrence developed in only one patient and no ocular or systemic side-effects of bevacizumab were observed. Repeated injections of bevacizumab may help to prevent the high recurrence rate of residual impending pterygium, due to its adjuvant role in decreasing lesion size, especially in the first year after surgery. © Springer Science+Business Media 2013.

Baudouin C.,Center Hospitalier National dOphtalmologie des Qinze Vingts and Vision Institute | Aragona P.,Messina University | Messmer E.M.,Ludwig Maximilians University of Munich | Tomlinson A.,Glasgow Caledonian University | And 6 more authors.
Ocular Surface | Year: 2013

Dry eye disease (DED), a multifactorial disease of the tears and ocular surface, is common and has a significant impact on quality of life. Reduced aqueous tear flow and/or increased evaporation of the aqueous tear phase leads to tear hyperosmolarity, a key step in the vicious circle of DED pathology. Tear hyperosmolarity gives rise to morphological changes such as apoptosis of cells of the conjunctiva and cornea, and triggers inflammatory cascades that contribute to further cell death, including loss of mucin-producing goblet cells. This exacerbates tear film instability and drives the cycle of events that perpetuate the condition. Traditional approaches to counteracting tear hyperosmolarity in DED include use of hypotonic tear substitutes, which have relatively short persistence in the eye. More recent attempts to counteract tear hyperosmolarity in DED have included osmoprotectants, small organic molecules that are used in many cell types throughout the natural world to restore cell volume and stabilize protein function, allowing adaptation to hyperosmolarity. There is now an expanding pool of clinical data on the efficacy of DED therapies that include osmoprotectants such as erythritol, taurine, trehalose and L-carnitine. Osmoprotectants in DED may directly protect cells against hyperosmolarity and thereby promote exit from the vicious circle of DED physiopathology. © 2013 The Authors. Published by Elsevier Inc.

Sahin I.,Surgery Academy | Ozturk S.,Surgery Academy | Deveci M.,Numune Egitim Ve Arastirma Hastanesi | Ural A.U.,Bayindir Hospital | And 2 more authors.
Journal of Plastic, Reconstructive and Aesthetic Surgery | Year: 2014

Neo-vascularisation of the acellular dermal matrix (ADM) is an essential procedure if a full-thickness wound is closed with ADM and skin is grafted over the ADM. In this study, we aimed to improve the neo-vascularisation of ADM by combining the effects of negative pressure wound therapy (NPWT) and mesenchymal stem cells (MSCs) on angiogenesis. In this study, 28 female Sprague-Dawley rats were used and divided into four groups. Full-thickness dorsal skin defects were created in 2 × 2 cm dimensions. The wounds were treated with only the ADM in group 1, the ADM and NPWT in group 2, the ADM and MSCs in group 3 and the ADM, NPWT and MSCs in group 4. By the ninth day of surgery, the excisional biopsy samples were histologically examined to identify the rates of ADM adherence to the recipient bed; the newly formed blood vessels which penetrate the ADM vertically and vascularisation were evaluated by immunohistochemical staining. The graft adherence rates were higher in group 4 than in the other groups statistically, p = 0.003. The numbers of cluster of differentiation 31 (CD31)-stained newly formed microvessels were higher in group 4 than in the other groups statistically, p < 0.05. All subjects in group 4 had the vertical vessels in normal calibration with open lumen vessels which penetrate the ADM. These findings suggest that MSC transplantation induces angiogenesis more efficiently than NPWT. The combination of the NPWT with MSC in this study has shown a synergistic effect on angiogenesis and has affected the neo-vascularisation of the ADM significantly. © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Cekirge H.S.,Bayindir Hospital | Saatci I.,Ankara University
American Journal of Neuroradiology | Year: 2016

A new classification is proposed for cerebral aneurysms treated with any endovascular technique, for example, coiling with or without adjunctive devices, flow diversion, intrasaccular flow modifiers, or any combination of the above. Raymond-Roy Occlusion Classification is expanded with novel subgroups such as class 1 represents complete occlusion and is subdivided if a branch is integrated to, or originated from, the aneurysm sac; class 2 represents neck filling; class 3 represents incomplete occlusion with aneurysm filling as in the previous classification; and class 4 describes the immediate postoperative status after extra- or intrasaccular flow modification treatment. A new concept, "stable remodeling," is included as class 5, which represents filling in the neck region that stays unchanged or reduced, as shown with at least 2 consecutive control angiographies, at least 6 months apart, for not <1 year, or the remodeled appearance of a dilated and/or tortuous vessel in continuation with the parent artery without sac filling. © 2016, American Society of Neuroradiology. All rights reserved.

Bakar B.,Kirikkale University | Tekkok I.H.,Bayindir Hospital
Turkish Neurosurgery | Year: 2015

The extent of the slice thickness in spinal axial and sagittal magnetic resonance imaging (MRI) is limited. We therefore, propose the idea of using coronal MRI to better delineate lumbar far lateral disc herniations. Six patients with coronal MR images who underwent surgery are presented in this study. Simple 2D vertebral column X-ray and MRI scans were used to diagnose the far lateral herniated disc. Intraoperative findings confirmed our preoperative MRI diagnosis in all patients. Recovery was excellent in all patients. In conclusion, coronal lumbar MRI, a simple and useful technique to reveal the nerve roots in foraminal and/or far lateral (extraforaminal) areas, is a must for accurate diagnosis of foraminal and/or far lateral lumbar disc herniations.

Savas Tepe M.,Bayindir Hospital
Gulhane Medical Journal | Year: 2013

Aim: To compare the dysfunction and complication rates of small bore and large bore gastrostomy catheters. Material and Methods: A total of 521 patients (291 males, 230 females, mean age 56 years, range 16-90 years) underwent percutaneous fluoroscopic gastrostomy placement between August 2000 and January 2009. Choice of catheter was based on the preference of the Radiologist. Data was collected retrospectively with institutional review board approval. Radiology reports provided clinical history, indication for gastrostomy, information of the catheter, technical success, and immediate outcome. Post procedural complications and clinical outcomes were obtained. Results: All catheters were placed successfully. 15 patients with anatomic difficulties for G tube placement were discarded from the study. Patients who received large bore and small bore catheters were compared. Patients with larger catheters (18F) had fewer short and long term complications and tube dysfunction compared to patients with smaller bore catheters (14F). Discussion and Conclusions: Patients who received small bore gastrostomy catheters were significantly more prone to tube dysfunction. Large bore catheters should be preferred for fewer complications in short and long term. © Gülhane Askeri Tip Akademisi 2013.

Aim: Bronchial artery embolization is known to be effective in the acute control of hemoptysis secondary to cystic fibrosis complication. In this retrospective study 14-year-experience of our clinic with embolization for treatment of hemoptysis in patients with cystic fibrosis is reviewed. The results with coil and polyvinyl alcohol microparticule embolizations are demonstrated. Material and Method: 15 patients (age range 19-54) with cystic fibrosis presented with major or persistent hemoptysis that required 33 embolizations from September 1994 to November 2009. Results: Hemoptysis stopped within a day after embolization in all fifteen patients. There were no major immediate complications within 24 hours for coil only or polyvinyl alcohol microparticule only sessions or the combination of these. Mean survival duration after the first embolization was 58 months (average follow up 72 months; range 3-168 months, including all patients). One patient died, two patients underwent lung transplant during the follow up period. Conclusion: In our retrospective study with 15 patients and 33 embolization sessions which include 9 patients with more than one embolization demonstrated high success rate in short term. Long term results however showed that 9 out of 15 patients (60%) required repeated embolization. © Gülhane Askeri Tip Akademisi 2013.

Ergin R.N.,Bayindir Hospital | Yayla M.,International Hospital
Journal of the Turkish German Gynecology Association | Year: 2012

Objective: Measurement of intracranial translucency (IT), which is a recent earlier recognizable sonographic marker, has been suggested for detection of spina bifida. In this prospective study we aimed to determine normative values of IT in the population of Turkish singleton pregnant women during the first trimester of pregnancy. Material and Methods: Between January 2011 and July 2011, all consecutive singleton pregnant women were screened for intracranial translucency. Pregnancies were followed until birth. Pregnancies with any detected/suspicious anatomical or genetic fetal anomalies, biochemical abnormalities, increased nuchal translucency measurements, pregnancies of artificial reproduction techniques and anomaly detected at birth were set to be excluded from the data analyses. Mean±standard deviation, median and percentile values of intracranial translucency were calculated. Linear regression analyses were done between the length of intracranial translucency and gestational week and CRL. Results: Data analyses included 201 fetuses. Median maternal age was 31 years. Median CRL was 62 mm. Median gestational week was 12.57 weeks. Median IT value for the first trimester was 1.7 mm (range 1.00-2.40). Calculated formulae are; IT (mm)=[0.237xGestational Week)]-1.27, R 2=0.302; p<0.001 and IT (mm)=[0.020xCRL (mm)]+0.44, R 2=0.381; p<0.001). IT measurements increased with increasing CRL and advancing gestational weeks. During follow up none of the fetuses was found to have any anatomical abnormality or anomaly. Conclusion: This study presents normative values of intracranial translucency in the first trimester screening of normal singleton pregnancies of the Turkish population. In accordance with previous reports, intracranial translucency increases linearly with advancing CRL. © 2012 by the Turkish-German Gynecological Education and Research Foundation.

Objectives: The purpose of this study was to compare the sensitivity of gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI) and gadolinium-enhanced FLAIR (fluid attenuated inversion recovery) MRI in detecting leptomeningeal carcinomatosis. Method: In all patients, all routine brain imaging sequences were performed, including T1- and T2-weighted axial and coronal unenhanced spin-echo sequences, FLAIR axial unenhanced sequence, as well as contrast-enhanced FLAIR, and T1-weighted sequences. These sequences were used in the study group consisted of 12 patients (5 male, 7 female, age range: 51-82; 4 breast carcinoma, 4 lung carcinoma, 2 melanoma, 2 lymphoma) with proven leptomeningeal carcinomatosis disease. Comparisons were made particularly between enhanced T1- and FLAIR- enhanced images. Results: In all 12 patients with clinically proven leptomeningeal disease (10 metastatic carcinoma, 2 lymphoma), contrast-enhanced FLAIR sequence demonstrated better and more extensive and conspicuous enhancement when compared to contrast-enhanced T1 sequence. Discussion: Gadolinium-enhanced FLAIR images were superior to gadolinium-enhanced T1 sequences for detecting pathologic leptomeninges. © Archives of Neuropsychiatry, published by Galenos Publishing.

Camgoz A.,Izmir Institute of Technology | Gencer E.B.,Izmir Institute of Technology | Ural A.U.,Bayindir Hospital | Baran Y.,Izmir Institute of Technology
Leukemia and Lymphoma | Year: 2013

Multidrug resistance remains a significant obstacle to successful chemotherapy. The ability to determine the possible resistance mechanisms and surmount the resistance is likely to improve chemotherapy. Nilotinib is a very effective drug in the treatment of imatinib-sensitive or -resistant patients. Although very successful hematologic and cytogenetic responses have been obtained in nilotinib-treated patients, in recent years cases showing resistance to nilotinib have been observed. We aimed to examine the mechanisms underlying nilotinib resistance and to provide new targets for the treatment of chronic myeloid leukemia (CML). There was an up-regulation of antiapoptotic BCR/ABL, GCS and SK-1 genes and MRP1 transporter gene and down-regulation of apoptotic Bax and CerS1 genes in nilotinib-resistant cells. There was no mutation in the nilotinib-binding region of BCR/ABL in resistant cells. Inhibiton of GCS and SK-1 restored nilotinib sensitivity. Targeting the proteins that are involved in nilotinib resistance in addition to the inhibition of BCR/ABL could be a better method of treatment in CML. © 2013 Informa UK, Ltd.

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