Wu Y.-K.,Capital Medical University |
Wang S.-W.,Capital Medical University |
Ma J.-H.,Bayi Brain Hospital Affiliated to the General Hospital of Beijing Military Region |
Yi B.,Bayi Brain Hospital Affiliated to the General Hospital of Beijing Military Region |
And 4 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014
BACKGROUND: With the medical development, prognostic outcomes of spinal cord injuries have not been improved significantly, and most patients also suffer from severe complications. Nowadays, lots of laboratories and clinical researches have suggested that cell therapy has a great potential, especially the application of umbilical cord blood stem cells in nervous system diseases. OBJECTIVE: To explore the feasibility and clinical effect of umbilical cord blood neural stem cells transplantation for patients with obsolete spinal cord injury. METHODS: Umbilical cord blood was harvested from newborns under aseptic condition, and differentiated into neural stem cells in vitro that were prepared into cell suspension at a concentration of 109/L. The cell suspension (3 mL) was injected via the L3-4 or L4-5 into the subarachnoid space. American Spinal Injury Association (ASIA) scores and the residual urine were assessed before and 3 months after transplantation. RESULTS AND CONCLUSION: After transplantation, all the patients showed a stable life indication. Three months later, ASIA scores were increased and the residual urine decreased, which significantly differed from those before transplantation (P < 0.05). These findings indicate that umbilical cord blood neural stem cells transplantation is a new treatment that can improve the limb function and life quality of patients with obsolete spinal cord injury. © 2015 Journal of Clinical Rehabilitative Tissue Engineering Research, All rights reserved.