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Patent
Bayer Pharma Aktiengesellschaft | Date: 2017-03-15

Disclosed herein is a method for monitoring the concentration of at least one kind of contaminant in a fluid stream, comprising the steps of providing at least two unit operations, providing a fluid stream, which passes said at least two unit operations in a flow path, sampling the fluid stream in a predetermined valid manner, determining the contaminant concentration in the sample in order to monitor the contaminant concentration in the fluid stream, wherein the method is carried out under continuous, closed and pathogen-reduced conditions.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2017-03-22

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa polypeptide named C4.4a , which is over expressed in tumors. C4.4a has a high abundance in metastases of several cancer types. The antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2017-01-25

The present invention relates to compounds of general formula (I) :^(1), R^(2), R^(3), R^(4), R^(6), R^(7), R^(8), R^(9), R^(10), R^(11), R^(12), R^(13) and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2017-04-05

The present invention relates to substituted tetrahydropyridothienopyrimidine compounds of general formula(I)as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2016-10-07

The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2016-10-07

The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2016-05-19

The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2016-01-27

The present invention relates to amino-substituted isoxazoles of general formula (I):


The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.


Patent
Bayer Pharma Aktiengesellschaft | Date: 2016-05-11

The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.

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