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Hospital de Órbigo, Spain

Munoz-Navas M.,University of Navarra | Calleja J.L.,Hospital Universitario Puerta Of Hierro | Payeras G.,Hospital Infanta Elena Valdemoro | Hervas A.J.,Hospital General Universitario Reina Sofia | And 14 more authors.
International Journal of Colorectal Disease

Purpose: The purpose of this study is to compare the efficacy and acceptability of an evening-before regimens of sodium picosulfate/magnesium citrate (SPMC) and polyethylene glycol (PEG) as bowel cleansers and to explore the results of a same-day regimen of SPMC. Methods: Multicenter, randomized, observer-blinded, parallel study carried out in subjects who were 18–80 years old and were undergoing diagnostic colonoscopy for the first time. The primary outcome was treatment success, which was a composite outcome defined by (1) the evaluation of the overall preparation quality as “excellent” or “good” by two blinded independent evaluators with the Fleet® Grading Scale for Bowel Cleansing and (2) a subject’s acceptability rating of “easy to take” or “tolerable.” The primary outcome was analyzed using a logistic regression with site, gender, and age group (age ≥65 years and <65 years) as factors. Results: Four hundred ninety subjects were included in the efficacy evaluation. Although treatment success was significantly higher in subjects assigned to the evening-before regimen of SPMC vs. subjects assigned to the evening-before PEG, when evaluating the two individual components for treatment success, there were significant differences in the ease of completion but not in the quality of preparation. The same-day SPMC regimen was superior to both the evening-before regimen of SPMC and PEG in terms of the quality of preparation, especially regarding the proximal colon. Conclusions: An evening-before regimen of SPMC is superior to an evening-before regimen of PEG in terms of subject’s acceptability. The same-day SPMC regimen provides better cleansing levels in the proximal colon. © 2015, Springer-Verlag Berlin Heidelberg. Source

Hijona E.,University of the Basque Country | Sanchez-Gonzalez J.,Philips | Alustiza J.M.,Osatek | Hijona L.,Hospital Basurto | And 7 more authors.
European Journal of Radiology

Aim: To assess the diagnostic accuracy of a new reconstruction technique for gradient-recalled-echo magnetic resonance (MR) sequences that provides a full decomposition of the water and fat content inside a voxel for nonalcoholic fatty liver disease (NAFLD) in rats. Material and methods: Rats were randomized into two groups. A control group (n = 10) was given free access to regular dry rat chow for 4 weeks. The steatosis (n = 40) group was given free access to feed and water 4 days per week, and fasted for the remaining 3 days for 4 weeks. All rats were killed at 4 weeks and assessed for fatty infiltration and biochemical method. Results: The average fat content using the gold standard method was 2.65 g (2.20-3.05) of fat/100 g liver for the control group and 4.14 g (1.95-8.60) of fat/100 g of liver for the overfed group (p < 0.05). The average fat-fraction obtained from the MR was 0.016 (0.01-0.02) for the control group and 0.057 (0.00-0.18) for the overfed group. The Pearson correlation coefficient between the samples was r 2 = 0.87. Conclusion: Multi-echo MR is a good technique to quantify liver fat in rats. © 2011 Elsevier Ireland Ltd. All rights reserved. Source

de-la-Pena J.,Hospital Virtual Valdecilla | Calderon A.,Hospital Basurto | Esteban J.M.,Hospital Clinico San Carlos | Lopez-Roses L.,Hospital Lucus Augusti | And 7 more authors.
Revista Espanola de Enfermedades Digestivas

Background: Endoscopic submucosal dissection (ESD) is an effective but time-consuming treatment for early neoplasia that requires a high level of expertise. Objective: The objective of this study was to assess the efficacy and learning curve of gastric ESD with a hybrid knife with highpressure water jet and to compare with standard ESD.Material and methods: We performed a prospective nonsurvival animal study comparing hybrid-knife and standard gastric ESD. Variables recorded were: Number of en-bloc ESD, number of ESD with all marks included (R0), size of specimens, time and speed of dissection and adverse events. Ten endoscopists performed a total of 50 gastric ESD (30 hybrid-knife and 20 standard).Results: Forty-six (92 %) ESD were en-bloc and 25 (50 %) R0 (hybrid-knife: n = 13, 44 %; standard: n = 16, 80 %; p = 0.04). Hybrid-knife ESD was faster than standard (time: 44.6 ± 21.4 minutes vs. 68.7 ± 33.5 minutes; p = 0.009 and velocity: 20.8 ± 9.2 mm2/ min vs. 14.3 ± 9.3 mm2/min (p = 0.079). Adverse events were not different. There was no change in speed with any of two techniques (hybrid-knife: From 20.33 ± 15.68 to 28.18 ± 20.07 mm2/min; p = 0.615 and standard: From 6.4 ± 0.3 to 19.48 ± 19.21 mm2/min; p = 0.607). The learning curve showed a significant improvement in R0 rate in the hybrid-knife group (from 30 % to 100 %).Conclusion: despite the initial performance of hybrid-knife ESD is worse than standard ESD, the learning curve with hybridknife ESD is short and is associated with a rapid improvement. The introduction of new tools to facilitate ESD should be implemented with caution in order to avoid a negative impact on the results. © 2014 Arán Ediciones, S. L. Source

Martin-Guerrero I.,University of the Basque Country | Enjuanes A.,University of Barcelona | Richter J.,University of Kiel | Ammerpohl O.,University of Kiel | And 7 more authors.
Genes Chromosomes and Cancer

Chronic lymphocytic leukemia (CLL) cells are characterized by several chromosomal lesions. Some of these aberrations imply chromosome breaks as a result of unrepaired double strand breaks (DSBs) in the DNA. The ATM (ataxia telangiectasia-mutated) protein is the principal integrator of cellular responses to DSBs. ATM deletion is also an adverse prognostic factor in CLL. Taking this into account, we evaluated if genetic and/or epigenetic variation in the ATM gene may modulate the individual susceptibility to develop CLL. Our case-control association study was performed in a large Spanish population of 1,503 individuals, including 742 patients with CLL and 761 controls. We identified one haplotype within the ATM gene that confers an increased risk of CLL development (OR = 1.33; 95% CI: 1.10-1.60). Two polymorphisms of this ATM haplotype eliminated one CpG site each in Introns 15 and 61, causing changes in DNA methylation pattern. These data provide the first evidence for the existence of a putative "hepitype" in the ATM gene associated with CLL risk. © 2011 Wiley-Liss, Inc. Source

Muniz C.,University of Salamanca | Martin-Martin L.,University of Salamanca | Lopez A.,University of Salamanca | Sanchez-Gonzalez B.,Hospital Del Mar | And 19 more authors.

Flow cytometry (FCM) ismore sensitive than conventional cytology for detection of occult leptomeningeal lymphoma; however, some FCM-negative patients show central nervous system (CNS) recurrence. Here, we evaluated the cerebrospinal fluid (CSF) levels of 13 B-cell-associated markers and their contribution to the diagnosis of CNS lymphoma in 91 diffuse large B-cell lymphomas (DLBCL) and 22 Burkitt lymphomas (BLs). From all markers tested, CD19 wasthe most informative. Thus, higher soluble CD19 (sCD19) levels were associated with a greater frequency of neurological symptoms in DLBCL and BL and with parenchymal CNS lymphoma in DLBCL; sCD19 emerged as a powerful predictor of event-free and overall survival in DLBCL and BL, particularly when combined with FCM detection of CNS disease. These results support the utility of combined FCM detection of lymphoma cells and assessment of sCD19 levels in CSF, for more accurate identification of CNS disease in DLBCL and BL patients. © 2014 by The American Society of Hematology. Source

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