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Sharma T.,Central University of Rajasthan | Hamilton R.,Northwest Vista CollegeTX | Hamilton R.,Basis Science | Mandal C.C.,Central University of Rajasthan
Future Oncology | Year: 2015

miRNAs (miRs), or small approximately 22-nucleotide-long single-stranded noncoding RNA molecules, interact with 3′ untranslated regions of target mRNAs, leading to inhibition of protein production. miR-214 is often dysregulated in various cancers, which governs both tumorigenic and tumor suppressive functions. This review focuses on the current knowledge of miR-214 switching in diverse forms of cancer either by its upregulation or downregulation and sheds light on the mechanism of its tumorigenic and suppressive roles. This article describes known targets and signaling pathways that impact tumorigenesis and tumor suppression and summarizes all information available on circulating levels of miR-214 to address whether miR-214 may function as a potential biomarker and therapy for cancer patients in the future. © 2015 Future Medicine Ltd.

Mediterranean and Asian diets are currently considered as the most healthy traditional feeding habits effective against risk of age-associated, particularly cardiovascular and neurodegenerative, diseases. A common feature of these two regimens is the abundance of foods and beverages of plant origin (green tea, extra virgin olive oil, red wine, spices, berries, and aromatic herbs) that are considered responsible for the observed beneficial effects. Epidemiological data suggest that the phenolic component remarkably enriched in these foods plays an important role in reducing the incidence of amyloid diseases, pathological conditions associated to tissue deposition of toxic protein aggregates responsible for progressive functional deterioration. Great effort is being spent to provide knowledge on the effects of several natural phenols in this context, moving from the test tube to animal models and, more slowly, to the patient's bed. An emerging feature that makes these molecules increasingly attractive for amyloid disease prevention and therapy is their wide spectrum of activity: recent pieces of evidence suggest that they can inhibit the production of amyloidogenic peptides from precursors, increase antioxidant enzyme activity, activate autophagy and reduce inflammation. Our concept should than shift from considering natural phenols simply as antioxidants or, at the best, as amyloid aggregation inhibitors, to describing them as potentially multitargeting drugs. A main concern is the low bioavailability of such compounds and efforts aimed at improving it are underway, with encapsulation strategies being the most promising ones. © 2014 International Union of Biochemistry and Molecular Biology.

Rubinsten O.,Haifa University | Rubinsten O.,Basis Science | Sury D.,Haifa University
PLoS ONE | Year: 2011

In contrast to quantity processing, up to date, the nature of ordinality has received little attention from researchers despite the fact that both quantity and ordinality are embodied in numerical information. Here we ask if there are two separate core systems that lie at the foundations of numerical cognition: (1) the traditionally and well accepted numerical magnitude system but also (2) core system for representing ordinal information. We report two novel experiments of ordinal processing that explored the relation between ordinal and numerical information processing in typically developing adults and adults with developmental dyscalculia (DD). Participants made "ordered" or "non-ordered" judgments about 3 groups of dots (non-symbolic numerical stimuli; in Experiment 1) and 3 numbers (symbolic task: Experiment 2). In contrast to previous findings and arguments about quantity deficit in DD participants, when quantity and ordinality are dissociated (as in the current tasks), DD participants exhibited a normal ratio effect in the non-symbolic ordinal task. They did not show, however, the ordinality effect. Ordinality effect in DD appeared only when area and density were randomized, but only in the descending direction. In the symbolic task, the ordinality effect was modulated by ratio and direction in both groups. These findings suggest that there might be two separate cognitive representations of ordinal and quantity information and that linguistic knowledge may facilitate estimation of ordinal information. © 2011 Rubinsten, Sury.

Basis Science | Date: 2013-10-21

A system and a method are disclosed for identifying and characterizing a stress state of a user based on features of blood flow identified from optical signals. One embodiment of a disclosed system (and method) includes an optical sensing system to detect features of blood flow and identify and characterize a stress state of a user based on those blood flow features. Light transmitted or reflected from tissue of the user is measured by an optical sensor. A processor analyzes the received optical signal to identify features of the blood flow. The stress state of the user is determined based on the identified features. The stress state is characterized according to a type of stress, a level of stress or both. Additionally stress events are identified.

Basis Science | Date: 2011-12-23

A biometric device configured to be attached to a portion of a body of a user measures biometric data of the user. The device includes an optical emitter, a wavelength filter, an optical sensor and a processor, for sending a light to the body of a user, receiving light received from the user, filtering and processing it to measure biometric data of the user, including for example, heart rate and blood flow rate. In addition, the biometric device may include other sensors, such as a galvanic skin response sensor, an ambient temperature sensor, skin temperature, motion sensor, etc., to enable the biometric device to measure arousal or conductivity changing events, ambient temperature, user temperature and motion associated with the user. Additionally, information from each sensor may be used to further filter noise in one or more signals received by the sensors to provide biometric data to the user.

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