Basilea Pharmaceutica China Ltd.

Jiaojiang, China

Basilea Pharmaceutica China Ltd.

Jiaojiang, China

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Zheng S.,Shanghai University of Traditional Chinese Medicine | Fu R.,East China University of Science and Technology | Shen Z.,Shanghai University of Traditional Chinese Medicine | Shen Z.,Basilea Pharmaceutica China Ltd.
Chinese Journal of Chemistry | Year: 2012

We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activity of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells. Copyright © 2012 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zheng S.,Shanghai University of Traditional Chinese Medicine | Zheng S.,Basilea Pharmaceutica China Ltd. | Yu C.,Shanghai University of Traditional Chinese Medicine | Yu C.,Basilea Pharmaceutica China Ltd. | And 2 more authors.
Organic Letters | Year: 2012

A new Pd-catalyzed cyanation reaction has been discovered using ethyl cyanoacetate as the cyanating reagent. A variety of electron-rich and electron-deficient aryl halides were efficiently converted into their corresponding nitriles in good to excellent yields. © 2012 American Chemical Society.


Zheng S.-Y.,Shanghai University of Traditional Chinese Medicine | Shen Z.-W.,Shanghai University of Traditional Chinese Medicine | Shen Z.-W.,Basilea Pharmaceutica China Ltd.
Tetrahedron Letters | Year: 2010

The first total synthesis of hirtellanines A is described. The key transformations include (i) base-mediated regioselective pyran ring formation, (ii) one-pot sequential boronation and Suzuki-Miyaura cross-coupling, and (iii) a tandem acid-induced deprotection and subsequent tautomerizations. © 2010 Elsevier Ltd. All rights reserved.


Qing T.,Shanghai University of Traditional Chinese Medicine | Qingyao S.,Shanghai University of Traditional Chinese Medicine | Sheng Z.,Shanghai University of Traditional Chinese Medicine | Zhengwu S.,Shanghai University of Traditional Chinese Medicine | Zhengwu S.,Basilea Pharmaceutica China Ltd
Chinese Journal of Chromatography (Se Pu) | Year: 2010

A method of reversed-phase high performance liquid chromatography (RP-HPLC) using diode array detection (DAD) was developed for the quantitative determination of 3'-geranyl-5,7,4'-trihydroxyisoflavone (compound 1) and 8,9-dihydroxy-1-methoxy-[6',6'-dimethylpyrano(2',3':2,3)] pterocarpene (compound 2) in Campylotropis hirtella. The separation and quantification were achieved using an Agilent Zorbax SB-C18 column (250 mm ×4.6 mm ,5 μm) ,and mobile phases of acetonitrile and 0.1% formic acid with gradient elution at a flow rate of 1.0 mL/min and 30 °C. The calibration curves fo r compounds 1 and 2 were linear in the ranges of 4.4 - 13.2 μg and 0.428 - 1.284 μg,respectively. The recoveries were 99. 65% and 99. 11 % w ith the relative standard deviations of 1. 83% and 2. 59% ( n p5 ) ,respectively. This RP-HPLC-DAD method is rather s im p le , accurate and convenient. It can be used fo r the quantitative determination of the active flavonoids in Campylotropis hirtella ( Franch. ) Schindl.


Tan Q.,Shanghai University of Traditional Chinese Medicine | Zhang S.,Shanghai University of Traditional Chinese Medicine | Shen Z.,Shanghai University of Traditional Chinese Medicine | Shen Z.,Basilea Pharmaceutica China Ltd.
Planta Medica | Year: 2011

Eight new flavonoids, including three pterocarpene derivatives, hirtellanines CE, two flavanones, hirtellanines F and G, three isoflavanones, hirtellanines HJ, as well as four known compounds were isolated from the roots of Campylotropis hirtella. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques. Pharmacological investigation indicated that the new compounds, particularly hirtellanines D and G, possessed potent immunosuppressive activities and low relative cytotoxicities. © Georg Thieme Verlag KG Stuttgart · New York.

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